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    I'm looking for a timeline. If it's five years .. I'll struggle though.

    If it's ten, I'll have to look at what's available now and none of it is appealing.

    If it's seven, it's going to be a very long seven miserable years.
    Roses are red. Tacos are enjoyable. Don't blame immigrants, because you're unemployable.

    T-11 Flaccid Paraplegic due to TM July 1985 @ age 12

    Comment


      Dear Lynnifer,

      I can't predict a timeline. I would have thought that chondroitinase would have been in clinical trials by now. All I can tell you for certain is that we have seen recovery of bladder function in severely and chronically cord contused rodents that have been treated with our bridging strategy. How long will it take for neurosurgeons to attempt this in humans in the USA, I don't know. I can only continue to provide positive data in hopes that an outstanding neurosurgical group will move forward into humans. I present Grand Rounds at the Mass General Hospital next week so, who knows, maybe things will start in Boston. I can assure you this. I will never stop trying.

      Comment


        Originally posted by jsilver View Post
        Dear Lynnifer,

        I can't predict a timeline. I would have thought that chondroitinase would have been in clinical trials by now. All I can tell you for certain is that we have seen recovery of bladder function in severely and chronically cord contused rodents that have been treated with our bridging strategy. How long will it take for neurosurgeons to attempt this in humans in the USA, I don't know. I can only continue to provide positive data in hopes that an outstanding neurosurgical group will move forward into humans. I present Grand Rounds at the Mass General Hospital next week so, who knows, maybe things will start in Boston. I can assure you this. I will never stop trying.
        Thank you Dr. Silver. You toil in relative obscurity but you are truly doing something great. I will never forget your name.

        Comment


          Look at that. A naturally occurring anti-inflammatory... doin work.
          1. J Neurosurg Spine. 2012 Feb 10. [Epub ahead of print] Recovery from spinal cord injury using naturally occurring antiinflammatory compound curcumin. Ormond DR, Peng H, Zeman R, Das K, Murali R, Jhanwar-Uniyal M. Departments of Neurosurgery. Object Spinal cord injury (SCI) is a debilitating disease. Primary SCI results from direct injury to the spinal cord, whereas secondary injury is a side effect from subsequent edema and ischemia followed by activation of proinflammatory cytokines. These cytokines activate the prosurvival molecule nuclear factor-κB and generate obstacles in spinal cord reinnervation due to gliosis. Curcumin longa is an active compound found in turmeric, which acts as an antiinflammatory agent primarily by inhibiting nuclear factor-κB. Here, the authors study the effect of curcumin on SCI recovery. Methods Fourteen female Sprague-Dawley rats underwent T9-10 laminectomy and spinal cord contusion using a weight-drop apparatus. Within 30 minutes after contusion and weekly thereafter, curcumin (60 mg/kg/ml body weight in dimethyl sulfoxide) or dimethyl sulfoxide (1 ml/kg body weight) was administered via percutaneous epidural injection at the injury site. Spinal cord injury recovery was assessed weekly by scoring hindlimb motor function. Animals were killed 6 weeks postcontusion for histopathological analysis of spinal cords and soleus muscle weight evaluation. Results Curcumin-treated rats had improved motor function compared with controls starting from Week 1. Body weight gain significantly improved, correlating with improved Basso-Beattie-Bresnahan scores. Soleus muscle weight was greater in curcumin-treated rats than controls. Histopathological analysis validated these results with increased neural element mass with less gliosis at the contusion site in curcumin-treated rats than controls. Conclusions Epidural administration of curcumin resulted in improved recovery from SCI. This occurred with no adverse effects noted in experimental animals. Therefore, curcumin treatment may translate into a novel therapy for humans with SCI.

          Comment


            Originally posted by jsilver View Post
            Dear Lynnifer,

            I can't predict a timeline. I would have thought that chondroitinase would have been in clinical trials by now. All I can tell you for certain is that we have seen recovery of bladder function in severely and chronically cord contused rodents that have been treated with our bridging strategy. How long will it take for neurosurgeons to attempt this in humans in the USA, I don't know. I can only continue to provide positive data in hopes that an outstanding neurosurgical group will move forward into humans. I present Grand Rounds at the Mass General Hospital next week so, who knows, maybe things will start in Boston. I can assure you this. I will never stop trying.
            Thanks for trying and not giving up.

            Is it just the funding the issue or some other problem ?
            Could you do the procedure or begin the procedure in another country?
            And please don't go national on me as we are all humans and i don't really give a rats bum which country it is done in, as long as its ligitimate.
            If its it happens to bne the USA then im going to have to ask a member here if its ok to stay awhile.

            Comment


              Originally posted by jsilver View Post
              Dear Lynnifer,

              I can't predict a timeline. I would have thought that chondroitinase would have been in clinical trials by now. All I can tell you for certain is that we have seen recovery of bladder function in severely and chronically cord contused rodents that have been treated with our bridging strategy. How long will it take for neurosurgeons to attempt this in humans in the USA, I don't know. I can only continue to provide positive data in hopes that an outstanding neurosurgical group will move forward into humans. I present Grand Rounds at the Mass General Hospital next week so, who knows, maybe things will start in Boston. I can assure you this. I will never stop trying.
              Thanks for all you do for us

              Comment


                Originally posted by jsilver View Post
                Dear Lynnifer,

                I can't predict a timeline. I would have thought that chondroitinase would have been in clinical trials by now. All I can tell you for certain is that we have seen recovery of bladder function in severely and chronically cord contused rodents that have been treated with our bridging strategy. How long will it take for neurosurgeons to attempt this in humans in the USA, I don't know. I can only continue to provide positive data in hopes that an outstanding neurosurgical group will move forward into humans. I present Grand Rounds at the Mass General Hospital next week so, who knows, maybe things will start in Boston. I can assure you this. I will never stop trying.
                Hi Jerry and Lynnifer,

                Why not take a little bit more proactive stance and contact neurosurgical networks and top-notch neurosurgeons also with specialties in stem cell research and so on such as professor Michael G. Fehlings from the University of Toronto and get a meeting with him to discuss strategies for clinical trials on chondroitinase, or for that matter on other remedies. It shouldn’t be to hard to set up such a meeting and Lynnifer as a Canadian could easily get in contact with dr. Fehlings to ask for such a meeting. No need to wait for the W2W Boston meeting, but as a tip for that meeting if dr. Fehlings is interested in collaboration, why not invite him to the meeting as well. It could have been quite interesting and Toronto isn’t that far from Boston

                Comment


                  Already tried to do that via my urologist, Dr Lesley Carr. No one wants to be creative.

                  It was my uro-gyne who did my partial hysto who wondered about a tissue expander in the bladder (she used to be in plastics - Dr Patricia Lee).

                  First priority is bladder capacity ...

                  Thanks Dr Silver. Perfect answer for a perplexing problem. Toronto is lovely in the Spring and you can walk on top of the CN Tower! Dinner Cruise on Lake Ontario? Niagara Region has the Falls and world-class wines!?! lol
                  Last edited by lynnifer; 19 Feb 2013, 11:32 AM.
                  Roses are red. Tacos are enjoyable. Don't blame immigrants, because you're unemployable.

                  T-11 Flaccid Paraplegic due to TM July 1985 @ age 12

                  Comment


                    Originally posted by Solan View Post
                    Paolo,
                    I'll give you an honest answere. I don't know! This trial won't involve me since I am Asia D and therefore I am waiting it out and haven't tried to find out the latest news about it.
                    Please don't twist my answere around to there not being a trial.
                    Solan,

                    thanks for your honest answer. I think you should still be interested in finding out more about SCINet Norway as if the therapy is safe and effective in ASIA A patients it may work also in ASIA D. Also the protocol in Norway could be designed in a way to include ASIA D, so if I were you I would look for more info. If you do, please let us know.

                    About twisting, I never did, but I agree that it may look like I do that sometimes for people who don't follow closely the discussions. My intention when I quote a small part of a post is to point out a specific and very rilevant detail that people may not catch.
                    The devil is in the details.

                    Paolo
                    In God we trust; all others bring data. - Edwards Deming

                    Comment


                      Originally posted by Fly_Pelican_Fly View Post

                      Of course. With regards to my question about the purity. What makes you think that the formula that Seigakaku have is not of the purity required for the spinal cord?

                      Cheers
                      Fly Pelican Fly
                      Check out AMSBIO. Researchers have been using their research regeant after Seigakaku shut off sales. This is a new highly purified according to the pdf announced today.

                      http://www.news-medical.net/news/20130221/Highly-purified-Chondroitinase-ABC-for-neural-regeneration-research-launched-by-AMSBIO.aspx
                      http://spinalcordresearchandadvocacy.wordpress.com/

                      Comment


                        Originally posted by GRAMMY View Post
                        Check out AMSBIO. Researchers have been using their research regeant after Seigakaku shut off sales. This is a new highly purified according to the pdf announced today.

                        http://www.news-medical.net/news/20130221/Highly-purified-Chondroitinase-ABC-for-neural-regeneration-research-launched-by-AMSBIO.aspx
                        Thanks Grammy. Very interesting!

                        @Wise, @Jerry - thoughts?

                        Comment


                          Originally posted by Fly_Pelican_Fly View Post
                          Thanks Grammy. Very interesting!

                          @Wise, @Jerry - thoughts?
                          If this is close to what is needed for clinical study in humans, I would strongly urge the both of you to throw any sway you have into making it a reality. Dr. Young himself has said that if any therapy has a clinical consensus it is Ch'ase and we obviously know how Dr. Silver feels about it. I would add that if you take a look at what therapies the SCI community is most excited about (from looking at this forum) Ch'ase is at or near the top of the list.

                          Comment


                            Originally posted by Fly_Pelican_Fly View Post
                            Thanks Grammy. Very interesting!

                            @Wise, @Jerry - thoughts?
                            I'm ecstatic!

                            Comment


                              Originally posted by GRAMMY View Post
                              Check out AMSBIO. Researchers have been using their research regeant after Seigakaku shut off sales. This is a new highly purified according to the pdf announced today.

                              http://www.news-medical.net/news/20130221/Highly-purified-Chondroitinase-ABC-for-neural-regeneration-research-launched-by-AMSBIO.aspx
                              Thanks Grammy. My interpretation of this announcement is that AMS Biotechnology is manufacturing this chondroitinase. It says that chondroitinase is formerly available from Seikagaku but I think that AMSBIO is making this chondroitinase on their own. If AMSBIO is willing to provide all the manufacturing specifications for this chondroitinase and they pass FDA approval and inspection, then it can be used in clinical trial. That is good news indeed.

                              Wise.

                              Comment


                                Originally posted by crabbyshark View Post
                                Look at that. A naturally occurring anti-inflammatory... doin work.
                                It will never be explored properly, no one can put a patent on it. There are plenty of naturally occurring potent anti inflamatory substances which can be tried.

                                Comment

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