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Live from Working 2 Walk 2011!

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    Live from Working 2 Walk 2011!

    Hi, everybody

    I can't believe it's here again, can't believe they've pulled it off again, can't believe I actually made it. The 5th year . . .

    But, here we go.

    It's Saturday night and people have been arriving for the last 24 hours or so; we're at a Hilton hotel near Bethesda, MD. This is one of those hotels where the rooms are arranged to rise up around a big open space; when I arrived there was a wedding party going on in that space, with tons of guests in formal wear and candles and flowers all over the place, canned music playing so loud you could hear it through all the halls.

    There are people here from all over the place -- 186 of 'em!! -- many from the eastern seaboard, but also from all over the USA as well as Ireland, the UK, Spain, France, Italy, the Netherlands, Japan, and Nepal. Kind of a destination wedding of sorts, eh?

    Here's a heads up about what to look for tomorrow:

    Presentations by Douglas Fields from the NIH, Richard Garr from Neuralstem, Joseph Gold from Geron Corporation, followed by a panel discussion with one of u2fp's board members, David Zacks . . . that's all before lunch.

    Gotta love this.

    Have a great meeting and thank you in advance! last year you were fantastic, we were not there but it seemed to be!


      Really looking forward to your posts, Kate
      "It's not the despair, I can handle the despair! It's the hope!" - John Cleese

      Don't ask what clinical trials can do for you, ask what you can do for clinical trials. (Ox)
      Please join me and donate a dollar a day at and copy and paste this message to the bottom of your signature.


        15 minutes to go

        Outside in DC it's like 70 degrees F, and here we are inside, the usual hotel "ballroom" (which I never understand cause what sort of ball could you have in a room with carpet on the floor?) . . . in front of me is a platform with four chairs for the panels and a lectern off to the side for the speaker. A pair of giant screens are off to the left and right. The floor of the ballroom holds dozens of round tables with white tablecloths; we get ice water and hard candy to sustain us, and every chair has a copy of this year's program.

        Which I read last night, and I gotta say, is a big leap even over last year. u2fp has found its voice. For those of you who weren't around when this thing got going, it started when a few people from CareCure -- devastated after Chris Reeve's sudden death -- asked themselves who would take his place. Who would speak up for a cure?

        Us, was the answer. u2fp started with a small rally in a park in DC in the spring of 2005, and in 2006 the first Working 2 Walk was held -- the idea was to create a space where scientists could meet with one another and with the paralysis community, where real information could be shared and --hopefully!-- people could become inspired to advocate on their own behalf.

        Gotta get more caffeine before we start . . .


          Hi Kate, I am there too, where are you in the room?
          Pharmacist, C4-5 injury but functional C6 (no triceps/flexors)


            Opening Remarks -- The Legacy of Justin Dart

            Marilyn Smith, who was one of the CC members who was at that first rally 6 years ago, is now the executive director of u2fp . . . which sounds, believe me, a lot more high rent than the actual position has been, at least so far. (Which is to say, she barely gets paid.)

            She's at the lectern, asking for quiet.

            We have a very, very full schedule and want to make sure our speakers get lots of time . . . coupla changes:

            The Geron speaker will be Dr. Joseph Gold and not the person named in your program. . . we're all eager to hear what's going on with their clinical trials.

            Also our patient advocate will not be Karen Miner, but instead David Zacks.

            This is our 6th event, and it's great to be back in DC, where we haven't been for some time. Thanks to our sponsors, who make this event affordable to anybody in the sci community who wants to be here. Please visit their displays and say hello and thanks. None of this would be possible without them. (People clap)

            Our speakers are very busy people; they take time from very demanding schedules to show up here, and we really appreciate the value they bring to this conference. They don't get many opportunities to talk to the people they're trying to cure. Just as you look forward to meeting them, they look forward to meeting you. Reach out to them, engage them in discussion, take advantage of this chance. It's unique.

            Finally, the army of volunteers . . . u2fp is pretty much a volunteer organization and something of a family operation. We have Sue Maus and the tribe from Minnesota, more of them every year. An incredible family and an incredible group of people. Also Donna Sullivan, who's here with her kids Melanie and Matt, working tech and doing photography . . . and many others.

            We have a pretty amazing group of international visitors here. I was amazed at the distances people were glad to travel to be here.

            Japan Spinal Cord Foundation
            PT from Nepal
            The European contingent, who are extremely knowledgeable

            I flew out here from Oregon on Frontier airlines. Appropriate, because I was going to a conference of pioneers. Curing sci is the holy grail of neurological research. As pioneers we can learn from this man named Justin Dart . . .

            Anybody heard of him? one person
            I'm surprised. He was a world-reknowned disability activity, the father of ADA. He described a revolution of empowerment, as one that eliminates obsolete thoughts . . . it's thanks to him that many of you were able to travel here, that you were able to ride on a ramp into the restaurant and bar. He was born into wealth, went to 7 different high schools and didn't graduate from any of them. Three events changed his life. At 18 in 1948 he got polio, was sent to a hospital in LA, given little time to live. He was overwhelmed by the people he met in that hospital. The 2nd thing was his discovery of Ghandi, and the idea of finding your own truth and living it. He went to college, went into business and built several successful companies. The third thing was a visit in 1969 to Vietnam to see children with polio. He thought he was going to see a rehab facility, but what he found was kids left to die on floors.

            He and his wife decided to spend their lives on creating a revolution of empowerment of the disability community . .. in 1988 he was appointed to chair a national task force on the rights of disabled people. The ADA was enacted two years later. He embraced the principle of inclusiveness as a means to empowerment. He gave credit for everything he'd been and done to the others who reached out to him and those who joined him. At his death, he was still calling for revolution.

            I think that if he were alive today, he'd be joining us. He'd be asking for the world to see that this is a curable condition, and he'd be looking for others to join the revolution. This room is full of pioneers.


            She's introducing Donna Sullivan . . . another sci mom. We affectionately call her the bulldog, because she never, ever gives up. She worked extremely hard this year to put together our program, which she's about to describe.

            Donna comes up and says welcome & that it's a privilege to be here.

            We've evolved a lot over the last few years. In the beginning this was all so opaque to me, and I still can't believe that we've come to a place where we're talking about clinical trials. Whatever your talents are -- and I came to this with no background, certainly in neurology, we just need to pull them together.

            The first time I heard about Douglas Fields was from our friend Martin (Irish sci), who told me about his book -- which is terrific and reads like a novel.


              Douglas Fields

              I'm delighted to be here, thank you all.

              This morning I want to talk about Glia, which I call the other brain. First what is it, then what's going on in my lab.

              We think of brains and cords as an electrical circuit, but the nervous system doesn't work like wires . . . and maybe this analogy has led us astray. Slide up of Dr. Cajal, who kind of invented this metaphor. New slide about the electron microscope, and a moving image of an electron microscope image zooming into the brain -- a dense gray mass -- and he says that only 15% of what we're looking at is neurons.

              The rest is glia.

              Neurons and glia both form networks; the higher you go up the evolutionary tree, the more glia . . . whoa, showing Einstein's brain, which has been shown to have had more glia than the average brain.

              List of glial functions, which go by too fast to catch, sorry . . . so why did we ignore them for so long? Needed fluorescent imaging techniques to really see them, and that's a recent development.

              Glia surround neurons, sending waves of calcium to one another in response to electrical charges in neurons. They're communicating just as neurons do, except neurons talk like land lines, and glia broadcast . . .

              Astrocytes (a kind of glial cell) have crazy interesting jobs . . . showing how an astrocyte caused a blood vessel to dilate.

              Glia have stem cell like properties . . they're both the problem and the answer in spinal cord injury. OPCs are glial cells, the ones that form myelin. The scar that forms after sci forms a non-permissive substrate, and astrocytes are the main component in this scar. The scar's job is to confine the damage to a localized region; this is a good thing.

              If you culture neurons without astrocytes, you don't get functional synapses.

              Four kinds of glial cells: astrocytes we just talked about,

              Next is microglia. Using in vivo imaging, you can watch a microglia send out processes looking for damage like fingers through the tissue . . . your own brain is doing this right now; they're cleaning up after injury -

              Microglia is also involved in chronic pain after injury. They release substances that are useful and necessary in the healing process, but that excite neurons; using morphine against them causes them to release more substances, which excites more neurons, which is how people get addicted -- marijuana, however, acts on glia, which is one of the reasons it works and is not addictive. (I think he just said pot works because it doesn't cause glia to release the substances that excite neurons. Interesting.)

              Talking now about myelinating glia, Schwann cells, oligodendrocytes. After a sci, we have a situation where nature has "booby-trapped" the myelin to prevent regeneration. Myelin keeps growing until early adulthood . . . myelin accelerates connections between neurons; it seems to have to do with learning. Human brain imaging has shown that piano-playing (among many other things) causes white matter tracts to change. So does juggling. And learning languages.

              So we must find out how myelin is formed, and how to stimulate its growth.

              They cultured mouse neurons and stimulated the glia around them with electricity. The question was, could you stimulate the formation of myelin in this way? They've found 4 different ways that they can get oligodendrocytes to make myelin in response to electricity.

              There's a paper just published in Science this summer about all this work, which he refers us to because he's going to run out of time.

              Conclusion: Glia are both the problem and the answer. Understanding the biology behind this is the key to treatments.


                Richard Garr, CEO & Director, Neuralstem, Inc.

                Donna is introducing him.

                I promise you this will be much less a scientific presentation. I'm going to talk with about the process of clinical trials. I'm going to . . .

                (They're messing with the connector so his laptop hooks to the screen)

                Precursor neuronal cells are where we focus. We don't try to push our cells to turn into either glia or neurons; we grow them in a regionally specific way . . .they're fetal derived, at 8 wk gestational stage. A single donated tissue from 2002 was used to create enough cells to treat every patient we'll ever want to treat.

                We've transplanted 12 patients with ALS, a neuronal disease that kills people between 3 and 5 yrs after diagnosis. There's nothing that slows down the generative process. We put our cells into the gray matter. We're going for both repair and replacement.

                In sci it's a little different. The fda looks at acute and chronic sci as two different conditions, and the requirements for trials are different.

                They have an underlying assumption that the higher up you go, the more danger for the patient. The fda only lets them put in 1/4 of the cells they want to put in, and not necessarily in the place where it would be optimal. Showing a slide of the actual surgery . . . yes, it's very invasive. Geez. He says it's important to know that -- this is not a pill, this is the operating table and somebody's back is opened up.

                You can go to the website (linked above) if you want to read the papers they've published on these methods.

                What appears to happen is that the cells they put in nurture or partly rescue some of the dying cells. Their als patients have seen impressive slowing of the progress of their illness.

                In sci, it appears that if you get cells in early enough, you can get prevent the waves of 2ndary damage. In chronics, you need to bridge gaps . . . what we know about long term problems come from what we're learning from pretty short term studies. The fda told us that they would want to see mri's every 3 months -- but a lot of patients have hardware, and that makes an mri impossible. So we're looking at removing hardware.

                So. They've made a device (a floating canula) that they're testing on pigs right now. They're trying to find the maximum # of cells they can put in.

                The fda lets them do 1 patient per month, then wait 6 months. Then
                They asked for permission to treat chronic scis last december in the usa, and the fda is asking for proof of long term safety before they'll say yes. Will the als patients' safety be enough evidence? It's going on 20 months . . .

                He expects that there will be a conversation, each side of which takes 30 days, which means it's a long process. The design of the sci trial has four centers involved, asia a patients, 16 patients, the first 8 only lower back, then a hard stop wait of six months, then 8 more upper back. These are safety trials, testing both the device and the cells.

                In als, they've been of course looking at things beyond safety, like functional recovery. We want some signposts that even in the lower doses that the fda requires, something is happening. . . and we are seeing that. We do expect that acute sci will behave sort of like als, but it's less clear how this will play out with chronics. We did include FES and activity-based therapy as part of the protocol in our filing for chronics, because we're aware that retraining will be essential.

                The fda is very concerned about rejection, too. We have no evidence that the immune system is bothered by them, but we've had to use immunosuppression anyway -- for life -- on the als patients. For sci, our protocol is only for 3 months of immunosuppression.

                We're looking at big sci trial in India in 5 centers, and we expect that the Indian gov't will not let us go ahead until the USA has permitted it. Their regulatory pathway is somewhat different . . . and their transportation issues make it impossible to even think about doing acutes or even subacutes, b/c you couldn't get them to the centers efficiently.

                We're also looking at stroke patients in China, but again we'll be needing to complete some things in the USA first.

                The fda requires them to keep doing trials on pigs even as they're going forward with human trials -- testing higher doses and upper back instead of lower back, etc.

                They'll be going back to the fda with their high quality als safety proof, asking permission to proceed with sci patients.



                  Geron's Oligodendrocyte Trial: Dr. Joseph Gold

                  Here's the update on information we first heard at working 2 walk 5 years ago from Hans Keirstead.
                  I'm a stem cell guy -- the first person hired to esc work at Geron 16 years ago.

                  You've heard all the "big talk" and hype around what stem cells can do, and all the talk about how useless they are. I'm here to talk about what's real.

                  Esc's are unique because they're immortal and can turn into anything, even, we now think, eggs and sperm. We've been using the same cells we originally isolated in 1998 from one egg.

                  Okay, slides are working.

                  Telomeres are like the plastic ends of shoelaces, hung on the end of a chromosome. When your cells are dividing, each time over the course of your life, they're losing a tiny bit of that telomere. Over the course of your life, you're in the process of losing telomeres . . . but there's a substance called telomerase that's expressed in esc's that prevents this. That's how you get immortality in a cell.

                  And immortality is what lets you make batches of cells and treat them basically as if they were drugs.

                  Geron's opc1 is a frozen preparation of oligodendrocyte progenitors that are capable of turning into oligodendrocytes, the kind of glia cells that make myelin.

                  We used to think that in trials of cells, the cells were themselves turning into the kind you needed. You put stem cells into the heart, you get new heart cells -- but we don't actually know that. It's just as possible that the new cells are somehow acting on the cells that are already there . . . either way that's a good thing.

                  (more trouble with the slides, gak)

                  What everybody worries about is the danger of undifferentiated stem cells -- because we don't want them in peoples' bodies turning randomly into other kinds of cells or into tumors. We tested endlessly with rodent models, specifically with this mouse called a shiverer mouse -- a mutation that is unable to make its own myelin.

                  Editorial comment: Okay. This is all known, right? You got approval from the fda and have done at least 2 patients already. What's going on with them?

                  Still talking about all the rat studies they did . . . all with no evidence of adverse effects. Well, except from the rats' point of view, eh? They were paralyzed, given injections, subjected to bowel and bladder routines, and finally sacrificed and autopsied at a microscopic level. Just sayin'.

                  Okay, the human trials. First, this is a phase 1 trial, in which the patients got about 1/10th of the cells they would get in an efficacy trial. The goal of this trial is just to prove that nobody will get hurt by these cells. The patients were asia a complete, t3 - t11, and we did them in the subacute phase, which means 7 - 14 days. The people who said yes to this therapy are pioneers. We inject the cells with a device we designed and developed ourselves. The patients get the same kind of immunosuppression as heart transplant patients, which we start to ramp down at about 45 days until it's gone at about 60 days. The patients have 9 mri's in the first year . . . they'll be followed for 15 years. The fda requires this because the first stem cells were developed on a layer of mouse cells . . . these cells have not been in contact with any non-human cells for many years, so we're not worried about that.

                  So far 4 patients have been treated. It was never our intent to publicize their identities or their progress. The first patient was treated a year ago. No adverse effects whatsoever, which was the goal, because it allows us to ramp up the dose from a "safety" range to a "beneficial function" range. Going forward, there will be cervical patients, higher doses, and efforts to break up the scar tissue so that whatever works in subacutes also helps chronics.

                  Alrighty then. Time for a quick break, and then a panel with those 3 people and our advocate David Zacks.


                    Panel Discussion

                    David Zacks, who has a complete cervical injury, a busy family, and a job -- he's also very funny . . . he's the guy who, years ago, came up and spoke with his daughter on his lap, turning the pages of his talk for him.

                    Protocol here is: audience asks questions, panel replies.

                    Q: Dr. Gold, is your trial only for people 4 to 6 wks out from injury?
                    A: No, I'm sorry if I said that, it's 7 to 14 days out.
                    Q: What about 5 to 10 years?
                    A. We're working on it.

                    Q from Stephen Davies: Dr Gold, question about allodynia. Didn't your studies work on immunosuppressed rats, and doesn't that mean you wouldn't see allodynia?
                    A: I appreciate the concern

                    Q: from Dalton Dietrich from Miami project: To Dr. Fields . . . about myelination
                    A: we stimulated for about 5 hours and looked at myelin in culture weeks later, in general does an oligodendrocyte know which axon to myelinate . . our work shows that we can promote myelination

                    Q: about Geron cells and adding growth factor to it . . .what else are you considering?
                    A: there are some approaches that would involve taking out the antibodies that get expressed

                    Q: (Davies) Dr Fields, thanks for championing the cause of glia . . how do you see the development of astrocyte therapies developing?
                    A: Still a lot of biology to be learned . . . we're only now understanding the things that will let us genetically engineer astrocytes and when we'd need to do it.

                    Q: (still Davies) couldn't hear it, more about astrocytes
                    A: There's still so much ignorance on this; there are probably as many different kinds of astrocytes as there are neurons. Calling it an astrocyte is too superficial and we need to know much more.

                    Q: (can't hear it)
                    A: Dr Fields says that we believe the process of making myelin takes place throughout life

                    Q: Dr. Dietrich: Dr gold, sometimes people think the fda gets in the way of getting things done . . . did you ever think about going offshore?
                    A: It was contemplated, but as frustrating as it was, they had reasons. It was a long education process and we gave them 21,000 pages that they were required by law to read and reply to in 30 days. We filed this under Bush and then within days after Obama was inaugurated, it was finally released, so it looked political. The world doesn't work like that. That's not what happened. There are other countries with lower standards, but we decided it was better to ride it out with the FDA.

                    Q: Dr Gold, in the subacute phase, a lot of things are still happening . . .like swelling. Isn't is hard to find the scientific data about what's your study and what's the body itself?
                    A: The reaction after injury does partly limit what you can do and when you can do. Suppressing the immune response or using cooling are some ways you might address that. Dr Fields: I think after a couple of days of talking it will be obvious that there will need to be combinations.

                    Q: Dr Gold, please tell us something about the patients you've treated at Geron.
                    A: No, I'm not allowed to talk about that. I do need to say that we'd be delighted, of course.

                    Q: for Dr. Gold
                    A: the fda didn't ask for large animal models in addition to the rat models? no

                    Q: for dr gold; what about other kinds of cells, like neurons?
                    A: we're not doing that right now . . . dr fields: demyelination might not be getting the attention it deserves. the fibers that weren't damaged aren't able to do their job, and they also can't survive long without myelination.

                    Q: for dr gold: if everything is perfect, what's the timeline to a real product, esp one that involves combinations?
                    A: it's important to know that when you're doing a clinical trial, I've heard as long as 8 years

                    Q: for David . . what advice would you give to advocates?
                    A: coming here is a good first step; this is a 2-way relationship. we need scientists and they need us. it's important to be involved.

                    Q: when you were talking about stem cells . . . they haven't degraded at all over 12 years?
                    A: when you make a cell bank, it's kind of suspended animation. what you do is freeze the cells down, so they're not cultured continuously. you freeze them normal, and thaw them normal.

                    Q: glial cells communicate by broadcasting calcium ions . . . does this have to do with the issue of spasms?
                    A: calcium is an important messenger in all cells . . it doesn't flow from one astrocyte to another, it's more like there's a chain reaction between astrocytes, and calcium is a piece of that chain reaction

                    Q: is there any agenda to address lower motor neuron issues?
                    A: not right now; it's a much harder problem to resolve


                      Thank you Kate - so much !! It feels like a conversation when you blog - like we're sitting next to each other commenting discussing and nodding our heads !! Keep up the great work

                      Every year I say - next year - so I'll say it again - "maybe next year" ...... I'll bring Beth and Linda with me ....and Bente and Jenn and Paul and cass and sci55 and Steven and Cheese etc etc ................ Oy vey wouldn't it be awesome .....

                      ~ Be the change you wish to see in the world ~ Mahatma Gandi

                      " calling all Angels ...... calling all Angels ....walk me through this one .. don't leave me alone .... calling all Angels .... calling all Angels .... we're tryin' and we're hopin' cause we're not sure how ....... this .... goes ..."
                      Jane Siberry


                        I am so happy to be here in person this year. I have used this live-blog in the past to follow this meeting. Thank you for live-blogging this meeting so that people who could not make it can share in some of the great feeling this meeting gives. Have a great meeting!


                        Jonathan Slotkin, MD
                        Invivo Therapeutics


                          Sue Maus

                          Donna saying that Sue first called her in 2007 to see if she'd be interested in helping out at u2fp. Turns out it's not possible to help out "a little bit."

                          Sue is a busy advocate who works full time, has raised two daughters, and has a high cervical injury. You're never, ever going to convince her that there's just no time to make a phone call or write a letter or show up.

                          Sue: Good morning. Colin and I just celebrated our 25th wedding anniversary, and I'd like to say that he's the reason I can do what I do. Just realized the reason I'm so nervous right now is that my mom is here . . . yeah, Jan! I'm also nervous, though, because this is just so important to me. This used to be like the impossible dream, and now here we are talking about clinical trials.


                          Advocate is a noun -- it's a person
                          Advocate is a verb -- it's an act
                          either way, it's a powerful change agent . . . it sounds simple but it's kind of daunting, especially at first.

                          There are 3 basic styles of advocacy, which you can do in any combination that works for you.

                          Community style is somebody who has never met a stranger! What do they do? Make themselves visible and respond willingly to questions. (Little girl who asked why she was in the chair, and after hearing that Sue can't walk, wanted to know why she needs shoes.) It's important to learn as much as you can; in the beginning I only grasped about 20% of what's going on but now I get about 80% of it. That takes time. Our model for community advocate is Joe White, who keeps it casual, real, and effective on a local level.

                          Media style is another option. What do they do? They're on the message boards, facebook, youtube, twitter . . . they're doing letters and newsletters, and not because they're great writers so much as because they're passionate. Our model for this is ProfessirX, who got involved with us by posting a youtube of himself doing a rap about Chris Reeve.

                          Legislative style is a third option. They're the spreadsheet fans, hard to distract, hard to annoy, good at tracking things, good at staying focused, don't know the word, enemy. The model for this is Leo Hallan, a good friend from South Dakota who is a genius at creating common ground.

                          How do you do this? Start with facts, which you already know or you wouldn't be here. Answer people's questions, respond to their objections, lead by example, focus on the positive, involve others, expect resistance and don't let yourself be discouraged. Communicate in multiple ways; be hard to ignore.

                          Never give up. Never shut up.
                          Anybody reading this blog or seeing the videos later is who I'm talking to.

                          Here's a Minnesota quote that I hang onto when I get discouraged. It's from Wayne Gretsky:

                          You miss 100% of the shots that you never take.

                          Thanks for your courage, and for being here.


                            Kickass Advocate Award

                            Marilyn is up saying that we wanted Karen Miner to hand this off. She won it last year. She was supposed to be here. She had to cancel at the very last minute due to sci issues.

                            That's why we have to do this.

                            The winner this year raised $50,000 in the Chicago marathon on his first try. His organization is known as SCI Sucks. That's kickass and that's telling it like is. Geoff Kent!!

                            First of all, what I do is nothing compared to what Marilyn and Donna and Sue and everyone involved with this organization does. Thank you for the award but I'm nothing compared to what you all do. So, yeah, the name SCI Sucks came about when I was first injured, a little angry, yeah. There's probably a hundred charities in the Chicago Marathon, and runners can sign up for any one on the list . . . lots of people choose our charity just because of the name.

                            We raised $300,000 for research last year.

                            All of us know somebody who's injured worse than you. No one is gonna advocate for the person you left behind in rehab who's got it worse than you, has a worse injury, got stuck in a nursing home somewhere. No one is gonna do that if we don't.

                            Those of us who can do this -- come to Washington -- need to do it. We're the only population in the world that's ever been. The invention of the plastic catheter makes our lives possible, and we have a responsibility.

                            If you know anyone who's doing races, we'd love to have you.

                            SCI Sucks!


                              Susan Testa: Gut and Digestive Health in SCI

                              Marilyn's making a joke about how we really might not want to do this before lunch, ahem. . . but this is an overlooked subject that matters a lot to maintaining your health as an sci survivor.

                              Last year I got to speak at a couple of breakout sessions in Phoenix w2w, where we talked about the prevelance of cardiovascular disease in sci.

                              This year I'm going to talk about gut bacteria. (woo hoo.)
                              This is for everybody, sci or not.

                              What is the gut? It's what starts at your mouth and ends at your anus. Today we're going to think about the small and large intestines . . . it's the platform for everything. Each person has their own profile for digesting & processing food, which affects everything from the brain to the immune system.

                              The integrity of your gut matters because you get optimal function, and you can protect that integrity. What are gut bacteria? Well, they're called "flora" and the live in the large bowel. Probably about 70% of fecal matter is bacteria. There are more bacteria in your gut than cells in your body. We all have bad and good bacteria . . . usually in a ratio of bad/good = 4/1.

                              Lots of people have issues that come from poor gut health that might surprise you -- things that can be mitigated with better gut health. Depression, for example.

                              We're supposed to have bad bacteria . . . but we have to manage them, i.e., make sure the balance is right. Things that mess with the good bacteria are antibiotics, stress, sugar, red meat, antacids. You can take (or eat) something called probiotics, which work to make sure you have the good stuff that might have been lost.

                              There are 2 main kind of probiotics, several varieties of each, but she's focusing on one variety called lactobacillus acidophilus, which improves nutrient absorption, aids digestion, helps prevent uti's, prevents bad bacteria from going wild, and normalizes cholesterol.

                              The other one is biffidobacteria bifidum. which help keep you regular, decrease side effects of antibiotics, manufacture b-complex vitamins, and help you increase absorption of minerals.

                              So. Take a freeze-dried probiotic that has the stuff bolded above.

                              Whoops, gotta charge up.
                              Edited to add: here's a link to her web page where this information is easy to figure out. She really does have a ton of good information for people trying to keep themselves in shape.
                              Last edited by kate; 16 Oct 2011, 12:27 PM.