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    Bruno,
    Yeah, I think the reflex arc starts in the area of T12. There's been much discussion on this website about injuries below the reflex arc. You could research the effects of an injury in this area on previous posts.

    One thing we should all be clear on, is that when we donate to the NTT Project we are not donating to a "human trial". A human trial depends on the success of the NTT Project. More money is needed to complete the project. The two objectives of the project are:
    1. Establish an across the skin injection of regenerative cells directly into the spinal cord to avoid the trauma of an invasive surgical procedure.
    2. Create regenerative cells that belong in your spinal cord by somatic nuclear transfer of your own DNA into the nucleus of an embryonic stem cell.

    If he gets the funds in a timely manner, and the research goes as he expects it will, the plan is to very quickly move on into human trials.

    Comment


      Hi PC, you are correct about the fact that the monies for Dr. McDonald's NTT program are not for the funding of a FDA trial in the USA, however we were told by Dr. McDonald that he did plan to have a limited human trial late 2004/ early 2005 in Columbia. This trial will follow the primate testing and is intended to prove-up the safety and show the recovery of his ESC injection treatment. Dr. McDonald hopes that, after this trial in Columbia, he could bring the trial to the U.S. with approval of the FDA.

      Comment


        Hi, this is kind of a translation of an article from www.eltiempo.com in Colombia in march 25.
        Sorry,the translation is not the best, and the article doesn´t say to much, but is good to know that is official.

        Colombia will be next year a latin american potency in cell regeneration.

        An advanced laboratory wih will be started in Bogota since June could treat, besides others, spinal cord injuries.

        Would be the first experimental lab in Latin America for therapeutic cell regeneration, with the same thecnology that is used in the center wich Dr Jhon McDonlad developes Christopher Reeve´s Rehab, In Missouri, USA.

        Last Year Dr McDonald came to Colombia to participate in the first "Cell regeneration for SCI" simposium, organized by Colsanitas.
        Since Then, his concern is to rehabilitate similar cases like Reeve´s in Colombia.


        McDonald himself, the Colombian scientific Enrique Osorio and Charlie Hall, with others, were working the idea to create this lab.

        Actuallly they are buying the equipment and thecnology, and there are colombian doctors receving training in the St Louis rehabilitation center in Missouri, where McDonald runs the SCI program.



        The Biomedical cience has experimented in order to obtain cells wich, with the right genetic information, could reproduce and eventually became tissue and even organs.

        Officialy they assure that tehy are far to realize Assisted Human Reproduction, but they prove that when stem cells are cultivated, those reproduces the major of their tissues.

        McDonald advance consist in experimented the regeneration of stem cells wich losses in consecuence of SCI, but from cells extracted from parts of the body.

        Once the Colombian potencial were confirmed, cells cultivaiation in Medellin verified, the idea was transpantate all that experience and advanced medical thecnology form Missouri to Colombia, under the direction of Jhon McDonald.

        The schedule shows that in june the lab will operate with the participation of important organizations.

        Berny.
        Berny.

        Comment


          One thing I don't get. This trial in Colombia is to find an alternative delivery method for the cells other than the laminectomy. I understand that this is important, but will it affect the outcome of the treatment? Will the cells be more effective depending on the way they are inserted or is this a matter of being less invasive? If its only a matter of being less invasive, why not try it with the laminectomy right now and save everyone a lot of time. If it proves useful, then they could start concentrating on perfecting it using less invasive methods. I'd rather have a procedure done on me now that causes me tons of pain and leaves a giant scar than having to wait another year.

          Sergio

          Comment


            Sergio you obviously dont know how bad pain can be.
            A CURE NOW!

            Comment


              I most certainly do!

              Comment


                Dr. McDonald still needs $200,000 for his project!!

                Please make this happen!!

                The sooner he gets the money the sooner we WALK!!!!

                Comment


                  Originally posted by bullrider:

                  If we would all contribute a little amount of money, we would be further ahead in this game.

                  Dr.McDonald is doing great things in Columbia, and his results will be seen this summer.

                  So PLEASE, Donate to his project!!!!!!!!!!! [img]/forum/images/smilies/cool.gif[/img]

                  This is the real deal and the best thing going for SCI.

                  Comment


                    bullrider,
                    My daughter, C-7, 20 mos post-injury, has been on the activity-based recovery program since June, 03 at The Rehabilitation Institute that is affiliated with Washington University's.Patti is Dr. Ruvinskaya'(a pediatric neurophysiatrist on Dr. John McDonald's team) patient.I am really impressed by Dr. Ruvinskaya. Every few months she thoroughly examines my daughter's progress during lengthy office visits. The optimism of that doctor for a future cure is almost as strong as Dr. Young's. She also gives us faith that Patti's intensive rehabilitation is working. And my daughter has made pretty significant progress already. During the last office visit (April 04), I asked Mrs. Linda Schultz about progress in Dr. McDonald's work. She told me no more than is already written in this thread. She said that they got very encouraging results in the laboratory study and the treatment will be ready for clinical trials in about two years. In my opinion, Dr. McDonald's work to find a cure is the most advanced in the US. I want to financially support their research as far as my budget will let me. Last February, I sent my donation to Barns Jewish Hospital, Spinal Cord Injury Research Fund.

                    Comment


                      Hallina,
                      You are right...the staff at Washington University have a completely different attitude than the doctors that we have encountered here in Texas regarding SCI.I believe it's the difference of believing in a future therapy that will get you out of the wheelchair... My husband is seeing Dr. Sadowsky and we have learned so much about his injury that we never knew since he first went there at the beginning of March, over 2 years post injury.
                      Just a reminder, when you send in donations, specify that it is for Dr. McDonald's NTT Project as that's the only way that he will be able to use your donation for his project.

                      Comment


                        Sergio, QuadPro - A less invasive procedure might also be more effective. If less of the cord is opened up and disrupted there might be a lot fewer immune cells penetrating the area and causing rejection. And less damage to the cord nd dura from the procedure is good, too. Opening a person up has a lot of risks... including infection. Developing the new delivery could be vital.


                        ~See you at the SCIWire-used-to-be-paralyzed Reunion ~
                        ~See you at the CareCure-used-to-be-paralyzed Reunion ~

                        Comment


                          You make a good point Jeff. I just think that we would all be better off testing this first on Humans without this prolonged trial. If it shows any benefits, then start working on a different delivery method, which may or may not prove more effective. First we should get something going, then start tweaking it. It makes sense to me, but this is just my opinion.

                          Comment


                            Sergio,
                            You are forgetting...Dr. McDonald has already done a phase I human clinical trial here in the US. The differences...
                            It was an invasive surgery and he used the stem cell sources of pigs.
                            One of the things he realized with this trial was that invasive surgery is unnecessary. He explained to us that the spinal cord is constantly moving. Think about the damage that is done when you are opened up that way and cut on. Then think of a tiny needle...an over the skin injection...what a big difference it will make in the outcome of the transfer of stem cells.
                            The other difference will be the cells that are transferred.
                            The cells that are being transferred preferrably should be your own and should belong in the spinal cord.
                            That's where somatic nuclear transfer comes in. As I understood, although somatic nuclear transfer has been done for a very long time, there are some very major differences in what Dr. McDonald will be doing, as compared to what has been done in the past... he will use an embryonic stem cell...not an egg. Dr. McDonald has done embryonic stem cell research for a very long time, and there are things he knows because of his results in the lab... he is also working together with others who are experienced with somatic nuclear transfer to quickly learn what is necessary but he will not move forward into human trials with this until he has proved in the lab that these cells are safe.
                            I have no doubt that Dr. McDonald is moving forward as quickly as is humanly possible. There are salaries that have to be paid...so it's understandable that lack of funding could very possibly hold things up in that respect.

                            [This message was edited by hope2findacure on 04-27-04 at 07:56 AM.]

                            Comment


                              Originally posted by hope2findacure:

                              Dr. McDonald will be doing, as compared to what has been done in the past... he will use an embryonic stem cell...not an egg.
                              I am surprised! Do you know why? Is it because the embryonic stem cells are more readily available/can be stored, whereas egg cells cannot be stored and SCNT has to be carefully timed to the harvest of the egg cells?

                              "Together we stand, divided we fall..."

                              Comment


                                Faye,
                                From what we understood, if an egg were used you could go on to clone a human...that's why somatic nuclear transfer is so controversial. But if a simple embryonic stem cell is used, the nucleus removed and then the individual's DNA put into it, you are creating a specific type of cells that have the individual's own DNA.

                                Comment

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