About Dra. Almudena Ramon Cueto

[KIM]

I used Babelfish translator on this news of what is going on with this line of research. Make your own picture of it.

The injury to medular affects seriously to the quality of life of thousands of citizens. Every year, more than 1,000 people in Spain and 100,000 in the world they acquire this type of injury. In our country two phenomena are taking place simultaneously. Firstly, which the investigations are being made more promising outposts and of the world in the scope of regeneration which they can give rise to that people like us, from all the countries, they can get to have one cures injury to medular it in a visible future. And in parallel and of inexplicable form, a confrontation that ruins and truncates the development of possibly most hopeful of those lines of investigation.

_____________

In the 2007 injury to medular has, hopes founded of solution through the scientific research on neuronal regeneration. According to affirmations in press and specialized publications of prestigious Spanish scientists like Manuel Grandson Sampedro and Almudena Ramon Fortified height, the technique of neuronal regeneration, using glía surrounding of the bulb olfatorio, is one of most promising repairing to injuries medulares.
So that any technique is applicable in humans, it must previously be proven successfully first in rats and soon in primates.
This technique of use of glía surrounding of the bulb olfatorio already has been proven successfully in rats in Spain, in investigations published by the Dra. Ramon Fortified height in year 2,000 [ 1 ].
According to public declarations of the Dra. Ramon Fortified height in February of 2007, the past year 2006 already took very to outpost the investigation of the use of this technique in primates and had partial results that indicated the objective neuronal recovery in a monkey in the Research center Prince dependent Felipe of the Consellería de Salud of the Valencian Community.
According to those same declarations, the month of July of the year of 2006, when the monkey had indications of recovery and without well-known nor documented reason, to the Dra. Ramon Fortified height was denied the access to him to this laboratory, thus being interrupted therefore the investigation in primates. Later the monkey was sacrificed without Ramon allowed itself the access to the Dra. Fortified height, losing itself therefore a valuable information for science. Still they are left in the Center other monkeys to experiment.
Like consequence, to day of today, the line nearest the tests in humans is stopped and therefore, the hope of possibility is delayed of cures of the injury to medular.
Other lines of investigation exist, but this one is the plus outpost, since it has been proven and talked back in rats and it was being proven in monkeys. Inexplicably, the possible priest is stopped and will undergo important delays without nobody has given an explanation, nor person in charge becomes of this frenazo.
Conscious of the immense work that entails establishment of a laboratory to experiment with monkeys and to develop investigation techniques, WE ASKED FOR and WE GATHER COMPANIES FOR:

• The immediate renewal of the investigation of neuronal regeneration in the same site in which already it was, in primates in the Research center Prince Felipe in Valencia, directed by the same investigator who took it, the Dra. Almudena Ramon Fortified height.
• The real and effective support to this one and all the lines of investigation related to neuronal regeneration.

[ 1 ] This success was object of the publication of the article "Functional Recovery of Paraplegic Rats and Motor Axon Regeneration in Their Spinal Cords by Olfactory Ensheathing Glia." in the Neuron magazine in year 2,000, one of most referenced in its specialty, according to measures of the Google Scholar.


http://www.imagina.org/regeneracion/#_ftnref1

[KIM]

Here is a link to a interview to Dra. Almudena Ramon Cueto where she explains how she has been banned of her own investigation. Unbelievable.
IT IS IN SPANISH.
http://personal.auna.com/ramongarlo

[Wise Young]

Can somebody who knows Spanish please make a proper translation of the materials. The translations are inaccurate. Thank you.

Wise.

[KIM]

The injury to medullar affects seriously to the quality of life of thousands of citizens. Every year, more than 1,000 people in Spain and 100,000 in the world they acquire this type of injury. In our country two phenomena are taking place simultaneously. Firstly, which the investigations are being made more promising outposts and of the world in the scope of regeneration which they can give rise to that people like us, from all the countries, they can get to have one cures injury to medullar it in a visible future. And in parallel and of inexplicable form, a confrontation that ruins and truncates the development of possibly most hopeful of those lines of investigation.

_____________
In the 2007 spinal cord injury has, hopes of solution through the scientific research on neuronal regeneration. According to affirmations in press and specialized publications of prestigious Spanish scientists like Manuel Nieto Sampedro and Almudena Ramon Cueto, the technique of neuronal regeneration, using glía surrounding of the olfactory bulb, is one of the most promising to repair injuries.
So that any technique is applicable in humans, it must have been previously proven successfully first in rats and soon in primates.
This technique of using glía surrounding of the olfactory bulb already has been proven successfully in rats in Spain, in investigations published by the Dra. Ramon Cueto in year 2,000 [1].
According to public declarations of the Dra. Ramon Cueto in February of 2007 the past year 2006 already took very to outpost the investigation of the use of this technique in primates and had partial results that indicated the objective neuronal recovery in a monkey in the Research center Prince Felipe dependent of the Consellería de Salud of the Valencian Community.
According to those same declarations, the month of July of the year of 2006, when the monkey had indications of recovery and without neither well-known nor documented reason, to the Dra. Ramon Cueto was denied her the access to this laboratory, thus being interrupted therefore the investigation in primates. Later the monkey was sacrificed without Ramon allowing the access to the Dra. Cueto, losing itself therefore valuable information for science. Still they are left in the Center other monkeys to experiment.
Consequence, the line nearest to the tests in humans is stopped and therefore, the hope of the possibility of cure is delayed.
Other lines of investigation exist, but this one is the outpost, since it has been proven and talked back in rats and it was being proven in monkeys. Inexplicably, the possible cure is stopped and will undergo important delays nobody has given an explanation, nor person in charge comes forward.
Conscious of the immense work that entails establishment of a laboratory to experiment with monkeys and to develop investigation techniques, WE ASKED FOR and WE GATHER COMPANIES FOR:
The immediate renewal of the investigation of neuronal regeneration in the same site in which it was already, in primates in the Research center Prince Felipe in Valencia, directed by the same investigator who took it, the Dra. Almudena Ramon Cueto.
The real and effective support to these one and all the lines of investigation related to neuronal regeneration.

[Wise Young]

KIM,

Thank you. The article or website claims that Almudena Ramon-Cueto has for unknown reasons not been allowed access to one of the monkeys that had received olfactory ensheathing glia that she was studying and the monkey was killed without her permission. This is really quite a bizarre situation and there was no explanation as to why this occurred.

I am not sure what the web site is calling for. According to your translation, the web site is seeking companies to support the immediate renewal of the investigation. But it is not clear who or what is stopping the investigation, or even that Dr. Ramon-Cueto's studies have stopped.

I am now trying to download the interview but it is very slow and has taken over an hour.

Wise.

[Wise Young]

KIM, I listened to the interview but could not understand enough of it to figure out what happened. Wise.

[carbar]

I can't understand it all but it seems to have something of a 'commerce' twist to it, in that the Dr says that the treatment is not possible to commercialize as the source comes from the patient him/herself. In other words there is no potential to develop and market a cure product. I think her position is that the treatment cannot be patented. That's what I understood of it. So the research work was shut down and the animal killed without the doctor having access to examine or salvage tissue for assessment.
I got this from another news article in Spanish, so maybe Kim can verify if this is correct.

[antiquity]

Bone marrow cells are used to treat leukemia, Proneuron used autologous cells to treat SCI. I don't think a treatment needs to be patentable in order to be commercially appealing or put into widespread use.

[Carmen]

you're right carbar.

It´s incredible what is happening with this great investigator.

The investigations were advanced, and in one year or two she wanted to start clinical trial with humans. The sacrificed monkey was regaining movement in left cuadriceps.

More powerful persons have isolated her, and now her case is being knew in mass media.

There is a web page in which you can sign in order to push toward the restablishment of the normality (almost, because this monkey is dead now)
http://www.firmasonline.com/1firmas/camp1.asp?C=510

[antiquity]

She isn't the first person to use autologous OEG's. Lima has been treating people with them for years with minimal benefit. I don't see why the "establishment" would feel the need to sabotage a treatment that has never been shown to be particularly effective.

[Isildur]

Is not the same, dra.cueto works with glia of olfatory bulb, and dr.lima with olfatory mucosa. The source of cells, the quality of glia, and the regenerative potencial isn´t the same.

[KIM]

Well all ended up with a meeting in which high level researchers claim that Dra. Almudena Ramon Cueto´s research is irrelevant therefore shutdown, in six years she hasn´t produced anything that may be of any use to the improvement of SCI.

[Wise Young]

Monkey experiments are not easy to do. That is what I understand Dr. Ramon-Cueto has been doing for the past five or six years. She worked very hard to establish a monkey spinal cord injury model and a system for caring for the monkeys. In terms of productivity, I agree that she has not published much in the past five years. I presume that she has lost her grant support for doing the studies.

Regarding olfactory ensheathing glial studies, I think that we should not be so eager to shut down that research avenue based on Carlos Lima. As I have pointed out on many occasions, it is not at all clear that Carlos Lima is transplanting olfactory ensheathing glia into the spinal cord. He and his colleagues have been cutting out part of the spinal cord and implanting pieces of nasal mucosa into the spinal cord. These may or may not contain any olfactory ensheathing glia.

Dr. McKay-Sims in Brisbane has transplanted adult olfactory ensheathing glial cells grown from the nasal mucosa into people. These are the patient's own cells and the results of these transplants have not yet been reported. These are from the same patients and should not be rejected. It would be of great interest and importance to find out the results of that study.

Dr. Huang in Beijing Xishan and several other hospitals in China, as well as Novosibirsk in Russia, have been transplanting fetal olfactory ensheathing glia from aborted fetuses into the spinal cord. Because these are not immunologically matched, they are likely to be rejected.

Wise.

[Quadcessible]

Monkey experiments are not easy to do. That is what I understand Dr. Ramon-Cueto has been doing for the past five or six years. She worked very hard to establish a monkey spinal cord injury model and a system for caring for the monkeys. In terms of productivity, I agree that she has not published much in the past five years. I presume that she has lost her grant support for doing the studies.

Regarding olfactory ensheathing glial studies, I think that we should not be so eager to shut down that research avenue based on Carlos Lima. As I have pointed out on many occasions, it is not at all clear that Carlos Lima is transplanting olfactory ensheathing glia into the spinal cord. He and his colleagues have been cutting out part of the spinal cord and implanting pieces of nasal mucosa into the spinal cord. These may or may not contain any olfactory ensheathing glia.

Dr. McKay-Sims in Brisbane has transplanted adult olfactory ensheathing glial cells grown from the nasal mucosa into people. These are the patient's own cells and the results of these transplants have not yet been reported. These are from the same patients and should not be rejected. It would be of great interest and importance to find out the results of that study.

Dr. Huang in Beijing Xishan and several other hospitals in China, as well as Novosibirsk in Russia, have been transplanting fetal olfactory ensheathing glia from aborted fetuses into the spinal cord. Because these are not immunologically matched, they are likely to be rejected.

Wise.

Dr Young,
I just don't get it. Why do Dr's use cells for transplantation into the spinal cord that are likely to be rejected. If I put gasoline into my engine when I change the oil, my engine won't run long. Common sense! If you put foreign cells into the body, they get rejected and won't work. Common Sense! So why use an approach that likely won't work to start with? This is science that is established with known results, aren't they just waisting time?

[Wise Young]

Dr Young,
I just don't get it. Why do Dr's use cells for transplantation into the spinal cord that are likely to be rejected. If I put gasoline into my engine when I change the oil, my engine won't run long. Common sense! If you put foreign cells into the body, they get rejected and won't work. Common Sense! So why use an approach that likely won't work to start with? This is science that is established with known results, aren't they just waisting time?

ChipD, that is because they believe the cells won't be rejected. This is the reasoning behind the Geron trial as well. Wise.