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    Does anyone have more info on this

    https://www.haaretz.com/science-and-...B1B5B4F86F725B
    "That's not smog! It's SMUG!! " - randy marsh, southpark

    "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


    2010 SCINet Clinical Trial Support Squad Member
    Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

    #2
    What does it say? Any clues? I don't want to pay for a subscription to the magazine.
    http://spinalcordresearchandadvocacy.wordpress.com/

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      #3
      Originally posted by GRAMMY View Post
      What does it say? Any clues? I don't want to pay for a subscription to the magazine.
      Israeli Scientists Make Paralyzed Rats Walk Again

      Using stem cell-based biomedical engineering to rehabilitate a severed spinal cord, scientists restore control of their legs – but it will be a long time before it can be used on humans

      Ido Efrati, Nov 12, 2017

      Paralyzed rats with severed spinal cords are walking again, after Israeli scientists restored their nervous function and sensation using tissue engineering.

      The researchers, from the Technion – Israel Institute of Technology and Tel Aviv University, developed a method to repair the damaged spinal cord based on tissue engineering and implantation of stem cells, taken from the oral mucosa membrane in the mouth near the gums. The rats regained sensation and control of their lower limbs, the team reports.

      Spinal damage can lead to irreversible paralysis as a result of damage to the nerve cells responsible for communicating between other nerves. Even though significant progress has been made in rehabilitation, and other areas such as neuronal transplants and tissue engineering, the effects of a fully severed spinal cord have never been reversed before.

      The research, which was published two weeks ago in the scientific journal Frontiers in Neuroscience, was led by Prof. Shulamit Levenberg, the dean of the faculty of biomedical engineering at the Technion, and Prof. Daniel Offen, of the medical school at Tel Aviv University and the head of the neuroscience lab. The lab research was headed by doctoral students Javier Ganz and Erez Shor.

      “In the past, scientists have managed to rehabilitate and injured spinal cord using stem cells,” says Levenberg. “But this is the first time that stem cells restored feeling in limbs and complex motor ability, including fast walking, in a significant way, within only a few weeks.”

      The researchers grew tissues to connect the two severed ends of the spinal cord of rats and produced new stem cells to restore sensitivity and motor function.
      The research involved four main stages: first, they isolated mature stem cells from the mouth, choosing them because they are relatively easy to produce, said Levenberg.

      The second stage was tissue engineering developed by Levenberg. The stem cells were placed on a three-dimensional scaffold, a sort of skeleton made of organic materials on which the tissue can develop. This scaffolding guides the direction of growth of the stem cells and neurons and gives the tissue its proper balance between flexibility and stiffness.

      The third stage utilizes Offen’s research: infusing the cells with growth factors that lead them to secrete proteins that support the renewed production of neurons.

      The fourth stage, after the engineered tissues are ready, is to implant them. Sixty days later the scaffold degrades and disappears.

      The process restored the coordination, motor capabilities and ability to walk, among 42 percent of the test rats within three weeks.

      On the accepted scale of functional rehabilitation, which ranges from 0 to 21, these rodents scored 17. Among the control group rats, who did not receive treatment, not a single one was able to walk.

      This means the complex functioning required for walking, that includes moving, placing, feeling the limbs, and supporting weight and balance, was restored.

      The implantation led to a gradual restoration of the severed spinal cord, regrowth of the neurons and cells and prevention of scar tissue, the scientists report. The rats began walking normally again, even without training or rehabilitation, said Levenberg.

      It's early days: the road to human experiments is long. Levenberg is confident that these new methods could change lives, in the future.

      "It is still not a medical breakthrough, but it is definitely a breakthrough in research,” said Dr. Nachshon Knoller, the director of spinal surgery at Sheba Medical Center at Tel Hashomer, who has worked with the researchers on the study. “All sorts of attempts have been made over the years to rehabilitate the spine. The studies in which implanting cells has been tried are not numerous. The combination of building a 3-D tissue in an attempt to rehabilitate the spine is completely new,” he added.

      What is new in the study is that it produced results in situations where the spinal cord hade been completely severed and spontaneous healing is impossible, said Knoller.

      http://www.haaretz.com/science-and-h...emium-1.822329
      "I'm manic as hell-
      But I'm goin' strong-
      Left my meds on the sink again-
      My head will be racing by lunchtime"

      <----Scott Weiland---->

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        #4
        Originally posted by GRAMMY View Post
        What does it say? Any clues? I don't want to pay for a subscription to the magazine.
        I didn't realize that it'd be blocked for you or something but ineedmyelin got it
        "That's not smog! It's SMUG!! " - randy marsh, southpark

        "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


        2010 SCINet Clinical Trial Support Squad Member
        Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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          #5
          The problem is your not a paralyzed rat.
          ^^(A)^^

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            #6
            Originally posted by darty View Post
            The problem is your not a paralyzed rat.
            ... Haven't heard THAT tired saying before... Yes it's going to take steps
            "That's not smog! It's SMUG!! " - randy marsh, southpark

            "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


            2010 SCINet Clinical Trial Support Squad Member
            Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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              #7
              Reeve used to champion Israel researchers because of all of the terrorist attacks there and spinal cord injured as a result.
              Roses are red. Tacos are enjoyable. Don't blame immigrants, because you're unemployable.

              T-11 Flaccid Paraplegic due to TM July 1985 @ age 12

              Comment


                #8
                i didn't even think of that... Israelis and high instances of sci due to terror attacks. Is that a thing
                "That's not smog! It's SMUG!! " - randy marsh, southpark

                "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


                2010 SCINet Clinical Trial Support Squad Member
                Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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                  #9
                  No doubt. There were at least 2 or 3 from the Columbine shooting. At least one in the recent Vegas shootings (all terrorist attacks on US soil). I imagine they get quality care to stay alive in Israel .. not so sure about poorer middle eastern countries though .. we are lucky where we live.

                  Even if I have lived paralyzed, it allowed me a somewhat full life where I lived, dated, etc. Even being alive was a privilege.
                  Roses are red. Tacos are enjoyable. Don't blame immigrants, because you're unemployable.

                  T-11 Flaccid Paraplegic due to TM July 1985 @ age 12

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                    #10
                    Best to keep to facts rather than hearsay.

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                      #11
                      Although some certain language in the article leads me to believe that it's an acute thing... Bummer
                      "That's not smog! It's SMUG!! " - randy marsh, southpark

                      "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


                      2010 SCINet Clinical Trial Support Squad Member
                      Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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                        #12
                        Originally posted by lunasicc42 View Post
                        Although some certain language in the article leads me to believe that it's an acute thing... Bummer
                        It sounds to be a take on the Neuroregen scaffold that was applied to chronic injuries with positive results for complete injuries. There they surgically resected scar tissues to eliminate the inhibitory effect of glial scarring on nerve regeneration.

                        https://www.ncbi.nlm.nih.gov/pubmed/28185615
                        https://link.springer.com/content/pd...016-5080-z.pdf

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                          #13
                          the line: "The implantation led to a gradual restoration of the severed spinal cord, regrowth of the neurons and cells and prevention of scar tissue" is what threw me to thinking it was an acute thing
                          "That's not smog! It's SMUG!! " - randy marsh, southpark

                          "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


                          2010 SCINet Clinical Trial Support Squad Member
                          Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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                            #14
                            Originally posted by lunasicc42 View Post
                            Although some certain language in the article leads me to believe that it's an acute thing... Bummer
                            Very acute. The rats were completely transected at T-10 and then the cell embedded scaffold was inserted.

                            Here's the full publication in Frontiers in Neuroscience.
                            http://spinalcordresearchandadvocacy.wordpress.com/

                            Comment


                              #15
                              Originally posted by lunasicc42 View Post
                              Although some certain language in the article leads me to believe that it's an acute thing... Bummer
                              When it comes to a severed spinal cord injury I don?t see how chronic or acute injuries would make a difference. A glial scar cannot form where there is no longer spinal cord... although axons severity of atrophy ( according to Dr. silver, axon death according to other doctors) throughout the body is a different issue unfortunately obviously for chronic’s.

                              Dr. Young used to explain this, and what I’ve come to understand from other researchers when it comes to chronic spinal cord injuries no matter what the treatment it will take years of intensive functional movement/training to cause substantial functional returns. Of course, along with the perfect treatment we have not figured out the perfect methodology for “functional movement/training“ that can be conducive for resprouting axons and/or Regeneration.

                              A chronic injury will never receive a surgery, or take a pill get an injection, etc. And have functional return if they just hope back in their wheelchairs and continue living their life in stagnation expecting their legs to magically starts moving one morning .
                              Last edited by JamesMcM; 15 Nov 2017, 12:09 AM.

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