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    Doctors might have figured out how to cure spinal cord injuries

    https://www.google.com/amp/s/bgr.com...ale-study/amp/

    Doctors might have figured out how to cure spinal cord injuries

    A disabled man is sitting in a wheelchair. He holds his hands on the wheel. Nearby are his colleagues Image source: VadimGuzhva/Adobe
    By Chris Smith @chris_writes
    February 24th, 2021 at 8:06 PM
    • Doctors from Yale successfully demonstrated a potential precursor for a paralysis cure following spinal cord injuries.
    • The researchers collected stem cells from the bone marrow of patients suffering from various types of spinal cord injuries and then injected the patients with their own stem cells.
    • Within weeks after the stem cell therapy, the doctors observed substantial improvements in more than half of the patients, including the ability to walk or use their hands.


    Accidents that impact the spinal cord can leave survivors with various degrees of paralysis. The worst type of spinal cord injuries can lead to permanent loss of sensory and motor function, meaning people will lose feeling below the region of the injury as well as movement. As it stands, there’s no way to restore spinal cord function.





    Researchers are studying various ways to treat spinal cord injuries, though. A team from Yale and the Sapporo Medical University in Japan has figured out a way to potentially cure paralysis and restore sensory and motor function. The doctors used stem cells procured directly from the injured volunteers to repair spinal cord injuries.

    The researchers collected stem cells (MSC) from a patient’s bone marrow, which were then injected intravenously into the same person. This led to significant improvement in motor function for more than half of the patients in the study. More than half regained the ability to walk or use their hands after receiving the treatment. According to a news release, the results were obtained within weeks of the injection, and the treatment had no substantial side effects.

    The patients sustained non-penetrating spinal cord injuries from falls or minor trauma. After the accidents, they lost motor function and coordination, reported sensory loss and bowel and bladder dysfunctions. The MSCs were cultured from each patient’s bone marrow via a process that took a few weeks to finish.

    The American Spinal Injury Association Impairment (ASIA) impairment scale is what’s used to measure spinal cord injury severity — here’s what it looks like:
    • Grade A: Complete sensory or motor function loss below the level of injury.
    • Grade B: Sensation is preserved below the level of injury, but motor function is lost.
    • Grade C: Motor function below the level of injury is preserved, with more than half of the main muscles receiving a less than 3 grade on the ASIA motor score.
    • Grade D: Motor function below the level of injury is preserved, with more than half of the main muscles receiving at least a 3 or greater grade on the ASIA motor score.
    • Grade E: Normal sensation and motor function.

    The ASIA scale is important to interpret the results of the study, as published in Journal of Clinical Neurology and Neurosurgery.:
    No serious adverse events were associated with MSC injection. There was neurologic improvement based on ASIA grade in 12 of the 13 patients at six months post-MSC infusion. Five of six patients classified as ASIA A prior to MSC infusion improved to ASIA B (3/6) or ASIA C (2/6), two ASIA B patients improved to ASIA C (1/2) or ASIA D (1/2), five ASIA C patients improved and reached a functional status of ASIA D (5/5). Notably, improvement from ASIA C to ASIA D was observed one day following MSC infusion for all five patients. Assessment of both ISCSCI-92, SCIM-III also demonstrated functional improvements at six months after MSC infusion, compared to the scores prior to MSC infusion in all patients.


    The International Standards for Neurological and Functional Classification of Spinal Cord (ISCSCI-92) and the Spinal Cord Independence Measure (SCIM-III) scales also measure spinal cord injury severity.

    Each patient represented their own control, as the scientists scored the function...

    [...]










    Last edited by Oddity; 21 Mar 2021, 8:56 AM. Reason: Cut post on half to conform to copyright law and site policy
    C-5, 6 SCI. Took about 6 months to walk. Walking full time. Without any assistance since Nov. 2003 and will make a full recovery

    #2
    Nice article mj23 - would be very interested in the follow up to this trial.

    Comment


      #3
      Seems kind of harmless to just throw this in with all other trials. I wonder how Dr Strittmatter feels about this??
      all of the researchers kind of forget two things, one is we will take however much of a cure they could give us and two we don’t care what works or why. Everyone seems to be convinced that repairing the spinal cord will take more than one approach together… Line up your three best guesses and give it to me! Combine Dr. Silver, Dr. Young, and epidural stimulation and ask if there are a half dozen of us that will give it a try.
      Last edited by Nicksdad; 20 Mar 2021, 2:08 PM.
      please . . .test what you already know; and give us what you have. we may not be dying, but we certainly are not living either

      Comment


        #4
        Originally posted by Nicksdad View Post
        Seems kind of harmless to just throw this in with all other trials. I wonder how Dr Strittmatter feels about this??
        all of the researchers kind of forget two things, one is we will take however much of a cure they could give us and two we don’t care what works or why. Everyone seems to be convinced that repairing the spinal cord will take more than one approach together… Line up your three best guesses and give it to me! Combine Dr. Silver, Dr. Young, and epidural stimulation and ask if there are a half dozen of us that will give it a try.
        100%!!!!!

        I've lost everything because of this miserable injury. Great job. Wife. Independence. Ability to do awesome things with my kids...

        ​​​​​​And I'm a damn incomplete who can ambulate to a certain degree. The pace of the studies is unbearably and pathetically slow!!

        I'm hardly exaggerating when I say, I would allow them to cut my head off and attach it to another body if they were 25% sure it would work.

        Comment


          #5
          Acute-injury-only study started during spinal shock period when no diagnosis is certain. To claim any causal link with improvement only sets us back.

          These phase one sensationalized results always Peter out upon more funding.

          Not worth reading in my opinion.
          T3 complete since Sept 2015.

          Comment


            #6
            I agree, they were too soon. I had 2 spinal cord injuries, my first injury was when I was 10 years old. After my surgery and I couldn't feel or move my legs at all. I was in shock but I gained a ton back. To the point a person wouldn't notice.

            My second injury was similar only I didn't gain much back. I gained some I'm incomplete but I didn't recover the same way. That time I was 16yo.

            Age has a lot to do with recovering. Acute therapy is hard to judge.

            I've been injured 22 years give the treatment to me. I'll tell you within 2 weeks if it works or not.

            Comment


              #7
              If you listen to the Miami project presentation, the slide where he says this is what we are beginning work on, half of the list is stuff someone else has done .. . . . scaffolding? why don’t they ask Invivo .. . . . Nogo? why don’t they ask Dr Stritmatter .. . . . glial scar? .. . . . why don’t they ask Dr Silver collaboration for spinal cord research sucks.
              please . . .test what you already know; and give us what you have. we may not be dying, but we certainly are not living either

              Comment


                #8
                How often have we heard or seen studies where extracting an individuals own stem cells, whether it be from bone marrow or simply lipo/fat suction, injecting it directly back into the blood stream to boost stem cells reaching all parts of the body and showing results of return and healing. Not only in sci but other neurological injuries, diseases. The costs of this are very low, which means profits are low. Which means not only very little interest but those with interests of their own to profit off off these injuries and diseases are motivated to disrupt any advance in these treatments. They may not be a cure all but if it could take me from complete to incomplete with improved motor function, I'd consider that to be very close.

                Comment

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