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UCSD Scientists Demonstrate Use of 3D Printing with Stem Cells

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  • UCSD Scientists Demonstrate Use of 3D Printing with Stem Cells

    Times of San Diego, January 15th, 2019 by Chris Jennewein

    UCSD Scientists Demonstrate Use of 3D Printing with Stem Cells for Spinal Repair

    UC San Diego medical researchers have for the first time used 3D printing technology to create a spinal cord and implant it with neural stem cells into rats with spinal cord injuries, the university announced Monday.

    The implant is designed to promote nerve growth and regrowth for victims of severe spinal cord injuries, according to the researchers. For the rats in the study, the 3D printed spinal cords spurred tissue growth, the regeneration of nerve cell extensions called axons and expansion of the implanted neural stem cells into the rat's natural spinal cord.

    The research appears in Monday?s issue of the journal Nature Medicine.

    "The new work puts us even closer to real thing," said Jacob Koffler, the study's co-first author. "The 3D scaffolding recapitulates the slender, bundled arrays of axons in the spinal cord. It helps organize regenerating axons to replicate the anatomy of the pre-injured spinal cord."

    For the rest of this story: https://timesofsandiego.com/tech/201...CrqcJScx0BtycA

    (KLD)
    The SCI-Nurses are advanced practice nurses specializing in SCI/D care. They are available to answer questions, provide education, and make suggestions which you should always discuss with your physician/primary health care provider before implementing. Medical diagnosis is not provided, nor do the SCI-Nurses provide nursing or medical care through their responses on the CareCure forums.

  • #2
    Wow. I'll chase the link but I assume the rats didn't recover much function or that would have been mentioned.
    T3 complete since Sept 2015.

    Comment


    • #3
      Made the Dailymail ! https://www.dailymail.co.uk/health/a...inal-cord.html
      If only we were rats!

      Don't rats recover function anyway ? and when they say walk again... do they mean stumble like a drunk ?
      Last edited by NW-Will; 01-16-2019, 08:01 PM.

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      • #4
        I think the 3D printed to size implant with stem cells intergrated is part of the cure, pair this with ISP protein injection and a couple months of therapy covers most of the bases possible.

        Comment


        • #5
          Originally posted by shitrock4 View Post
          I think the 3D printed to size implant with stem cells intergrated is part of the cure, pair this with ISP protein injection and a couple months of therapy covers most of the bases possible.

          Hello shitrock... Awesome name, welcome to the community
          "That's not smog! It's SMUG!! " - randy marsh, southpark

          "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


          2010 SCINet Clinical Trial Support Squad Member
          Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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          • #6
            Putting 3D Printing to Work to Heal Spinal Cord Injury

            Dr. Francis Collins
            http://spinalcordresearchandadvocacy.wordpress.com/

            Comment


            • #7
              Originally posted by GRAMMY View Post
              It sounds like a great idea, and makes loads of sense.

              Unfortunately they seem to be going the same path to a long long process.

              The UCSD team continues to work on further improvements, including the addition of growth factors or other ingredients that may further encourage neuron growth and functional recovery. If all goes well, the team hopes to launch human clinical trials of their cell-based treatments for spinal cord injury within a few years.
              If they think it works, why not go to human trials with what they have now, and refine it in parallel.

              Comment


              • #8
                To me it sounds just as realistic as the head transplant article.
                "Talk without the support of action means nothing..."
                ― DaShanne Stokes

                ***Unite(D) to Fight Paralyses***

                Comment


                • #9
                  Originally posted by niallel View Post
                  If they think it works, why not go to human trials with what they have now, and refine it in parallel.
                  Considering the cost and time involved in human clinical trials, it wouldn't make sense to test a product for market that may need additional growth factors or other key ingredients. A car with 3-1/2 wheels wouldn't perform and sell very well, right? (They'll only have one shot. They best try to make it a viable product).
                  http://spinalcordresearchandadvocacy.wordpress.com/

                  Comment


                  • #10
                    why not just inject the growth factors alone to the original cord, in most sci cases there's no 'gap' to fill in a 3D printed cord unless you cut and 'glue' both ends, even if succes printing a real cord, makes no sense to fuse 2 cuts instead of 1... Media hype at its best, thats why rats are used since they cant defend themselves IMO. Great marketing technique to free publicity to raise funds that may lead nowhere except money in the pockets... just pisses me off
                    Last edited by Moe; 06-10-2019, 11:24 AM.
                    "Talk without the support of action means nothing..."
                    ― DaShanne Stokes

                    ***Unite(D) to Fight Paralyses***

                    Comment


                    • #11
                      Originally posted by Moe View Post
                      To me it sounds just as realistic as the head transplant article.
                      Originally posted by Moe View Post
                      why not just inject the growth factors alone to the original cord, in most sci cases there's no 'gap' to fill in a 3D printed cord unless you cut and 'glue' both ends, even if succes printing a real cord, makes no sense to fuse 2 cuts instead of 1... Media hype at its best, thats why rats are used since they cant defend themselves IMO. Great marketing technique to free publicity to raise funds that may lead nowhere except money in the pockets... just pisses me off
                      That's still all you've got?

                      You're lonely, desperate for attention and come to CareCure to post silly redundant responses because you enjoy reading the media about the SCI research but don't understand any of it nor the biology of the cord. Or, is it the trolling you find entertaining?

                      Repairing a spinal cord is more complicated than filling it with WD-40 and frosting it with glue. If it was easy, those defenseless rats you talk about could have strapped on new limbs with duct tape, saved their money and started wealthy rodent colonies instead.

                      The article I just posted here in the SCI Nurse's thread from January was from the NIH Directors blog. Dr. Collins is not fundraising, he's reporting on research already funded by National Institute of Health in the U.S. He did not ask you for any Canadian money, so cry more.

                      Originally posted by Moe View Post
                      Nobody here asked you anything and you're not a CC moderator to tell what to do neither. Nobody has to be lonely to share thoughts, so keep those ignorant comments to yourself.
                      Actually, you DID ask. I'll continue to post articles/abstracts and comment on them whenever I please. You own nothing here.

                      If you can't post anything but the same old butt hurt topics to be pissed off about, then stop trolling my posts and launching childish tantrums when I post articles at the forum. The blubbering and nutty insults you post in all the threads have grown tiresome. You've paid for nothing, contributed nothing and you get nothing. Nobody posting information here at carecure owes you anything. That includes me. Get over it.

                      Originally posted by Moe View Post
                      Too dangerous for human trials, over the years I learned not to believe everything the media publishes, no matter how much someone worships them by playing wannabe news anchor. Fundraising is all it matters to some and I find it discusting
                      Someone is in dire need of a nap and dad burn discusting spell checker app...
                      Last edited by GRAMMY; 06-11-2019, 03:38 AM.
                      http://spinalcordresearchandadvocacy.wordpress.com/

                      Comment


                      • #12
                        Originally posted by GRAMMY View Post
                        You're lonely and come to CareCure to post silliness because you enjoy reading the media about the SCI research but don't understand any of it nor the biology of the cord.

                        Repairing a spinal cord is more complicated than filling it with WD-40 and frosting it with glue. If it was easy, the defenseless rats could have strapped on new limbs with duct tape, saved their money and started wealthy rodent colonies instead.

                        The article I posted was from the NIH Directors blog. He's not fundraising, he's reporting on research already funded by National Institute of Health.
                        Oh really, getting personal aren't we? This is not about you so you can stop butting-in playing news anchor to be relevant to sci research.

                        Stick to Unite to Fight (what your org is really supposedto do) , you're not even paralyzed so bug off with your wd-40 and glue and shame on your org, it's not what it used to be.

                        Nobody here asked you anything and you're not a CC moderator to tell what to do neither. Nobody has to be lonely to share thoughts, so keep those ignorant comments to yourself.
                        Last edited by Moe; 06-10-2019, 03:06 PM.
                        "Talk without the support of action means nothing..."
                        ― DaShanne Stokes

                        ***Unite(D) to Fight Paralyses***

                        Comment


                        • #13
                          Originally posted by Moe View Post
                          why not just inject the growth factors alone to the original cord, in most sci cases there's no 'gap' to fill in a 3D printed cord unless you cut and 'glue' both ends, even if succes printing a real cord, makes no sense to fuse 2 cuts instead of 1...
                          I'm not so sure that this is all about the stem cells or growth factors, its might be about the way that they are put into the cord so that axons align properly (or at least go in the right direction).

                          Take a look at the pictures at the following link that shows the growth of the axons with the 3d printed scaffold and when the stem cells are put in without this method. You might be right that they won't align properly at each end, but isn't that what plasticity is all about? As long as there is a connection we can "learn" to make the connections work.

                          https://medschool.ucsd.edu/som/neuro...b-koffler.aspx

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                          • #14
                            Originally posted by niallel View Post
                            I'm not so sure that this is all about the stem cells or growth factors, its might be about the way that they are put into the cord so that axons align properly (or at least go in the right direction).

                            Take a look at the pictures at the following link that shows the growth of the axons with the 3d printed scaffold and when the stem cells are put in without this method. You might be right that they won't align properly at each end, but isn't that what plasticity is all about? As long as there is a connection we can "learn" to make the connections work.

                            https://medschool.ucsd.edu/som/neuro...b-koffler.aspx

                            In the context of spinal cord injury we also load scaffolds with neural stem cells that form a neuronal relay between host regenerating axons through the lesion site and into the caudal intact spinal cord.
                            Axonal projections in the spinal cord are linearly organized into regions (fascicles) containing axons of related function. Motor systems are shown in green and sensory systems in blue. C, Corticospinal tract. Ru, Rubrospinal tract; Ra, Raphespinal tract; Ret,Reticulospinal tract; Pr, Propriospinal tract; ST, Spinothalamic tract; DC, dorsal column sensory axons. Channels are precisely printed in 3D space. Collaboration with Dr. Shaochen Chen, Deprtment of Nanoengineering, UCSD.

                            Hypothetical alignment and guidance of regenerating host axons and stem cell axons: Scaffold walls confine both host and stem cell axon growth to linear rostral-caudal planes. Thus, a lesioned host axon (e.g. CST, Rubroor Reticulospinal axons) regeneratesinto the scaffold and forms a synapse onto a stem cell neuron inside a channel, and the stem cell neuron in turn extends an axon out of the scaffold below the injury site (green lines) into the same white matter fasciculus below the lesion, guided by the microchannel architecture of the scaffold. The scaffold maintains the exact 3D coordinates throughout the lesion site, matching natural host architecture.
                            http://spinalcordresearchandadvocacy.wordpress.com/

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                            • #15
                              So would you say the take away from all of this is that this is a much better way of doing scaffolding?

                              They may or may not be using the best stem cells, and could enhance whatever they use with growth factors, but the real news is the 3d scaffolding?

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