No announcement yet.

Neurontin vs Pregabalin

  • Filter
  • Time
  • Show
Clear All
new posts

    Originally posted by luke00

    I have been taking 1200mg of Neurontin 3x daily for nearly 2 years and with little effect (I am taking a whole host of other pain killers to help it out). I realise that 1000mg x3 daily of Neurontin is the maximum recommended dosage.

    Pregabalin has just be introduced here in Australia and my pain team have been able to prescribe it for me privately. Instead of paying the normal $4 prescription fee, I pay either AU$85 for 56x75mg capsules or AU$120 for 56x150mg capsules. The doctors are fighting for it to be added to the PBS scheme

    In the meantime, not exactly cheap but if it works I will hand over the money with a smile on my face!

    As the drug is so new here the Pain Team were able to offer very little advice on common side effects other than the general ones associated with most medication... nausea, dizziness etc.

    Also, there is little information on how successful a change from Neurontin to Pregabalin will be.

    Finally, the question of dosage is still not exactly known. The pain team have said that any transfer should be on the conservative side and can be increased if needed. they have suggested initially dropping one dose of 1200mg and replacing it with 150mg of Pregabalin. If this works, drop another dose. It is anticipated that the Pregabalin is to be taken 2x daily, instead of 3.
    Pregabalin is supposedly 6-7 times stronger than Neurontin, which means that 150mg falls short of my current Neurontin dose. In saying that, Pregabalin is supposed to be more effective and therefore, in theory I shouldn't need an equivalent dose.

    If anyone can offer ANY advice I would REALLY appreciate it, especially anyone who has made the change from Neurontin to Pregabalin.

    You should try to check an online pharmacy site for drug interactions.


      [quote=luke00]Woooaaahhhh!!! Hang on a minute. We seem to have got side tracked from my initial question.

      Basically I have been taking Neurontin (Gabapentin to some of you) and I am about to change to Pregabalin (Lyrica to some of you).

      My point was not to start a discussion on the difference in brand names and generic names, although this might make an interesting thread of its own if anyone would like to start it.[End Quote]

      Luke- Hi. I think I found the answers you were looking for at:
      It looks like Lyrica is absorbed faster as well as in lower doses than the gabapentin (Neurontin). Two of my doctors (one work comp related) and one, my primary care physician have mentioned Lyrica to me now. I am thinking about it, but yes, I better check my insurance coverage unless Work Comp pays for it. I'm in the U.S. (CA).

      I suffer from undiagnosed fibromyalgia symptoms. The Work comp case is carpal tunnel and DeQuervain's tendonitis (thumb). Now I feel scapula, shoulder and neck pain. I have a bulging disk in my neck 2mm. I will get an epidural injection in 2 weeks, I believe to my neck. Anyone have experience with this?


        Pain Management with Neurontin and/or Lyrica

        I was on Neurontin for a short while but it made me so groggy I couldn't wake up until mid-afternoon. I was then switched to Lyrica (about a year and a half ago). Although I'm on a relatively low dose (75mg each night), I started having serious short-term memory problems. After more misplaced items than I could possibly count, missed appointments, forgotten phone messages, etc., I decided to get off the stuff. Unfortunately, I didn't consult my doctor and tried just quitting "cold turkey". Since then, I've had the most bizarre symptoms imaginable -- nausea, diarrhea, headaches, creepy-crawly sensations in my limbs, and worst of all, feeling like I want to jump out of my skin. Needless to say, I'm going back to my doc to help me get off the stuff permanently. I was taking these meds for sciatic nerve pain due to degenerative disk disease in my lower back. Frankly, I've done about as well in managing the pain with heat packs, Lidoderm patches, and a TENS unit. My advice is to be very wary of these meds -- they're bad news! And to the guy who is getting the epidural injections for his bulging disk, be aware that they only work for a few people. They didn't work for me and I don't know anybody else they worked for.


          Sorry to hear about your experience, Catslave. They definitely aren't for everyone, but there's a lot of people helped by each of them.


            Lyrica has saved my life. Currently I am on 225mgs and will be going up to a therapeutic somewhere in between 400-600mgs. I cannot begin to tell you how much better I feel. I have Fibromyalgia, Lupus, Osteoarthritis and Facet Joint arthritis along with neuroforaminal L4-L5 and L5-S1.

            I was on neurontin and it did nothing for me so I tapered off that and when first put on Lyrica I noticed the difference. I also take pain medication but it was the Lyrica that has helped me most. I need to write the makers and tell them they have come out with a wonder drug. I hope your question has been answered. From what my doc tells me the therapeutic dose is anywhere between 400-600mgs.


              my doc gave me lyrica for arthritis pain in spine and nerve going to my pinky
              we in horribe pain
              i took a pill as soon as i got home and within an hour the pain was gone
              take 75 twice daily
              no side effects
              i take no other meds
              sigpicLET A SMILE BE YOUR UMBRELLA


                Originally posted by alan
                Lyrica caused me gum and teeth pain the first time I tried it. I may try it again at some point, for lack of anything else.
                first time when i used lyrica i could not feel my tongue or to enjoy the taste of food [75 mg only] pain relief......damn meds and their side effects.
                i will never use it again.



                  I take 1400mg x 3 a day of gabapentin and I read that pregabalin is the successor of gabapentin and I was wondering is any of you have tried both and is there any difference between the two???


                    I went back and forth started with pregabalin, my dose got up to 600mg and it stoped working for me. switched to gabapeptin kept incresing the dose till i was at 3000mg, and I still felt nothing. the neurotin did not work for me, but i belive it really varries some do better on lyrica vs. neurotin. so now i switched back to lyrica trying not to increase dose past 300mg, mix that with lamotrigene 50mg, baclofen 30-60mg , and tramadol 200mg daily. I am pretty sure i have autonomic nutrient deficient nerupoathy or some thing like that,cant prove it(minus vit D low at 6 now 16-shooting for 60) and rockstar types just get kicked out of doctors offices anyway going to give my doctor 3 months more till i quit all these drugs, you know the switch kinda sucks, i get horable headaces but it takes my mind off the torture of feeling like i am burning alive, want to roll around on the ground-stop drop and roll, dash to the nearest sorce of water or ER. all the while this psycho mad scientist is injecting me with this ice-numbing octopus tentacle syringe that is ripping through my insides. but i am a fighter. my next step is telling these doctors to *&($% off. I am going to buy my own acupunture needles and learn to self electro puncture, move to a country where opiates are legal (I always stayed away from hard addiction drugs, now its like either do it right or black market it and i think i would rather live right and not become a junkie), get down to earth and try some radical ayahuasca treatments. and anything else i can this system is a joke, the only way i am gona make it through is if i heal myself. i wish you all the best, good luck


                      I know this is an old thread, but my neurologist DOES NOT recommend Lyrica,
                      Pfizer's "new brain child" because of the terrible side effects.
                      For those of you who are unschooled in generics, there is a small percentage of us who
                      cannot use generic brands of some drugs. It's in the binding - how the pill is
                      combined with gabapentin that makes the difference.
                      Last edited by gd828; 2 May 2010, 8:08 PM. Reason: misspelling and clarification



                        Originally posted by luke00 View Post
                        Woooaaahhhh!!! Hang on a minute. We seem to have got side tracked from my initial question.

                        Basically I have been taking Neurontin (Gabapentin to some of you) and I am about to change to Pregabalin (Lyrica to some of you).

                        My point was not to start a discussion on the difference in brand names and generic names, although this might make an interesting thread of its own if anyone would like to start it.

                        It is very new here in Australia and not fully licensed, hence being very expensive. This might also be the case in America, I am not sure.

                        As this website is world wide and not just for U.S. users, I am hoping that someone somewhere might have some information that they can offer on changing over and dosage etc (as per my original post ).

                        Lyrica ruined our lives. It killed my husbands libdo. It was like living with a vegetable. Almost three years later and he still has lasting side effects. I have called several pain specialists and have done a ton of research. Neither drug works for a lot of people. Lyrica came out when the patten for gabapentin had expired. Also look up gabapentin and the RICO act. Doctors really need to stay better informed.


                          part of the problem is many of the people in the usa that were getting relief with neurontin, when it was patent only, before the generics came out. When the generic came out they lost the releif. Also right around this time , lyrica came out , a new patent by pfeizzer .
                          personally i have had relief with neurontin, name brand, , and zero luck with Lyrica, It was a shame the pain managment doc i was seeing at the time beleive all the hype from the pharmicutucals sales people and the spinal stim salespeople and didnt listen to his patients.
                          the docs should hace a chart on the dose eqivalents changing fron neurontin to lyrica, they had it in app like form , this was before the iphone days, but it was like a dell axion or the other pre android devices. i am sure pfizzer has a link to a online one.
                          cauda equina


                            I was on gabapentin and asked if pain could cause me to lose my mind. Was told yes. Switched to Lyrcia, still have pain but not nearly as much. So I have to say it helped me.


                              I tried Lyrica for six days, I know they tell you to keep on it for 3 weeks, but by the sixth day I could not remember my own name, and I was becoming a babbling ideate, so it was time to quite. To bad because it was helping with the pain. Of course if this pain gets much worse, a babbling ideate might become the person to be. You all know the drill, the more pain, the more wiliness to live with side affects.
                              T12L1 Incomplete Still here This is the place to be 58 years old


                                I have to take SOMETHING for neuropathic pain. My physiatrist who specializes in pain management slowly reduced my neurontin as he equally slowly replaced it with lyrica. I don't like the foggy brain side effects, nor the fear of what they might discover in the future, but I have to take something & to the best of my research, this is the best they have right now for me. To take nothing and increase my pain would put me in a worse condition.

                                I have taken it for 5-6 years. Every so often I try to slowly reduce it and have found the minimum that I can handle which is 50 mg 3X/day. It has a short half life so I think 3X a day is best.

                                How is it going since your original question?
                                my website & blog