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Could Cancer Genes Help Repair Spinal Cord Injuries? - NEWS

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  • Could Cancer Genes Help Repair Spinal Cord Injuries? - NEWS

    Could Cancer Genes Help Repair Spinal Cord Injuries? By Mitch Teich & Joy Powers ? 1 hour ago

    A Marquette University researcher hopes his work could be a promising step towards a cure for spinal cord injuries and the paralysis they cause.
    Dr. Murray Blackmore turned to an unlikely ally in his work - cancer genes.
    The most recent data from the National Spinal Cord Injury Statistical Center shows that more than 12,000 people in the U.S. suffer significant spinal cord injuries each year. The injuries are both physically and financially vexing.

    Current medical practices cannot heal a spinal cord injury, because nerve cells are unable to regenerate in the spine. This is where cancer genes come in, since cancer is the unregulated growth of cells in different parts of the body.

    ?The processes that go wrong in cancer turn out to be exactly the processes we want to engage to repair the nervous system,? says Dr. Blackmore. He's the lead researcher on this study as well as an assistant professor of biomedical sciences in Marquette University?s College of Health Sciences.
    Dr. Blackmore?s work is being supported by a seed grant from the Milwaukee-based Bryon Riesch Paralysis Foundation. Riesch founded his eponymous foundation, after he was paralyzed in an accident at Marquette University nearly two decades ago.

    The foundation gives money to scientists conducting new research on how to fix spinal cord injuries, a feat the scientific community has yet to achieve. Riesch says he has hope for the future.

    ?For me to be injured in this time period... it?s exciting because you see research such as Murray?s and other ones that are going on at the medical college and across the nation. And it?s exciting to see that,? he says. ?It gives me, as somebody that?s paralyzed, hope that my life is going to change and even get better.?

    SOURCE

    Visit the source and listen to the audio feed, interesting stuff... -Moe
    Last edited by Moe; 02-24-2016, 06:31 PM. Reason: FORMATTING
    "Talk without the support of action means nothing..."
    ― DaShanne Stokes

    ***Unite(D) to Fight Paralyses***

  • #2
    What a waste of $. Why are they still doing basic research in labs? BS. They've already cured rats 100x over. We need human trials now. Even Dr. Young has said he has gotten the spinal cord to regenerate across the injury site using Umbilical Cord Blood + Lithium in his HUMAN trials. Someone should tell this to Dr. Blackmore so that he gives up on genes and refocuses on using umbilical cord blood cells in his research...to find ways to enhance the regeneration that UCB obviously creates.

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    • #3
      NM, don't misquote people, Wise never said that.

      Comment


      • #4
        Rather stay the way I am than eff around with cancer genes. Thanks but no thanks.
        Roses are red. Tacos are enjoyable. Don't blame immigrants, because you're unemployable.

        T-11 Flaccid Paraplegic due to TM July 1985 @ age 12

        Comment


        • #5
          Originally posted by Jim View Post
          NM, don't misquote people, Wise never said that.
          He said he believed he saw regenerating axons growing across the injury site. The imaging was DTI I think.

          Comment


          • #6
            Post #1274 in Chinasci Update thread

            "First, we found that evidence of white matter regrowth in 2 of 5 subjects after UCMBC transplants, not just across the gap but apparently long distances both up and down the spinal cord. All ASIA A subjects showed a white matter gap before treatment. None had shown white matter growth across the gap before cell transplantation. The growth does not seem to correspond with motor and sensory scores in the subjects. We believe that this may be because the growing fibers have not yet reached their targets, i.e. have not connected with neurons in the brainstem that would be necessary for sensory improvement or in the lumbosacral spinal cord for voluntary activation of the leg muscles." ~ Dr. Young

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            • #7
              When quoting someone, do so correctly the first time, not the third.

              Comment


              • #8
                The good news "we cured your spinal cord injury" the bad news, "You have 6 months to live, you are dying of Cancer".
                "Life is about how you
                respond to not only the
                challenges you're dealt but
                the challenges you seek...If
                you have no goals, no
                mountains to climb, your
                soul dies".~Liz Fordred

                Comment


                • #9
                  Originally posted by lynnifer View Post
                  Rather stay the way I am than eff around with cancer genes. Thanks but no thanks.
                  Dr. Blackmore is studying the overexpression in early postnatal cortical neurons that are reduced in both initial axonogenesis and the rate of axon elongation. He's looking for gene roles involved in restricting axon growth in the developing CNS, and substantiate the hypothesis that previously identified oncogenes and tumor suppressors can play conserved roles in axon extension. Which genes are causing the problems of only allowing a tiny bit of axon growth when what we need is longer growing axons in repair. Which genes would give us better axon growth? The cancer field is already working in the axon growth field, Dr. Blackmore's lab is mining the data and analyzing it for the SCI field.
                  Last edited by GRAMMY; 02-25-2016, 03:07 AM.
                  http://spinalcordresearchandadvocacy.wordpress.com/

                  Comment


                  • #10
                    Originally posted by Curt Leatherbee View Post
                    The good news "we cured your spinal cord injury" the bad news, "You have 6 months to live, you are dying of Cancer".
                    The most dangerous phrase in the language is "We've always done it this way".
                    http://spinalcordresearchandadvocacy.wordpress.com/

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                    • #11
                      Genetic therapy of any kind - not for me. Won't see this in my lifetime anyway.
                      Roses are red. Tacos are enjoyable. Don't blame immigrants, because you're unemployable.

                      T-11 Flaccid Paraplegic due to TM July 1985 @ age 12

                      Comment


                      • #12
                        Originally posted by Curt Leatherbee View Post
                        The good news "we cured your spinal cord injury" the bad news, "You have 6 months to live, you are dying of Cancer".
                        If I was 100% after and had my settlement in hand. I would gladly take that with open arms, no hesitation! A life of dependency, or six months of total freedom and a "dignified" end... Nobody would be touching me until I was long gone. Easy decision wouldn't even have to Think about it...

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                        • #13
                          Originally posted by Jim View Post
                          When quoting someone, do so correctly the first time, not the third.
                          I guess you do not understand the difference between a quote and a paraphrase.

                          What's worse is that you work for Dr.Young (I think), you are the administrator, and yet you have forgotten that Dr. Wise ever said that he saw evidence of long distance spinal cord regeneration in his human trials. It seems like that would be the most important thing to remember.

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                          • #14
                            Yes, I work for Wise and have heard him discuss this topic dozens of times. He has purposely not used the word regenerate, so you should not say he has.

                            Comment


                            • #15
                              Originally posted by Jim View Post
                              Yes, I work for Wise and have heard him discuss this topic dozens of times. He has purposely not used the word regenerate, so you should not say he has.
                              "First, we found that evidence of white matter regrowth in 2 of 5 subjects after UCMBC transplants, not just across the gap but apparently long distances both up and down the spinal cord. All ASIA A subjects showed a white matter gap before treatment. None had shown white matter growth across the gap before cell transplantation. The growth does not seem to correspond with motor and sensory scores in the subjects. We believe that this may be because the growing fibers have not yet reached their targets, i.e. have not connected with neurons in the brainstem that would be necessary for sensory improvement or in the lumbosacral spinal cord for voluntary activation of the leg muscles." ~ Dr. Young


                              What is the difference in meaning between "regrowth"/ "growing" vs. "regenerating" ?

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