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    Anyone familiar with this line of work?

    I never even heard of this and haven't seen it discussed here


    https://www.wingsforlife.com/en/late...d-repair-1485/
    "That's not smog! It's SMUG!! " - randy marsh, southpark

    "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


    2010 SCINet Clinical Trial Support Squad Member
    Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

    #2
    The article is two years old so I'm assuming it is a dud so far.
    T3 complete since Sept 2015.

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      #3
      One of the doctors in the picture is Dr. Elizabeth Bradbury who discovered chondroitinase and Dr. Silver talked very highly of her in one his presentations.

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        #4
        Originally posted by scimike View Post
        One of the doctors in the picture is Dr. Elizabeth Bradbury who discovered chondroitinase and Dr. Silver talked very highly of her in one his presentations.
        The Bradbury lab didn't discover the enzyme but they have worked extensively with it including viral vector delivery. Animal studies using the enzyme for SCI actually date back decades far before Elizabeth Bradbury's career.
        https://www.ncbi.nlm.nih.gov/pubmed/25319196
        http://spinalcordresearchandadvocacy.wordpress.com/

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          #5
          Originally posted by GRAMMY View Post
          The Bradbury lab didn't discover the enzyme but they have worked extensively with it including viral vector delivery. Animal studies using the enzyme for SCI actually date back decades far before Elizabeth Bradbury's career.
          https://www.ncbi.nlm.nih.gov/pubmed/25319196
          Hi Grammy,


          Thank you for correcting me. I should not have used the word discover if I did not have the correct information.


          I was just trying to point out that there were really good researchers in that picture and hopefully their works will help us all.

          Comment


            #6
            Originally posted by scimike View Post
            Hi Grammy, Thank you for correcting me. I should not have used the word discover if I did not have the correct information.
            I was just trying to point out that there were really good researchers in that picture and hopefully their works will help us all.

            You're welcome scimike, and you are right, we do have a lot of really good dedicated researchers that are working on all aspects of SCI that need study and results.

            (Just FYI for the record): Actually it was Jerry Silver who first used it in models of CNS development and regeneration to degrade CSPGs and improve axonal outgrowth. The very first paper was Snow et al 1990 and then lots more. The Brits didn't get involved until 2002 with using Chondroitinase. It was over a decade later that Liz Bradbury and James Fawcett's labs got heavily involved with it after the Silver lab first started using it. The work on this really goes back a long way!
            Last edited by GRAMMY; 25 Apr 2019, 7:53 PM.
            http://spinalcordresearchandadvocacy.wordpress.com/

            Comment


              #7
              Originally posted by GRAMMY View Post

              You're welcome scimike, and you are right, we do have a lot of really good dedicated researchers that are working on all aspects of SCI that need study and results.

              (Just FYI for the record): Actually it was Jerry Silver who first used it in models of CNS development and regeneration to degrade CSPGs and improve axonal outgrowth. The very first paper was Snow et al 1990 and then lots more. The Brits didn't get involved until 2002 with using Chondroitinase. It was over a decade later that Liz Bradbury and James Fawcett's labs got heavily involved with it after the Silver lab first started using it. The work on this really goes back a long way!
              Pretty depressing that Chondroitinase has been around for some 30 years yet there seems to be no trials on the horizon.

              Comment


                #8
                Has there ever been any use of chondroitinase abc use in a human before? even one case?

                Comment


                  #9
                  Originally posted by Grubby View Post
                  Has there ever been any use of chondroitinase abc use in a human before? even one case?
                  A generic of the enzyme. Many people injected in a herniated disc trial in Japan. https://www.ncbi.nlm.nih.gov/pubmed/29257028
                  http://spinalcordresearchandadvocacy.wordpress.com/

                  Comment


                    #10
                    All... I wasn't even concerned with talk of chondroitinase in this thread which is what the conversation got diverted to. I was looking for information or to see if anyone was aware of this "neuroegulin-1"... Or is Neuroregulin another term for chondroitinase or something?
                    "That's not smog! It's SMUG!! " - randy marsh, southpark

                    "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


                    2010 SCINet Clinical Trial Support Squad Member
                    Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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                      #11
                      Originally posted by Mize View Post
                      The article is two years old so I'm assuming it is a dud so far.
                      Originally posted by lunasicc42 View Post
                      All... I wasn't even concerned with talk of chondroitinase in this thread which is what the conversation got diverted to. I was looking for information or to see if anyone was aware of this "neuroegulin-1"... Or is Neuroregulin another term for chondroitinase or something?
                      Pop Quiz?

                      Why is studying the molecular switch to drive remyelination important (https://www.wingsforlife.com/en/late...d-repair-1485/) when the Tetzlaff lab has reported spontaneous locomotor recovery after SCI is not altered by remyelination failure? (https://www.nature.com/articles/s41467-018-05473-1)
                      http://spinalcordresearchandadvocacy.wordpress.com/

                      Comment


                        #12
                        Originally posted by lurch View Post
                        Pretty depressing that Chondroitinase has been around for some 30 years yet there seems to be no trials on the horizon.
                        It is. My own personal thought is that there won't be a trial because of many various issues including the delivery. In the meantime, there are efforts to find something that will work just as well in humans without all the issues that make Chondroitinase a problem to trial and market.
                        http://spinalcordresearchandadvocacy.wordpress.com/

                        Comment


                          #13
                          Does chondroitinase abc have trial on human beings?
                          Caregiver of SCI/D with more than 10 years of experience.

                          Comment


                            #14
                            Originally posted by Grubby View Post
                            Has there ever been any use of chondroitinase abc use in a human before? even one case?
                            Originally posted by samcheng0327 View Post
                            Does chondroitinase abc have trial on human beings?
                            Originally posted by GRAMMY View Post
                            A generic of the enzyme. Many people injected in a herniated disc trial in Japan. https://www.ncbi.nlm.nih.gov/pubmed/29257028
                            No trial of Chondroitinase for SCI.
                            http://spinalcordresearchandadvocacy.wordpress.com/

                            Comment


                              #15
                              Originally posted by samcheng0327 View Post
                              Does chondroitinase abc have trial on human beings?
                              No not at the moment I understand, but I am led to believe that the medical reasearch council are casting their eye over it . Grammy has said before the antibiotic used to switch off the vectors does not compleatly switch it off, but I spoke to Proff Elizabeth Bradbury just before christmas and she said the expression left does not do anything and that equates to 1% approx, but neverther the less its still present ,, thats the issue

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