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Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitin

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    Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitin

    http://www.ncbi.nlm.nih.gov/pubmed/15689553

    I wonder is any group trying this seemingly powerful combination therapy?

    #2
    Christopher when this enzyme is being used in research for years then i can not understand why not been included yet in any trials anywhere?

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      #3
      Money - how they can make the most profit from this.
      Roses are red. Tacos are enjoyable. Don't blame immigrants, because you're unemployable.

      T-11 Flaccid Paraplegic due to TM July 1985 @ age 12

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        #4
        Lynnifer this is so sad news that for money purpose they are playing with the emotions of millions of patients around the world. Shame on making money in such way.

        Dont know where organizations are and where is advocacy?

        No pressure from anyside for starting trials and such therapies.

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          #5
          really? Money?... How?.... How is anyone making money on chondroitinase by not using it or holding it back? Please explain
          "That's not smog! It's SMUG!! " - randy marsh, southpark

          "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


          2010 SCINet Clinical Trial Support Squad Member
          Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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            #6
            greed sux

            Originally posted by lynnifer View Post
            Money - how they can make the most profit from this.
            i am old enough to remember when we lived with the fear of death by nuclear war. while we still have nucs today its the financial greed thats killing allot of people.
            "I'm manic as hell-
            But I'm goin' strong-
            Left my meds on the sink again-
            My head will be racing by lunchtime"

            <----Scott Weiland---->

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              #7
              This is a perfect example of how tough translation is and how it is even more difficult to combine approaches. Let's break it down.

              Ch'ase - this has already been discussed on here extensively. Patents. Availability of human-grade enzyme. Method of delivery. More questions than answers. Some scientists say "get the bacterial enzyme into people now" and others will say "more pre-clinical studies are needed".

              OECs - there are many questions marks about the quality and quantity of OECs extracted from the nasal mucosa for human usage. At least one scientists claims a bulbectomy will provide a better source of cells (which of course if far more invasive) but is unable to get the financial backing to start a trial with this procedure. Other scientists claim that OECs cannot create a sufficiently significant bridge in human-sized lesions and will therefore need to be combined with a biomaterial-based scaffold.

              Schwann cells - again this has been extensively discussed. The Miami Project have been working on this like forever. They are now approaching a clinical trial for acutes. However, the challenge will be when it comes to chronic as it is well known that schwann cells do not integrate with astrocytes (the main constituent of the glial scar). James Fawcett's most recent work is looking into the receptors involved in allowing schwann cells and astrocytes to integrate. This work involves the role Ch'ase in enhancing this integration.

              So, as you can see, it is tricky to achieve this combination in humans without more pre-clinical work as well as some kind of laser focused Manhatten Project whereby experts in each line of science are working together.
              Last edited by Fly_Pelican_Fly; 5 Nov 2011, 1:56 PM.

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                #8
                I ask again... How does anyone make money from holding back condroitinase?
                "That's not smog! It's SMUG!! " - randy marsh, southpark

                "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


                2010 SCINet Clinical Trial Support Squad Member
                Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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                  #9
                  Originally posted by lunasicc42 View Post
                  I ask again... How does anyone make money from holding back condroitinase?
                  i dont believe anyone said "make money from holding back condroitinase". i believe the jest of this conversation is that if a company doesnt see immediate or substantial profits from a particular drug then they dont push to develope it more. big pharmas are first and foremost in it for profits especially if they have stockholders to answer to.
                  "I'm manic as hell-
                  But I'm goin' strong-
                  Left my meds on the sink again-
                  My head will be racing by lunchtime"

                  <----Scott Weiland---->

                  Comment


                    #10
                    Originally posted by ineedmyelin View Post
                    i am old enough to remember when we lived with the fear of death by nuclear war. while we still have nucs today its the financial greed thats killing allot of people.
                    Nature of capitalism

                    Comment


                      #11
                      Originally posted by lynnifer View Post
                      Money - how they can make the most profit from this.

                      How is that not trying to say that people are holding condroitinase back for financial reasons?
                      "That's not smog! It's SMUG!! " - randy marsh, southpark

                      "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


                      2010 SCINet Clinical Trial Support Squad Member
                      Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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                        #12
                        it's unfounded speculation
                        "That's not smog! It's SMUG!! " - randy marsh, southpark

                        "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


                        2010 SCINet Clinical Trial Support Squad Member
                        Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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                          #13
                          Christopher - the paper you cite is a collobaration between The Miami Project, University of Alberta and the Schwabb lab in Switzerland. My understanding is that the research is ongoing and The Miami Project is excited about it's possibility for chronics as they move forward with their human trials. I also know that they are researching other drugs that have shown good results in dissolving scar tissue.

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                            #14
                            Originally posted by LetsGo View Post
                            Christopher - the paper you cite is a collobaration between The Miami Project, University of Alberta and the Schwabb lab in Switzerland. My understanding is that the research is ongoing and The Miami Project is excited about it's possibility for chronics as they move forward with their human trials. I also know that they are researching other drugs that have shown good results in dissolving scar tissue.
                            unfortunately I have been told that the outcome of the trial Miami Project is about to start won't be available to the clinic for at least 10 to 15 years, which is the same old story really - everything is 10 or more years away and then it never materializes anyway

                            oneday something must actually work..............and SOON I hope

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                              #15
                              I understand everyone's frustration with hearing the "in 5 years" but every organization is in the same situation not just The Miami Project. It is the process it takes to translate the science from the lab to benchside. I feel for the scientists in someways because I always hear them say they don't want to give a timeframe for when the research could be translated to care. Then people get mad because they don't give them a timeframe and keep at them until they do. They usually say in the best case scenario but science never works in the best case scenario.

                              From what I've been told, The Miami Project has been working with the FDA for 4 or 5 years on this trial. Every time they think they can submit their IND, the FDA comes back with additional questions. Every question they raise requires almost 1 year's worth of research and evalutaion to get back to the FDA and costs them on average of an additional $1 million in expenses. Everyone talks about all the money that The Miami Project raises but no one looks at how expensive it is to take something to actual trial.

                              How many other research organization have successful gone to trial in regeneration? No one. I'm venting a little Christopher and I apologize. I'm just frustrated reading all these other posts in this forum and lack of people applying the same criteria of evaluation equally to other organizations. Also, I think this community forgets that when scientific and medical community needed to understand the biology of the central nervous system and how it all works before the field could even be where it is today. All those years of "wasted research" by The Miami Project (but not of any other organization) was basic science needed just to understand the neverous system and brain. For example, scientits had to understand why the body would attack new neurons growing from the site of injury, the process of program cell death and when and how to turn it off and on. No cure can be found until you understand how the body works which has taken the past 20+ years to get to.

                              Even today, the scientiifc community doesn't fully understand the biology of the body. People criticize all the years worth of research that was needed as well as the advances needed in scientific equipment just to get where the field is today lacks a real understanding of scientific research in general. I wish these people would go and study every other disease and step back from their anger to see how quickly this field has progressed in such little time compared to other diseases.

                              Sorry for my rant. It wasn't personal to you.
                              Last edited by LetsGo; 7 Nov 2011, 1:19 AM.

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