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Paralyzed mice with spinal cord injury made to walk again.

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  • Paralyzed mice with spinal cord injury made to walk again.

    Please forgive me if this has already been posted.

    https://www.sciencedaily.com/release...0719142035.htm

  • #2
    Just had one of my PCAs who is a physical therapist tell me about this one less than 12 hours ago, looks promising.

    A drug that can simulate the gains made with the effects of epidural electrical stimulation, with a pacemaker of sorts attached to your back, is absolutely the way to go, could be close to what might be the most appropriate route.
    Injured on July 8th 2017 at 28 years old.
    Fractured C4 - C7, Incomplete.

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    • #3
      Combining this chemistry with transcutaneous stim could be very good stuff.
      T3 complete since Sept 2015.

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      • #4
        Acute injuries in the mice almost certainly unfortunately

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        • #5
          Ahhhhhh...what a time to be a mouse. Must be nice.
          "I have great faith in fools; self-confidence my friends call it." - Edgar Allen Poe

          "If you only know your side of an issue, you know nothing." -John Stuart Mill, On Liberty

          "Even what those with the greatest reputation for knowing it all claim to understand and defend are but opinions..." -Heraclitus, Fragments

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          • #6
            Are the cured mice reproducing?

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            • #7
              Originally posted by Oddity View Post
              Ahhhhhh...what a time to be a mouse. Must be nice.
              CC regularly makes me envious of mice and rats. Must be nice to be the obvious cure priority.
              I hear insurance for mice even covers commode chairs.
              T3 complete since Sept 2015.

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              • #8
                Hey Mize, Do you think first treatment with CLP290 and than Parastep training?

                Originally posted by Mize View Post
                Combining this chemistry with transcutaneous stim could be very good stuff.
                www.MiracleofWalk.com

                Miracles are not contrary to nature, but only contrary
                to what we know about nature
                Saint Augustine

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                • #9
                  Originally posted by lunasicc42 View Post
                  However that prediction of 5 years might be true
                  I LOVE seeing references to the " five year " plan.
                  When I got into the "cure watch" thing in the months following my injury in 2002, my SCI Doctor, super intelligent, well respected, cure oriented scientific type, he used the "5 year" prediction as well...but always held back when it came to defining "cure" as near full recovery, but he did clearly project "significant improvements" within a 3 to 5 year period. Especially upon introducing me to C. Reeve and both inviting me to meet with Wise and visit the Keck Center SCI program claiming that international research collaboration along with CR's star power will soon yield significant advancements towards the cure. Still, and this was back when just the mere thought of living quad for even 6 months was enough to strike fear and panic in me. I immersed myself into contributing in any way I could, even going overseas to join in the OEG cell clinical trials: spending contributions from friends and neighborhood fundraisers just to be a guinea pig. I think the whole anti-stem cell thing in the US actually served to increase the press coverage for those of us suffering from SCI. The Internet was full of encouraging news of potential cure breakthroughs being studied in all corners of the world. More and more broken-necked rats were recovering each day, albeit it won't happen overnight for we humans. OK, I reasoned with myself, SCI is a complicated condition, I may have to accept the unthinkabLe and stick out the full 5 years to get my body back, after all it wasn't all that long ago that spinal injuries were a guaranteed death sentence, for sure as severe an injury like mine...so buck up buckeroo and deal with it.
                  Fast forward to 2018, most people think the first Superman remake was G. Clooney, more research is dedicated to cyber bullying, erectile disfunction and obesity than SCI. Those SCI cases making the network news do so only because their positive upbeat attitudes, preaching their dogged determination to someday walk again,despite their "remaining life in a wheelchair" diagnosis makes good journalistic human-interest stories, or "person of the week" clip to fill in the last five minutes of the news report. Several reports however do come out under the "new in technology" corner of the news hour spotlighting mechanized attachments for the walking-challenged to become real-life robocops.....but not one story on any incremental recovery.
                  That will happen in five more years, stay tuned.

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                  • #10
                    Yes, if you have $ 13,000 you can buy it here:
                    http://sigmedics.com/
                    for some people would be sufficient as is and for some like me additional weight support railing will be necessary.
                    I have tested Parastep (transcranial electrical stepping stimulation system) in your neighborhood in Mason Ohio (former Sci-Step Clinic)
                    and I never had faster improvement. Unfortunately, I didn't have enough $ to proceed there...
                    I still think some enhancer drug as CLP290 or 4AP-3-MeOH in combination with Parastep will yield fantastic results for many Incomplete SCI people..


                    Originally posted by Mize
                    I missed this earlier. Yes, is Parastep still around?
                    www.MiracleofWalk.com

                    Miracles are not contrary to nature, but only contrary
                    to what we know about nature
                    Saint Augustine

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                    • #11
                      These are dirty research reagents used in labs on animals and sold to qualified scientists. They haven't been made in approved GMP facilities for human consumption and sales as marketable pharmaceuticals. They are not clean/pure nor are they intended to be sold to the general public for human consumption.
                      Last edited by Jim; 03-18-2019, 03:52 PM. Reason: removed quote
                      http://spinalcordresearchandadvocacy.wordpress.com/

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                      • #12
                        Interesting finding about CLP-290 in 2013 Research
                        www.MiracleofWalk.com

                        Miracles are not contrary to nature, but only contrary
                        to what we know about nature
                        Saint Augustine

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                        • #13
                          Wow... great breaking news that was never heard of... paralyzed mice can walk again. Amazing...
                          "Talk without the support of action means nothing..."
                          ― DaShanne Stokes

                          ***Unite(D) to Fight Paralyses***

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