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    #16
    Originally posted by Wise Young View Post
    tomsonsite, the central pattern generator CPG has receptors to neurotransmitters. Scientists have long known (like 50+ years) that it is possible to stimulate the CPG by injecting serotonin and other excitatory neurotransmitters intrathecally (into the cerebrospinal fluid surrounding the spinal cord). It has been a while since I looked at this trial but I assume that the spinalon combination is being injected intrathecally into patients with a pump (much like baclofen is injected but for shorter periods and under manual control, so that the person can apply the drug when walking is needed). One can of course stimulate the CPG electrically as well. Wise.
    Do CPG neurons respond to different neurotransmitters, or perhaps a specific combination of them, as opposed to other neurons? Or does the CPG act the way it does because of the neuronal "wiring", so to speak?

    Originally posted by GRAMMY View Post
    http://spinalcordresearchandadvocacy...dical-officer/

    Nordic Life Science Pipeline Inc. names new acting Chief Medical Officer


    They are planning to conduct a Spinalon phase II-B trial (expected for 2015) in US, Europe, Canada.
    I had forgotten about this trial, I wonder how it's going. Can they get approval to do a phase II trial without first completing the phase I? Or can they just send the FDA the results without having the study published first?

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      #17
      Originally posted by tomsonite View Post
      Do CPG neurons respond to different neurotransmitters, or perhaps a specific combination of them, as opposed to other neurons? Or does the CPG act the way it does because of the neuronal "wiring", so to speak?

      I had forgotten about this trial, I wonder how it's going. Can they get approval to do a phase II trial without first completing the phase I? Or can they just send the FDA the results without having the study published first?
      http://www.jneurosci.org/content/33/2/734.full.pdf

      I believe the first trial was a 2 arm (Phase 1 and 2-A). The upcoming one would be a 2-B.

      The current trial on 51 people had this organization on it for the Phase 1 & 2A.
      The proposed study is a combination of 1 and 2-arm designs. First, a 2-arm design will be used, the first arm being composed of 3 subjects receiving the lowest dose of the study drug, and the second arm being composed of 1 subject receiving a placebo. This 2-arm design will be repeated consecutively (not simultaneously) with increasing doses of SPINALON, as long as the dose is well tolerated. Six (6) groups are expected to be tested with this 2-arm design.This will be followed by a 2-arm composed of 1 group with 1 subject receiving placebo and 1 larger group (10 subjects) who will receive SPINALON at MTD as identified in the previous 2-arm groups.
      Last edited by GRAMMY; 10 May 2014, 12:56 AM.
      http://spinalcordresearchandadvocacy.wordpress.com/

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        #18
        The first Spinalon trial has been completed. LINK
        http://spinalcordresearchandadvocacy.wordpress.com/

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          #19
          "This worldwide ground-breaking discovery enables preparation of the next step – that is even larger-scale studies (1000 patients) to seek approval for sales within 5 years in Canada, Europe and United States" Holy hell, still 5 yrs away. I will be dead in another three or four intervals of 5 yr

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            #20
            Another 2-3 five year intervals and I'll be dead also.

            Comment


              #21
              Me too. That's life though. It goes awfully quick. Live every day like it's your last.
              http://spinalcordresearchandadvocacy.wordpress.com/

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                #22
                Did anyone comprehend possible use of this involontary
                walkng drug except for trademil exercise sessions?
                All sounds like headless chicken run....

                BTW ... when we are already looking @ Quebec on the map -
                Does anyone know what is going on with Dr. Ahlfors project?
                Very hard to get real picture here...
                www.MiracleofWalk.com

                Miracles are not contrary to nature, but only contrary
                to what we know about nature
                Saint Augustine

                Comment


                  #23
                  "Spinalon" is aimed to become a treatment against secondary complications and comorbid problems associated with chronic paralysis. It doesn't regenerate broken axons or grow new nerves.

                  As such, Spinalon was developed to become a chronic treatment (physical activity-based approach driven pharmacologically) against the multiple health problems or so-called 'secondary complications' associated specifically with the lack of physical activity such as (sarcopenia, osteoporosis, cardiovascular problems, dyslipidemia, obesity, type II diabetes, anemia, immune system deficiency, deep vein cloth, depression, etc.).
                  http://spinalcordresearchandadvocacy.wordpress.com/

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                    #24
                    Lol. I'll just take the pill and run out my front door and see where my legs take me. It'll be a new adventure every day!

                    Comment


                      #25
                      Originally posted by comad View Post
                      All sounds like headless chicken run....
                      Why would a headless chicken cross the road?

                      Do you 'give it up?' Well, then: 'Because it wants to get on the other side!'
                      Here are some of my favorite replies to the question Why did the chicken cross the road?
                      Any kindergarten teacher: To get to the other side.
                      Sir Edmund Hilary: Because it is there.
                      Confucius: Chicken who cross road at 5pm get very flat.
                      Barack H. Obama: The chicken crossed the road because it was time for change! The chicken wanted change.
                      Richard M. Nixon: The chicken did not cross the road. I repeat, the chicken did not cross the road.
                      Dick Cheney: Did you say chicken? Where’s my gun?
                      Bill Clinton: I did not cross the road with that chick.
                      Al Gore: I invented the road and the chicken, but I regret inventing the chicken. It emits too many greenhouse gases.
                      Martin Luther King : It had a dream.
                      L.A. Police Department: Give us ten minutes with the chicken and we'll find out.
                      Grandparents: In our day, we didn't ask why the chicken crossed the road. Someone told us that the chicken had crossed the road, and that was good enough for us. And besides that, it had to cross it barefoot, while walking 10 miles to school in the snow before breakfast.

                      Plato: For the greater good.
                      Aristotle: To actualize its potential.
                      Karl Marx: It was a historical inevitability.
                      Salvador Dali: The Fish.
                      John Locke: Because he was exercising his natural right to liberty.
                      Albert Camus: It doesn't matter; the chicken's actions have no meaning except to him.
                      Albert Einstein: Did the chicken really cross the road, or did the road move beneath the chicken?
                      Charles Darwin: Chickens, over great periods of time, have been naturally selected in such a way that they are now genetically predisposed to crossing roads. Besides, it was the logical next step after coming down from the trees.
                      Hippocrates: Because of an excess of phlegm in its pancreas.
                      Machiavelli: The point is that the chicken crossed the road. Who cares why? The ends of crossing the road justify whatever motive there was.
                      Emily Dickinson: Because it could not stop for death.
                      Ralph Waldo Emerson: It didn't cross the road; it transcended it.
                      Ernest Hemingway: To die. In the rain.
                      George Orwell: Because the government had fooled him into thinking that he was crossing the road of his own free will, when he was really only serving their interests.
                      Mark Twain: The news of its crossing has been greatly exaggerated.
                      Robert Frost: To cross the road less traveled by.
                      Hamlet: That is not the question.
                      O.J. Simpson: It didn't. I was playing golf with the chicken at the time.
                      Gilligan: The traffic started getting rough; the chicken had to cross. If not for the plumage of its peerless tail, the chicken would be lost ... the chicken would be lost!
                      Captain James T. Kirk: To boldly go where no chicken has gone before.
                      Forrest Gump: My mama always says, "Stupid is what stupid does."
                      Queen of Hearts: It doesn't matter. Off with its head.
                      Sherlock Holmes: Elementary, my dear Watson. She was chased across by a nine-month old white Persian cat with a broken tail and a rose thorn in its right forepaw.
                      Martha Stewart: No one called me to warn me which way that chicken was going. I had a standing order at the Farmer's Market to sell my eggs when the price dropped to a certain level. No little bird gave me any insider information.
                      Dr. Seuss:
                      Did the chicken cross the road?
                      Did he cross it with a toad?
                      Yes! The chicken crossed the road,
                      But why it crossed it, I've not been told!
                      Colonel Sanders: Did I miss one?!
                      link
                      Last edited by GRAMMY; 11 Jan 2016, 12:24 PM.
                      http://spinalcordresearchandadvocacy.wordpress.com/

                      Comment


                        #26
                        Somehow, I manage to laugh with you Grammy!
                        however, don't be surprised if someone grumpier than me
                        disapointed with medicine science inability to accelerate
                        anything towards real cure, find out that with Spinalon
                        we are becoming laughing stock.
                        well...someone can say again - its good for our health
                        its good to laugh....save us from depression ...
                        www.MiracleofWalk.com

                        Miracles are not contrary to nature, but only contrary
                        to what we know about nature
                        Saint Augustine

                        Comment


                          #27
                          Originally posted by comad View Post
                          Somehow, I manage to laugh with you Grammy!
                          however, don't be surprised if someone grumpier than me
                          disapointed with medicine science inability to accelerate
                          anything towards real cure, find out that with Spinalon
                          we are becoming laughing stock.
                          well...someone can say again - its good for our health
                          its good to laugh....save us from depression ...
                          The G-Therapeutic implant will dispense a pharmacological cocktail of 5HT receptor agonist for patients that need it in conjunction with their epidural stimulation. Then there's the Edgerton lab that gives a drug called Quipazine (a 5HT receptor agonist) to help control the CPG.. Then there's the Spinalon drug being developed to help people in their rehabilitation routines (it's a tri-therapy of levodopa + carbidopa + buspirone).

                          Surely not everyone will partake in a medication that assists them during their SCI rehabilitation, but many will. For those that may choose to use any one of these future medication options for recovery and work out routines would be anything but a laughing stock in my opinion. There's nothing else sitting on the shelf at the SCI medical clinic so it would be a stretch to use the med as a pet theory scapegoat. The exception would be the thread about 4-AP-3-MeOH medication where you have not been attacked for speaking about sci medication... The usual sourpuss grumpers have been silent with their favorite cure conspiracy dogma so maybe they've moved on to a new hobby or something. We really didn't think we'd see a headless chicken crossing the road either ! !
                          Last edited by GRAMMY; 11 Jan 2016, 2:43 PM. Reason: spelling
                          http://spinalcordresearchandadvocacy.wordpress.com/

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                            #28
                            Originally posted by comad View Post
                            Very hard to get real picture here...
                            Yes. Yes it is. If this pill was available today; What exactly do you think it would do?

                            What would it say on the bottle?

                            Comment


                              #29
                              For the exercising point of view, I'm more convinced that the electrical stimulator implant more effective vs. a pill that activates the CPG that promotes involuntary movements... the e-stim seems to have a lot more control...

                              Watching again these e-stim vids convinces me:
                              http://www.catholic.org/news/health/story.php?id=66333
                              "Talk without the support of action means nothing..."
                              ― DaShanne Stokes

                              ***Unite(D) to Fight Paralyses***

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                                #30
                                I think there won't be a one size fits all therapy since everyone's injury is so vastly different from each other. There's probably lots of people that would benefit from a simple pharmaceutical rather than needing to be more drastic and having a surgically implanted device. (Many will need both, but not everyone). Lots of incompletes will be getting by with the non-invasive transcutaneous model because they have enough sparing. For instance the G-therapeutics device is being designed so medication can be delivered but it doesn't have to be for those that would not benefit from it. LINK

                                I think in the future the clinicians will have more than one option in their tool chest for their patients. (Which is an excellent situation).
                                Last edited by GRAMMY; 17 Jan 2016, 12:45 PM.
                                http://spinalcordresearchandadvocacy.wordpress.com/

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