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Both 4-AP and stem cell treatment target demyelinated axons for better CNS conduction

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  • #31
    Originally posted by luckydog View Post
    Does anyone know if 4-ap could potentially help someone who had a spinal cord stroke; C2-t2 infarction? I'm full time walking. My quality of life issues are bladder and bowel, which I'm wondering if it might help. I've been reading about it on here for the last 10 years, but I've never understood if I would be a good candidate. - thanks
    4ap improves conduction down demyelinated axons. Those being motor and sensory. In your case, there is no harm in trying 4AP to see what gains you get. Those gains then indicative of what stem cell treatment like Asterias' AST-OPC1 could offer you.

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    • #32
      Are there SCI events more commonly associated with demyelination?
      I.e. Contusion vs. Cut etc
      T3 complete since Sept 2015.

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      • #33
        Originally posted by Mize View Post
        Are there SCI events more commonly associated with demyelination?
        I.e. Contusion vs. Cut etc
        I read somewhere (sorry, can't remember where) that compression fractures are the most likely to have demyelination.
        For anyone interested here's some info that Dr. Young wrote about 4-AP.
        http:///index.php?page=viewarticle&a...nopyridine.htm

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        • #34
          Originally posted by Wills77 View Post
          I just ordered the 4-AP-3-MeOH from mod4all also. I'm a c6 ais C so I hope I notice decreased spasms and some benefits from it.
          Does anybody know if it affects blood pressure? I currently take midodrine to raise my bp.
          Any results? What dosage are you taking?
          T3 complete since Sept 2015.

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          • #35
            I ordered the 4-AP-3-MeOH from mod4all on dec 24th. They arrived today but the capsules are pretty much empty. Theres specs of white powder sticking to the inside edge but not enough to pile up by tapping on one side of the capsule. I havent tried them yet. Heres a photo of what I received... is this what everyone elses looked like?
            c6 inc since 2-19-11
            ex pro-am motocross racer
            tilite aero z s2

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            • #36
              That's rip-off. Suppose to be 0.5 mg in each capsule.
              I was ordering before from mod4all and I know that quantity of substance in capsules is not big -
              but at least take 15% of capsule volume - and that is way more than you got.
              I am staying away from mod4all until we find another supplier.
              Unfortunately, mod4all is running one man show in London UK and can not be
              trustworthy due to his own problems / health issues.

              Grammy found major production source of 4-AP-3-MeOH in USA.
              Name of this company is Alfa Asear but they are dealing only with compound pharmacies and bulk orders.
              I have tried to contact them but they never bother to reply.
              If anyone have Idea and figure out how we can get Alfa Asear supplying some
              compound pharmacy in US that will supply us, that would be change things here...
              www.MiracleofWalk.com

              Miracles are not contrary to nature, but only contrary
              to what we know about nature
              Saint Augustine

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              • #37
                That's what mine look like. Came from Japan.
                T3 complete since Sept 2015.

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                • #38
                  Originally posted by Mize View Post
                  That's what mine look like. Came from Japan.
                  Are they working? Can your Japanese connection be posted?
                  www.MiracleofWalk.com

                  Miracles are not contrary to nature, but only contrary
                  to what we know about nature
                  Saint Augustine

                  Comment


                  • #39
                    Originally posted by Wills77 View Post
                    I ordered the 4-AP-3-MeOH from mod4all on dec 24th. They arrived today but the capsules are pretty much empty. Theres specs of white powder sticking to the inside edge but not enough to pile up by tapping on one side of the capsule. I havent tried them yet. Heres a photo of what I received... is this what everyone elses looked like?
                    Mine came from mod4all as well, they are shipped from Japan. He has been prompt in answering my emails. They look the same as yours. Here's what he said about them: "Note, the capsules contain 0.5mg 4-ap-3-meoh + 10mg L-threonine. We tried filling them up all the way with filler, but they were all useless. The capsules are 99% empty. Really, we should use smaller, coloured capsules, but they are expensive." and in another email "Well, each capsule is 0.5mg 4-AP-3-MeOH, so this is comparable to 5mg of 4-AP. Remember 0.5mg is a half a thousandth of a gram. A miniscule dose."

                    I took my first one on Wednesday and am ramping up, took two yesterday and three today. Will top out at four tomorrow, six hours apart. I thought the same about so little drug in each capsule but I can feel effects after taking one.

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                    • #40
                      Originally posted by comad View Post
                      Are they working? Can your Japanese connection be posted?
                      Sorry, I was unnecessarily vague.
                      Mine are from mod4all and shipped to me from Japan. I took a single capsule to nights ago and noticed nothing. Not really clear how many/much to take and reasonably sure that mod4all is just a guy with friends overseas who ship these things to his buyers. Still, for $60, I figured with.

                      Any idea what the dosing should be?
                      T3 complete since Sept 2015.

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                      • #41
                        Originally posted by Mize View Post
                        Sorry, I was unnecessarily vague.
                        Mine are from mod4all and shipped to me from Japan. I took a single capsule to nights ago and noticed nothing. Not really clear how many/much to take and reasonably sure that mod4all is just a guy with friends overseas who ship these things to his buyers. Still, for $60, I figured with.

                        Any idea what the dosing should be?
                        Dr. Young wrote quite a bit about 4-AP, including dosage, here: http:///index.php?page=viewarticle&a...nopyridine.htm
                        I'm taking it by the dosage he suggests for 4-AP.

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                        • #42
                          Wondering if I have the 4AP ; can I get the 3-MeOH and take it as the same time ? begs the question how to buy it..

                          3-MeOH .. a google search gives me 3-methanol.

                          how much of this are folks taking in combination ?

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                          • #43
                            Originally posted by tumbleweeds View Post
                            Dr. Young wrote quite a bit about 4-AP, including dosage, here: http:///index.php?page=viewarticle&a...nopyridine.htm
                            I'm taking it by the dosage he suggests for 4-AP.
                            Are there dosage guidelines for the 3-MeOH variety? What results are you seeing?
                            T3 complete since Sept 2015.

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                            • #44
                              Originally posted by Mize View Post
                              Are there dosage guidelines for the 3-MeOH variety? What results are you seeing?
                              I haven't seen specific dosage guidelines for 3-meoh, so I'm going with the 4-AP guidelines. I've been ramping up, so far results are slim though I am getting a light contraction in my right quadricep, and some buzzing in my legs. I can feel the weight of my right leg too. I will keep ramping up until I get to the equivalent of 40mg a day of 4-AP. Right now I'm at 4x a day at the equivalent of 20mg 4-AP.

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                              • #45
                                How do you choose between 4-AP and 4- AP 3-MeOH? What's the difference? I'm about to start LDN compounded from Skips in Florida and was thinking 4-AP comes next. They compound at least regular 4-AP.

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