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  • Latest breakthrough in SCI research

    ....
    "This may seem like a small bit of medical news?though it will have immediate clinical implications?but what's important is how it was discovered in the first place."

    ...
    "This wasn?t the result of a new, long-term study, but a meta-analysis of $60 million worth of basic research written off as useless 20 years ago by a team of neuroscientists and statisticians led by the University of California San Francisco and partnering with the software firm Ayasdi, using mathematical and machine learning techniques that hadn?t been invented yet when the trials took place."

    ....

    "Twenty years after Christopher Reeve?s paralysis shone a spotlight on their field, there haven?t been any breakthroughs. "There are no drugs," Ferguson says. "It doesn?t have any real, agreed-upon therapeutic approach. That?s embarrassing. We should have something, at least."

    Link


    In God we trust; all others bring data. - Edwards Deming

  • #2
    Originally posted by paolocipolla View Post
    ....
    "This may seem like a small bit of medical news?though it will have immediate clinical implications?but what's important is how it was discovered in the first place."
    ...
    "This wasn?t the result of a new, long-term study, but a meta-analysis of $60 million worth of basic research written off as useless 20 years ago by a team of neuroscientists and statisticians led by the University of California San Francisco and partnering with the software firm Ayasdi, using mathematical and machine learning techniques that hadn?t been invented yet when the trials took place."
    ....
    "Twenty years after Christopher Reeve?s paralysis shone a spotlight on their field, there haven?t been any breakthroughs. "There are no drugs," Ferguson says. "It doesn?t have any real, agreed-upon therapeutic approach. That?s embarrassing. We should have something, at least."
    Link
    But the discovery of high blood pressure's detrimental effects on long-term recovery has immediate implications for human patients, namely whether the use of hypertension drugs immediately after their injuries and before surgery could improve outcomes, a hypothesis Ferguson and colleagues intend to test shortly at UCSF. In the long run, Ferguson believes retroactive data mining is "a worthwhile approach," especially considering how much less expensive it is to sift old data again than run new trials. "For a little more than a million dollars, we've opened $60 million worth of value."

    Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury. LINK Open Access Paper

    Super! The impact on recovery from such an easy intervention at an acute stage could have major implications! There's tons of mid-1990's data on acute models and all kinds of hypertension drugs already on the market now to lower blood pressure for someone that presents at a trauma center with a fresh spinal cord injury. I hope someone starts funding such a human clinical trial right away if that pans out in San Francisco. It wouldn't be as expensive as some of the stem cell trials, that's for sure.
    Last edited by GRAMMY; 10-16-2015, 10:46 AM. Reason: spelling
    http://spinalcordresearchandadvocacy.wordpress.com/

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    • #3
      Here is something somewhat exciting for brain injuries. "We have discovered a cocktail of small molecules that can reprogram human brain astroglial cells into neuron-like cells after eight-to-ten days of chemical treatment,"--Gong chen at PSU. http://science.psu.edu/news-and-even...ws/Chen10-2015
      Only a life lived for others is a life worthwhile.
      -A.E.

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      • #4
        Originally posted by MN_Adam View Post
        Here is something somewhat exciting for brain injuries. "We have discovered a cocktail of small molecules that can reprogram human brain astroglial cells into neuron-like cells after eight-to-ten days of chemical treatment,"--Gong chen at PSU. http://science.psu.edu/news-and-even...ws/Chen10-2015
        That's interesting, hope they can do the same thing invivo.

        I also wonder how much SCI research can benefit from CRISPR/CAS9

        https://www.youtube.com/watch?v=0dRT7slyGhs
        In God we trust; all others bring data. - Edwards Deming

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