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Blood Stem Cells Shown To Be Capable of Generating Neural Stem Cells

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    Blood Stem Cells Shown To Be Capable of Generating Neural Stem Cells

    LARCHMONT, N.Y.--(BUSINESS WIRE)--Feb. 28, 2003--Hematopoietic stem cells taken from fetal human liver and grown in a suitable microenvironment are able to generate neural stem cells, and those cells can then differentiate to become astrocytes, according to a paper to be published in the February 2003 (Volume 12, Number 2) issue of Journal of Hematotherapy & Stem Cell Research, a peer-reviewed journal published by Mary Ann Liebert, Inc. (
    The paper, entitled "Fetal Human Hematopoietic Stem Cells Can Differentiate Sequentially into Neural Stem Cells and Then Astrocytes In Vitro," will be available free online at
    The results of this study suggest that human hematopoietic stem cells may be a valuable "resource for the generation of neural stem cells for therapy of central nervous system defects resulting from disease or trauma," conclude the authors, Hsaio-Nan Hao, M.D., Jiun Zhao, M.D., Ronald Thomas, Ph.D., Graham Parker, Ph.D., and William Lyman Ph.D. of the Departments of Pediatrics and Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, and Children's Research Center of Michigan at the Children's Hospital of Michigan.

    According to Denis English, Ph.D., journal Editor, Director, Experimental Cell Research Program, The Methodist Research Institute, and Associate Professor, Allied Health Sciences, Indiana University School of Medicine, "the results, while exciting, must be viewed as preliminary." Dr. English points out the fact that the therapeutic potential-even the characteristics and derivation--of these putative stem cells is the subject of a vigorous controversy in the field of stem cell research. "It is absolutely premature at this time to conclude that the hopes of stem cell research-cures for afflictions ranging from Alzheimer's disease to spinal cord injury, liver damage and disorders of other organs--will be realized with cells from non-embryonic sources."

    The researchers cultured fetal liver-derived hematopoietic stem cells (HSC) under one of three conditions: in astrocyte-conditioned medium; in a double-chamber system in which the HSC were co-cultured, but not in direct contact with astrocytes; or under control conditions. The HSC grown in astrocyte-conditioned medium or in co-culture with astrocytes expressed cell markers characteristic of neural stem cells, including nestin and BMP-2, demonstrating that they had activated genes normally expressed by neural precursor cells. The HSC grown under control conditions did not express these markers. Cells expressing the neural stem cell markers were able to differentiate in vitro into astrocytes, as was evident based on their morphology, their rate of proliferation, and their ability to express the astrocytic markers glial fibrillary acidic protein and S100. The teams' work was supported by the Children's Research Center of Michigan Endowment and Jean and Samuel Frankel.

    Journal of Hematotherapy & Stem Cell Research is an authoritative peer-reviewed journal published bimonthly in print and online. The journal is dedicated to communication and objective analysis of developments in the biology, characteristics, and therapeutic utility of stem cells, especially those of the hematopoietic system. A complete table of contents and free sample issue may be viewed online at
    Mary Ann Liebert, Inc., is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Cloning and Stem Cells, Human Gene Therapy, and Tissue Engineering. Its biotechnology trade magazine, Genetic Engineering News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 60 journals, books, and newsletters is available at
    Mary Ann Liebert, Inc., Larchmont
    Vicki Cohn, 914/834-3100, ext. 617

    [This message was edited by seneca on 02-28-03 at 12:10.]


    Cells came from aborted fetuses. This procedure not likely to get pass US House! [img]/forum/images/smilies/frown.gif[/img]
    Jake's Pop


      Dr. JJ,

      Neural stem cells [NSCs] have also been derived from hematopoietic stem cells [HSCs] in adult animals. Leukine and Neupogen are two injectable drugs that make the body release HSCs into the bloodstream for easy extraction.

      I am trying to get some researchers down here in South Carolina to do some tests to figure out how to culture NSCs from HSCs in adult humans. The benefits would be:

      -Safety and Efficacy trials for Leukine and Neupogen already exist
      -A method for converting HSCs to NSCs would allow autologous transplants [1]
      -Autologous transplants mean no immune rejection
      -No fetal or embryonic stem cells required [img]/forum/images/smilies/smile.gif[/img]

      Also, NSCs have been transplanted into the brain of a woman with Parkinson's before with beneficial results and no safety problems. Evidence already exists that shows NSC transplantation into the injured animal spinal cord results in some functional recovery.

      Maybe, possibly, if we had method [1], an IRB would allow for human trials of SCI. [img]/forum/images/smilies/smile.gif[/img]

      -Steven's worse than we thought. it turns out the people at the white house are not secret muslims, they're nerds.


        [img]/forum/images/smilies/smile.gif[/img]You need to apply for funding from CRV foundation!
        Jake's Pop