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    Originally posted by Scaper1 View Post
    I don't think 7 patients is anything to sneer at, that's 7 more than most researchers.
    Scaper, I'm sorry I didn't make my post more clear. I wasn't "sneering" at the number of participants. (I believe that Dr. Davies trials with rats were with groups of 9.) What I was "sneering" at was the apparent inability of the PhD researchers to count to three.

    The announcement was that "SOME" of the seven patients had "SOME" recovery of sensation. What in the world is that supposed to mean? "SOME" must mean more than one, right? But if it were four or more, they would have said "MOST". So by the process of elimination, "SOME" must mean either "two" or "three".

    Well, which is it? Do PhD researchers have a difficult time telling the difference between "two" and "three"? If it were two, why not just say "two"? Or if it were three, why not just say "three"? Or did "SOME" really mean just "one"?

    Comment


      As a research scientist in a different field (non-medical) I am often struck by the way that spinal cord researchers, like pure mathematicians, seem to be fascinated by theoretical solutions. Aside from a minority that includes Stephen Davies and Wise Young, they don't seem to be particularly interested in pushing their discoveries on through the human clinical trial stage. To draw a parallel, if rocket scientists had this same approach, the earth would be overflowing with model rockets, all with great potential, but we would never have sent a man to the moon. Now, I am sure I'm being a bit unfair here, but that's the way it sometimes appears.

      Comment


        Originally posted by dukevanwillem View Post
        As a research scientist in a different field (non-medical) I am often struck by the way that spinal cord researchers, like pure mathematicians, seem to be fascinated by theoretical solutions. Aside from a minority that includes Stephen Davies and Wise Young, they don't seem to be particularly interested in pushing their discoveries on through the human clinical trial stage. To draw a parallel, if rocket scientists had this same approach, the earth would be overflowing with model rockets, all with great potential, but we would never have sent a man to the moon. Now, I am sure I'm being a bit unfair here, but that's the way it sometimes appears.
        I must say that your comments sure sound true to me.
        The other day I read in the paper that NASA was now working on a super rocket and instead of talking about the 'future', they gave a timeline of five years to have the tests ready and it looks like they have a real plan to go to congress with to get the money.
        Dennis Tesolat
        www.StemCellsandAtomBombs.blogspot.com

        "Change does not roll in on the wheels of inevitability, but comes through continuous struggle. And so we must straighten our backs and work for our freedom."
        Martin Luther King

        Comment


          Does anyone know anything about the regenexx procedures? Regenexx.com.
          An NFL athlete supposedly went to this clinic for stem cell therapy, and had really good results. He was back to his game shortly afterward. Seems promising that stem cell results have been good for some injuries.
          ESPN magazine listed this therapy in an October 17 article.

          Comment


            on the list of their "treated conditions", Spinal cord injury is not on the list
            "That's not smog! It's SMUG!! " - randy marsh, southpark

            "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


            2010 SCINet Clinical Trial Support Squad Member
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              You are correct lunasicc. However, it does say of the "treated conditions", that they do treat conditions on the back, which did not have ANY success two years ago. They also claim to have success on neuropathic pain, which I know many on Carcureforum have. Apparently, they have had success. And they are treating patients in Colorado.
              An NFL athlete was helped there. It was in an ESPN magazine article on October 17.
              I just thought any success in stem cells, particularly in Colorado is positive news. ESPN reported on the athletes success.
              Has anyone else heard of this company? Regenexx.com

              Comment


                Originally posted by dukevanwillem View Post
                As a research scientist in a different field (non-medical) I am often struck by the way that spinal cord researchers, like pure mathematicians, seem to be fascinated by theoretical solutions. Aside from a minority that includes Stephen Davies and Wise Young, they don't seem to be particularly interested in pushing their discoveries on through the human clinical trial stage. To draw a parallel, if rocket scientists had this same approach, the earth would be overflowing with model rockets, all with great potential, but we would never have sent a man to the moon. Now, I am sure I'm being a bit unfair here, but that's the way it sometimes appears.
                Landing a man on the moon was horrendously complicated and so is repairing the damaged spinal cord. I think we have to ask ourselves, are we willing to take a risk?

                By the way, speaking from experience, clinical trials take too long and are too costly. We need to find another way.
                The test of success is not what you do when you are on top. Success is how high you bounce when you hit the bottom
                --General George Patton

                Complex problems need to be solved collectively.
                ––Paul Nussbaum
                usc87.blogspot.com

                Comment


                  Landing on the moon was achieved in a defined time frame ie 1961 to 1969 because Kennedy declared that it had to.

                  Medical science has no time limits on it. Just vague statements like 10 to 15 years then 10 years later it's 10 to 15 years again until you die never having been cured........

                  Comment


                    Originally posted by PN View Post
                    Landing a man on the moon was horrendously complicated and so is repairing the damaged spinal cord. I think we have to ask ourselves, are we willing to take a risk?

                    By the way, speaking from experience, clinical trials take too long and are too costly. We need to find another way.
                    Yes we need an alternative to the current clinical trial process, but also to the whole research process.

                    The sistem is broken and is not going to get us out of w/c. We need to take control of it.

                    Here are some ideas (but not enough IMO):

                    http://www.youtube.com/watch?v=NZR9V...ure=plpp_video

                    Paolo
                    In God we trust; all others bring data. - Edwards Deming

                    Comment


                      question about decorin

                      I wondered if it's possible to encourage the body's ability to make decorin. It's leucine-rich and that's a branched chain amino acid (BCAA) that helps to build muscle and promotes nitrogen storage. So could supplementing with BCAAs help not only muscles but decorin production? I'm a long time vegan, but get plenty of protein from other sources and yet maybe I need more to make decorin and dissolve my spinal cord scar. I have a contusion at C3/4 and walk with a walker around house, but spasticity makes me use electric scooter with lift otherwise. I did order BCAA supplement anyway. Thoughts? Thanks!

                      Jan

                      Comment


                        Originally posted by Christopher Paddon View Post
                        Landing on the moon was achieved in a defined time frame ie 1961 to 1969 because Kennedy declared that it had to.

                        Medical science has no time limits on it. Just vague statements like 10 to 15 years then 10 years later it's 10 to 15 years again until you die never having been cured........
                        If we were in a rush to cure the first SCI before the commies in order to secure a strategic political-economic position you could believe that 10 year window.
                        No one ever became unsuccessful by helping others out

                        Comment


                          Originally posted by PN View Post
                          Landing a man on the moon was horrendously complicated and so is repairing the damaged spinal cord. I think we have to ask ourselves, are we willing to take a risk?

                          By the way, speaking from experience, clinical trials take too long and are too costly. We need to find another way.
                          This seems so true. The only reason that I can see for trials is to safety. Clearly in conditions where the only outcome to not performing an unorthodox procedure is almost certain death, this aspect is almost secondary. This make explain the phenomenal advances made in some types of surgery.
                          2010 SCINet Clinical Trial Support Squad Member
                          Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature.

                          Comment


                            Originally posted by FellowHawkeye View Post
                            I wondered if it's possible to encourage the body's ability to make decorin. It's leucine-rich and that's a branched chain amino acid (BCAA) that helps to build muscle and promotes nitrogen storage. So could supplementing with BCAAs help not only muscles but decorin production? I'm a long time vegan, but get plenty of protein from other sources and yet maybe I need more to make decorin and dissolve my spinal cord scar. I have a contusion at C3/4 and walk with a walker around house, but spasticity makes me use electric scooter with lift otherwise. I did order BCAA supplement anyway. Thoughts? Thanks!

                            Jan
                            Jan, what an interesting question! I am not sure that the production of decorin is substrate limited. In fact, a quick perusal of the factors that affect decorin's role in overcoming inhibition and regulate its synthesis and secretion suggest that the situation is quite complicated. Nevertheless, it would be interesting to see if BCAA supplementation will increase its expression in extracellular matrix of the spinal cord.

                            Decorin is ubiquitously expressed by many connective tissues, where it "decorates" collagen. It may itself sport a side-chain that includes chondroitin-6-sulfate and thereby inhibit growth. Decorin, however, also bind growth factor receptors, including epidermal growth factor, receptor tyrosine kinase receptors (which include neurotrophins), insulin-like growth, and low density lipoprotein receptors, through which it may affect other receptors, such TGF-beta receptor [source]http://www.sinobiological.com/article.php?id=458&gclid=CNDrgcuL5qwCFcfd4Aodwjo0N g[/source]. These interactions with growth receptors may overcome its growth inhibition properties [source]http://mcr.aacrjournals.org/content/6/5/785.full.pdf[/source]

                            Recently, the Davies group [source]http://brain.oxfordjournals.org/content/134/4/1140.abstract[/source] reported that decorin reduces expression of semaphorin 3A messenger RNA, in addition to suppressing levels of chondroitin-6-sulfate proteoglycan production. The mechanism apparently depends on a nuclear factor "activator of transcription factor 3". Semaporins are well known to be growth cone guidance molecules [source]http://en.wikipedia.org/wiki/Semaphorin[/source].

                            In 1993, Haneman, et al. [source]http://www.ncbi.nlm.nih.gov/pubmed/8354878[/source] reported that decorin is highly expressed in peripheral nerve and central nervous system. In rat spinal cord, apparently motoneurons and other neurons express the decorin mRNA [source]http://www.ncbi.nlm.nih.gov/pubmed/8354878[/source]. The factors that govern synthesis and secretion of decorin core protein are complicated [source]http://www.jbc.org/content/280/52/42774.full.pdf[/source], including N-linked oligosacharides, which promote folding of the molecule and interaction with molecules that help fold and secrete the molecule.

                            Wise.
                            Last edited by Wise Young; 3 Dec 2011, 10:54 AM.

                            Comment


                              Originally posted by FellowHawkeye View Post
                              I wondered if it's possible to encourage the body's ability to make decorin. It's leucine-rich and that's a branched chain amino acid (BCAA) that helps to build muscle and promotes nitrogen storage. So could supplementing with BCAAs help not only muscles but decorin production? I'm a long time vegan, but get plenty of protein from other sources and yet maybe I need more to make decorin and dissolve my spinal cord scar. I have a contusion at C3/4 and walk with a walker around house, but spasticity makes me use electric scooter with lift otherwise. I did order BCAA supplement anyway. Thoughts? Thanks!

                              Jan
                              What brand or kind of BCAA supplement is good.
                              Some Findings
                              www.MiracleofWalk.com

                              Miracles are not contrary to nature, but only contrary
                              to what we know about nature
                              Saint Augustine

                              Comment


                                can any body tell us . will we see any up dates from Stephen Davies be fore the year is out
                                AS I SIT HERE IN MY CHAIR . I LOOK OUT UPON THE GROUND .I WONDER WILL I EVER GET UP AND WALK A ROUND ??


                                http://justadollarplease.org

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