Announcement

Collapse
No announcement yet.

Both 4-AP and stem cell treatment target demyelinated axons for better CNS conduction

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

    Both 4-AP and stem cell treatment target demyelinated axons for better CNS conduction

    I noticed some similarities between wumedical's anecdotal SCI neural stem cell treatment case, Asteria's prelim cervical AST-OPC1 reports and reports about use of 4-AP (4-Aminopyridine), a potassium channel blocker. They all appear to target demyelinated axons with poor conduction, a consequence of SCI. Asteria even mentions the target of their AST-OPC1 stem cells is demyelinated axons.

    So I got 4-AP compounded and tested it at 10mg x 4 times a day dose (later went down to 5mg 4x a day due to nausea), after which, as a C4-incomplete I noticed:

    - greatly reduced spasticity allowing noticably faster heel-to-toe walking
    - sweating for the first time down my back -> a marked improvement in sensation
    - increased firmess through the core
    - better hand dexterity and alleviation of shoulder tightness/pain

    These are similar benefits to what wumedical stories say.

    I've then concluded then that anybody contemplating stem cell therapy should consider trying 4-AP first to gauge how much remyelination potential exists, along with functional gains obtained. 4-AP is a lot cheaper than say the US$25k Wumedical stem cell therapy though of course when you're not on it, the benefit is gone.

    Asteria's AST-OPC1 stem cell treatment above and below the injury site is about as good as it gets. Though that's still at a clinical trial phase .


    4-AP or even better 4-AP-3-MeOH support references

    SCI

    http://www.sci-therapies.info/Pharm-Chronic.htm#4AP
    https://www.carecure.net/forum/showt...CI-Dr-Riyi-Shi
    https://miracleofwalk.wordpress.com/2015/09/28/my-testing-of-4ap-3-meoh/



    AMN/MS

    http://www.mult-sclerosis.org/news/May2000/4APFAQ.html
    https://healthunlocked.com/amneasier...nosed-with-amn
    https://healthunlocked.com/amneasier/posts/133633198/4-ap-anyone-tried-it
    https://healthunlocked.com/amneasier/posts/131982109/4-aminopyridine-3-methanol-4-ap-3-meoh-.


    Where to buy 4-AP or the even better 4-AP-3-MeOH?

    4-AP is available from your local compounding pharmacy with a prescription. Looking at 5mg every 2-4 hours dosage. I found 10mg in such doses caused nausea. In Australia, I was paying AU$100 for 100 tablets. A bit expensive for what used to be a bird repellent, so I found a significantly cheaper source that even stocks the better 4-AP-3-MeOH, though that form costs 3.33 times more than 4-AP.

    https://www.mod4all.com/zencart/index.php?main_page=index&cPath=2


    I'm yet to try 4-AP-3-MeOH but the "requires 1/10 dose of 4-AP" literature of Dr. Shi is attracting me to do so.
    Last edited by Pauly1; 22 Dec 2016, 9:33 PM.

    #2
    https://www.ncbi.nlm.nih.gov/pubmed/27861125

    Came across that a week or two ago. I've been taking 4-ap for about two years now. I have a high level of function, full time walking, semi professional cyclist, after being diagnosed as a complete injury 13 years ago. In theory, I'd thought that 4-ap would possible cause mylein to regrow, slow rate, but would be possible. What I've seen in my recovery tells me it has happened.

    Comment


      #3
      I took Ampyra for 3 years, then I had a spinal stimulator surgically installed. I let the prescription run out (wrong) and I have some older stuff here that I had compounded a while ago. My best walking was with the 4-AP and the stimulator. I decided do to the cost to just used the stimulator, lately I have been turning it down more and more. I feel it if it isn?t even on, it?s been a year since I had this done. I am going to get back on the 4-AP and see what?s going on now. As of now, I can feel the cold breeze on my ankle from time to time and things are just generally weird, going to go back to San Diego where I had it done for a tune up, as I know what and where I need more function, it?s been just a bad and hectic year for me on other sides, and now I have a plan. Plus I found out I have gout, and no valves in my internal blood veins so I have this wonderful water problem, the key is to keep moving at all costs, and I'm no spring chicken, stubborn to say the least.

      Comment


        #4
        Originally posted by matt414 View Post
        https://www.ncbi.nlm.nih.gov/pubmed/27861125

        Came across that a week or two ago. I've been taking 4-ap for about two years now. I have a high level of function, full time walking, semi professional cyclist, after being diagnosed as a complete injury 13 years ago. In theory, I'd thought that 4-ap would possible cause mylein to regrow, slow rate, but would be possible. What I've seen in my recovery tells me it has happened.
        You've come a long way since you posted this years ago. LINK

        Here's the full publication link instead of the abstract on the mice treated beginning at 24 hours post injury for their peripheral nerve injury.
        http://spinalcordresearchandadvocacy.wordpress.com/

        Comment


          #5
          Originally posted by alhavel View Post
          I took Ampyra for 3 years, then I had a spinal stimulator surgically installed. I let the prescription run out (wrong) and I have some older stuff here that I had compounded a while ago. My best walking was with the 4-AP and the stimulator. I decided do to the cost to just used the stimulator, lately I have been turning it down more and more. I feel it if it isn?t even on, it?s been a year since I had this done. I am going to get back on the 4-AP and see what?s going on now. As of now, I can feel the cold breeze on my ankle from time to time and things are just generally weird, going to go back to San Diego where I had it done for a tune up, as I know what and where I need more function, it?s been just a bad and hectic year for me on other sides, and now I have a plan. Plus I found out I have gout, and no valves in my internal blood veins so I have this wonderful water problem, the key is to keep moving at all costs, and I'm no spring chicken, stubborn to say the least.
          Glad to hear you're staying with the program and still working forward. Best of luck on your return trip to San Diego!
          http://spinalcordresearchandadvocacy.wordpress.com/

          Comment


            #6
            Thanks! I have. It's been a VERY long road. I've explored pretty much every road out there. I am still chasing what most would call a "cure", for me nothing is enough. Which I've often called a curse and a blessing. it's what has gotten me this far, but keeps me up most nights.

            Comment


              #7
              You?re are right. I have done the same, and i have
              been able to progress so far, but it's not enough, I want more, a reversal of time so to speak.

              Comment


                #8
                I'm interested in trying this out. Do you take baclofen?
                c6 inc since 2-19-11
                ex pro-am motocross racer
                tilite aero z s2

                Comment


                  #9
                  Will this work for Chronic Complete SCI?

                  Comment


                    #10
                    There are lots of 4-AP threads here at the forum where people have talked about their results. Just type 4-AP in the search box to access them.
                    http://spinalcordresearchandadvocacy.wordpress.com/

                    Comment


                      #11
                      Yes

                      Comment


                        #12
                        Originally posted by Wills77 View Post
                        I'm interested in trying this out. Do you take baclofen?
                        Yes.

                        Comment


                          #13
                          Pauly, I'm so glad the 4-AP is helping you so much! I ordered the 4-AP-3-MeOH, but it had quality filler upping price and it doesn't help me or others according to mod4all and so am waiting for delivery of it w/o filler, which is what helped me a lot before. Little needed to really help me and I'm a C3/4 incomplete similar to you. -Jan

                          Comment


                            #14
                            I just ordered the 4-AP-3-MeOH from mod4all also. I'm a c6 ais C so I hope I notice decreased spasms and some benefits from it.
                            Does anybody know if it affects blood pressure? I currently take midodrine to raise my bp.
                            Last edited by Wills77; 26 Dec 2016, 3:13 PM.
                            c6 inc since 2-19-11
                            ex pro-am motocross racer
                            tilite aero z s2

                            Comment


                              #15
                              Originally posted by Wills77 View Post
                              I just ordered the 4-AP-3-MeOH from mod4all also. I'm a c6 ais C so I hope I notice decreased spasms and some benefits from it.
                              Does anybody know if it affects blood pressure? I currently take midodrine to raise my bp.
                              I'm not sure if it increases your blood pressure, what I do know is I had orthostatic hypotension and after I took 4-ap it went away. What would happen is if I lay down, then sit up, my blood pressure would drop, then if I stood up it would drop again, I would get a little dizzy, sometimes almost blacking out. Other than that, 4-ap didn't help much, but I'm going to try it again.
                              "Would you rather reduce deficits and interest rates by raising revenue from those who are not now paying their fair share, or would you rather accept larger budget deficits, higher interest rates, and higher unemployment? And I think I know your answer." Ronald Reagan"

                              Comment

                              Working...
                              X