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Bases for Hope in Spinal Cord Injury Research

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  • Bases for Hope in Spinal Cord Injury Research

    http://carecure.rutgers.edu/spinewir...SCIHope03c.htm

    Many people have been asking me for the lecture that I have been giving, summarizing spinal cord injury research from 1995 to now. The above is a link to an html version of the powerpoint file. If you have any questions, please ask.

  • #2
    Very clean presentation. Alot of good info. Thanks Dr. Young for your endless hard work. Who knows what the future will bring. Merry Xmas!

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    • #3
      Hello Dr. Young -

      Do you think the pipeline is full enough with potential therapies? I remember you were always mentioning that as important. From my read of your presentation, the pipeline is pretty full, almost confusingly so.

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      • #4
        Thanks Dr. Young for the informative Power Point and for your endless work in the area of SCI cure. Nan

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        • #5
          Very nice presentation, Wise.
          Thanks
          Please donate a dollar a day at http://justadollarplease.org.
          Copy and paste this message to the bottom of your signature.

          Thanks!

          Comment


          • #6
            Dr. Young:

            Can you please explain the following in your presentation on the results of Dr. Huang's OEG trial? The average motor score, touch score, and pinprick score improvement in the patients at 4-6 weeks after transplantation for each age group. I am unfamiliar with this scoring system. Is is similar to ASIA score? How does it translate to improvement in levels of SCI?

            Thanks:


            JJG
            Jake's Pop

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            • #7
              Dear Wise,
              The Assosiation of Hungarian Spinal Cord Injured (http://neko.srv.hu) would like this ppt in Hungarian. Is there any way someone could translate it?
              Bubo

              Originally posted by Wise Young:

              http://carecure.rutgers.edu/spinewir...SCIHope03c.htm

              Many people have been asking me for the lecture that I have been giving, summarizing spinal cord injury research from 1995 to now. The above is a link to an html version of the powerpoint file. If you have any questions, please ask.

              Comment


              • #8
                Originally posted by Dr. J. J.:

                Dr. Young:

                Can you please explain the following in your presentation on the results of Dr. Huang's OEG trial? The average motor score, touch score, and pinprick score improvement in the patients at 4-6 weeks after transplantation for each age group. I am unfamiliar with this scoring system. Is is similar to ASIA score? How does it translate to improvement in levels of SCI?

                Thanks:


                JJG
                JJ, these are neurological change scores. The motor scores represent muscle scores (each muscle is scored on the standard scale of 0-5 where 0 is no movement, 1 is trace movement, 2 is visible movement, 3 is movement sufficient to oppose gravity, 4 is movement against resistance, 5 is normal), pinprick or pain scores (each dermatome on each side of the body is scored on the scale of 0-2 where 0 is no sensation, 1 is abnormal sensation, and 2 is normal sensation), and touch (same scoring system as pinprick).

                The score given the mean change of score before and within 6 weeks after transplanation. The ±value given is the standard deviation of the scores.

                Wise.

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                • #9
                  Originally posted by Bubo-Hungary:

                  Dear Wise,
                  The Assosiation of Hungarian Spinal Cord Injured (http://neko.srv.hu) would like this ppt in Hungarian. Is there any way someone could translate it?
                  Bubo
                  I wouldn't know how to translate it into Hungarian but if somebody would like to do it, I would not mind.

                  Wise.

                  Comment


                  • #10
                    Dr Young, Thanks again for the presentation Friday night. It was very informative and motivating. (I found the info on the many different types of therapies in progress and/or coming in the near future very interesting, and the info on 'repetative use' and 'reverse learned non-use' interesting as well). Unfortunately, we were unable to stay for the entire presentation or the Q&A session. I just finished viewing your presentation tonight. Question: I am starting to take Elavil for my neurogenic pain - what is the recommended dosage? Is there additional information available on Elavil? I am currently taking 25mg once a day at night and it is not working. (Previously, I had tried zonegran and neurontin without success). Thanks. Bob

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                    • #11
                      bobg, you are very welcome. I was thinking that people were too tired to hear the whole thing and am glad that it was informative.

                      Regarding elavil for neurogenic pain, there is no clear recommended dose. However, several studies suggest that the dose does not need to be as high as the doses that are used to combat depression (it is an anti-depressant drug because it prevents the breakdown of catecholamine neurotransmitters). There are reports that doses as low as 20 mg per day is sufficient to take the edge off the classic burning or pressure-like neurogenic pain. How high of a dose of neurontin did you try? What kind of pain do you have? Intermittent and spasmodic neurogenic pain tend to be less responsive. Wise.

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                      • #12
                        Bubo
                        i'm hungarian and if i can get the english text i would be happy to translate.
                        let me know, you can email me @
                        macska61@yahoo.ca
                        andrea
                        My mouth is like a magician's hat, never know what might come out of it.

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                        • #13
                          You can download a pdf file of the lecture and notes at http://carecure.rutgers.edu/spinewir...SCIHope03c.pdf

                          Wise.

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                          • #14
                            Dr. Young, I was taking 1200mg of Neurontin per day (600mg in AM, 600mg in PM) for about 3 months. Should I have tried to increase to a larger dose before quitting. I am now taking 25mg of Elavil (once at night). I've been taking Elavil for approx. 2 months. The pain I experience is the burning, pressure-like, cramping pain in both legs (upper and lower). I have no feeling in my left leg (upper/lower); I don't have feeling in my right lower leg. I do have feeling in my right upper leg. It is intermittent (some days - a few times, some days - 10-20 times). The pain ranges from 2 to a 9. My next step is to increase the Elavil to 50mg per day. Thanks. Bob

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                            • #15
                              Originally posted by bobg514:

                              Dr Young, Thanks again for the presentation Friday night. It was very informative and motivating. (I found the info on the many different types of therapies in progress and/or coming in the near future very interesting, and the info on 'repetative use' and 'reverse learned non-use' interesting as well). Unfortunately, we were unable to stay for the entire presentation or the Q&A session. I just finished viewing your presentation tonight. Question: I am starting to take Elavil for my neurogenic pain - what is the recommended dosage? Is there additional information available on Elavil? I am currently taking 25mg once a day at night and it is not working. (Previously, I had tried zonegran and neurontin without success). Thanks. Bob
                              hi bob i also take neurontin but had to increase the dose i take 1800mg 2x aday and it helps only thing is i get a little drowsy. hope this helps .lol gloria

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