Announcement

Collapse
No announcement yet.

DPLA - Natural Pain Killing Power

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

    #16
    Thanks for letting us know, Christopher, and thanks for volunteering to be the "guinea pig" (yet again). Looking forward to your report, hoping for positive results, understanding that that will require your pain level increase for a certain period of time. Dig in, all the best.
    Last edited by quadvet; 10 Jul 2008, 9:28 PM.
    get busy living or get busy dying

    Comment


      #17
      I've tried to cut back and the pain just returns. No less than 1500mg/day for me.
      Paralyze resistance with persistence.
      T-12

      Comment


        #18
        Cl~
        My wife lives with level 8 daily. C1-incomplete. She has pins and needles with burning sensation from her waist to her toes. Going to doctor tomorrow and will ask her opinion on DPLA.
        Bry

        Comment


          #19
          Did the fatigue continue? Any other side effects noted or reported in literature?
          Foolish

          "We have met the enemy and he is us."-POGO.

          "I have great faith in fools; self-confidence my friends call it."~Edgar Allan Poe

          "Dream big, you might never wake up!"- Snoop Dogg

          Comment


            #20
            I don't see why this would have conflict with any medications because it's a natural occurring amino acid.

            Fatigue is gone.

            http://www.lef.org/protocols/health_...ic_pain_01.htm
            Phenylalanine and Pain

            Phenylalanine is an essential amino acid found in milk and meat (Mahan LK et al 1996). It was first tested to treat pain in a 1978 study. Researchers discovered that injecting phenylalanine intraperitoneally (into the peritoneal cavity of the abdomen) blocked pain in 70 percent of mice subjected to painful stimuli. The pain-blocking action actually grew stronger with time (Ehrenpreis S 1978). Scientists later tested the pain-blocking capacity of phenylalanine on 10 patients who had chronic pain that did not respond to treatment. All patients found pain relief with this simple amino acid (Ehrenpreis S 1978). There were no harmful side effects, and no one became addicted (Ehrenpreis S 1978).

            Phenylalanine does not work as rapidly as aspirin and other pain medications (Balagot RC et al. 1983). This is because phenylalanine helps relieve pain by increasing the body's supply of endorphins rather than by attacking pain directly (Kitade T et al 1990; Russell AL et al 2000). In animals, DL-phenylalanine has been shown to block the activity of carboxypeptidase, an enzyme that degrades enkephalins, endogenous morphine-like substances. DL-phenylalanine administered orally before acupuncture prolonged the pain relief induced by acupuncture. In 56 patients, tooth extraction was performed while the patients were under acupuncture anesthesia. In addition to the acupuncture, 18 of the 56 patients also received 4 grams of DL-phenylalanine orally 30 minutes before the extractions. The pain-relieving capacity was excellent in eight of the patients, good in six of them, fair in three, and poor in one. The patients who had excellent and good pain relief were compared to 38 patients who received a placebo. The effect in the patients who received DL-phenylalanine in addition to acupuncture was significantly increased (P ‹.01) by 35 percent (Kitade T et al 1990).

            Some people cannot use phenylalanine. These include those who have a genetic deficiency called phenylketonuria (which prevents the body from metabolizing phenylalanine), people who have high blood pressure (phenylalanine can further elevate blood pressure in people who already have high blood pressure), and those who have cancer (phenylalanine can promote the division of cancer cells) (Guyton AC et al 2001; Mahan LK et al 1996).

            Comment


              #21
              Started up on the DPLA again yesterday. (only made it 6 days w/out )

              Didn't see the need to be so miserable all the time. I think it is just starting to cool down the blazing fire a bit and the Steam Roller is now in reverse in my arm/hand.

              It's amazing how easily I always forget how damn nasty and life consuming this neuro-pain is until it's eating your soul away again.

              I recommend people giving this a try if they can. I take 1000mg on an empty stomach (which causes a bit of discomfort for 10-20 min.) 2X a day

              Comment


                #22
                DLPA ? I'll have to try it, I take very little meds any more, but,,,,,,,, MY LEGS ARE ON FIRE all the time, it's probably a good sign. But I could sure use a little fixin. I don't like Pharm's this could be a "good thing"

                Comment


                  #23
                  cljanney

                  what brand do you use, and were do you get it, and how much do you pay for it?
                  This sounds like what I have been looking for


                  Thanks
                  Stevie P

                  Comment


                    #24
                    Originally posted by StevieP
                    cljanney

                    what brand do you use, and were do you get it, and how much do you pay for it?
                    This sounds like what I have been looking for


                    Thanks
                    Stevie P
                    Hey Steve,

                    I was recommended by someone else having success using DLPA to use the "Country Life" 1000mg with B-6 capsules. B-6 assists with the DLPA being ingested and should be taken on an empty stomach.

                    I get it from amazon.com

                    Good Luck,
                    Christopher

                    Comment


                      #25
                      This article came up on a quick search about DPLA. I've underlined a bit of the important information for those that don't want to wade through the mass.

                      Judge for your self....



                      http://www.afpafitness.com/articles/...-chronic-pain/
                      ================================================== ====
                      DLPA: Natural Relief for Chronic Pain

                      By Ritchi Morris, Ph.D., H.M.D., D.N., R.H.

                      Professional Member AANC

                      There is a plethora of clinical and research datasubstantiating the extraordinary therapeutic efficacy of DLPA.

                      Abstract

                      In this day and age the incidence of severe acute and chronic pain has been burgeoning progressively. This trend has spanned a multi-million dollar industry of pain control surgical procedures and chemical pain suppressors. Unfortunately, these approaches have not been without debilitating side effects of their own. This experience has motivated health professionals, pain treatment clinics, homeopaths, and naturopaths to seek more natural, less damaging alternatives.

                      Mother Nature has provided such an alternative:

                      DL-phenylalanine. Recent empirical studies have documented the efficacy of utilizing this essential amino acid for the control of such chronic and/or acute pain syndromes as lower lumbar back pain, joint pains resulting from rheumatoid arthritis, osteoarthritis, and other usage stresses; migraines; severe premenstrual spasms; neuritis; neuralgia; and postoperative conditions.

                      Thus, scientific research has demonstrated that relief from the above pain syndromes is available without the necessity of taking any radical measures, simply by supplementing one’s present diet with this spectacular combined form of phenylalanine.

                      What are amino acids?

                      One of the most important "essential" amino acids is phenylalanine. Amino acids form the very foundation upon which all the other parts of our bodies rest. For without these "building blocks" the other vital substances (e.g. protein) cannot be processed. These organic acids contain amines that are connected together in specific chains to form polypeptides and proteins. But even amino acids are accountable to a more basic substance: DNA (deoxyribonucleic acid.) DNA contains the "biological blueprints" that delineate the specific ways that the body is built and repaired.

                      These blueprints specify the variety of ways the body can interact with the environment.

                      The "messenger service" for the DNA is RNA (ribonucleic acid) which carries out instructions for the formation of polypeptides and proteins. Here the essential amino acids are constructed into chains in order to implement the chemical messages in our blood/body system. There are 26 common amino acids and eight "essential" ones. These eight are called "essential" because they cannot be synthesized by our bodies and, therefore, we must ingest them either nutritionally or via supplementation.

                      There are three forms of phenylalanine: L; D; and DL. The L form is the most commonly occurring type. The brain utilizes this substance as a precursor to produce norepinephrine (NE). It helps one’s brain restore the depleted stores of NE. For it is well known that stress and overwork tax one’s "brain-well" of NE levels thus leaving one feeling mentally "drained." With the conversion of phenylalanine and another amino acid (tyrosine), vital to this process, the brain’s well of NE can be refilled. As Durk Pearson/Sandy Shaw explain, "You can literally refill the storage pouches on your nerves by using - phenylalanine. Large amounts of vitamin C and B6 are required for the conversion of phenylalanine and tyrosine to NE.(1)

                      The D-Form derives its name from the fact that the NH2 particle occurs to the right of the carbon particle in this phenyl molecule. Hence, the D stands for "dextro" or right-handed seat, rendering this molecule a mirror-image of the L Form.

                      The most abundant sources for the D-Form are bacteria and plant tissue. Eventually, this D-Form becomes an L-Form as the human system converts it slowly before it can be assimilated and utilized for its identified bodily functions. (2)

                      The third or DL-Form is obviously a combination of the two forms above. Not until very recently has much been known or investigated about this form. However, since phenylalanine exists in all protein that we consume, our metabolic and digestive systems are designed organically to absorb and utilize this form and its by-products without difficulty just as easily as they absorb the separate L- and D- forms.

                      Until recently, the only major avenue explored for DLPA has been that of weight control. It seems that research by Nobel prize winner Rosalyn Yalow (3) yielded the fact that there is a brain hormone, cholecystokinin (C.C.K.) which seems to control satiation. It was further discovered by Dr. J. Gibbs (4) that this "saity signal" can be modulated by the L- and DL-Forms. Fortunately, with the furor over weight problems and fad dieting in this hemisphere, a dearth of experimentation occurred. From this, the role of DLPA in retarding the breakdown of endorphins and enkephalines (the brain’s natural pain killers and anesthetics) was unearthed.

                      Furthermore, research has shown that the nutritional value of DLPA rivals that of the L- and D-Forms. In this sense, the toxicity is very low - comparable to that of the complex carbohydrates (sugars occurring in raw fruits and vegetables.) Indeed, Rose, et al. demonstrated that DLPA can be substituted in the human diet for the L-Form without any adverse effects on health. Parenthetically, Rose (5) determined that the daily requirements for each are the same - 2.2 gm./day. Also, it has been shown that DLPA is very non-acidic. For example, it is approximately 1/10th as acidic as ascorbic acid (Vitamin C.)

                      The purpose of D-L Phenylalanine

                      Finally, in the last decade, specific values for DLPA have been identified. After years of private research, perhaps the foremost authority on DLPA, Dr. Seymour Ehrenpreis, presented his findings to the Second World Congress on Pain.(6) Dr. Ehrenpreis et al. declared that, at least good, if not excellent relief from pain was observed in every patient using DLPA.

                      Further documentation of the powerful analgesic capabilities of DLPA were furnished by a 1979 study at the University of Chicago again conducted by Dr. Ehrenpreis (13) In treating various arthritic conditions with average doses of 375 mg. daily, highly significant results were obtained; better than 75 percent of the chronic pain patients experienced good to complete relief within a period of one week to one month. It was also discovered that the DL-Form actually supplants com-pletely the L-Form in the body and nourishes it better than does the L-Form.

                      We have enjoyed marked success with many patients who had already sought most every medical treatment known - to no avail. The most extreme case of this where I succeeded has been with a 37-year old Viet Nam vet who had been suffering for eight years with crippling pain in his back, neck and extremities. He had sought help from hospitals and doctors (veterans and civilian) and clinics specializing in joint diseases here and in other countries.

                      The most essential feature of DLPA (aside from its pain- relieving qualities, of course) is that DLPA accomplishes the same as or even better amount of pain-relief than these synthetic invasions of the body, but via natural, non-invasive means.

                      The function of D-L Phenylalanine


                      All forms of phenylalanine are intimately associated with several different brain functions. One major link is with the pain relief systems of human (and in mammals in general.) Empirical research has identified such a self-contained system complete with signal activators, response hormones and neuronal sensation relief. When signals of pain (e.g. injury, duress, chronic) from a particular sector of the body reach the brain, the dorphin hormones are released and directed to the given point of trauma.

                      It appears that man-made pain killers such as morphine, Demerol and Codeine mimic this endorphin substance in that a loss of pain sensation results from saturation with it. The anesthetic power of this endorphine system extends into the realm of chronic pain as well. Further research in the late 1970’s by the Ehrenpreis group demonstrated that inflammatory conditions such as rheumatoid arthritis, osteoarthritis, neuralgia and/or degenerative conditions such as spinal disc damage, body joints, and postoperative pain could be effectively relieved by treatment with endorphine substance. (14)

                      However, this natural substance pain-relief system does not function without some complications. It has been determined that certain enzymes in the body serve to destroy the endorphins before they reach the particular traumatized areas. It seems that MAO-based enzymes such as carboxypeptidase "A" and "enkephalinase" tend to void the action of endorphins upon contact "pac-man" style. This quandary was averted initially by injecting these endorphins. However, this presented several serious side effects (to be discussed below.)

                      Recent efforts to solve this dilemma fostered experimentation with various substances known to negate or neutralize MAO and other such enzymes. It was discovered that combining the L- and D-Form of phenylalanine brought about the desired effects upon these enzymes. In effect, the DLPA acts like a downfield blocker in football. It places a "bodyblock" on these enzymes which impedes their contact with the passing endorphins, thereby enabling the endorphins to reach their designated areas of trauma.

                      The latest interest of the Ehrenpreis Croup (15) demonstrated that the blood of chronic pain sufferers displayed significantly lower degrees of endorphin activity. This was also true for their cerebrospinal fluid levels. Administration of DLPA to these subjects resulted in a rapid normalization of these levels. Herein seems to lie the crux of DLPA’s amazing analgesic power on sources of chronic pain.

                      DLPA seems to focus on chronic pain only. Studies demonstrate that DLPA does not interfere with or mask the triggering system in the brain for acute, short-term pain (e.g.: lacerations, broken bones, sprains, etc.) while dissolving chronic pain so well. Therefore, DLPA displays a selectivity for the nagging, long-term pains while functioning in tandem with the body’s short-term acute pain system. Furthermore, DLPA plays the crucial role of protecting the brain’s own natural analgesic hormone-endorphin - thus enabling the endorphins to complete their analgesic mission and do so more effectively for a much longer period than that of the pharmaceuticals.

                      What are the "appropriate" dosages?


                      It must be emphasized that the "appropriate" dosages for each individual is contingent upon a constellation of factors: body weight; height; duration; frequency of occurrences of the pain syndrome; metabolic type; and age. Also, there are mental and emotional factors that must be considered. For instance, whenever an individual experiences pain, especially of a chronic nature, a "negative feedback cycle" tends to develop. That is, the individual begins to experience anticipatory anxieties or becomes "fear-conditioned" with the onset of the particular pain symptoms or even the mere hint of them. Thus, it is difficult to calculate just what percentage of pain is truly physical and which is mental (expectations) after one has endured chronic, recurrent pain for a while. Hence, I always recommend the "cross-ties" approach at this point: consulting a medical doctor (ortho, neuro, osteo) a homeopath, and a chiropractor in order to cross-reference their diagnoses and recommendations and sift out the common denominators. But, most importantly, one must not delay in seeking these examinations if one has reached this point without relief from consuming DLPA.

                      All available studies and clinical reports reveal that approximately 85 to 100 percent of the individuals who utilize a DLPA regime properly achieve the relief desired. However, DLPA is not a miracle cure and not every case can be helped. Relief is usually forthcoming within the first week. In most cases, the dosage can be reduced progressively by 500 mg./day every three days until the minimum appropriate dosage for the given individual is established. Once this level is found, it should be taken throughout the day - not in one mega dose.

                      A last benefit of the use of DLPA is that it can be taken concomitantly with any other prescription pain relievers. It has been demonstrated that such common chemical analgesics like Motrin, Butasolidan, Nalfon and Indocin function quite compatibly with DLPA. Indeed, the majority of clinical reports reveal a much more effective net effect when both are used together than when either is taken alone. Moreover, when DLPA is taken along with aspirin-based formulas
                      (approximately 3-6 tablets a day) this seems to be the most effective regimen.

                      As with all substances, there are cautions for the use of DLPA. Host importantly, the proper dosage must be followed strictly. All recent studies confirm that the most effective results are gained by such careful adherence. Secondly, DLPA is not to be taken by pregnant persons or those who are allergic to it (phenylketonurics). Thirdly, people with circulatory problems or hypertension should be careful to take DLPA after meals only. Lastly, this is not a miracle cure and professional help should be sought if no relief is attained as outlined above.




                      DLPA - Administration & Dosage Schedule

                      * Form Capsule or tablet
                      * Strengths 350 or 500 mg
                      * Initial Dosage Up to 2,000 mg/day
                      * Phase 1 First 2 weeks
                      * Phase 2 3,500 mg/day - Weeks 3-6
                      * Phase 3 (if necessary) 4,500 mg/day - Weeks 7-10
                      * Ideal level for maintenance: Reduce by 500 mg/day until the discomfort slightly disappears
                      * Consumption Rate 2-3 times throughout the day. Never in one large dose!
                      * Consumption Method 15 minutes before or 1 hour after meals and at bedtime on an empty stomach!
                      * Cautions Stop at 4,500 mg - more is not better
                      * Always take amino acids on an empty stomach to maximize absorption



                      If no noticeable relief is detected within 3-4 weeks, continue to increase dosage to a maximum of 4,500 mg/day but, after 2 weeks at this level, consult a healing arts professional.




                      References

                      1. Pearson, D. and Shaw, S. Life Extensions–A Practical Scientific Approach. Warner Books, N.Y.C., N.Y., pp. 185-186.
                      2. Ibid. Pearson and Shaw, p. 130.
                      3. Nutrition News, "DLPA in the Nutritional Control of Arthritis and Chronic Pain," Pomona, Cal., 1983.
                      4. Yalow, R. "Nobelist Ties Gut Hormone to Appetite Control by Brain Medical World News, Feb. 5, 1979, p. 18.
                      5. Smith, Gibbs, Young, "Cholecystokinin and Intestinal Satiety in the Rat," Fed. Proc. 33(5): May, 1974, pp. 11-46-49.
                      6. Pert, C. "Oplole Antagonist Counters Obesity," Science News, Feb. 14, 1981.
                      7. Atone, I., "Clonidine HCL Reduces Heroin Withdrawal Symptoms," J. Amer. Med. Assoc., 243(3): Jan. 25, 1980, p. 343.
                      8. Rose, W.C., "Amino Acid Requirements of Man," Nutrition Reviews, Vol. 34(10), 1967, pp. 307-309.
                      9. Ehrenpreis, S., Balagot, R.C., Myles, S. Advocate, C. and Comaty, J.E:, "Further Studies on the Analgesic Activity of D-Phenylalanine in Mice and Humans," Procedures of the International Narcotic Research Club Convention, E. Leong Way (ed.) 1979, pp. 379-382.
                      10. Budd, K. "Use of D-Phenylalanine, and Enkephalinase Inhibitor in the of Intractable Pain," Advances in Pain Research and Therapy J.J. Bonica et al. (ed.), Vol. 5, Raven Press, N.Y., 1983,289-293.
                      11. Bagalot,R.C. et al. Advances in Pain Research and Therapy, J.J. Bonics, et al. (edits). Vol. 5, Raven Press, N.Y., 1983.
                      12. 12K Myles, S.B. , et al. , "Naloxone Reversible Analgesia in Mice Pr~ducedby D-Phenylalanine and Hydrocinnamic Acid, Inhibitors of Carboxypeptidose A." In Advances in Pain Research and Therapy. J.J. Bonica, et al. (edits). Vol. 5, Raven Press, N.Y., 1983, pp. 479-488.
                      13. Op. Clt., Ehrenpreis, et al., 1979, pp. 379-382.
                      14. Ibid, Ehrenpreis, et al:,1978, 1979.
                      15. Ibid, Ehrenpreis, et al:,1978, 1979.

                      Comment


                        #26
                        clj

                        Have you yourself used DLPA. How would you rate it so far as its effects on you?

                        Comment


                          #27
                          Originally posted by dejerine
                          clj

                          Have you yourself used DLPA. How would you rate it so far as its effects on you?
                          Yes I have... read earlier posts in this thread.

                          Comment


                            #28
                            Has anyone else tried this stuff?!

                            I swear by it now.

                            I've had so many times when I've missed a dosage or two and the burning/searing reminds me I've forgotten.
                            I'm actually amazed at its effectiveness.

                            Comment


                              #29
                              Originally posted by cljanney
                              Has anyone else tried this stuff?!

                              I swear by it now.

                              I've had so many times when I've missed a dosage or two and the burning/searing reminds me I've forgotten.
                              I'm actually amazed at its effectiveness.
                              I second the above. If I miss more than two dosages the pain will return and I will pay the price.

                              Good stuff recommend it - http://www.vitacost.com/NSI-DL-Phenylalanine

                              Best $20 you can spend.
                              Paralyze resistance with persistence.
                              T-12

                              Comment


                                #30
                                Is this the same as the one you're taking ? I don't want to order the wrong stuff ... so please provide an amazon link if you can ...

                                What kind of pain meds were you using before ? do you take any pain meds alongside the DLPA ?

                                Thanks a lot cljanney, I'm willing to give this a try and I hope it will work.

                                Neo

                                Comment

                                Working...
                                X