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    #16
    Hopefully Chilacas is able to contact Dr and get update

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      #17
      I'm wondering if it might help chronic, incomplete sci....

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        #18
        They were 1 to 5 years post injury, I don't see why incomplete would be a problem.
        Debating on CareCure is like participating in the special-olympics. You may win, but you're still disabled.

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          #19
          any link to an actual published paper?
          "That's not smog! It's SMUG!! " - randy marsh, southpark

          "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


          2010 SCINet Clinical Trial Support Squad Member
          Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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            #20
            Originally posted by lunasicc42 View Post
            any link to an actual published paper?
            http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=11;spage=1819;epage =1824;aulast=D%EDaz-Galindo

            The most common consequence of SCI is the paralysis due to neural circuit interruptions. Although there is some degree of spontaneous recovery, lost connections are hardly restored. It is an option to consider the use of neurotrophic factors to induce nerve regeneration. Neurotrophic factors have a key role in the modulation of neuronal survival, neurite outgrowth, synaptic plasticity and neurotransmission in both intact and injured nervous system.

            In this study, we found that LA, a GnRH agonist, significantly regained locomotor activity of SCI rats. Calderon-Vallejo and Quintanar (2012) reported that GnRH treatment recovered locomotor activity with similar findings to ours. Both results are strongly tied, because these effects are probably mediated through activation of GnRH receptors, which have been described in the spinal cord motoneurons (Dolan et al., 2003; Quintanar et al., 2007). In an experimental autoimmune encephalomyelitis model, LA administration produces an increase in the axonal growth and in neurofilaments and myelin basic protein expression (Guzmαn-Soto et al., 2012), which could explain the improvement in locomotor activity found in our experiments. The degree of locomotor activity recovery in rats treated with LA was higher than in those treated with GnRH (Calderon-Vallejo and Quintanar, 2012), which suggests that LA has greater potential for clinical application than GnRH.

            In kinematic analysis, we observed that LA treatment in SCI rats decreased step cycle, stance phase, and swing phase durations, but it resulted in increases in the stride distance and speed. LA rats spent less time in each step phase, traveled greater distance, and performed faster steps. These results can be considered as a sign of locomotor activity recovery, which were not observed in rats with physiological saline solution treatment. These results are similar to the outcomes by Hamers et al. (2001) who studied gait parameters in two different SCI types, i.e., transection of the dorsal half of the spinal cord and spinal cord contusion.

            The locomotor activity recovery in LA-treated animals is due to different mechanisms including remyelination (Guzman-Soto et al., 2012) or increases in microfilament protein expression, neurite outgrowth (Calderon-Vallejo and Quintanar, 2012), and axonal diameter (Quintanar et al., 2011). These results can be explained by reorganization of local networks via propriospinal circuitry. These local networks control the involuntary movements, which do not require cortico- or rubrospinal tracts, proposed as an explanation for the ability of spinal cord injured animals to produce walking movements (Ek et al., 2010). However, supraspinal tracts were likely involved in the control of voluntary movements observed in animals treated with LA. It could be related to reconnections going through injured area originated from supraspinal neurons.

            Propiospinal circuits provide an explanation for the restorations of micturition reflex in LA animals, in which the number of days that they need assistance of manual bladder emptying was reduced. This is possible due to the reorganization in reflex pathways inside the spinal cord, as reported by Groat and Yoshimura (2012).

            In this study, LA administration modified the gray and white matter areas, decreasing scar area and promoting thte recovery of spared tissue in SCI rats. High BBB scores were positively correlated with spared tissue in the spinal cord lesion (Basso et al., 1995). Structural conformation of the spinal cord is kept by both sufficient numbers of neurons and axons including their myelin. In traumatized spinal cord, only remnants of both gray and white matter exist due to the presence of hypercellularity, inflammation, cavitation, increased extracellular space and a loose fibrous matrix (Totoiu and Keirstead, 2005). Our results showed that in the LA group, spared tissue was increased, BBB scores were higher, faster stride speed and longer stride distance were observed in the LA group than in the sham group. These results reflect the new integration of spared descending and afferent-driven signals, as recovery after contusive SCI has been reported to be identified by changes in gait biomechanics and muscle activation patterns (Hansen et al., 2012).

            In the LA group, significantly higher BBB score and improved gait were observed at the 1 st and 2 nd weeks during the evaluation period compared to the sham group. As a consequence of SCI, microglia considerably increased independently of spared tissue. An early infiltration of macrophages/microglia in traumatic lesions of spinal cords has been observed in a rat model of SCI. The immune cell cascade involves infiltration of neutrophils and activation of resident microglia, followed by subsequent accumulation of monocyte-derived macrophages and the later entry of lymphocytes into the lesion site. The monocytes that infiltrate the injured area acquire a pro-inflammatory/classical profile (Raposo and Schartz, 2014). The reduction in the density of microglial cells observed in the LA group is probably associated with the locomotor activity in these rats.

            In conclusion, administration of LA partially improves lotomotor activity, gait, micturition reflex, spinal cord morphology and decreases microglial area in a rat model of SCI. Promotion of neuronal survival by administration of neurotrophic factors and a possible immunomodulation to counteract secondary injury are a promising approach to repair of SCI. Additionally, even LA administered via intramuscular injection is able to cross the blood-spinal cord barrier as observed in previous studies on patients with prostate cancer. LA is a potential alternative treatment of SCI because of its safety and ease in use as well as few side effects.[21]

            Last edited by Pauly1; 23 Oct 2016, 11:56 PM.

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              #21
              Thanks Pauly
              "That's not smog! It's SMUG!! " - randy marsh, southpark

              "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


              2010 SCINet Clinical Trial Support Squad Member
              Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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                #22
                Rather than rat studies, you're looking for the publication and data on the 45 treated patients.
                http://spinalcordresearchandadvocacy.wordpress.com/

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                  #23
                  @fti or and admin, would you mind changing the thread title to be more informative that summarizes the important info in this thread? eg:

                  Mexico: Leuprolide acetate injections see up to 40% SCI recovery

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                    #24
                    Originally posted by GRAMMY View Post
                    Rather than rat studies, you're looking for the publication and data on the 45 treated patients.

                    Do you have access to it?
                    "That's not smog! It's SMUG!! " - randy marsh, southpark

                    "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


                    2010 SCINet Clinical Trial Support Squad Member
                    Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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                      #25
                      Originally posted by lunasicc42 View Post
                      Do you have access to it?
                      I don't know that one actually even exists.
                      http://spinalcordresearchandadvocacy.wordpress.com/

                      Comment


                        #26
                        Originally posted by Pauly1 View Post
                        @fti or and admin, would you mind changing the thread title to be more informative that summarizes the important info in this thread? eg:

                        Mexico: Leuprolide acetate injections see up to 40% SCI recovery
                        Be nice if we could ascertain what 40% improvement means.
                        T3 complete since Sept 2015.

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                          #27
                          Originally posted by Mize View Post
                          Nowhere does the article describe the injections. I assume they are into the cord.
                          Leuprolide acetate is known to break the blood brain barrier, it can be administered intermuscular - subcutaneous or depot. It wouldn't have to be injected directly into the cord. Several companies market it under different brand names for various conditions.

                          Originally posted by Mize View Post
                          Be nice if we could ascertain what 40% improvement means.
                          Here's the Basso, Beattie and Bresnahan (BBB) locomotor scale method explanation: http://pages.jh.edu/SCI/characterization/bbb.shtml

                          This is the charted results for the rat study total of 5 weeks.

                          http://www.nrronline.org/viewimage.asp?img=NeuralRegenRes_2015_10_11_1819_1 70311_f1.jpg


                          I believe it shows the LA group data at 8 which is sweeping with no weight. Basically the rat can flex and extend while laying on it's side but doesn't support weight. Usually on day one of surgery they rate 0, but rats do slowly recover naturally from a SCI. Here's a good explanation by Jerry Silver on how the BBB scale is used towards viewing translational therapies. He was talking more about NY Impactor vs. the Infinite Horizon rather than a baloon style compression (which is rarely used in a US SCI lab), but the discussion is still valid. LINK

                          At the 5th week, leuprolide acetate-treated rats showed locomotor activity recovery by 38%, had improvement in kinematic gait and exhibited voiding reflex recovery by 60%, as compared with the 1st week. By contrast, saline solution-treated rats showed locomotor activity recovery only by 7%, but voiding reflex did not recover.


                          In other words, a 5 week natural rat recovery to 8 isn't that remarkable.
                          Last edited by GRAMMY; 25 Oct 2016, 12:02 PM. Reason: spelling
                          http://spinalcordresearchandadvocacy.wordpress.com/

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                            #28
                            Here's an english link not posted yet:

                            A Drug Used For Cancer Causes Notable Improvements in Patients with Spinal Cord Injuries

                            http://www.salud.carlosslim.org/english2/a-drug-used-for-cancer-causes-notable-improvements-in-patients-with-spinal-cord-injuries/

                            A group of 45 patients who received an injection of leuprolide acetate each month have experienced improvements in body movement, sphincter muscles control and partial recovery of sensation in their extremities.


                            The results showed that the recovery rate is variable, depending on several factors like injury’s magnitude, level and time elapsed since it was suffered. On average, it was recorded a 40 regeneration in the group of patients, and the effects are permanent.
                            ...
                            They chose candidates in people with spinal cord injury with certain characteristics; for example, all of them suffered their injuries from one to five years. All patients showed an improvement, which varied depending on the type of injury, its location, its magnitude, and time since it was suffered. Some patients were able to walk again, patients who did not control their sphincter muscles were able to control them, and kids with practically total paralysis could move their legs, Quintanar Stephano said

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                              #29
                              Originally posted by Pauly1 View Post
                              Here's an english link not posted yet:
                              A Drug Used For Cancer Causes Notable Improvements in Patients with Spinal Cord Injuries

                              http://www.salud.carlosslim.org/engl...cord-injuries/
                              That's the news article Chilacas translated a few days ago put out from the Carlos Slim Foundation but nobody has found a scientific publication about human testing.

                              Here's a list of the other SCI treatments they've posted about.

                              I wouldn't get too excited about a repurposed drug news article until we can see some human trial data and know what extent of SCI was involved.
                              Last edited by GRAMMY; 25 Oct 2016, 12:42 AM.
                              http://spinalcordresearchandadvocacy.wordpress.com/

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                                #30
                                Thanks, once again, Grammy. You always come through.

                                So it appears that 40% recovery means getting back to 40% of normal function. That's truly impressive if reproducible.
                                T3 complete since Sept 2015.

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