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    #16
    Dr. Silver, in the paper it states that the study was not “optimised for effects upon the forelimb” in your rodents. Will your very next study be? If not, will it be a central focus in the near future? And a deep thank you for committing your life to this work.
    C4/5 complete

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      #17
      Originally posted by UpAndAdam View Post
      Dr. Silver, in the paper it states that the study was not ?optimised for effects upon the forelimb? in your rodents. Will your very next study be? If not, will it be a central focus in the near future? And a deep thank you for committing your life to this work.

      Thanks for the question. In our initial study we were attempting to target only the motor neurons that project out to the diaphragm. They are called "phrenic" motor neurons and they form a cigar shaped collection of cells that lie between cervical level 3 (C3) thru cervical level 6 (C6). So we focused our one-time, single microinjection of the enzyme only at C4. However, there are also motor neuron pools at C5 that project out to some of the muscles of the upper arm. Thus, likely because of diffusion of the enzyme a bit more "south" to levels C5-6, return of upper arm function occurred but was not targeted by design. It was just a nice and unexpected side effect. The major motor neuron pools for hand function are down a bit lower around C6-8. So, we are now repeating our experiments but focusing on levels C5-8.

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        #18
        Dr Silver--About how long did it take from the time of the injections to when your team began to notice changes in function in the mice experiments? If possible, could you forecast a guess as to how long this change of function time would take in humans if your experiments worked as well in humans. Further, IF this treatment worked as well in chronic humans, would you expect to see one area of the body recovering or all areas below the injury site gaining some functional recovery?

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          #19
          Originally posted by 6 Shooter View Post
          Dr Silver--About how long did it take from the time of the injections to when your team began to notice changes in function in the mice experiments? If possible, could you forecast a guess as to how long this change of function time would take in humans if your experiments worked as well in humans. Further, IF this treatment worked as well in chronic humans, would you expect to see one area of the body recovering or all areas below the injury site gaining some functional recovery?
          Just to be clear, our experiments were in adult rats, not mice. Even up to 1.5 years following the spinal cord injury, we began to see recovery in a little as 1 week following enzyme administration. By 3 weeks, recovery was maximal with full restoration of diaphragm function in all animals even though they had persistent and total diaphragm paralysis. If the biology is similar in humans ( and I have no reason to believe that such basic mechanisms would be remarkably different) then I would not be surprised to see recovery in the same rapid time frame. We will have to do further experiments to maximize recovery in other systems below the level of the phrenic motor pool. However, return of upper arm function also occurred rapidly. Importantly, there is recent evidence from the Tuszynski lab that the chondroitinase enzyme has significant therapeutic effects in a primate model of cervical hemisection induced paralysis of the hand. However, in his work, the monkeys were not allowed to recover nearly as long as did our rats, so who knows what might happen if a much longer time post injury occurs prior to treatment.

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            #20
            Originally posted by jsilver View Post
            Importantly, there is recent evidence from the Tuszynski lab that the chondroitinase enzyme has significant therapeutic effects in a primate model of cervical hemisection induced paralysis of the hand. However, in his work, the monkeys were not allowed to recover nearly as long as did our rats, so who knows what might happen if a much longer time post injury occurs prior to treatment.
            For those that may have missed the Tuszynski lab experiment ...LINK
            http://spinalcordresearchandadvocacy.wordpress.com/

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              #21
              Grammy no details about Krassioukov Andrei and Dennis Bourbeau Epidural Stimulation trials and results after this years W2W? How soon Epidural Stimulation Therapy can be available publicly to restore BBS function in lower chronic injuries?

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                #22
                Jerry, what exactly can we do from a patient standpoint to get this treatment to we the people ASAP. Like can we write letters en masse to anyone in particular or raise money for a certain entity... Is there anything that we can do at all to help expedite this process
                "That's not smog! It's SMUG!! " - randy marsh, southpark

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                2010 SCINet Clinical Trial Support Squad Member
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                  #23
                  Maybe a rise up, heavy protests would help speed up the processes, removing the red tapes, less obstacles, quicker approvals, etc

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                    #24
                    Originally posted by lunasicc42 View Post
                    Jerry, what exactly can we do from a patient standpoint to get this treatment to we the people ASAP. Like can we write letters en masse to anyone in particular or raise money for a certain entity... Is there anything that we can do at all to help expedite this process
                    +1 We need to get involved.

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                      #25
                      @Jerry, how much would it be to buy your peptide / chABC technology such that it becomes public domain and others can experiment with it?

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                        #26
                        Link
                        http://spinalcordresearchandadvocacy.wordpress.com/

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                          #27
                          Originally posted by lunasicc42 View Post
                          Jerry, what exactly can we do from a patient standpoint to get this treatment to we the people ASAP. Like can we write letters en masse to anyone in particular or raise money for a certain entity... Is there anything that we can do at all to help expedite this process

                          I suggest that you check out the "NIH Conference on SCI Research" thread that lies just above mine. Take the survey that Skipow just posted (https://www.surveymonkey.com/r/SCI2020). Make your opinion known that there should have been a special session and a strong presence of scientists focused on CHRONIC SCI at the forthcoming 2020 NIH meeting.

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                            #28
                            Originally posted by jsilver View Post
                            I suggest that you check out the "NIH Conference on SCI Research" thread that lies just above mine. Take the survey that Skipow just posted (https://www.surveymonkey.com/r/SCI2020). Make your opinion known that there should have been a special session and a strong presence of scientists focused on CHRONIC SCI at the forthcoming 2020 NIH meeting.

                            Also, check this out at the End Paralysis foundation website https://endparalysis.org/nih-disrupt...jury-research/

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                              #29
                              Originally posted by jsilver View Post
                              I suggest that you check out the "NIH Conference on SCI Research" thread that lies just above mine. Take the survey that Skipow just posted (https://www.surveymonkey.com/r/SCI2020). Make your opinion known that there should have been a special session and a strong presence of scientists focused on CHRONIC SCI at the forthcoming 2020 NIH meeting.
                              That’s great Dr. Silver.
                              Everybody should definitely take the survey! It’s a very good step forward

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                                #30
                                I just took it. Pretty good survey!
                                No one ever became unsuccessful by helping others out

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