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Drug limits spinal cord damage: Antibiotic reduces cell death in spinal injuries

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    Drug limits spinal cord damage: Antibiotic reduces cell death in spinal injuries

    Drug limits spinal cord damage
    Antibiotic reduces cell death in spinal injuries
    By William J. Cromie
    Harvard News Office

    http://www.news.harvard.edu/gazette/...pinalcord.html

    A common antibiotic used to treat arthritis and acne shows promise for limiting the severity of spinal cord and brain injuries.
    When a fall, car crash, bullet, or knife crushes or cuts a spinal cord, the injury does not stop there. Rather, tissues continue to discharge toxic chemicals for hours, even days and weeks. These chemicals kill and disable nerve cells some distance away from the core injury, compounding the damage and making rehabilitation more difficult or impossible.
    "I QUESS THEY'LL HAVE TO RUN OUT OF RATS, BEFORE THEY TRY IT OUT IN HUMANS. WAKE ME UP WHEN IT'S OVER !!!"

    #2
    Thanks Jeremy,

    Minocycline, if proven as effective in humans, could be an outstanding achievement in the treatment of acute sci.

    Time and testing will tell.

    Comment


      #3
      Author Topic:   Harvard researchers Ted Tang and Bob Friedlande reports than minocycline reduces cell death in SCI

      Wise Young

      Administrator posted 04-01-04 10:50 PM  
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      http://www.news.harvard.edu/gazette/...pinalcord.html
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      Posts: 12428 | From: New Brunswick, NJ, USA | Registered: 07-23-01

      Comment


        #4
        Jeremy

        Member

        posted 04-02-04 04:45 PM

        Source: Integra LifeSciences Holdings Corp.
        Integra LifeSciences Supports Study On Spinal Cord Injuries
        http://www.primezone.com/newsroom/ne....mhtml?d=55286
        PLAINSBORO, N.J., April 2, 2004 (PRIMEZONE) -- Integra LifeSciences Holdings Corporation (NASDAQ:IART) today announced its participation in a study published last month in the European Journal of Neuroscience. The study concluded that infusing a naturally occurring anti-scarring agent called decorin into the damaged spinal cords of rats suppresses key molecules that block nerve regeneration after spinal cord injury. Integra LifeSciences supported the study through grants and the donation of the genetically engineered form of human decorin utilized in the study.
        The scientists at Integra LifeSciences and Baylor College of Medicine (BCM) who authored the paper demonstrated the ability of decorin to suppress inflammation and scar formation in spinal cord injuries. Glial scar tissue that forms as a result of spinal cord injury not only presents a physical barrier to nerve regeneration but also contains molecules called chondroitin sulfate proteoglycans that are inhibitory to nerve fiber growth. Pro-inflammatory transforming growth factors are released in spinal cord injuries. These molecules are known to promote scar tissue formation and their action is inhibited by decorin. The successful suppression of scarring achieved by the application of decorin directly into spinal cord lesions opens the door to possible therapies for spinal cord injury that could result in functional recovery.

        Posts: 456 |  Registered: 07-24-01

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