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Chronic Pain Alleviation after SCI

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    Chronic Pain Alleviation after SCI

    The paper just came out on-line J Neurotrauma
    http://www.liebertonline.com/doi/abs...archHistoryKey=

    Dr. Ching-Yi Lin, Ph.D.
    Lerner Research Institute, Neurosciences, Cleveland, Ohio, United States; linc@ccf.org
    Dr. Yu-Shang Lee
    Lerner Research Institute, Neurosciences, Cleveland, Ohio, United States; leey2@ccf.org
    Dr. Vernon W. Lin
    Cleveland Clinic, Physical Medicine and Rehabilitation, Cleveland, Ohio, United States; linv@ccf.org
    Dr. Jerry Silver
    Case Western Reserve University, Neuroscience, Cleveland, Ohio, United States; jxs10@case.edu

    Chronic pain following spinal cord injury (SCI) is a highly prevalent clinical condition that is difficult to treat. Using both von Frey filaments and radiant infrared heat to assess mechanical allodynia and thermal hyperalgesia, respectively, we have demonstrated that a one-time injection of fibronectin (50 μg/ml) into spinal dorsal column (1 μl/min each injection for total 5 μl) immediately after SCI inhibits the development of mechanical allodynia (but not thermal hyperalgesia) over an 8-month observation period following spinal cord dorsal column crush (DCC). DCC will only induce mechanical allodynia but not thermal hyperalgesia nor overt motor deficits. By applying various fibronectin fragments as well as competitive inhibitors, these effects were shown to be dependent on the CS-1 motif of fibronectin. Furthermore, we found that acute fibronectin treatment diminished inflammation and blood spinal cord barrier permeability which, in turn, leads to enhanced fiber sparing and sprouting. In particular, the reduction of 5-HT in the superficial dorsal horn, an important descending brainstem system in the modulation of pain, was blocked with fibronectin treatment. We conclude that treatment of SCI with fibronectin preserves sensory regulation and prevents the development of chronic allodynia, providing a potential therapeutic intervention to treat chronic pain following SCI.
    http://spinalcordresearchandadvocacy.wordpress.com/
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