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    Originally posted by lynnifer View Post
    Yes a former boss used to sing that to me all the time.

    I'm Canadian. We have our corrupt Rick Hansen evil corp here.
    Hi Lynnifer,

    Sorry, I forgot you were from Canada. In the US the federal government is nearly immune to public opinion. However many cities and states have ballot initiatives that can be started by citizens. Represent Us has a plan to clean up politics, and it is actually working. Perhaps a similar thing could be done in Canada. It may be worthwhile to investigate the local laws. If this is allowed, one could coordinate with Represent Us to actually fix the system.

    The problem:
    https://youtu.be/5tu32CCA_Ig

    The solution:
    https://youtu.be/qXsf3ICgy50

    In the UK they have a law that if a citizen-initiated petition gains 100,000 signatures within 6 months, Parliament must consider it. If it reaches 200,000 signatures, Parliament must debate it on the floor. Recently they started a petition to ban Donald Trump from entering the country. There is a precedent for that, as the UK has already banned specific individuals from entering due to their use of hate speech to incite violence. The petition to ban Donald Trump has received the highest number of signatures in history, exceeding 500,000 in less than a month.

    Surely there is something similar that could work in Canada...

    Jennifer Juniper, hair of golden flax
    Jennifer Juniper longs for what she lacks
    Do you like her? Yes, I do, sir
    Would you love her? Yes, I would, sir
    Whatcha doing Jennifer, my love?

    Comment


      Originally posted by paolocipolla View Post
      Thanks for the link, I have watched it carefully few weeks ago. If I got things right patients didn't show any recovery so far. I predict patients will never show significant recovery.

      Time will tell.
      I doubt anybody expects significant recovery in these 4 people from the small sample size dose given to them in the Phase 1 safety trial.
      http://spinalcordresearchandadvocacy.wordpress.com/

      Comment


        Just let this thread die. Dude was a fraud n nothin else. Time and money had definitely shown that.

        Comment


          Originally posted by GRAMMY View Post
          I doubt anybody expects significant recovery in these 4 people from the small sample size dose given to them in the Phase 1 safety trial.
          I am rather sure they got the highest safety dose used in ALS patients. Do you know is they are planning to do more patients with a higher number of cells?
          In God we trust; all others bring data. - Edwards Deming

          Comment


            Originally posted by paolocipolla View Post
            If I got things right patients didn't show any recovery so far. I predict patients will never show significant recovery.
            No, you got it wrong, they did show positive results. A few weeks ago the company announced their intentions to start into their Phase 3 this coming summer due to data from Phase 2. (The protocol for the future upcoming ALS trial has not been made public). http://investor.neuralstem.com/2015-...e-II-ALS-Trial

            The 'cervical' trial got 8 million cells in 20 bilateral injections. (They do believe through individual muscle group measurements they may now be able to differentiate the responders from the non-responders). In the 'cervical and lumbar' combination patients they did 16 million cells in 40 injections. For ALS they are transplanting NSI-566 cells directly into specific segments of the cord where the cells integrate into the host motor neurons.

            So far, these NSI-566 cells have been safely administered to 40 patients, in dosing ranges of 1.2 million to 24 million cells per patient, in four investigational safety trials.

            http://investor.neuralstem.com/2016-...rld-Conference

            However, if implanting 40 patients in Ph.1/2 safety trials with neural stem cells is already being deemed a failure, it would be no surprise that some have embraced exoskeletons and various implant devices with such unprecedented gusto instead of interest in biological type cures. . .

            The cells have been tested in rats and mini-pig in spite of what you are telling people.

            Last edited by GRAMMY; 24 Feb 2016, 12:58 AM.
            http://spinalcordresearchandadvocacy.wordpress.com/

            Comment


              Originally posted by GRAMMY View Post
              No, you got it wrong, they did show positive results. A few weeks ago the company announced their intentions to start into their Phase 3 this coming summer due to data from Phase 2. (The protocol for the future upcoming ALS trial has not been made public). http://investor.neuralstem.com/2015-...e-II-ALS-Trial

              The 'cervical' trial got 8 million cells in 20 bilateral injections. (They do believe through individual muscle group measurements they may now be able to differentiate the responders from the non-responders). In the 'cervical and lumbar' combination patients they did 16 million cells in 40 injections. For ALS they are transplanting NSI-566 cells directly into specific segments of the cord where the cells integrate into the host motor neurons.

              So far, these NSI-566 cells have been safely administered to 40 patients, in dosing ranges of 1.2 million to 24 million cells per patient, in four investigational safety trials.

              http://investor.neuralstem.com/2016-...rld-Conference

              However, if implanting 40 patients in Ph.1/2 safety trials with neural stem cells is already being deemed a failure, it would be no surprise that some have embraced exoskeletons and various implant devices with such unprecedented gusto instead of interest in biological type cures. . .
              If you read back my posts you can see I was talking about SCI, not ALS.
              In God we trust; all others bring data. - Edwards Deming

              Comment


                Originally posted by paolocipolla View Post
                If you read back my posts you can see I was talking about SCI, not ALS.
                You seriously thought those 4 patients just injected in a Phase 1 safety trial dosage to be showing "significant recovery"? It's a wonder we have anyone willing to enroll in spinal cord trials. Biological measures won't be producing instant miracle cures right off the bat.
                http://spinalcordresearchandadvocacy.wordpress.com/

                Comment


                  Originally posted by GRAMMY View Post
                  You seriously thought those 4 patients just injected in a Phase 1 safety trial dosage to be showing "significant recovery"? It's a wonder we have anyone willing to enroll in spinal cord trials. Biological measures won't be producing instant miracle cures right off the bat.
                  That is a point you missed of what I am saying. They did not even do a single study on rodents with chronic SCI (let alone large animals), how can anyone expect the cells they are using can produce significant recovery? That would be just luck, not science.
                  In God we trust; all others bring data. - Edwards Deming

                  Comment


                    Originally posted by paolocipolla View Post
                    That is a point you missed of what I am saying. They did not even do a single study on rodents with chronic SCI (let alone large animals), how can anyone expect the cells they are using can produce significant recovery? That would be just luck, not science.
                    No, you are wrong Paolo. They did rodent and mini-pig studies along with primate work also.

                    You think the FDA will allow just any cell to be put in combination chronic therapies without being tested for safety? They'll require scaffolding and molecules to be tested before being added too.

                    The Martin Marsala mini pig studies didn't count? Ever hear of the guy Mark Tuszynski that's worked with NS-566 for years in rat and primate? LINK This research program tests the ability of cells and growth factors to promote regeneration after SCI. Tested cells include stem cells, autologous bone marrow cells, Schwann cells, and fibroblasts. The Tuszynski group is examining both acute and chronic models of SCI. http://www.cell.com/cell/fulltext/S0092-8674(12)01018-5

                    Many labs throughout the world are working with neural stem cells. Maybe biological cure with stem cells is something they should stop testing, but each and every component of a combination therapy has to be tested in order for the FDA to eventually approve the therapy. It would be silly to assume each piece of a combo will all alone provide significant recovery in it's Phase 1 safety stage. If that were the case, there would be no need for a combination therapy to help chronic SCI, we would just be waiting for an undiscovered miracle cell or pharma drug.
                    Last edited by GRAMMY; 24 Feb 2016, 1:00 AM.
                    http://spinalcordresearchandadvocacy.wordpress.com/

                    Comment


                      Originally posted by Han Solo View Post
                      Just let this thread die. Dude was a fraud n nothin else. Time and money had definitely shown that.
                      Hi Han,

                      Why do you say that?

                      Thanks,
                      Charley

                      Comment


                        I stuck up n stood by him for years, and I honestly feel like if he had something that was as he claimed, he'd have trials n everything else. I heard his results couldn't even be replicated. With all the money we sent him, something should've showed something. He gave us all promises of gold n glory and faded off into the night.

                        Comment


                          If I recall, my little bit of money went to Baylor for his program .. once he left, I would assume that's Baylor's money.
                          Roses are red. Tacos are enjoyable. Don't blame immigrants, because you're unemployable.

                          T-11 Flaccid Paraplegic due to TM July 1985 @ age 12

                          Comment


                            Han, it is not fair to call him a fraud without having concrete evidence. Maybe he was doing the right thing and just make it happen. I can tell you this, clinical trials are very tough to pull off, even with rock solid results.

                            Comment


                              Originally posted by GRAMMY View Post
                              You think the FDA allowed that after all the Geron Co. went through?

                              The Martin Marsala mini pig studies didn't count?

                              Ever hear of the guy Mark Tuszynski that's worked with NS-566 for years? LINK
                              This research program tests the ability of cells and growth factors to promote regeneration after SCI. Tested cells include stem cells, autologous bone marrow cells, Schwann cells, and fibroblasts. The Tuszynski group is examining both acute and chronic models of SCI. http://www.cell.com/cell/fulltext/S0092-8674(12)01018-5

                              Many labs throughout the world are working with neural stem cells. Maybe biological cure with stem cells is something they should stop testing.
                              You are skating around my points.. or you just don't get them..

                              I am not against this line of research, but I am just pointing out the weak points, so people can adjust their expectations. I would suggest you to do the same with your blog. If researchers can't survive a good dose of criticism means their evidence is weak.

                              Finally can you understand that all I want to see people walking out of wheel chairs? And I would be happy to see YOUR SON walking out of chair (and all the quads) before me!

                              I am not your enemy! Got it?
                              In God we trust; all others bring data. - Edwards Deming

                              Comment


                                Originally posted by GRAMMY View Post
                                You think the FDA will allow just any cell to be put in combination chronic therapies without being tested for safety? They'll require scaffolding and molecules to be tested before being added too.

                                Many labs throughout the world are working with neural stem cells. Maybe biological cure with stem cells is something they should stop testing, but each and every component of a combination therapy has to be tested in order for the FDA to eventually approve the therapy. It would be silly to assume each piece of a combo will all alone provide significant recovery in it's Phase 1 safety stage. If that were the case, there would be no need for a combination therapy to help chronic SCI, we would just be waiting for an undiscovered miracle cell or pharma drug.
                                Originally posted by paolocipolla View Post
                                Or consider Neuralstem SCI trial. They did animal studies just on acute SCI that showed modest recovery and now they did 4 patients with chronic SCI.
                                Guess what? It does not work.

                                Probably they went straight on chronics because they didn't have money to do an acute trial, but they should have done chronic animal studies, not acute. Maybe their approach has a real potential (probably not) that could have been identified with proper animal studies that will be lost if the company will go bankrupt..
                                I'm not skating around your points Paolo. I'm facing them head on because I do "get it". There's no reason to give this kind of rhetoric a pass. You don't make a case or supply data that you demand of others when you spout this "off the cuff" whimsical statement that clearly is not true or accurate. The weak point you talk about doesn't exist. These cells were worked on for years in both acute and chronic models in rat and pig. I know you say the patients will never show significant recovery but that certainly isn't what the patient video's look like so far. These cells did not just drop out of the sky into chronic human trials. There were not only hundreds of rats but the large animal chronic model was done in 80 mini-pig which was "Navarro et al. Journal of Neurotrauma 2012" shown in the video below and was required by the FDA before any chronic human trials could even begin. The costs and the work required by the FDA were very significant and the situation was disclosed in the panel discussion video below.

                                Here's another important point. The FDA will require each and every component of a combination chronic therapy to undergo a safety trial. I know you don't like that, but it's the way it works. Each piece of the combo will not be some miracle spontaneous cure all by itself. People are capable of looking at the data prepared onto slides and listening to the presentations as the level of recovery is disclosed. These companies do a great job explaining why they are moving forward with more trials or their decision to abandon the therapy or treatment (be it lack of funding or efficacy). The number of cells administered so far is not extraordinarily high in this safety study. They are now learning that much depends on where the injections are made for different diseases. Joe explains that they were able to safely give up to 20 injections in the animals and hopes to give larger injections over a bigger area. They've also explained their work in imagining so they can look at what is actually happening in the cord. Their initial human treatment has been very conservative. Why would Neuralstem think to abandon chronic given the results shown so far in one of their first four patients or by the ones in the StemCells Inc. group? Or, why is StemCells Inc. announcing they are totally focusing now on chronic SCI only? Why would InVivo want to introduce their bioengineered neuraltrails?


                                Last edited by GRAMMY; 24 Feb 2016, 9:16 PM.
                                http://spinalcordresearchandadvocacy.wordpress.com/

                                Comment

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