Announcement

Collapse
No announcement yet.

Jerry Silver talks to me

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

    #16
    "My name is Netta Ganor and I am 20 years old. I am a c-4/5 quad from Israel. I was struck down with Acute TM on November 25th, 1994, at the age of 15. It all started one Friday afternoon, after I came back from school. After lunch, I suddenly started to feel a terrible sharp pain in my upper back (behind the shoulders). Gradually, but quite fast, in less than one hour, I lost sensation and the ability to move my hands and finally my legs. My mother immediately called an ambulance, which took me to the hospital. I was taken to the IC department and was diagnosed after 10 days with Acute TM at c-3. Of course, I was ventilated. After three months, more or less, I saw the first improvement; my left arm started to move. Gradually, in the next one and a half years, I got rid of the vent due to hard work in exercising my breathing muscles. ... Today, I still have no sensation from the shoulders down, including my arms. I move the left arm without feeling it." http://www.myelitis.org/newsletters/...tter3-2-16.htm

    jsilver, what are the chances that chondroitinase administration will revive nerve circuits and assist to reestablish synapses in Netta Ganor case? Whether the non-traumatic nature of the lesion is a good factor here?
    Comment, please, on this: "ChABC-mediated sprouting of spared fibers does not necessarily translate into functional recovery." http://acnescarremovals.blogspot.com...inase-abc.html

    Comment


      #17
      Originally posted by kivi66 View Post
      "My name is Netta Ganor and I am 20 years old. I am a c-4/5 quad from Israel. I was struck down with Acute TM on November 25th, 1994, at the age of 15. It all started one Friday afternoon, after I came back from school. After lunch, I suddenly started to feel a terrible sharp pain in my upper back (behind the shoulders). Gradually, but quite fast, in less than one hour, I lost sensation and the ability to move my hands and finally my legs. My mother immediately called an ambulance, which took me to the hospital. I was taken to the IC department and was diagnosed after 10 days with Acute TM at c-3. Of course, I was ventilated. After three months, more or less, I saw the first improvement; my left arm started to move. Gradually, in the next one and a half years, I got rid of the vent due to hard work in exercising my breathing muscles. ... Today, I still have no sensation from the shoulders down, including my arms. I move the left arm without feeling it." http://www.myelitis.org/newsletters/...tter3-2-16.htm

      jsilver, what are the chances that chondroitinase administration will revive nerve circuits and assist to reestablish synapses in Netta Ganor case? Whether the non-traumatic nature of the lesion is a good factor here?
      Comment, please, on this: "ChABC-mediated sprouting of spared fibers does not necessarily translate into functional recovery." http://acnescarremovals.blogspot.com...inase-abc.html
      Dr.Wise, how you estimate chances of your first candidate(UBC+Li) to do here what it is supposed to do? Do you agree with jsilver that for TM-caused damage repairing one is "don't need neurotransplantation", what is required is "axonal regeneration, terminal arborization/sprouting near a potential target and synapse re-formation"? I do agree, with the addition of remyelination. Dr.Wise, what task from mentioned above you assign to UBC+Li? Regarding its safety -- it is safe.

      Comment


        #18
        Kivi ,where did you get the information on tm and what is needed for regeneration? Have you been to the Myelin Repair Foundation web site? They are working for ms cures and talk about tm.

        Anthony

        Comment


          #19
          Originally posted by keeping on View Post
          Kivi ,where did you get the information on tm and what is needed for regeneration? Have you been to the Myelin Repair Foundation web site? They are working for ms cures and talk about tm.
          Anthony
          Anthony, I've been to Transverse Myelitis Association website (http://www.myelitis.org/).
          The info is here:
          Originally posted by jsilver View Post
          Dear kivi66,
          I fully understand the issues involved with chronic injury and I appreciate your comments. I did mention the hurdles that need to be overcome in my post #234. However, just like after trauma both sensory and motor axons that were severed remain essentially indefinitely with dystrophic end balls at the outer edge of the penumbra of your lesion. Yes, we may need further strategies (likely neurotrophin support) to re-awaken these sleepy neurons or we may need to regulate the PTEN gene to strengthen their growth potential but they potentially could be triggered back to a growth mode. Whether they can reconnect with the neuropil beyond the lesion after many years is still unknown but we surely won't know unless we try and that is exactly what we wish to do. You don't need neurotransplantation, you need axonal regeneration, terminal arborization/sprouting near a potential target and synapse re-formation.
          Originally posted by jsilver View Post
          Dear Kivi66,
          One would need neurotransplantation (if that were possible and if the new neurons were the right type and could reconnect properly which they have a hard time doing without help) for neurodegenerative diseases that destroy neurons (for instance Parkinsons, Huntingtons, ALS or cord injuries that kill lower motor neurons). Most cord injuries spare motor neurons in vital places. The key problem that leads to paralysis after most CNS trauma as well as TM is white matter damage that involves both axotomy and demyelination. The electrical cables are cut or they have lost insulation but the neuron cell bodies DON'T DIE, they just atrophy and their severed axon tips remain in place in the white matter for decades. There is a normal, painstakingly slow plasticity that occurs above and below the lesion that can be augmented and directed with physical therapy but especially with a combination of patterned exercise and chondroitinase and sometimes well placed neurotrophins. Stem cells of a wide variety of types are extremely valuable in preventing secondary inflammatory mediated axotomy and demyelination and they can also stimulate a measure of further plasticity at least at acute stages. There is little credible evidence, thus far, that stem/progenitor cells can form bridges for axon regeneration into and most importantly back out of the lesion on the other side. There is little credible evidence that, by themselves, stem cells can restore function via regeneration or sprouting at chronic stages. The only exciting stem cell therapy that I have seen good evidence for functional restoration at sub-chronic times after SCI in a rodent model is that of Aileen Anderson and Brian Cummings. Thus, for spinal cord injury there is almost never a need for neurotransplantation. We need enhanced sprouting from spared axons and regeneration from those that are severed and it would be great if we could remyelinate the axons that have regenerated/sprouted.

          Comment


            #20
            Originally posted by kivi66 View Post
            "My name is Netta Ganor and I am 20 years old. I am a c-4/5 quad from Israel. I was struck down with Acute TM on November 25th, 1994, at the age of 15. It all started one Friday afternoon, after I came back from school. After lunch, I suddenly started to feel a terrible sharp pain in my upper back (behind the shoulders). Gradually, but quite fast, in less than one hour, I lost sensation and the ability to move my hands and finally my legs. My mother immediately called an ambulance, which took me to the hospital. I was taken to the IC department and was diagnosed after 10 days with Acute TM at c-3. Of course, I was ventilated. After three months, more or less, I saw the first improvement; my left arm started to move. Gradually, in the next one and a half years, I got rid of the vent due to hard work in exercising my breathing muscles. ... Today, I still have no sensation from the shoulders down, including my arms. I move the left arm without feeling it." http://www.myelitis.org/newsletters/...tter3-2-16.htm

            jsilver, what are the chances that chondroitinase administration will revive nerve circuits and assist to reestablish synapses in Netta Ganor case? Whether the non-traumatic nature of the lesion is a good factor here?
            Comment, please, on this: "ChABC-mediated sprouting of spared fibers does not necessarily translate into functional recovery." http://acnescarremovals.blogspot.com...inase-abc.html
            jsilver, I have to admit that, if WY's replies not actually interest me, then your opinions I still would like to know. And, though
            Originally posted by jsilver View Post
            Frankly, I don't have a cord injury so I could never ever put myself in the place of all of you who do.
            I suppose that cited above story deserves some clicks on the keyboard.

            Comment


              #21
              http://vimeo.com/24575964 Not the greatest audio, but large auditoriums aren't the perfect place for that or maybe the microphone was made in -----.
              Last edited by GRAMMY; 20 Dec 2011, 2:15 AM.
              http://spinalcordresearchandadvocacy.wordpress.com/

              Comment


                #22
                The audio is horrible!
                Roses are red. Tacos are enjoyable. Don't blame immigrants, because you're unemployable.

                T-11 Flaccid Paraplegic due to TM July 1985 @ age 12

                Comment


                  #23
                  Dr.Silver, how's your old rat doing, still breathing by itself? I ask that seriously, really would like to know.

                  Comment


                    #24
                    kivi, Dr silver is at Acorda today to meet with them to explore a trial with chase. Unbfotuantely, no live presentation and /dr /silver says he will give us feedback if allowed. Best we can do at this time. remeber thsi therapy if proves successful, may be an avenue to remove vents from our brothers.

                    anthony

                    Comment


                      #25
                      Lets hope all is going well with him. It would be great to finally make things happen instead of empty promises being made and hopes being crushed.

                      Comment


                        #26
                        Originally posted by Han Solo View Post
                        Lets hope all is going well with him. It would be great to finally make things happen instead of empty promises being made and hopes being crushed.
                        What empty promises have been made?

                        Comment


                          #27
                          Not by him but like people like Dr Davies with his 3-5 yrs bullshit then blamin yrs if procrastination of publishing. No reproductions in ither labs just phrases like "the only people who will be disappointed will be competitors in this field." Cmon man it is what it is i aint makin it up.

                          Comment


                            #28
                            I was meaning what empty promises has Jerry Silver made - this thread seemed to be about Jerry Silver

                            Your opinion of Dr Davies may or may not be correct

                            Comment


                              #29
                              Jerry Silver is never like others. It is because of his work and great efforts that chase is being considered for human trials. Thing is that we want trial as soon as possible. I hope Jerry will give some news to us.

                              Comment


                                #30
                                Hey Chris, i dont kno if ur lookin to try n argue, be combative or jus confused. Im sayin i hope his therapy works cause im tired of gettin my hopes up just to be let down. Then i gave u an example of how iv been let down. Nobodys trynna get things off topic. I hope ur jus confused by how i said it or somethin cause im not tryin to take shit off topic, take my word for it. I like Dr Silver n believe in his shit. Point blank period. Chill out man.

                                Comment

                                Working...
                                X