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What you all think about how long it will take?

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  • What you all think about how long it will take?

    Just curious how long the community thinks it will take to get a "cure"? Or the first cure seeing as sci are wide in range. This all considering jsilvers's work, dr youngs, reeves-irvine, stemcells inc, etc starting to seem vary promising
    T6 complete since 3/21/2012

  • #2
    As they have been telling many of us the last 30 years; "in 5 years"

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    • #3
      I don't think that because it hasn't happened in the last 30 years (I had my accident in 1982 so I've waited exactly that long), is a logical argument for saying it won't happen in 5 years from now. It makes no sense to say it hasn't happened in the past so it won't happen any time soon. And I dont remember any of the reputable scientists giving promises like 5 years - I wonder who people have been listening to.

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      • #4
        my guess is 2014 for chronic s, pretty much now for some newly injured.
        In five years, hopefully anyone injured has a better chance of recovery.

        now they have to figure out how to make cars that prevent sci.

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        • #5
          Wise i think estimated 3 years at the beginning of this year i think. sounds ok to me. of course i wish it was here now. but then i just sit and think about the people that have been wishing for it for 30 years.

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          • #6
            Originally posted by #LHB# View Post
            Dr. Silver how far away is your therapy from humans? Is it still 3-5 years away or if everything fall's right in the near future?
            Originally posted by jsilver View Post
            The International Spinal Research Trust (ISRT) is a wonderful SCI Foundation in the UK and is now pushing hard toward clinical trials with Ch'ase. I firmly believe that before 3 years is possible.
            Originally posted by Steve View Post
            Hi everyone,
            I had my accident in 19991...C4 complete.
            Im member since 2001. The first 4-5 years, I was very excited to visit the website (cure section) . I was believing that cure could happen. Since then, I m desperate for a cure for people like me so I don't visit the website more than 2-3 times/year.
            What you think about my oinion about possible cure for us?
            If someone can boost me with something possible soon, let me read you
            Maybe I missed something interesting here...
            Steve
            Quote:
            Originally Posted by jsilver
            OK just a bit more. I will post our abstract of the work when it is published by the Society for Neuroscience later this summer. We have an NIH grant (which is public record if your interested to read the details) to develop a small peptide that blocks the newly discovered receptor on neurons that mediates regeneration/sprouting inhibitory actions of proteoglycans. The receptor was first revealed in a 2009 Science paper from the John Flanagan/Jerry Silver labs.
            PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration
            Yingjie Shen, Alan P. Tenney, Sarah A. Busch, Kevin P. Horn, Fernando X. Cuascut, Kai Liu, Zhigang He, Jerry Silver, and John G. Flanagan
            Science 23 October 2009: 592-596.Published online 15 October 2009 [DOI:10.1126/science.1178310] ABSTRACT
            Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration. However, no specific receptor for the inhibitory effect of CSPGs has been identified. We showed that a transmembrane protein tyrosine phosphatase, PTPσ, binds with high affinity to neural CSPGs. Binding involves the chondroitin sulfate chains and a specific site on the first immunoglobulin-like domain of PTPσ. In culture, PTPσ–/– neurons show reduced inhibition by CSPG. A PTPσ fusion protein probe can detect cognate ligands that are up-regulated specifically at neural lesion sites. After spinal cord injury, PTPσ gene disruption enhanced the ability of axons to penetrate regions containing CSPG. These results indicate that PTPσ can act as a receptor for CSPGs and may provide new therapeutic approaches to neural regeneration.
            We have now constructed the peptide which can be simply injected under the skin or via other potential easy routes of administration. It is designed to penetrate into the CNS even if given systemically. We are doing both acute and, of course, chronic experiments.

            Quote:
            Originally Posted by jsilver
            We are testing this new peptide at both acute and chronic time points after cord injury in rats using the Infinite Horizon impactor device to create severe contusive injuries. In these experiments , we are analyzing return of locomotor and bladder function. We are also testing the peptide at both acute and chronic time points after C2 hemisection lesion in rats focusing here on return of respiratory function. I will present all of our results to date at SFN in New Orleans and at W2W in the fall and, of course, we are now in the process or writing this up for publication.

            Steve, that are responsible words of the responsible scientist and researcher, figuratively speaking, not a "chinese fake".

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            • #7
              Originally posted by Christopher Paddon View Post
              I don't think that because it hasn't happened in the last 30 years (I had my accident in 1982 so I've waited exactly that long), is a logical argument for saying it won't happen in 5 years from now. It makes no sense to say it hasn't happened in the past so it won't happen any time soon. And I dont remember any of the reputable scientists giving promises like 5 years - I wonder who people have been listening to.
              Christopher, hi, I had my accident in 1982 too. It was on January 2,1982. I don't remember what happened but I always remember the date. Time flies.

              manouli.

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              • #8
                Originally posted by Christopher Paddon View Post
                I don't think that because it hasn't happened in the last 30 years (I had my accident in 1982 so I've waited exactly that long), is a logical argument for saying it won't happen in 5 years from now. It makes no sense to say it hasn't happened in the past so it won't happen any time soon. And I dont remember any of the reputable scientists giving promises like 5 years - I wonder who people have been listening to.
                Who said it won't happen if 5 years. He asked a question and from the other posts, they say approx. the same.

                I'm not being negative, just more of a reminder not to be concerned how quickly for a cure but to get on with life and maximize your potential for when it does come down the pike.

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                • #9
                  from tomorrow to ? We don't know when a scientist will dig in gold. They're digging everyday.

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                  • #10
                    Originally posted by DupeNet View Post
                    from tomorrow to ? We don't know when a scientist will dig in gold. They're digging everyday.
                    wow! This is a good one! Well said.

                    manouli.

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                    • #11
                      Originally posted by Patrick Madsen View Post
                      As they have been telling many of us the last 30 years; "in 5 years"
                      This is the rule of thumb.

                      Everything has been "promising" since I was injured in '99.

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                      • #12
                        I don't expect any significant change the next 10 years. And i don't wait - i never have done it

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                        • #13
                          I really don't think it will happen in most of our lifetimes, I hope like hell I'm wrong especially for higher level injuries which must be a real nightmare. I'd give up my spot in line for any higher level injuries. I have a huge amount of respect for all that can deal with this horrible injury on a day to day basis, it is not easy at all even as a para.
                          "Life is about how you
                          respond to not only the
                          challenges you're dealt but
                          the challenges you seek...If
                          you have no goals, no
                          mountains to climb, your
                          soul dies".~Liz Fordred

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                          • #14
                            I would to Curt.

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                            • #15
                              Originally posted by -scott- View Post
                              This is the rule of thumb.

                              Everything has been "promising" since I was injured in '99.
                              I started hearing that in 74.

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