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Homologous Recombination

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  • Homologous Recombination

    This is a great explanation of one of the most important technological advances in molecular biology. It is responsible for most of the major of the genetic approaches that we are using in medicine today.

    Homologous recombination, also known as general recombination, is a type of genetic recombination that involves a genetic exchange between two similar or identical strands of DNA. Although most widely used in cells to accurately repair double-strand breaks in DNA, homologous recombination also produces new combinations of DNA sequences during chromosomal crossover in meiosis. These new combinations of DNA in turn produce genetic variation (e.g. new, possibly beneficial alleles) in populations as they reproduce, allowing them to evolutionarily adapt to environmental conditions over time.[1]

    The process of homologous recombination involves the alignment of similar (i.e. homologous) DNA sequences, formation of a Holliday junction, and breaking and repair, known as resolution, of the DNA to produce an exchange of material between the strands. Widely conserved among both prokaryotes and eukaryotes, homologous recombination is also used as a technique in molecular biology for introducing genetic changes into target organisms.

    <much more and worthwhile reading>

  • #2
    theoretically, we can detect people prone to cancer and genetically modify their own stem cells and put them back into the patient? in theory? could that happen?

    right now they're just suppressing genes in mice with esc's to see the effects but we could make people resistant to disease..........
    Last edited by jhope; 01-02-2009, 05:12 AM.
    Han: "We are all ready to win, just as we are born knowing only life. It is defeat that you must learn to prepare for"