kilgore,
What Mary Bunge found in their study was that taking rolipram alone did not raise cAMP. You have to understand what rolipram does. It prevents breakdown of cAMP but, by itself, it does not increase cAMP to sufficient levels. However, when they injected dibutyryl cAMP (a form of cAMP that gets across cell membranes) into the spinal cord at the time of Schwann cell transplants and treated with rolipram for 2 weeks, they got a rise of cAMP in the spinal cord that was sustained for 2 weeks. This was then associated with very significant regeneration.
Wise.
What Mary Bunge found in their study was that taking rolipram alone did not raise cAMP. You have to understand what rolipram does. It prevents breakdown of cAMP but, by itself, it does not increase cAMP to sufficient levels. However, when they injected dibutyryl cAMP (a form of cAMP that gets across cell membranes) into the spinal cord at the time of Schwann cell transplants and treated with rolipram for 2 weeks, they got a rise of cAMP in the spinal cord that was sustained for 2 weeks. This was then associated with very significant regeneration.
Wise.
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