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Both 4-AP and stem cell treatment target demyelinated axons for better CNS conduction

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  • #46
    I've also been ramping up my capsules of 4- AP 3-MeOH and tokyo air. I'm up to 4 a day for the past 4 days.
    So far I've noticed
    - My spasms are much worse. It could be interfering with my 100mg a day of baclofen.
    - Frequent erections throughout the day haha could be related to above.
    - More frequent urges to cath. I start to get minor AD when my bladder isn't close to full.
    - Waking up with more energy and more energy while working out
    - I started taking less senna

    I can usually tell my uti symptoms and don't feel like I have one but will get checked this week.
    I've been taking 1 pill every 6 hours and don't know if I should ramp up to 2 every 6 hours or 1 every 3 hours
    .
    Last edited by Wills77; 01-30-2017, 09:04 PM.
    c6 inc since 2-19-11
    ex pro-am motocross racer
    tilite aero z s2

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    • #47
      Originally posted by Sheri View Post
      How do you choose between 4-AP and 4- AP 3-MeOH? What's the difference? I'm about to start LDN compounded from Skips in Florida and was thinking 4-AP comes next. They compound at least regular 4-AP.
      Here's a pretty good in-depth answer Sheri - http://jn.physiology.org/content/103/1/469

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      • #48
        I know - 4-AP-3-MeOH is very good, the best stuff you can find.
        It is at least 5x better than just 4-AP or Ampyra (Famprydine) I have tested too.
        After all - I was a guinea pig . See my self - test remarks & experience here.
        Also very important note - 4-AP-3-MeOH substance works the best in combination with exercises / walking exercises.
        However, I am struggling to obtain quality supply with reasonable price.
        The best results I had with 3 mg or 6 capsules x 0.5 mg daily.
        Considering one capsule = 1 $ or $ 6.00 daily for me or US $ 180 monthly was hefty price but still I would take it
        if I know next month I will get pure 4-AP-3-MeOH when I order it.
        Unfortunately mod4all (through some unknown Japan connection) is the only known source & supplier that can disappear
        overnight (as he did before due to his own health troubles) and that's why I am in frantic search for better supplier...
        If someone find it - please, post it.
        Originally posted by tumbleweeds View Post
        Here's a pretty good in-depth answer Sheri - http://jn.physiology.org/content/103/1/469
        www.MiracleofWalk.com

        Miracles are not contrary to nature, but only contrary
        to what we know about nature
        Saint Augustine

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        • #49
          Are there human studies? Why has this gone nowhere?

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          • #50
            Originally posted by Sheri View Post
            Are there human studies? Why has this gone nowhere?
            See post #16 in this thread Sheri. They are currently recruiting.

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            • #51
              Comad, just went to your site to note there have been no human studies. But it looks so promising! What gives? And, yes, thank you, I will remember your words about how easily gains are lost. Been working a ton after getting set way back from crazy spasticity then pump implant. Definitely feeling progress so will NOT take it easy!

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              • #52
                Originally posted by tumbleweeds View Post
                I haven't seen specific dosage guidelines for 3-meoh, so I'm going with the 4-AP guidelines. I've been ramping up, so far results are slim though I am getting a light contraction in my right quadricep, and some buzzing in my legs. I can feel the weight of my right leg too. I will keep ramping up until I get to the equivalent of 40mg a day of 4-AP. Right now I'm at 4x a day at the equivalent of 20mg 4-AP.
                Just an update on what I've noticed so far. I'm taking four tablets, 1 tablet every 6 hours. That is equal to 20mg a day. Side effects are minimal, mostly a metallic taste in my mouth. Same as Wills77 I have also noticed an increase in energy, especially while working out. My strength or stamina has increased as well. I've doubled my reps with dumbbells. I have not experienced shoulder pain as I have in the past from increased reps. My right tricep is really firing nicely and across a much broader area. I'm a C6, still trace tricep in my left no change there.

                I've had increased erections as well.

                No change in spasms, They've always been pretty mild.

                I now have detectable contractions in both quads. I don't want to give the wrong impression to anyone, these are light and detectable by feel only, they're not strong enough to see yet. But something is firing in both legs. Both legs feel warm on the inside and today I did an hour 15 minutes on a motorized bike (that I just got fixed again) and both legs are burning, calves and quads, like they got a good workout. I'll do it again this evening.

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                • #53
                  Well, I'm being screwy and taking 5 mg of local 4-AP, 5 mg of London 4AP and two .5 mg 4-AP-3-MeOH. Not getting worse with spasticity, but no better. I'll try taking more. Comad, the Japanese chemist's name is Ken Saito and I still haven't written him about ordering 4AP3MeOH, need a Global Forever Stamp, but I intend to....Jan

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                  • #54
                    Keep up good fight!!! Thank you for visiting my Blog!

                    Originally posted by Sheri View Post
                    Comad, just went to your site to note there have been no human studies. But it looks so promising! What gives? And, yes, thank you, I will remember your words about how easily gains are lost. Been working a ton after getting set way back from crazy spasticity then pump implant. Definitely feeling progress so will NOT take it easy!
                    www.MiracleofWalk.com

                    Miracles are not contrary to nature, but only contrary
                    to what we know about nature
                    Saint Augustine

                    Comment


                    • #55
                      Originally posted by comad View Post
                      Unfortunately mod4all (through some unknown Japan connection) is the only known source & supplier that can disappear
                      overnight (as he did before due to his own health troubles) and that's why I am in frantic search for better supplier...
                      If someone find it - please, post it.
                      From mod4all
                      We aren't shipping any of this product for now. We've had problems with the compounding. We'll fix the problem, re-fill the most recent orders, then put it back online.
                      Anyone having luck getting is elsewhere? I'm trying a local compounding pharmacy, but they've never heard of it and are looking into what it takes to make it.

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                      • #56
                        Yeah...still nothing... if your compounding pharmacy figure out how to make 4-AP-3-MeOH - please, let me know??

                        Originally posted by tumbleweeds View Post
                        From mod4all
                        Anyone having luck getting is elsewhere? I'm trying a local compounding pharmacy, but they've never heard of it and are looking into what it takes to make it.
                        www.MiracleofWalk.com

                        Miracles are not contrary to nature, but only contrary
                        to what we know about nature
                        Saint Augustine

                        Comment


                        • #57
                          Looks like mod4all improved website and showing some signs of life...
                          So..anyone ordered recently from that company? Any comments about
                          delivery and quality? Please, post.
                          www.MiracleofWalk.com

                          Miracles are not contrary to nature, but only contrary
                          to what we know about nature
                          Saint Augustine

                          Comment


                          • #58
                            Originally posted by comad View Post
                            Yeah...still nothing... if your compounding pharmacy figure out how to make 4-AP-3-MeOH - please, let me know??
                            Nothing yet. My doctor contacted the compounding pharmacy he uses but they hadn't heard of it either. They were going to look into it. I wonder why the difficulty since it's been around awhile and is used for MS and ALS.

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                            • #59
                              That's very interesting that 4AP3MEOH is used for MS and ALS. Where? Should be available to us as compassionate use. I haven't ordered anything from mod4all lately and he said he'd send samples and didn't. I'm not as interested in it. I really want to try CBD oil under my tongue and am waiting for an aide to get well and pick it up......Jan

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                              • #60
                                Here Jan - https://www.ncbi.nlm.nih.gov/pubmed/21093437 and http://www.nrronline.org/article.asp...27;aulast=Page

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