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  • Viagra & neurogenesis?

    Does viagra really spur brain neurogenesis? and what about spinal cord neurogenesis?

  • #2
    Originally posted by drnader
    Does viagra really spur brain neurogenesis? and what about spinal cord neurogenesis?
    Not to my knowledge. Where did you hear this? Wise.

    Comment


    • #3
      If it did, I'd be walking by now.
      "Life is about how you
      respond to not only the
      challenges you're dealt but
      the challenges you seek...If
      you have no goals, no
      mountains to climb, your
      soul dies".~Liz Fordred

      Comment


      • #4
        Originally posted by Wise Young
        Not to my knowledge. Where did you hear this? Wise.
        http://stroke.ahajournals.org/cgi/co...act/33/11/2675

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        • #5
          Antiquity,

          Thanks. Many drugs have been reported to increase hippocampal neurogenesis. In a recent Science article, Scharfman & Hen asked, "Is More Neurogenesis Always Better". They pointed out that many drugs have been reported to increase neurogenesis. http://www.sciencemag.org/cgi/content/full/315/5810/336

          Antidepressants (19, 20, 22)
          Tricyclic antidepressants
          Selective serotonin reuptake inhibitors
          Mood stabilizers (22)
          Lithium
          Valproic acid
          Cognitive enhancers (23)
          Galantamine
          Memantine
          Anesthetics (24)
          Ketamine
          Steroids (1, 22)
          Estradiol
          Dehydroepiandrosterone
          Other (22)
          Rolipram
          Statins
          Sildenafil (Viagra)

          Incidentally, running enhances neurogenesis, learning, and long-term potentiation in mice (Source).

          Given the large number of people here who have taken Viagra, has anybody seen improved long-term functional improvement associated with taking of that drug? Has it improved the memory, cognition, and intelligence of the people?

          The study by Chopp, et al. you cited showed that oral sildenafil (2-5 mg/kg) given 2 or 24 hour after induction of stroke by a middle cerebral artery occlusion did not change the infarct site at 25 days bu the rats had enhanced neurological recovery, increased neurogenesis in the ipsilateral subventricular zone and striatum. The rats treated at 24 hours after stroke had significantly increased angiogenesis and capillary formation in the ischemic boundaries.

          The mechanisms of these effects, however, are unclear. In a more recent study this year, the same group reported that rats showed improved cerebral blood flow after embolic stroke when treated with Sildenafil. http://www.pubmedcentral.nih.gov/art...?artid=1885791

          Wise.
          Last edited by Wise Young; 07-16-2007, 09:31 AM.

          Comment


          • #6
            http://penfield.psych.uiuc.edu/omnib...erections.html

            http://sexualhealth.e-healthsource.c...ews1&id=528519

            Comment


            • #7
              Originally posted by Wise Young
              Antiquity,

              Thanks. Many drugs have been reported to increase hippocampal neurogenesis. In a recent Science article, Scharfman & Hen asked, "Is More Neurogenesis Always Better". They pointed out that many drugs have been reported to increase neurogenesis. http://www.sciencemag.org/cgi/content/full/315/5810/336

              Antidepressants (19, 20, 22)
              Tricyclic antidepressants
              Selective serotonin reuptake inhibitors
              Mood stabilizers (22)
              Lithium
              Valproic acid
              Cognitive enhancers (23)
              Galantamine
              Memantine
              Anesthetics (24)
              Ketamine
              Steroids (1, 22)
              Estradiol
              Dehydroepiandrosterone
              Other (22)
              Rolipram
              Statins
              Sildenafil (Viagra)

              Incidentally, running enhances neurogenesis, learning, and long-term potentiation in mice (Source).

              Given the large number of people here who have taken Viagra, has anybody seen improved long-term functional improvement associated with taking of that drug? Has it improved the memory, cognition, and intelligence of the people?

              The study by Chopp, et al. you cited showed that oral sildenafil (2-5 mg/kg) given 2 or 24 hour after induction of stroke by a middle cerebral artery occlusion did not change the infarct site at 25 days bu the rats had enhanced neurological recovery, increased neurogenesis in the ipsilateral subventricular zone and striatum. The rats treated at 24 hours after stroke had significantly increased angiogenesis and capillary formation in the ischemic boundaries.

              The mechanisms of these effects, however, are unclear. In a more recent study this year, the same group reported that rats showed improved cerebral blood flow after embolic stroke when treated with Sildenafil. http://www.pubmedcentral.nih.gov/art...?artid=1885791

              Wise.
              That'll be interesting to find out. I'll link this to R/S.

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