Announcement

Collapse
No announcement yet.

Cancer Drug Epothilone Causes Damaged Nerve Cells In Spinal Cord Injuries To Regrow

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Cancer Drug Epothilone Causes Damaged Nerve Cells In Spinal Cord Injuries To Regrow

    http://www.science20.com/news_articl..._regrow-153980


    Cancer Drug Epothilone Causes Damaged Nerve Cells In Spinal Cord Injuries To Regrow
    By News Staff | March 12th 2015 05:02 PM | Print | E-mail | Track Comments
    Tweet
    Damage to the spinal cord is often permanent because injured nerve cells fail to regenerate due to scar tissue of their long nerve fibers.

    Nerve cells are wire-like conductors that transmit and receive signals in the form of electrical impulses. This function can be impaired by accidents or disease. Whether or not the affected nerves can recover largely depends on their location: for instance nerve cells in the limbs, torso and nose can regenerate to some degree and regain some or all of their function.

    In contrast, the neurons in the brain and spinal cord do not have this ability. If they are damaged by accident or disease, the patient is likely to suffer long-term paralysis or other disabilities. But why is regeneration of these neurons and their long nerve fibers impeded? It is already known that inhibiting factors in newly formed scar tissue and other cellular processes block axon regrowth.

    A new study shows that, in animal studies, the cancer drug epothilone reduced the formation of scar tissue in injuries to the spinal cord and stimulated growth in damaged nerve cells. Both promoted neuronal regeneration and improved the animals' motor skills.


  • #2
    Very interesting....

    Comment


    • #3
      I guess the question is who will try it first...

      Comment


      • #4
        >...years?...same ol' talk I'd imagine
        "That's not smog! It's SMUG!! " - randy marsh, southpark

        "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


        2010 SCINet Clinical Trial Support Squad Member
        Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

        Comment


        • #5
          Originally posted by wesmaister View Post
          I guess the question is who will try it first...
          I believe they're already running an Epothilone B clinical trial in ALS...
          Last edited by GRAMMY; 03-13-2015, 11:20 PM.
          http://spinalcordresearchandadvocacy.wordpress.com/

          Comment


          • #6
            Originally posted by tarheelandy View Post
            Very interesting....
            I agree. It'd be interesting to just be able to repurpose a drug that has already made it through all the FDA safety trials and is on the market! It would shave off years of waiting and expenses too.
            http://spinalcordresearchandadvocacy.wordpress.com/

            Comment


            • #7
              Originally posted by lunasicc42 View Post
              >...years?...same ol' talk I'd imagine
              Your same ol' talk or do you mean Frank's strategy of repurposing a low dose of Epothilone?

              Franks lab also worked on transparency in the cord...LINK

              Franks lab was also working on repurposing Taxol. LINK
              Last edited by GRAMMY; 03-13-2015, 11:36 PM.
              http://spinalcordresearchandadvocacy.wordpress.com/

              Comment


              • #8
                Grammy always comes with details. Thank you dear.

                Comment


                • #9
                  Originally posted by GRAMMY View Post
                  Your same ol' talk or do you mean Frank's strategy of repurposing a low dose of Epothilone?

                  Franks lab also worked on transparency in the cord...LINK

                  Franks lab was also working on repurposing Taxol. LINK

                  I was just getting really weary of all the articles that are like "potential new drug to combat spinal injuries!". As a Spinal cord injured person I think thats great but I think we already have some Possibly potential therapies, I would rather see some of the already promising treatments tried faster than discovering potential therapy after potential therapy like we're still at square one ...to crudely quote another members signature from memory: "test what you have and give us what you already know"
                  I could have just woke up on the wrong side of the bed though
                  "That's not smog! It's SMUG!! " - randy marsh, southpark

                  "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


                  2010 SCINet Clinical Trial Support Squad Member
                  Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

                  Comment


                  • #10
                    Originally posted by lunasicc42 View Post
                    I was just getting really weary of all the articles that are like "potential new drug to combat spinal injuries!". As a Spinal cord injured person I think thats great but I think we already have some Possibly potential therapies, I would rather see some of the already promising treatments tried faster than discovering potential therapy after potential therapy like we're still at square one ...to crudely quote another members signature from memory: "test what you have and give us what you already know"
                    I could have just woke up on the wrong side of the bed though
                    (That would then require the shutdown of the cure forum at the CareCure website). It's the only place on the forum to post the latest research and potential discovery information for the community in spite of most all the threads digressing to unrelated trash.
                    http://spinalcordresearchandadvocacy.wordpress.com/

                    Comment


                    • #11
                      Originally posted by GRAMMY View Post
                      (That would then require the shutdown of the cure forum at the CareCure website). It's the only place on the forum to post the latest research and potential discovery information for the community in spite of most all the threads digressing to unrelated trash.
                      I don't mean to sound crass but I think the ultimate goal of the carecure community is to make sure that it sees itself become irrelevant and extinct

                      On another note, Apparently the miami project is showing interest in this drug: https://www.themiamiproject.org/sslpage.aspx?pid=1213
                      "That's not smog! It's SMUG!! " - randy marsh, southpark

                      "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


                      2010 SCINet Clinical Trial Support Squad Member
                      Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

                      Comment


                      • #12
                        Originally posted by wesmaister View Post
                        I guess the question is who will try it first...
                        I will, right now. Let me try it!

                        Comment


                        • #13
                          Originally posted by lunasicc42 View Post
                          I don't mean to sound crass but I think the ultimate goal of the carecure community is to make sure that it sees itself become irrelevant and extinct.
                          That's right, but it would be best to have the research completed, clinical trials ran and a treatment taken to bedside before disintegration of the cure threads due to weariness of talking about our options. We don't have a cure yet so we need to allow the meaningful discussions to take place rather than digressing all the threads into a bitch and whine fest which is not helpful.
                          http://spinalcordresearchandadvocacy.wordpress.com/

                          Comment


                          • #14
                            Originally posted by lunasicc42 View Post
                            Apparently the miami project is showing interest in this drug: https://www.themiamiproject.org/sslpage.aspx?pid=1213
                            I don't mean to sound crass either, but Miami Project is indeed part of the original group mentioned and cited in the Science article posted at the beginning of the thread by Chilacas two weeks ago! Within two hours you posted on the thread that you weren't interested in the same ole talk and yet you're posting even more links on the Epothilone study? ... Isn't this weary stuff you think should be condemned by the community or did you just now notice that the folks at Miami Project were involved in one of their newsletters? Why else would you still be posting more links about this repurposing drug study when you crudely quote that other therapies should be tested first and so on... This is a drug that's already FDA approved and on the market. It doesn't get easier than this my friend so I would keep an open mind and at least be willing to learn about these other options as they present themselves so sci CAN become irrelevant and extinct in the future if that's to be your ultimate goal for the carecure community. We can hopefully look forward to a therapy(s) making it to bedside someday and maybe you'll have learned about the discovery here in the cure threads first if the forum isn't made extinct prematurely by it's members...

                            Citation: Jrg Ruschel, Farida Hellal, Kevin C. Flynn, Sebastian Dupraz, David A. Elliott, Andrea Tedeschi, Margaret Bates, Christopher Sliwinski, Gary Brook, Kristina Dobrint, Michael Peitz, Oliver Brstle, Michael D. Norenberg, Armin Blesch, Norbert Weidner, Mary Bartlett Bunge, John L. Bixby and Frank Bradke, "Systemic administration of epothilone B promotes axon regeneration after spinal cord injury", Science doi: 10.1126/science.aaa2958
                            Ruschel J1, Hellal F1, Flynn KC1, Dupraz S1, Elliott DA1, Tedeschi A1, Bates M2, Sliwinski C3, Brook G4, Dobrindt K5, Peitz M5, Brstle O5, Norenberg MD6, Blesch A3, Weidner N3, Bunge MB2, Bixby JL2, Bradke F7.
                            Author information

                            • 1Axonal Growth and Regeneration, German Center for Neurodegenerative Diseases, Ludwig-Erhard-Allee 2, 53175 Bonn, Germany.
                            • 2The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, 1095 Northwest 14th Terrace, Miami, FL33136, USA.
                            • 3Spinal Cord Injury Center, Heidelberg University Hospital, Schlierbacher Landstr. 200A, 69118 Heidelberg, Germany.
                            • 4Institute for Neuropathology, RWTH Aachen University, Steinbergweg 20, 52074, Aachen, Germany. J?lich-Aachen Research Alliance-Translational Brain Medicine.
                            • 5Institute of Reconstructive Neurobiology, Life&Brain Center, University of Bonn and Hertie Foundation, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.
                            • 6Departments of Pathology, Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, FL 33101, USA.
                            • 7Axonal Growth and Regeneration, German Center for Neurodegenerative Diseases, Ludwig-Erhard-Allee 2, 53175 Bonn, Germany. frank.bradke@dzne.de.
                              Abstract

                              After central nervous system (CNS) injury, inhibitory factors in the lesion scar and poor axon growth potential prevent axon regeneration. Microtubule stabilization reduces scarring and promotes axon growth. However, the cellular mechanisms of this dual effect remain unclear. Here, delayed systemic administration of a blood-brain barrier permeable microtubule stabilizing drug, epothilone B (epoB), decreased scarring after rodent spinal cord injury (SCI) by abrogating polarization and directed migration of scar-forming fibroblasts. Conversely, epothilone B reactivated neuronal polarization by inducing concerted microtubule polymerization into the axon tip, which propelled axon growth through an inhibitory environment. Together, these drug elicited effects promoted axon regeneration and improved motor function after SCI. With recent clinical approval, epothilones hold promise for clinical use after CNS injury.
                            Last edited by GRAMMY; 03-28-2015, 08:51 AM.
                            http://spinalcordresearchandadvocacy.wordpress.com/

                            Comment


                            • #15
                              yes, I, myself was growing weary of all the new drugs being touted when we should be accelerating the options that we already have. but I posted the article because while "I" might be jaded at certain things, I can still see good reason to share this information with the community
                              "That's not smog! It's SMUG!! " - randy marsh, southpark

                              "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


                              2010 SCINet Clinical Trial Support Squad Member
                              Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

                              Comment

                              Working...
                              X