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  • #16
    Originally posted by PC720 View Post
    Hey guys UPMC stands for University Pittsburgh Medical Center. If you would like to know more at the bottom of the article is a phone number
    I looked up to see where the trial sites were located. There are 13 trial locations in the United States. They are in Houston, TX; Miami, FL; Salt Lake City, UT; Minneapolis, MN; Milwaukee, WI; Chicago, IL; Ann Arbor, MI; Pittsburg, PA; Baltimore, MD; Philadelphia, PA; New York, NY; Palo Alto and Downey CA. There may be other sites opening up in the future.
    http://spinalcordresearchandadvocacy.wordpress.com/

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    • #17
      Ermm... where and why was this post moved??

      EDIT looks like it was moved to the cure section as opposed to out of it... i think.


      Great info guys, it's reassuring to know alots going on with SCI.

      For those that are more learned/experienced, is it fair to say that in the past few years alot of progress or atleast interest in SCI is being made?

      Or has stuff like this been mentioned for decades?

      Regards x

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      • #18
        Originally posted by taymas View Post
        Ermm... where and why was this post moved??

        EDIT looks like it was moved to the cure section as opposed to out of it... i think.


        Great info guys, it's reassuring to know alots going on with SCI.

        For those that are more learned/experienced, is it fair to say that in the past few years alot of progress or atleast interest in SCI is being made?

        Or has stuff like this been mentioned for decades?

        Regards x
        There were two threads in cure about this same UPMC trial location that were probably combined. UPMC is just one location out of the 13 sites available for this PATHWAY CLINICAL TRIAL.
        http://spinalcordresearchandadvocacy.wordpress.com/

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        • #19
          Here's an article that appeared a couple days ago about one of the two sites in California. LINK
          http://spinalcordresearchandadvocacy.wordpress.com/

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          • #20
            Grammy, is there so many major clinical trials like these past 2-3years last time? Or is it just like this all along? sorry for my poor command of english.

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            • #21
              Originally posted by Tyran21 View Post
              Grammy, is there so many major clinical trials like these past 2-3years last time? Or is it just like this all along? sorry for my poor command of english.
              No, your English is fine Tyran21. I think I understand what you are asking. I believe we now have many more relevant trials being tested by biotech companies along with more trial sites made available than in the past. Our clinical trial list at u2fp is a lot bigger than past years. We have neurosurgeons and hospitals now that have to compete for patients a bit because of the different factors but they do need business and they're willing to work within the guidelines that clinical trials must meet. Many are trauma one hospitals and can easily meet the criteria if they have personnel with expertise there to deliver the therapy. Another factor is timing and patient condition especially on some of the acute trials you see. Biotech's will spread lots of sites out across the country to try to capture as many acute patients as possible. There's only a certain percentage of SCI that are actually willing to participate. It's easier to get the treatments to the hospitals that qualify with treatment protocols and delivery than trying to transport patients that are in poor condition. For instance the Neuralstem trial used a very special cannula for delivery of the cells that not all hospitals had available. Acute trials are definitely more difficult to fill with participants.

              We do have a network for SCI trials amongst hospitals but it doesn't appear to make much difference when sponsors set up their sites. Many hospitals in the network participate, but you'll also see hospitals participating that have nothing to do with the SCI network. I think there are different factors at play depending on the treatment that needs to be tested and if the hospital site can meet all the designated protocol required in the trial. A factor is also if proper cell storage is available and specialized equipment is available like the cannulas or the new one that will InVivo will be using for laying trails of neural cell scaffold. Not all neurosurgeons have the expertise to do a trial and some don't want the paperwork required for data collection. I hope this answers your questions.
              Last edited by GRAMMY; 04-04-2016, 12:24 PM.
              http://spinalcordresearchandadvocacy.wordpress.com/

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              • #22
                Thanks for the answer, hopefully one of these many trials produce some good results

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                • #23
                  Grammy, I have read somewhere that InVivo will give neural stem cells to the first five patients that have received the scaffold. If you know anything about it, thanks.

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                  • #24
                    Grammy Arethere usually neurosurgeons involved with these clinical trials, as in part of the company? If there isn't does the head surgeon that is mainly responsible for administering or dictating the procedure at the selected hospitals usually get invited on board. What's the incentive ?

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                    • #25
                      Trials have a principal investigator (P.I.) in charge of the study at each location. (It may or may not be the head surgeon of the hospital or division). They receive the necessary training to carry out the trial in advance along with having the expertise to be selected when the sites are chosen. I don't know how much the companies are charged by the hospital systems participating or what type of pay scale is involved. Some companies do have neurosurgeons on their scientific advisory boards and a few have company positions. Their involvement in the actual studies varies.

                      Here is link that explains general studies. LINK
                      Last edited by GRAMMY; 04-05-2016, 09:22 PM.
                      http://spinalcordresearchandadvocacy.wordpress.com/

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                      • #26
                        Originally posted by scimike View Post
                        Grammy, I have read somewhere that InVivo will give neural stem cells to the first five patients that have received the scaffold. If you know anything about it, thanks.
                        I haven't heard that scimike. I believe the patients will not get any additional treatments for awhile anyway. They generally have a time table laid out in advance on how long the company must follow the patients for safety and data. Some of the stem cell trials have patients being followed for 5 years after they were treated. I suppose once their time limit is met, I image they could apply for bioengineered neural stem cell scaffold but I rather doubt they would be accepted because of data difficulty.
                        http://spinalcordresearchandadvocacy.wordpress.com/

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                        • #27
                          Thanks Grammy. What you say makes sense.

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                          • #28
                            Originally posted by scimike View Post
                            Thanks Grammy. What you say makes sense.
                            Perhaps we can figure out more when InVivo actually announces which company they're going to contract with for cells. (I don't believe they've actually made a public announcement that I'm aware of). There's always the possibility of getting cells at a later time point once the initial participants have all their data recorded. We'll see what the future brings.
                            http://spinalcordresearchandadvocacy.wordpress.com/

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