ActionXPotential
Junior Member
"Am a basic science researcher for the SCI field and motivated by an SCI sustained by my brother."
Last Activity: Today, 2:44 PM
Joined: 2 Jul 2021
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ActionXPotential replied to Any interest in having a group of scientists help explain the emerging literature?in CureSo it sounds like there is interest in understanding things being performed at the forefronts of clinical translation. i will arrange to talk about the story behind CSPGs and how/why these seem to have promise for both acute and chronic SCI (this is the focus of Nervgen). This work has been a long-time... -
ActionXPotential commented on Gearhead's to Any interest in having a group of scientists help explain the emerging literature?in CureThere is a fairly good degree of collaboration amongst SCI researchers (relative to other fields) but you are correct that we tend to keep our research ideas and directions protected out of concern for our own careers. Many of these walls are slowly being broken down in the research world. There are... -
ActionXPotential replied to Any interest in having a group of scientists help explain the emerging literature?in CureSo for those who expressed interest lets start trying to get a conversation going. What articles (news coverage or actual scientific paper) or general topic did you have in mind or would like help with interpretation.
Also I exist in Eastern Standard Time and could probably wrangle up the...Leave a comment:
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ActionXPotential replied to Any interest in having a group of scientists help explain the emerging literature?in CureSo im still going to wait a bit before moving forward with anything to see if others would be interested, then I will ask for recommendations of things to cover (such as a news reporting, original article, or overarching topic).
For now I did want to say that for those interested there...Leave a comment:
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ActionXPotential commented on sriv's to Any interest in having a group of scientists help explain the emerging literature?in CureI think that what you said is part of what we had in mind. Break down what they did, is it relevant to acute or chronic SCI, what things are being done to get stuff like this to people and/or what implications does it have to change the way things are being done, or will be done, in people. However... -
ActionXPotential started a topic Any interest in having a group of scientists help explain the emerging literature?in CureAny interest in having a group of scientists help explain the emerging literature?
Hello all,
The title pretty much explains it all. I have been browsing this care cure community as well as other social media platforms related to SCI and noticed that there may be demand for the scientists to help break down what is goin on in those papers, and help put things into perspective.... -
Perhaps I can help. In the lab where I work we are also working on this same project (slightly different focus). Actually seeing this here is quite a bummer for us because that means we got "scooped" after about 5 years of hard work (these authors published first).
Dont think...Last edited by ActionXPotential; 9 Jan 2022, 8:14 PM.Leave a comment:
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ActionXPotential commented on lunasicc42's to Scientists reverse paralysis in mice, seek human trialsin CureThis was one of the papers I was referencing yes. Its a good read. Thank you for providing a link. -
ActionXPotential commented on lunasicc42's to Scientists reverse paralysis in mice, seek human trialsin Cureyeah sorry about that, i think its just because the anti NoGo stuff has been off my radar for a while. For some reason i see this stuff as having overlapping effects similar to the PTPsigma/chondroitinase stuff. Essentially when it comes to axon growth and plasticity in the nervous system there are... -
ActionXPotential commented on FellowHawkeye's to Scientists reverse paralysis in mice, seek human trialsin Curei am not entirely familiar with the company. i looked at their website and didnt see any mention of clinical trials in SCI. Do you know of anything they dont have advertised up front? It looks like most of their products were designed to deliver viral vectors that replace proteins that are otherwise... -
typically its the other way. Mice are smaller and their injuries are less comparable to humans. Mice are used because they are easy to genetically manipulate, where-by actionable targets can be identified, strategies can be tested, then moved to rats. Many things that work in mice fail in rats because... -
ActionXPotential commented on ActionXPotential's to Scientists reverse paralysis in mice, seek human trialsin CureGooooood question. That same question can be asked about several treatment strategies applied in rodent models. Let me preface by saying that it was this very question that drove me to want to do SCI research about 12 years ago. I was in the hospital with my brother who had just had an SCI, and the...Last edited by ActionXPotential; 4 Jan 2022, 9:37 AM. -
I dont know the specifics of this study but in general there has been an emerging strategy to treat the glial scar with viral vectors that can produce a protein called Sox2, which helps to convert cells of different origins into new neurons. Sox2 is a protein called a transcription factor that regulates...Last edited by ActionXPotential; 3 Jan 2022, 9:32 PM.Leave a comment:
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