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  • Neurontin and Lyrica are a Death Sentence

    http://www.wellnessresources.com/freedom/articles/neurontin_and_lyrica_are_a_death_sentence_for_new_ brain_synapses/?fb_action_ids=509767192448402&fb_action_types=og. likes&fb_source=other_multiline&action_object_map= {%22509767192448402%22%3A10150101794448536}&action _type_map={%22509767192448402%22%3A%22og.likes%22} &action_ref_map=

    Wednesday, October 14, 2009
    Byron J. Richards,
    Board Certified Clinical Nutritionist
    Print E-mail





    Neurontin and its newer more potent version, Lyrica, are widely used for off-label indications that are an outright flagrant danger to the public. These blockbuster drugs were approved for use even though the FDA had no idea what they actually did in the brain. A shocking new study shows that they block the formation of new brain synapses1, drastically reducing the potential for rejuvenating brain plasticity – meaning that these drugs will cause brain decline faster than any substance known to mankind.
    The problem of these drugs is compounded by their flagrant illegal marketing. Neurontin was approved by the FDA for epilepsy back in 1994. The drug underwent massive illegal off-label promotion that cost Warner-Lambert 430 million dollars (the very first big fine for off-label promotion). The drug is now owned by Pfizer. Pfizer also owns Lyrica, a super-potent version of Neurontin. It has been approved by the FDA for various types of pain and fibromyalgia. Lyrica is one of four drugs which a subsidiary of Pfizer illegally marketed, resulting in a $2.3 billion settlement against Pfizer.
    Even though the marketing of these drugs has been heavily fined, they continue to rack up billions in sales from the off-label uses. Doctors use them for all manner of nerve issues because they are good at suppressing symptoms. However, such uses can no longer be justified because the actual mechanism of the drugs is finally understood and they are creating a significant long-term reduction in nerve health.
    The researchers in the above study try to downplay the serious nature of the drugs by saying “adult neurons don’t form many new synapses.” That is simply not true. The new science is showing that brain health during aging relies on the formation of new synapses. Even these researchers managed to question the common use of these medications in pregnant women. How is a fetus supposed to make new nerve cells when the mother is taking a drug that blocks them?
    These are the kind of situations the FDA should be all over. As usual, the FDA is sitting around pondering a suicide warning for Lyrica while its off-label uses include bi-polar disorder and migraine headaches. The FDA is likely to twiddle its thumbs for the next decade on the brain damage issue. Consumer beware.

    Wish I didn't know now what I didn't know then.
    Bob Seger

  • #2
    None of us are getting out alive. Life is a death sentence. Tvot - may I ask you if you have been on these meds? Do you have neuropathic pain? What do you use, if anything, to help?...

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    • #3
      We might as well just shut down the FDA. This is incredible!
      ____________________

      "We are the ones we've been waiting for. We are the change that we seek."
      - Barack Obama

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      • #4
        Originally posted by tvot
        The FDA is likely to twiddle its thumbs for the next decade on the brain damage issue. Consumer beware.
        Maybe the cause of dementia and alzhiemers(sp) is within our medication industry.
        ____________________

        "We are the ones we've been waiting for. We are the change that we seek."
        - Barack Obama

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        • #5
          OMG. Must be true 'cause the bro is a "Board Certified Clinical Nutritionist" and all. I know because I'm actually a group approved forum commentator.
          ______
          Awe at my magnificent coq!

          "You may say I'm a dreamer
          but I'm not" - J. Lennon

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          • #6
            Originally posted by eks
            OMG. Must be true 'cause the bro is a "Board Certified Clinical Nutritionist" and all. I know because I'm actually a group approved forum commentator.
            I think it's true. Below is a small part of a research paper published in 2010. It's written in medical terms, but the following snipet is fairly understandable.

            FYI - - α2δ-1 is the high affinity receptor for two commonly prescribed anti-epileptic, anti-neuropathic pain medications gabapentin (GBP, Neurontin) and pregabalin (Lyrica)

            A recent study using a knock-in mouse that expresses a mutant α2δ-1 which cannot bind GBP or pregabalin has shown that α2δ-1 is the in vivo target for these drugs, and that these drugs mediate their therapeutic action through binding to α2δ-1 (Field et al., 2006). GBP or pregabalin do not affect the single channel kinetics of calcium channels and has only modest effects on neurotransmission (Dooley et al., 2007). Thus the cellular mechanisms underlying the mode of action of these drugs are unclear.

            In this study, we show that EGF-like domains of TSP directly bind to α2δ-1 and mediate its synapse-inducing activity via this receptor. These findings identify α2δ–1 as a neuronal TSP receptor that is required for CNS synapse formation. This function of α2δ-1 is independent of calcium channel function. We also show that GBP is a potent inhibitor of TSP/astrocyte-induced excitatory synapse formation in vitro and in vivo. This function of GBP may be a central part of its mechanism of action. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791798
            ____________________

            "We are the ones we've been waiting for. We are the change that we seek."
            - Barack Obama

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            • #7
              My mom has one or the other in very late stage form and never took any drugs. It's horrible. Since I take the max dose of Lyrica and it helps me a lot, I'll be thinking hard about these studies while I can still think.....
              2012 SCINetUSA Clinical Trial Support Squad Member
              Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature.

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              • #8
                And yet pot is illegal in most of the country because… It is more harmful than prescription drugs? BS.

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                • #9
                  i would happily take a slow acting terminal poison to be pain free for a while

                  ket

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                  • #10
                    that article sure is filled with hyperbole - the most hyperbole that has ever been written in history of man ( I am trying to write like that). I wonder if this Clinical Nutritionist has neuropathic pain and has tried these meds. I am amazed that I have been on them for 12 years and can still wake up, get out of bed, and do medical consulting if these drugs cause brain decline faster than any substance know to mankind. Maybe I started with a lot of neurons and connections to begin with.

                    I am just having fun. It is a serious matter, I think it is valid that we don't know how these central acting drugs really work and we spread them around like candy, I can tell you this about me- if you take Lyrica away - I could not make it though the morning. Thank you Pfizer - could you just lower the cost of the med -
                    Has anyone purdhased it over the internet from Canada or India and felt they got the right product and it worked? I have been reluctant to do this with this med.

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                    • #11
                      I think a good question to figure out, is why some people can take lyrica like candy, and others can't take it at all. What is the acceptable side affect profile on any given drug. I was on a drug for my paralyze stomach, and when I looked up the studies done on the drug, 15 present could not take it at all and another 15 percent had to quite taking it after a few days, but this was considered acceptable. Fortunately there is a drug that does the same thing without the side affects but is not USDA approved in the USA. I wonder what percent of people who tried Lyrica had unacceptable side affects?
                      I know I sure wish I could tolerate the stuff, this pain is the pits.
                      T12L1 Incomplete Still here This is the place to be 58 years old

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                      • #12
                        I've been taking gabapentin [2700 mg/day] for 8 yrs. Not only am I still here but I can honestly "blame" the fact that I am on the gaba.
                        Rick Goldstein
                        GO! Mobility Solutions
                        facebook.com/goes.anywhere

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                        • #13
                          Originally posted by arndog
                          Has anyone purdhased it over the internet from Canada or India and felt they got the right product and it worked? I have been reluctant to do this with this med.[/I]
                          I think you are smart to be nervous about it.

                          ____________________

                          "We are the ones we've been waiting for. We are the change that we seek."
                          - Barack Obama

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                          • #14
                            I took it for four days and had several "blackouts" where I kept functioning and others had no clue I was "gone". I didn't realize it either. Around he 4th day I started speaking gibberish. Luckily, Bill knew it was the only thing I'd changed so, he took it away. It took me about a week to come around to 'normal'. The first few days after quiting, I'd "wake up" doing something weird. Once, I discovered myself just pulling my clothes out of a dresser drawer and piling them on the bed.
                            ____________________

                            "We are the ones we've been waiting for. We are the change that we seek."
                            - Barack Obama

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                            • #15
                              Been on 'em for 10 years, and I'm still the smartest person I know

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