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    Brushing up/Total Record/Responses please

    Looking for educated insight, perhaps Steven Edwards or Wise. Since they are rarely mentioned, yet from recent inquireys to Sir Eric Ahlfors, are certainly at the top of my todem pole.I like talking about this companys ventures, exceptionally more advancing in this field we are all dependant on. Why does all who post their "leading prospects to a cure," fail to mention Total Record? I want to commence on a few specifics and am looking to aquire feedback. Im just concieving some thoughts since amazingly/how the @$%/Total Record recieved FDA apporoval for approxamitely 30 surgeries/human trials commencing around what? September 06 was it? And especially because they are moving onto testing with the 2nd Generation Matrix, the tissue engineers most recent advancment and well veiled secret for providing nerve regeneration,scar inhibition,neurothropic up-patterning (all the good stuff).Just a few pointers for discussion that I need help with.Im only 25 semi knowledgable about this chaos.C-5/6 Asia A.

    -Dr.John McDonald on the Board of Advisors w/ T.R.,why is he off doing his own individual efforts with whatever,and not a collaborator working aside Ahlfors?and so many others working toward the same goal?Ahlfors has been working secretly for a number of years and keeping his work secret and advancing at an alarming rate.

    -In this seemingly vast findings/research yet closely targeted field of curing SCI,is it the individual credit one is after,the trophy if you will,I mean,scientist A has found this treatment,Sci. B is ontop of the same finding yet has taken it a step further,it seems so many are on the same track why not collectively collaborate,it is maddening to me.

    -There is a member of the FDA also on his Board of Advisors,yet how could they recieve such quick acceptance of go-head for this testing?So many others keep agrivatingly and prudently stating their findings are "years away" God I hate rereading that.If these close coming human trials, obviously lower injuries at first, do what Ahlfors suggest and hit "fast track status for FDA approval,he HAS the Manufacturing Facility,the RMx2 gets mass produced, the treatment procedure adopted and applied,people get better,he gets crowned king of SCI and the $billions$ it costs to upkeep neurodegenerative conditions,not just SCI his treatment has produced results,go's into economy?(politics not my forte')

    -Will having a metal fusion stabilizer effect recieving treatment?

    Please anyone share ideas, I truely envision this to become reality very soon.
    I am not your rolling wheels
    I am the highway
    I am not your carpet ride
    I am the sky
    I am not your blowing wind
    I am the lightning
    I am not your autumn moon
    I am the night, the night..

    #2
    Originally posted by Stormycoon
    -Dr.John McDonald on the Board of Advisors w/ T.R.,why is he off doing his own individual efforts with whatever,and not a collaborator working aside Ahlfors?and so many others working toward the same goal?Ahlfors has been working secretly for a number of years and keeping his work secret and advancing at an alarming rate.

    .



    I find this very interesting.
    Birds Fly in Flocks, but Eagles Fly Alone...

    Comment


      #3
      Originally posted by Stormycoon
      -Dr.John McDonald on the Board of Advisors w/ T.R.,why is he off doing his own individual efforts with whatever,and not a collaborator working aside Ahlfors?and so many others working toward the same goal?Ahlfors has been working secretly for a number of years and keeping his work secret and advancing at an alarming rate
      I was informed McDonald's name was more for marketing than anything else, perhaps even to increase donations/funding.

      Comment


        #4
        Originally posted by Schmeky
        I was informed McDonald's name was more for marketing than anything else, perhaps even to increase donations/funding.
        by whom?

        Comment


          #5
          Keeping his work secret? You hit the nail on the head.

          Originally posted by Stormycoon
          -Dr.John McDonald on the Board of Advisors w/ T.R.,why is he off doing his own individual efforts with whatever,and not a collaborator working aside Ahlfors?and so many others working toward the same goal?Ahlfors has been working secretly for a number of years and keeping his work secret and advancing at an alarming rate.

          -In this seemingly vast findings/research yet closely targeted field of curing SCI,is it the individual credit one is after,the trophy if you will,I mean,scientist A has found this treatment,Sci. B is ontop of the same finding yet has taken it a step further,it seems so many are on the same track why not collectively collaborate,it is maddening to me.

          -There is a member of the FDA also on his Board of Advisors,yet how could they recieve such quick acceptance of go-head for this testing?So many others keep agrivatingly and prudently stating their findings are "years away" God I hate rereading that.If these close coming human trials, obviously lower injuries at first, do what Ahlfors suggest and hit "fast track status for FDA approval,he HAS the Manufacturing Facility,the RMx2 gets mass produced, the treatment procedure adopted and applied,people get better,he gets crowned king of SCI and the $billions$ it costs to upkeep neurodegenerative conditions,not just SCI his treatment has produced results,go's into economy?(politics not my forte')

          -Will having a metal fusion stabilizer effect recieving treatment?

          Please anyone share ideas, I truely envision this to become reality very soon.
          it is maddening to me too.

          The real biotech world has much dirty competition and this happens more than we think, I am totally convinced that if scientist would work together in good faith, egos aside, we would have a cure by now, yes in a way they have the cure hidden away in different labs around the globe, How sad
          Glider

          Comment


            #6
            Originally posted by Schmeky
            I was informed McDonald's name was more for marketing than anything else, perhaps even to increase donations/funding.
            YES Schmeky by whom???????

            let the information out.
            Glider

            Comment


              #7
              I can't remember where I read this, but I will search it out. It's not a secret. McDonald's main contribution is continually pushing his activity based recovery and if I can find what I read, this is his main contribution to Total Record.

              I am absolutely certain Total Record made a previous statement that RMx is not in itself a cure, but a component in a combination strategy. Initial testing will be for safety, as with all phase I clinical trials.

              Comment


                #8
                Stormy,

                I think Total Record could be one of the top groups when it comes to curing SCI. I'll try to remember what all Ahlfors told me and post later.

                The thing I remember most is that RMx is mainly a platform technology, where different things/components/combinations can be added as necessary.
                ...it's worse than we thought. it turns out the people at the white house are not secret muslims, they're nerds.

                Comment


                  #9
                  http://www.sci-recovery.org/a3.htm

                  Press Release from Total ReCord, Inc.

                  New Therapy for Spinal Cord Injuries


                  WORCESTER, Mass., Nov. 2, 2005 /PRNewswire/ -- Massachusetts-based company Total ReCord, Inc., an early-stage company founded for the specific purpose of developing and commercializing new therapies for neurodegenerative diseases, plans to begin clinical trials in early 2006 with a new treatment for patients with spinal cord injuries.
                  RMx™, Total ReCord's lead product, is a new non-cellular, non-drug based class of biotherapeutics that draws on the body's natural regenerative processes to stimulate the growth of new central nervous system tissue. "RMx is a promising alternative to embryonic stem cells that may have significant potential in the treatment of spinal cord injuries," says Dr. John McDonald, the Executive VP and Director of the International Center for Spinal Cord Injury at the Kennedy Krieger Institute.
                  RMx's regenerative matrix is a new method of treatment for spinal cord injuries that has shown promising results in preclinical studies in animal models. Total ReCord has created RMx based on the principle of suppressing certain wound healing processes that interfere with central nervous system (CNS) tissue regeneration, while enhancing the desirable traits of these processes.
                  RMx first works to clean out the site of damaged tissue and allow for new cell growth. It then slows the development of scar tissue that can inhibit the regeneration of surviving axons while simultaneously promoting new blood vessel formation. Both of these processes are crucial for the formation of new, healthy CNS tissue. Furthermore, RMx has certain stimulatory effects on the formation and elongation of new neurites. After this new tissue is grown, it can be trained to function in the body to restore movement, even weight- bearing steps in patients with spinal cord injuries.
                  In pre-clinical studies, animals that had experienced traumatic damage to their spinal cords and were initially completely paralyzed were soon able to move about after treatment with RMx. In most cases, they were able to make weight-bearing steps. Total ReCord is confident that the human implants that have been successfully used in their animal studies will be effective in treating patients with spinal cord injuries. However, the extent of recovery that can be achieved with RMx in human patients will only become evident after the human clinical studies. RMx has also been found to have no toxic side- effects in animals.
                  Founder and CEO Jan-Eric Ahlfors is hopeful that following the first phases of human clinical trials, RMx will be placed on fast-track status for FDA approval and may soon be applied even to conditions that have kept patients permanently wheelchair-bound for decades. Total ReCord's innovations can potentially provide restored movement to victims of paralysis, stroke, and Multiple Sclerosis.

                  If you are a spinal cord injury survivor or a family member or friend of a SCI survivor and would like to receive a FREE SCI Resource Center information packet or to make a request, please fill out the following form (U.S. only please) or call us at 1-877-640-0400:

                  Comment


                    #10
                    From an earlier post:

                    Originally posted by Steven Edwards
                    RMx itself is not the treatment. Rather, it is a vehicle in which future therapies can be delivered. The vehicle likely contains a base set of growth factors that have been shown to allow neurogenesis to occur, but it can easily be modified to treat you based on your type of injury. (e.g., contusion, hemisection, transverse)

                    There are claims that this technology could potentially restore a person to a 20 (the highest) on the BBB scale within three months. Whether or not these claims have been proven in animals, I am unsure.

                    This is for acutes and chronics. However, I do not yet know who will be eligible for the first human trials.
                    ETA: A good friend recently asked me to do a follow-up interview with Ahlfors. I guess it's time.
                    Last edited by Steven Edwards; 31 Jul 2006, 9:00 PM.
                    ...it's worse than we thought. it turns out the people at the white house are not secret muslims, they're nerds.

                    Comment


                      #11
                      Where are the peer reviewed research/abstracts on Total Records RMx? I don't remember reading any.

                      The claims for RMx are bold, and at the same time very vague. What are the mechanisms of recovery? RMx is a vehicle and not the actual means of recovery? What? The vehicle will likely contain growth factors that will allow neurogensis to occur? So this is something new? Sounds like a glorified baclofen pump.

                      I smell something funky, really funky.

                      Comment


                        #12
                        Originally posted by Steven Edwards
                        From an earlier post:

                        ETA: A good friend recently asked me to do a follow-up interview with Ahlfors. I guess it's time.
                        can you get an interview with mp? mp was talking noise about their Camp, rolipram, and schwann therapy being ready in 3 years. that was 2.5 years ago.

                        Comment


                          #13
                          Originally posted by Steven Edwards
                          From an earlier post:

                          ETA: A good friend recently asked me to do a follow-up interview with Ahlfors. I guess it's time.
                          Remember that Ahlfors said this as recently as 05-22-2006;
                          Hi Everybody,
                          I was asked by a number of you (Stormycoon, Cherrylips, Schmeky) to come here and answer some questions. It seems that you have been able to answer many of the questions among yourselves already, which makes me feel good inside.

                          One of the big questions that I see popping up constantly is whether RMx will work on chronic SCI? This key question is understandable since none of us would be here if we weren't looking for a solution to chronic SCI. The truth is that I am more interested in finding a solution to chronic SCI than acute SCI, and thus Total ReCord has concentrated more heavily on chronic rather than acute spinal cord injury. There are several reasons for this: 1) a treatment for chronic SCI will eventually be beneficial to all SCI patients (both acute & chronic); 2) there is not as much R&D on chronic as there is on acute and having Total ReCord concentrate on chronic will help to balance this equation; 3) I am a tissue engineer by training (I studied under the Vacanti brothers) with a speciality in tissue regeneration, which means that I am better at figuring out how to regrow things rather than figuring out how to prevent further damage (a major problem in acutes).

                          RMx was designed primarily for chronic SCI with applications in certain types of acute SCI. Another product -- RMi -- is being designed primarily for acute SCI, MS, and as a booster for RMx in chronics. The effects of RMx do not wear off over time; the RMi booster would just help to widen the area of effect during RMx's 3-month regenerative process. I do not have an estimate on when RMi will hit clinical trials; RMx will start clinical trials later this year in patients with chronic SCI (I cannot disclose the patients or location at this time, but maybe late this year or early next year). It will be a Phase I/II trial. I do not know what the results will be, nor do I want to make a guess as to what the results might be. I am hoping that RMx will at least turn out to be safe because at a minimum this would pave the way to rapid development of new versions of RMx and combinations with other factors (drugs, cells, etc.) -- this is because RMx is a platform technology, the only platform technology in existence for treating SCI. It might even be the only true platform technology in the field of Regenerative Medicine at this point.

                          In terms of animal studies, we have used 3 different SCI models: contusion, 5mm wide full transection, and 5mm wide right-side hemisection. All toxicity studies have shown no signs of toxicity. Each of these models gives answers to different questions. For example, contusion more closely simulates the moment of spinal cord injury in humans, while full transection (and removal) more closely simulates the spinal cord injury environment in humans over time. Hemisections allow the untouched side of the spinal cord to serve as a control, the most accurate type of control since it is intrinsic. Most therapies being currently developed result in a significant improvement on a certain type of model, but not in the other models. Although our animal experiments have not consisted of large numbers of animals, RMx has shown significant improvement in all models tested. We have also tested RMx in pigs with similar results (NOTE: we could not test the contusion model in pigs because no contusion model apparatus exists for pigs; there were plans in place with Wise Young to create such a device at Total ReCord, but the estimate of creating and validating such a device was both time- and cost-prohibitive). We did not find any toxicity or safety concerns in the pigs that received RMx.

                          I hope that I have been able to answer all of your questions.

                          Please realize that I am very grateful for all of your support, but I do not want to become very active in this -- you need to understand that I and the rest of my team will need our privacy so that we can fully concentrate on the task at hand, i.e. come up with a solution for chronic SCI. I do not yet know how RMx will fare in the clinic (the pre-clinical data looks pretty good, so I am keeping my fingers crossed), which is why I am working on several other products, each of which attacks the problem from a different angle. This, of course, also creates a much bigger work load. Additional funding would of course always help. If you were a rat or a pig, I know that I could help you. As a human - I just don't know yet. Also, we will not start looking for additional candidates for the clinical trials until sometime next year because the pool of preliminary candidates have already been picked -- so please do not send any requests until we are ready to do so sometime next year (which will of course depend on whether the preliminary results are encouraging or not). I can always make time for public speeches and discussions every now and then, but I do not consider myself as being very active in the public discussions arena. I am more interested in actions than words. I hope you can understand.

                          Thanks again for all of your support. If you have any further questions, please group them all together so it will be easier for me to answer them.

                          Jan-Eric Ahlfors

                          Source.
                          Group some questions and send them, then he might come back and reply.

                          Comment


                            #14
                            Originally posted by DA
                            can you get an interview with mp? mp was talking noise about their Camp, rolipram, and schwann therapy being ready in 3 years. that was 2.5 years ago.
                            I can certainly try. Do you have a preference as to which researcher I interview?
                            ...it's worse than we thought. it turns out the people at the white house are not secret muslims, they're nerds.

                            Comment


                              #15
                              I emailed Laurie @ Total-Record a little while ago regarding answering some questions via email. I'm in the process of putting something together but I'm not sure how much has changed since Jan Ahlfors post on 5-22-2005. Is there any particular questions you want me to include?

                              Steven, is this something you want to handle?

                              Comment

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