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    #16
    Originally posted by lunasicc42 View Post
    I thought the exact same thing .....about them saying that they were excited about their interim results in a newsletter not too long ago...now the total opposite?
    I was never impressed with the interim results nor the pre-clinical animal studies (were very weak in my opinion). I couldn't believe they ever initiated this trial. But I live SCI and have been on this board for years. Those investors probably know jack sh*t about SCI, which made it a dangerous investment for them. They probably had nothing to go by except word from management.

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      #17
      This U. of Miami Hospital article was published in April, prior to the May 31 StemCells Inc. announcement.

      http://ummd.med.miami.edu/news/2016/...d-injury-after


      Motor Improvement Seen in Patients with Cervical Spinal Cord Injury After Stem Cell Implantation

      ALLAN D. LEVI, M.D.

      Spinal cord injured patients in the StemCells, Inc. trial being conducted at University of Miami Hospital are demonstrating improvements in both hand strength and function. They are the first cohort in the Phase II pathway study, Allan D. Levi, M.D., Ph.D., professor and chair of the Department of Neurological Surgery and staff scientist at The Miami Project to Cure Paralysis, is one of the lead sites. The study is designed to measure the effects of implanting stem cells in patients with cervical spinal cord injury (SCI). The assessment of motor function involved using tests of dexterity and grip.
      Levi was the first investigator to perform a stem cell transplant into the chronically injured cervical spinal cord of a patient. This first cohort of the study was designed to assess the safety and preliminary signs of efficacy of cell administration into the cervical spinal cord and help determine the dose level for the 40-patient second cohort — a randomized, controlled, and single-blinded arm of the trial, which is already underway.
      “The safety of the procedure with increasing doses of stem cells is one of the first important observations of this trial,” said Levi.
      The patients in the study were selected because they had complete loss of motor control below the level of injury, the most severe degree of SCI as defined by the American Spinal Injury Association Impairment Scale. Clinicians used both International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) and Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP) measures to establish a pre-transplant baseline for each patient, and to assess post-transplant progress.
      Based on the six-month follow-up for the first cohort, an overall pattern of motor improvement was detected in four of the six patients as measured by gains in both strength and function on the collective ISNCSCI and GRASSP outcomes.
      “Any improvement in motor function is incredibly important to this patient population, and as a researcher and clinician is very exciting to observe,” said Levi.


      Additional highlights of the interim results include improved muscle strength in five of the six patients, with four of the five patients having gains in muscle strength and also demonstrating improved performance in functional tasks assessing dexterity and fine motor skills. Four of the six patients had improvement in the spinal level of injury as defined by the ISNCSCI assessment; three upgraded one level and one upgraded two levels. Additionally, changes in muscle strength and function were observed around three months post-transplant, consistent with the onset of sensory improvements seen in the company’s initial Phase I/II thoracic study, and no adverse events were attributed to the cells.

      “The emerging data are the first clinical evidence of a treatment improving muscle strength and function following cellular transplant in spinal cord injuries,” said Armin Curt, M.D., the principal investigator at the University of Zurich, Switzerland, for the company’s previous Phase I/II thoracic spinal cord injury study. “These findings are even more compelling given that all the patients are between one and two years post-injury.”
      To refer a patient to a UHealth Neurosurgeon call (305) 243-UMMD (8663).



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        #18
        Damn. According to the most recent New Mobility they are still recruiting quads for a phase 2 since the safety was established. At my age I was still looking at all the info but basically had decided to give this one a go.

        As far as keeping such companies going, well, first they need enough from VC and angels to get them to where they can be listed. Then, the best and safest way to invest in these companies is an ETF of biotechs. A good investment ETF would be heavy on more established companies like Celgene, Pfizer and Acorda then have a bit of several smaller companies like StemCell Inc, NeuralStem, etc. ETFs are like mutual funds but often specialize in one area of the economy or a group of companies in a country or a group of companies from a group of countries like the former WARSAW Pact.
        Courage doesn't always roar. Sometimes courage is the quiet voice at the end of the day saying, "I will try again tomorrow."

        Disclaimer: Answers, suggestions, and/or comments do not constitute medical advice expressed or implied and are based solely on my experiences as a SCI patient. Please consult your attending physician for medical advise and treatment. In the event of a medical emergency please call 911.

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          #19
          Stem cells inc is still recruiting?
          C5-C6 #quadlife

          Comment


            #20
            https://clinicaltrials.gov/ct2/show/...+injury&rank=4

            Originally posted by legitsrs View Post
            Stem cells inc is still recruiting?

            Comment


              #21

              This is confusing
              "That's not smog! It's SMUG!! " - randy marsh, southpark

              "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


              2010 SCINet Clinical Trial Support Squad Member
              Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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                #22
                Yes it is.
                Originally posted by lunasicc42 View Post
                This is confusing

                Comment


                  #23
                  I didn't understand it either

                  Comment


                    #24
                    Dr. Huhn reports on the data obtained from the Stem Cells, Inc. clinical trial using HuCNS-SC, as well as the challenges that ultimately led to suspension of the trial.

                    http://spinalcordresearchandadvocacy.wordpress.com/

                    Comment


                      #25
                      http://www.cell.com/stem-cell-report...mpaignId=10608
                      "That's not smog! It's SMUG!! " - randy marsh, southpark

                      "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


                      2010 SCINet Clinical Trial Support Squad Member
                      Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

                      Comment


                        #26
                        They knew it was not going to work before starting the trial, but they went forward anyway....
                        I attended a presentation of this study well before Stem Cell Inc. stopped the trial and I could not believe to what I was hearing... I guess investors somehow kept this news silent long enough to get rid of some shares before loosing all their investment..

                        If someone had told the truth long time ago I guess it would have been accused of proposing one more "conspiracy theory"...

                        More BS like that will come to surface in the coming years.. We need some whistleblowers!
                        In God we trust; all others bring data. - Edwards Deming

                        Comment


                          #27
                          Originally posted by paolocipolla View Post
                          They knew it was not going to work before starting the trial, but they went forward anyway....
                          I attended a presentation of this study well before Stem Cell Inc. stopped the trial and I could not believe to what I was hearing... I guess investors somehow kept this news silent long enough to get rid of some shares before loosing all their investment..

                          If someone had told the truth long time ago I guess it would have been accused of proposing one more "conspiracy theory"...

                          More BS like that will come to surface in the coming years.. We need some whistleblowers!

                          Yes, it's a shame indeed that Stemcells inc hasn't listened to you.
                          "Talk without the support of action means nothing..."
                          ― DaShanne Stokes

                          ***Unite(D) to Fight Paralyses***

                          Comment


                            #28
                            Originally posted by Moe View Post
                            Yes, it's a shame indeed that Stemcells inc hasn't listened to you.
                            As I expected you don't seem to understand what has happened and what I wrote either. You may want to start reading the paper.

                            Take care my friend.
                            In God we trust; all others bring data. - Edwards Deming

                            Comment


                              #29
                              Originally posted by paolocipolla View Post
                              As I expected you don't seem to understand what has happened and what I wrote either. You may want to start reading the paper.

                              Take care my friend.
                              Sorry, I wasn't listening...
                              "Talk without the support of action means nothing..."
                              ― DaShanne Stokes

                              ***Unite(D) to Fight Paralyses***

                              Comment

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