No announcement yet.

Spinal Cord Injury: Rebuilding from the Ground Up

  • Filter
  • Time
  • Show
Clear All
new posts

    Spinal Cord Injury: Rebuilding from the Ground Up

    Spinal Cord Injury: Rebuilding from the Ground Up

    I like this quote:


    This is a major step forward in spinal cord injury research,” says Dr. Fehlings. “The ability to restore the myelin insulation is a key component of a therapeutic strategy, and our study is the first to show this exciting result. Our future work will focus on generating neural precursor cells from alternative sources including embryonic stem cells and in applying this technology is concert with tissue engineering approaches to repair chronic spinal cord injury."

    This is being done in humans now, but using cultured schwann cells to remylinate.

    I also thought this is what McDonald did in 1999 using ESC's.

    This is step in the right direction since oligodentrocytes are indigenious within the spinal cord architecture.


      I'm a walking incomplete quad who would benifit a great deal from remyelination. Where exactly is this being done in humans. I'm 17 plus years post and going downhill pretty fast.
      "I'm manic as hell-
      But I'm goin' strong-
      Left my meds on the sink again-
      My head will be racing by lunchtime"

      <----Scott Weiland---->


        So have many more years before it perfect & completely safe & we can get out of the stupid wheelchairs? It's great they're working on stuff for the old injuries, and believing get in the muscle back but what about bone density? Getting tired getting old getting desperate.


          Sangamo BioSciences Announces Presentation of ZFP Therapeutic Data From Nerve Regeneration Program at American Society for Neural Therapy and Repair Meeting

          PR NEWSWIRE

          RICHMOND, Calif., May 3 /PRNewswire-FirstCall/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today the presentation of preclinical data from its ZFP Therapeutic(TM) program in nerve regeneration at the Fourteenth Annual Conference of the American Society for Neural Therapy and Repair. The data generated, in a model of spinal cord injury (SCI), demonstrate that treatment of the spinal cord at the time of injury with a VEGF ZFP TF had a statistically significant effect on recovery of hind-limb function as well as a number of other measures of nerve integrity and health.

          The work was carried out in the laboratory of Dr. Michael Fehlings who holds the Krembil Chair in Neural Repair and Regeneration at the Krembil Neuroscience Center, Toronto Western Hospital and the Division of Neurosurgery, Faculty of Medicine, University of Toronto, Ontario, Canada. Dr. Fehlings is a Christopher Reeve Foundation Scientific Advisory Council member and a leading expert in the molecular mechanisms and treatment of SCI.

          In collaboration with Dr. Fehlings and his colleagues, Sangamo is evaluating a zinc finger DNA-binding protein transcription factor (ZFP TF(TM)), designed to upregulate the expression of the gene encoding vascular endothelial growth factor (VEGF-A) in spinal cord injury (SCI) models. In addition to its effects on angiogenesis or blood vessel growth, VEGF-A has been demonstrated to have direct neurotrophic and neuroprotective properties in several models that assess nerve integrity and health. In addition, Sangamo is currently developing SB-509, a plasmid formulation of this same ZFP TF, for the treatment of diabetic neuropathy and has two ongoing Phase 2 trials in this area.

          Dr. Fehlings and his colleagues observed that administration of the ZFP TF into the spinal cord at the time of injury produced measurable VEGF ZFP TF and increased levels of all of the major isoforms of the VEGF protein. They observed a corresponding neuroprotective effect with a statistically significant decrease in nerve fiber degradation and post-injury nerve cell death. They also noted an increase in blood vessel density around the injury. Most importantly, in a severe model of SCI where animals are paraplegic post- injury, they observed a statistically significant (p<0.0001) improvement of hind-limb function over time.