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Large animal trial for Chondroitinase is underway

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    #31
    http://www.msn.com/en-us/video/anima...ain/vi-BB83Pxr

    The large animal trial with Chondroitinase on MSN video.
    http://spinalcordresearchandadvocacy.wordpress.com/

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      #32
      more info re dates/ dog trial

      http://www.iowastatedaily.com/news/a...9bb2963f4.html

      seems trial ends July 2016

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        #33
        It was listed as a 3 year trial and started in July 2013. I believe they were hoping to treat around 20 per year. So far they've treated 15. Hopefully recruitment stays at a brisk pace so they finish the trial with as close to 60 as possible. They have about 45 to go.
        http://spinalcordresearchandadvocacy.wordpress.com/

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          #34
          The trial is going well. A 2014 thank you video from the Iowa State University College of Vet Medicine. LINK:
          http://spinalcordresearchandadvocacy.wordpress.com/

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            #35
            great. When do the human trials start.

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              #36
              Originally posted by ian View Post
              great. When do the human trials start.
              They do not even have the results and data from the large animal (dog) trial yet. We'll be able to find out more when the dog trial has actually finished and the data gets analyzed. They're in the middle of the trial right now.
              http://spinalcordresearchandadvocacy.wordpress.com/

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                #37
                Im being sarcastic. Chondroitinase has been around for quite a while. Dog trials are worthless to the SCI community. Its hope, but its false hope.

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                  #38
                  Never having seen a paralyzed dog I have to wonder, do their owners have to use catheters on their dog?

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                    #39
                    Peter Fry who has passed away used to tell me the story of a SCI dog he knew of who the owners used to cath all the time.

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                      #40
                      Originally posted by ian View Post
                      Im being sarcastic. Chondroitinase has been around for quite a while. Dog trials are worthless to the SCI community. Its hope, but its false hope.
                      On top of being able to tell us something about walking and motor function, dogs can be trained when and where they are allowed to go to the bathroom, which makes learning about bowel and bladder function much easier. Additionally, these are all dogs with "real world" spinal cord injuries, rather than ones perfectly created in a lab, so this trial will tell us what affect ch'ase has on those types of injuries. Lastly, it will give us insight into whether or not ch'ase plus rehabilitation can be effective in mammals larger than rats. If this trial shows no efficacy for anything, it lets us know that ch'ase may not be worth pursuing any further (at least as it was used in this trial.) If this trial shows positive results, it will greatly accelerate the pace at which human trials may begin.

                      This trial is probably one of the most important animal trials to date.

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                        #41
                        No animal trial for sci will ever translate into a human one, thats just a fact. Your comment about accelerating human trials is incorrect, if it was correct we would have had a cure for sci 20 years ago. Chondroitinase has already shown positive results many times. Animal trials are not required, by supporting animal trials you are actually delaying the cure, why cant you people understand this? That thinking is one of the main reasons we could have an effective treatment for sci and dont. We know how to cure dogs, rats , mice and sundry other animal species. Enough already, demand human trials.

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                          #42
                          ian agreed with you.

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                            #43
                            Originally posted by tomsonite View Post
                            On top of being able to tell us something about walking and motor function, dogs can be trained when and where they are allowed to go to the bathroom, which makes learning about bowel and bladder function much easier. Additionally, these are all dogs with "real world" spinal cord injuries, rather than ones perfectly created in a lab, so this trial will tell us what affect ch'ase has on those types of injuries. Lastly, it will give us insight into whether or not ch'ase plus rehabilitation can be effective in mammals larger than rats. If this trial shows no efficacy for anything, it lets us know that ch'ase may not be worth pursuing any further (at least as it was used in this trial.) If this trial shows positive results, it will greatly accelerate the pace at which human trials may begin.

                            This trial is probably one of the most important animal trials to date.
                            Thanks Tomsonite, You do a great job explaining the need to have the trial. Most every country simply won't allow their citizens to be used as lab rats.

                            There is work going on to make the dirty research reagent used in the animal lab experiments into a clean form that can be used on human beings.

                            For anyone wanting to follow the trial via their Facebook, here's the FACEBOOK link...

                            http://www.spinal-research.org/wp-co...e-edition2.pdf

                            They now have 23 patients in the trial - only 37 more to go before they can finish the study.
                            Last edited by GRAMMY; 28 Dec 2014, 1:28 PM.
                            http://spinalcordresearchandadvocacy.wordpress.com/

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                              #44
                              Jesus h. We have known the efficacy of Chondroitinase since at least 2002, we dont need any more animal trials. Pull your heads out and stop delaying effective treatments for sci. Chondroitinase needs to be used on humans, we already know and have known for more than a decade that it works, how hard is it to understand. Stop being dupes for these people who are just replicating trials on animals to continue their research funding. No wonder people are deserting this site in droves, you people are stopping treatments from happening, not promoting them.

                              [quote]Nature 416, 636-640 (11 April 2002) | doi:10.1038/416636a; Received 4 September 2001; Accepted 8 February 2002Chondroitinase ABC promotes functional recovery after spinal cord injury

                              Elizabeth J. Bradbury1, Lawrence D. F. Moon2,4, Reena J. Popat1, Von R. King3, Gavin S. Bennett1, Preena N. Patel1, James W. Fawcett2 & Stephen B. McMahon1
                              [quote]
                              http://www.nature.com/nature/journal/v416/n6881/full/416636a.html

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                                #45
                                Originally posted by ian View Post
                                No animal trial for sci will ever translate into a human one, thats just a fact.
                                That is not a fact. That is an opinion.

                                Originally posted by ian View Post
                                Your comment about accelerating human trials is incorrect, if it was correct we would have had a cure for sci 20 years ago.
                                If, 20 years ago, animals had been completely cured of SCIs, then you would be correct

                                Originally posted by ian View Post
                                Chondroitinase has already shown positive results many times. Animal trials are not required, by supporting animal trials you are actually delaying the cure, why cant you people understand this? That thinking is one of the main reasons we could have an effective treatment for sci and dont. We know how to cure dogs, rats , mice and sundry other animal species. Enough already, demand human trials.
                                Please provide the research done in which dogs, cats, mice, or other animals have been cured from chronic, complete spinal cord injuries.

                                I am not aware of any study in which an animal completely lost bowel, bladder, sexual, and autonomic function as well as all ability to voluntarily control their limbs or effectively ambulate, stay injured to a chronic time point at which their neurological condition was stable, then re-gain all of those functions to the degree that an untrained eye couldn't tell they had ever been injured. If you think anything less than that is a cure, then your definition is different from most other people.

                                If there was a reason to just say "screw the mechanism, let's test things on humans", why are you complaining about it on here? Scientists will never be allowed to test things on humans without solid animal evidence to back it up first. It is not the scientists that don't want to do human trials, it is regulatory agencies like the FDA (i'm sure you have something similar in Australia) that don't allow that to happen in the first place.

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