Frank Reynolds - Invivo 4/29/13 video

[stephen212]

From Canada's Business News Network.

http://watch.bnn.ca/the-close/the-cl...13/#clip915623

[Buck503]

Nice to see these guys getting the attention they deserve around
here.

[wesmaister]

It looks like a cartridge with web from spider-man movies. What cells thay have used with primates?

[lynnifer]

Why do you feel that way Majed? Honest question ... I'm not convinced.

[Chaz19]

lynnifer- he has been incredibly supportive of the chronic population here in Boston. He sponsors events, reaches out to patients, and has really lifted the spirit of patients. He's working on the chronic model.

[c473s]

From Canada's Business News Network.

http://watch.bnn.ca/the-close/the-cl...13/#clip915623

I will be very interested to see if there are trauma surgeons who step up and implant these. Frank Reynolds makes no claims about repair but rather "preventing further damage" by giving cells a structure to cling to rather than collapsing from the injury.

We can all hope that the scaffolding does indeed prevent further damage. The real issues will be how many hours post contusion damage continues and how many get the device in a short window. So far nobody knows what the window of time truly is whether for this or cell interventions.

I have to be honest and say that I do not have the expertise to evaluate the cell actions that occur but remain skeptical until enough evidence presents for positive beliefs. If this does not work his stock will tank.

Late this year, the FDA approved the Humanitarian Use Device (HUD) route of InVivo's marketing permission application, allowing the trial of polymer scaffold into human beings early next year. It's absolutely a good green-light path for InVivo because the HUD designation and a subsequent approved Humanitarian Device Exemption (HDE) would enable InVivo to commercialize the devices in the U.S. faster than the regular Pre-Market (PMA) approval process. Moreover, the FDA committee also reduced the required number of human being to be tested from 10 to 5.

[Chaz19]

Hey c473s, did geron seek the HUD?

[Buck503]

Why do you feel that way Majed? Honest question ... I'm not convinced.

It all comes down to judge of character. Some dismiss their animal
results as misleading, but I don't think people like Bob Langer,
Richard Roberts and Reggie Edgerton would risk their reputations
on bogus results. They have an accomplished team, promising
results, plenty of ambition, and they have the ability to raise tens
of millions of dollars.

And I don't think they're less convincing than aynone else.

I agree with Wise Young that more clinical trials, trying many
different treatments is the key to success.

[paolocipolla]

Hey c473s, did geron seek the HUD?

That I know the answer is NO.
Geron NEVER really intended to cure SCI, so they didn't care about HUD/ORPHAN drug status.
For geron SCI was just the fastest and cheapest way to prove safety of embrionic stem cells products to then move to more profittable deseases.

Unfortunatly very few people understands the real game so at the end of the day we keep supporting the ones that in fact f...k us.

Paolo

[ineedmyelin]

It all comes down to judge of character. Some dismiss their animal
results as misleading, but I don't think people like Bob Langer,
Richard Roberts and Reggie Edgerton would risk their reputations
on bogus results. They have an accomplished team, promising
results, plenty of ambition, and they have the ability to raise tens
of millions of dollars.

And I don't think they're less convincing than aynone else.

I agree with Wise Young that more clinical trials, trying many
different treatments is the key to success.

Ditto, Bob Langer has a great track record and reputation in the world of science. Hopefully it want be to long before they start adding some type of stem cells to their scaffolding.

[c473s]

Hey c473s, did geron seek the HUD?

No they moved it through without that. I was a bit surprised they stopped after the amount of money they had invested. With hindsight there were not and have not been significant sensory or motor movements but with only 5 subjects was that enough.

I hope Hans Kirstead can find somebody to pick the trial back up but with every passing day those odds drop.

I feel Geron bailed early and went after lower hanging fruit with the cancer market or they like so many find that cancer draws money at a far better rate of funding. I really dislike that choices are driven by economic factors but that is life unless a government or a Bill Gates steps in to SCI with a heart for the chase. Miami has not had enough $ to chase at a faster pace nor have any of the other "cure" foundations. (CDRF, Stifel, Bedford.....)

So many possible trials to chase and so far such a limited source of funding.

[c473s]

It all comes down to judge of character. Some dismiss their animal
results as misleading, but I don't think people like Bob Langer,
Richard Roberts and Reggie Edgerton would risk their reputations
on bogus results. They have an accomplished team, promising
results, plenty of ambition, and they have the ability to raise tens
of millions of dollars.

And I don't think they're less convincing than aynone else.

I agree with Wise Young that more clinical trials, trying many
different treatments is the key to success.

Is Ed Wirth still there ? I think I heard he departed but maybe just rumor mill.

[GRAMMY]

Is Ed Wirth still there ? I think I heard he departed but maybe just rumor mill.

Ed is gone. Lots of new staff on the roster that's been there less than a year.

[nrf]

Ed is gone. Lots of new staff on the roster that's been there less than a year.

Is there a good balance of Neuro-scientists to Investment Bankers?

[Barrington314mx]

He's working on the chronic model.

Source? I hope its not just word of mouth. You know, he needs our support too for this acute stuff. It makes me wonder if the chronic talk is just mumbo jumbo to get our support. Then once this acute trial becomes therapy, they'll forget about us. The long run money is with acutes, right? Once you heal all the chronics, well thats that. No more money to be made on chronics.