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Glial Scar - Alternatives to Chondroitinase ABC?

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    Glial Scar - Alternatives to Chondroitinase ABC?

    As I understand it, a human version of Chondroitinase will not be ready until 2006. Are there any alternatives to Chondroitinase ABC in order to bypass the glial scar problem?
    "Oh yeah life goes on
    Long after the thrill of livin is gone"

    John Cougar Mellencamp

    #2
    Magnetic Therapy

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      #3
      MK,

      Does this mean available for human testing in 2006? Or does it mean ready for human application in 2006? Big difference, as you know.

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        #4
        Mike, Rho inhibitors and antagonists [such as Cethrin from BioAxone in Canada] are possible alternatives. [Briefly, inhibition of regrowth by the glial scar is believed to be due to the chondroitin sulfate proteoglycans (CSPGs). CSPGs prevent regeneration by acting through the Rho pathways. Interfere with Rho, and everything's great.]

        Great question!

        [update: a search for Rho at the CRISP database shows that 388 grants are currently being funded by the NIH to study Rho.]

        -Steven
        ...how did it end up like this? it was only a kiss, it was only a kiss.
        ...it's worse than we thought. it turns out the people at the white house are not secret muslims, they're nerds.

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          #5
          Decorin is halfway thru according to the 3 year estimate from Steven Davies in Houstin.

          And they say decorin is already been used for 25 years and there is probably not much FDA gripe with this one yet, AS far as I know of.

          Davies seemed pretty sure a little over a year ago when he wrote back.


          David

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            #6
            Hi MK99, are you referring to Acorda's version? Acorda manufactures the highest quality of Chond. ABC available in the world so if a human version is made, I'm sure it'll be developed by them.

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              #7
              hmm... actually I was thinking more about Seikaguku (Japanese company making Chondroitinase). I don't know what the situation is with Accorda.

              Dr. Young will Accorda's formulation be ready for testing in human before Seikaguku's version? And who else (besides Bioaxone) makes Chondroitinase ABC or some other RHO inhibitors?

              2006 is not that far off anyway. Scary.


              Seneca what are you doing online at 4:17am anyway?
              "Oh yeah life goes on
              Long after the thrill of livin is gone"

              John Cougar Mellencamp

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                #8
                details...

                http://www.kscirc.org/XuLab/pdfs/2004-FASEB-Chondroitinase%20ABC%20enhance%20regrowth%20(Chau) .pdf

                [note: tried fixing the link, not working... sorry]

                [This message was edited by Steven Edwards on 05-16-05 at 08:57 PM.]

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                  #9
                  trying this,

                  http://www.kscirc.org/XuLab/

                  look under publications

                  "All you have to decide is what to do with the time that is given you."
                  Gandolf the Gray
                  http://justadollarplease.org/

                  2010 SCINet Clinical Trial Support Squad Member

                  "You kids and your cures, why back when I was injured they gave us a wheelchair and that's the way it was and we liked it!" Grumpy Old Man

                  .."i used to be able to goof around so much because i knew Superman had my back. now all i've got is his example -- and that's gonna have to be enough."

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                    #10
                    Perhaps Cordaneurin?

                    http://www.neuraxo.com/5.0.html?&L=2

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