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Researchers discover a known neurotoxin may cause chronic pain in people who suffer from paralysis

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    Researchers discover a known neurotoxin may cause chronic pain in people who suffer from paralysis

    (Medical Xpress)—Researchers have discovered that a known neurotoxin may cause chronic pain in people who suffer from paralysis, and a drug that has been shown to remove the toxin might be used to treat the pain.

    The toxin, called acrolein, is produced in the body after nerve cells are injured, triggering a cascade of biochemical events thought to worsen the injury's severity. The drug hydralazine, which has been approved by the U.S. Food and Drug Administration for hypertension, has been shown to be effective in reducing acrolein levels in the body.
    New research shows hydralazine is effective in reducing chronic pain in laboratory animals and potentially in people who have suffered neurotrauma resulting in paralysis, said Riyi Shi (pronounced Ree Shee), a professor of neuroscience and biomedical engineering in Purdue's Department of Basic Medical Sciences, School of Veterinary Medicine, and Weldon School of Biomedical Engineering.
    "Beyond paralysis, chronic neuropathic pain drastically impairs the quality of life for spinal cord injury victims. " he said. "Pain can persist for decades post-injury, which could contribute to depression and suicide."
    The research is a collaboration between Purdue and the Indiana University School of Medicine. New findings are detailed in a research paper appearing this month in the Journal of Neurochemistry.
    Researchers studied the role acrolein plays in hypersensitivity to pain in laboratory rats and the effectiveness of hydralazine in reducing the pain.
    "It turns out that acrolein is a very important compound behind neuropathic pain," Shi said. "In a chronic pain situation, a stimulus that ordinarily might feel pleasant, even just a little touch, could cause pain."
    Findings show the quantity of acrolein increases after a spinal cord injury and may activate pain receptors - protein channels called TRPA1 - contained in pain-sensory nerve fibers of dorsal root ganglia located alongside the spine. Following spinal cord injury, the dorsal root ganglia could be affected biochemically or directly through physical trauma.
    "The amplification of pain can be exacerbated in spinal cord injury due to acrolein's direct activation of pain receptors, as well as acrolein-induced inflammation that further intensifies pain sensation," Shi said. "Sometimes you have pain even without stimulation. You can have excruciating pain just sitting there."
    Findings also indicate that injury causes a three-fold increase in the number of TRPA1 channels, which could further amplify pain caused by acrolein. The research showed hydralazine significantly reduces pain in experiments that measure a rat's reaction to stimulation.
    "Even if we delay administration of hydralazine we can still reduce the pain, meaning not only acute but chronic pain might be reduced by acrolein-scavenging treatment," Shi said. "This could be promising news for millions of spinal cord injury victims who may suffer from debilitating pain."
    Explore further: Testing method promising for spinal cord injuries, multiple sclerosis
    More information: Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat, Michael R. Due, Jonghyuck Park, Lingxing Zheng, Michael Walls, Yohance M. Allette, Fletcher A. White, and Riyi Shi, Journal of Neurochemistry, 2013.
    Growing evidence suggests that oxidative stress, as associated with spinal cord injury (SCI), may play a critical role in both neuroinflammation and neuropathic pain conditions. The production of the endogenous aldehyde acrolein, following lipid peroxidation during the inflammatory response, may contribute to peripheral sensitization and hyperreflexia following SCI via the TRPA1-dependent mechanism. Here we report that there are enhanced levels of acrolein and increased neuronal sensitivity to the aldehyde for at least 14 days after SCI. Concurrent with injury-induced increases in acrolein concentration, is an increased expression of TRPA1 in the lumbar (L3-L6) sensory ganglia. As proof of the potential pronociceptive role for acrolein, intrathecal injections of acrolein revealed enhanced sensitivity to both tactile and thermal stimuli for up to 10 days, supporting the compound's pro-nociceptive functionality. Treatment of SCI animals with the acrolein scavenger, hydralazine, produced moderate improvement in tactile responses as well as robust changes in thermal sensitivity for up to 49 days. Taken together, these data suggests that acrolein directly modulates SCI-associated pain behavior, making it a novel vietherapeutic target for preclinical and clinical SCI as an analgesic.

    Journal reference: Journal of Neurochemistry
    Provided by Purdue University

    I saw this too. I wonder if we could ask our doctors to prescribe it for us.....and I wonder what the dosage would be for just the pain. I would definitely be willing to try it!


      interesting article thanks for the information

      The SCI-Nurses are advanced practice nurses specializing in SCI/D care. They are available to answer questions, provide education, and make suggestions which you should always discuss with your physician/primary health care provider before implementing. Medical diagnosis is not provided, nor do the SCI-Nurses provide nursing or medical care through their responses on the CareCure forums.


        Dr Shi mentioned acrolein during his talk at this year's W2W. He didn't say anything about an upcoming publication. All that chasing down this toxin for nothing. OK, actually I learned a lot from that word chase. This is great news!
        Courage doesn't always roar. Sometimes courage is the quiet voice at the end of the day saying, "I will try again tomorrow."

        Disclaimer: Answers, suggestions, and/or comments do not constitute medical advice expressed or implied and are based solely on my experiences as a SCI patient. Please consult your attending physician for medical advise and treatment. In the event of a medical emergency please call 911.


          Unfortunately my other debilitating issue is low blood pressure. Seems a medicine that helps in reducing BP would suck for me...of course!

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            I looked up the med and it has a lot of severe side effects.