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  • #16
    Originally posted by kate View Post
    Agree. It's going to take for effing ever to see how this plays out, eh? 6 months post intervention before the first sensation returns. Wow.

    For grins, here's what Sam Maddox wrote about the OEG approach just a few months ago. It's a good cautionary tale, IMO, about why as much as we all hate the snail's pace of science, there's a downside to rushing in.

    The gist of his article is that getting ahead of a promising therapy before its time is not always going to turn out well.
    Agreed. I'd be concerned about using the ‘raw’ nasal mucosa OEG as used by Lima... Agreed. I'd be concerned about using the ‘raw’ nasal mucosa OEG as used by Lima... According to this article however, working alongside the British researchers, Dr Tabakow developed the technique to implant cultured OECs harvested from a patient’s own olfactory bulb - and another type of nasal cell known as a fibroblast - on the stumps of a severed spinal cord. A scaffolding of nerve tissue was taken from the ankle to join the two ends of the cord to encourage bridging by the cells.
    Last edited by GRAMMY; 10-21-2014, 05:25 AM.
    http://spinalcordresearchandadvocacy.wordpress.com/

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    • #17
      would this be technically still feasible with a burst cord as apposed to severed ?

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      • #18
        Originally posted by scurl View Post
        would this be technically still feasible with a burst cord as apposed to severed ?
        Do you mean "contusion" like a bruised cord?
        http://spinalcordresearchandadvocacy.wordpress.com/

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        • #19
          Originally posted by GRAMMY View Post
          Do you mean "contusion" like a bruised cord?
          hmm no my injury is c6/c7 burst the cord. I guess due to compression.

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          • #20
            Originally posted by scurl View Post
            would this be technically still feasible with a burst cord as apposed to severed ?
            This nerve graft study was done in particular on a severed injury (stab wound) resulting in an 8mm gap. I think they'll need to do additional studies to know for sure which injuries may benefit from the procedure and how feasible recovery would be for other types of injury.
            http://spinalcordresearchandadvocacy.wordpress.com/

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            • #21
              This is the new publication:

              http://www.ingentaconnect.com/conten..._Tabakow_et_al

              Abstract: Treatment of patients sustaining a complete spinal cord injury remains an unsolved clinical problem because of the lack of spontaneous regeneration of injured central axons. A 38-year-old man sustained traumatic transection of the thoracic spinal cord at upper vertebral level Th9. At 21 months after injury the patient presented symptoms of a clinically complete spinal cord injury (American Spinal Injury Association class A-ASIA A). One of the patient's olfactory bulbs was removed and used to derive a culture containing olfactory ensheathing cells and olfactory nerve fibroblasts. Following resection of the glial scar the cultured cells were transplanted into the spinal cord stumps above and below the injury, and the 8 mm gap bridged by 4 strips of autologous sural nerve. The patient underwent an intense pre- and post-operative neurorehabilitation program. No adverse effects were seen at 19 months postoperatively, and unexpectedly, the removal of the olfactory bulb did not lead to persistent unilateral anosmia. The patient improved from ASIA A to ASIA C. There was improved trunk stability, partial recovery of the voluntary movements of the lower extremities, and an increase of the muscle mass in the left thigh, as well as partial recovery of superficial and deep sensation. There was also some indication of improved visceral sensation and improved vascular autoregulation in the left lower limb. The pattern of recovery suggests functional regeneration of both efferent and afferent long-distance fibers. Imaging confirmed that the grafts had bridged the left side of the spinal cord, where the majority of the nerve grafts were implanted, and neurophysiological examinations confirmed the restitution of the integrity of the corticospinal tracts and the voluntary character of recorded muscle contractions. To our knowledge, this is the first clinical indication of beneficial effects of transplanted autologous bulbar cells.
              In God we trust; all others bring data. - Edwards Deming

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              • #22
                This was the old one:

                Abstract: Numerous studies in animals have shown the unique property of olfactory ensheathing cells to stimulate regeneration of lesioned axons in the spinal cord. In a Phase I clinical trial, we assessed the safety and feasibility of transplantation of autologous mucosal olfactory ensheathing cells and olfactory nerve fibroblasts in patients with complete spinal cord injury. Six patients with chronic thoracic paraplegia (American Spinal Injury Association class A-ASIA A) were enrolled for the study. Three patients were operated, and three served as a control group. The trial protocol consisted of pre- and postoperative neurorehabilitation, olfactory mucosal biopsy, culture of olfactory ensheathing cells, and intraspinal cell grafting. Patient's clinical state was evaluated by clinical, neurophysiological, and radiological tests. There were no adverse findings related to olfactory mucosa biopsy or transplantation of olfactory ensheathing cells at 1 year after surgery. There was no evidence of neurological deterioration, neuropathic pain, neuroinfection, or tumorigenesis. In one cell-grafted patient, an asymptomatic syringomyelia was observed. Neurological improvement was observed only in transplant recipients. The first two operated patients improved from ASIA A to ASIA C and ASIA B. Diffusion tensor imaging showed restitution of continuity of some white matter tracts throughout the focus of spinal cord injury in these patients. The third operated patient, although remaining ASIA A, showed improved motor and sensory function of the first spinal cords segments below the level of injury. Neurophysiological examinations showed improvement in spinal cord transmission and activity of lower extremity muscles in surgically treated patients but not in patients receiving only neurorehabilitation. Observations at 1 year indicate that the obtaining, culture, and intraspinal transplantation of autologous olfactory ensheathing cells were safe and feasible. The significance of the neurological improvement in the transplant recipients and the extent to which the cell transplants contributed to it will require larger numbers of patients.

                http://www.ncbi.nlm.nih.gov/pubmed/24007776
                In God we trust; all others bring data. - Edwards Deming

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                • #23
                  Hi all, it is my knowledge that at least one patient being involved in OEC grafts experienced problems with cells sprouting around the spinal cord and compressing the spinal cord..
                  Am I correrct ??..
                  Thanks
                  G78

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                  • #24
                    http://m.bbc.com/news/health-29700007 video

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                    • #25
                      wait a minute, wasn't there a person in Poland about 6 months ago to ended upfinding a tumor in her back from of surgery she had 2 years ago transplanting olfactory cells?

                      Edit: yup. http://www.sciencedaily.com/releases...0708091121.htm
                      Last edited by PC720; 10-21-2014, 07:05 AM.

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                      • #26
                        Originally posted by PC720 View Post
                        wait a minute, wasn't there a person in Poland about 6 months ago to ended upfinding a tumor in her back from of surgery she had 2 years ago transplanting olfactory cells?

                        Edit: yup. http://www.sciencedaily.com/releases...0708091121.htm
                        That was Portugal you ignorant american!
                        Debating on CareCure is like participating in the special-olympics. You may win, but you're still disabled.

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                        • #27
                          I'm not impressed. At no time can he stand on his own with any balance (look at him grip that wood near the end). In fact, watch closely .. he is using hip movement to move his legs not unlike brace walking .. even cycling while laying down he uses his body weight.

                          Not buying into it.
                          Roses are red. Tacos are enjoyable. Don't blame immigrants, because you're unemployable.

                          T-11 Flaccid Paraplegic due to TM July 1985 @ age 12

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                          • #28
                            Paralysed man walks again - cure for paralysis possible

                            http://www.virgin.com/richard-branso...lysis-possible

                            Delighted to share the incredible news that Darek Fidyka, a paralysed man, has been able to walk again. This gives hope that a possible cure for paralysis could be developed.

                            Image from BBC Pamorama/nsif
                            This historic medical breakthrough was funded by the Nicholls Spinal Injury Foundation (nsif), which I am a proud patron of. Darek underwent therapy in Poland that involved transplanting cells from his nasal cavity into his spinal cord.
                            After being paralysed from the chest down in a knife attack in 2010, Darek thought he would never walk again.
                            Now, after 15 months with no movement, he can walk unaided with sticks and has described it as ?an incredible feeling?.

                            Image from BBC Pamorama/nsif


                            Image from BBC Pamorama/nsif
                            Prof Geoff Raisman, leader of the research team and chair of neural regeneration at University College London's Institute of Neurology, said the success was "more impressive than man walking on the moon".
                            Nsif and the UK Stem Cell Foundation supported the research, giving ?1.24m to fund work in London and Poland.
                            Nsif is a very small charity founded by David Nicholls after his son suffered a tragic accident. I came on board as a patron after coming across their tremendous work supporting pioneering research.






                            For more information on the breakthrough, read the details in the journal Cell Transplantation and watch Panorama tonight on BBC One at 22.35 GMT.
                            Congratulations to everyone involved in this breakthrough, which gives hope to the three million paralysed people around the world, and future generations striving to achieve incredible dreams. Nothing is impossible. If you ever think something can't be done, just remember this remarkable story.

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                            • #29
                              As a T6 complete injury I would be overjoyed to be able to stand long enough to pull up my own trousers; to make transfers easier; to have better circulation and muscle mass preventing debilitating pressure sores....and don't even get me started on B/B/S!!

                              I know now it's early but Raisman has been studying OEC's for some time, and Mr El Masri who makes comment has only just finished as the long term director of the Midlands Centre For SCI in the UK - neither of these men are snake oil salesmen and that in itself gives me hope.....it may still be a few years away, but the promise of it being almost visible over the distant horizon may be the hope that those thinking of giving up desperately need.

                              i live my life to the best of my current ability, and keep myself as healthy and as fit as possible.....just in case����

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                              • #30
                                For those of you in the UK or for those who can view BBC Iplayer from outside the UK (usinga VPN/proxy for example) there will be a 60 minute tv piece on this tonight at 22.35 UK time.

                                In a world exclusive, Panorama tells the story of a paralysed man who is able to walk again after a pioneering transplant using the regenerative cells that repair and renew our sense of smell.
                                http://www.bbc.co.uk/programmes/b04mm8zl

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