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Spinal Cord Injury Articles Posted by Manouli

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    NEWS RELEASE 15-MAR-2021
    UofL, Medtronic to develop epidural stimulation algorithms for spinal cord injury
    $7.8 million from NIH will fund development of a closed-loop system to monitor and adjust for multiple functions, use wireless monitoring

    LOUISVILLE, Ky. - Researchers at the University of Louisville made news worldwide in 2018 when two people diagnosed with complete spinal cord injuries recovered the ability to walk thanks to experimental use of a therapy known as epidural stimulation. The news gave hope to people living with complete spinal cord injuries, a diagnosis that historically meant they were unlikely to regain function below their level of injury.


      One step closer to treating spinal cord injury with our own stem cells
      March 15th 2021
      Justin Varholick, PhD

      Recently, a team of scientists from Yale University and Sapparo Medical University in Japan treated spinal cord injury patients with their own bone marrow derived mesenchymal stem cells (MSCs), increasing their ability to walk and use their hands. Previous to the treatment, 13 patients had sustained falls or minor spinal trauma resulting in loss of motor function, coordination, sensory loss, as well as bowel and bladder dysfunction. After being bedridden for several weeks from an unexpected fall, the first patient was extremely thankful to be able to independently use a wheelchair and walk upright with a walker. Thanks to their own stem cells.

      NEWS RELEASE 11-MAY-2021
      Cell reprogramming could aid spinal cord injury recovery


      Cells called astrocytes normally support our neurons, and now scientists are working to reprogram the star-shaped cells into neurons that help reconnect the brain and body after a spinal cord injury.

      "We are at the stage of optimization. We know this reprogramming is feasible and we can do it," says Dr. Hedong Li, molecular neuroscientist in the Department of Neuroscience and Regenerative Medicine at the Medical College of Georgia.

      Last edited by manouli; 24 May 2021, 4:15 PM.


        MARCH 23, 2021
        Nanobiomaterial boosts neuronal growth in mice with spinal cord injuries
        by Tongji Hospital of Tongji University

        Researchers from the Department of Orthopedics of Tongji Hospital at Tongji University in Shanghai have successfully used a nanobiomaterial called layered double hydroxide (LDH) to inhibit the inflammatory environment surrounding spinal cord injuries in mice, accelerating regeneration of neurons and reconstruction of the neural circuit in the spine. The researchers were also able to identify the underlying genetic mechanism by which LDH works. This understanding should allow further modification of the therapy which, in combination with other elements, could finally produce a comprehensive, clinically applicable system for spinal cord injury relief in humans.



          I everybody! On April 10, I did the J&J Vaccine then, the next day saying about blood clot, lol. I feel good no problems! I am checking my self every day, but I am not worry everything is looking good. I wish all of you to be healthy! Soon, I'll post some new articles so we can see what's going on with the cure. I am getting older by the day, I want some good news for all of us! We have lost so many people and is so sad! xxxooo,manouli
          Last edited by manouli; 20 Apr 2021, 3:35 PM.


            God bless you Dear Manouli. Yes we need cure before we die


              Inflammatory response could hamper spinal cord injury

              Spinal Cord injury is a major condition in the United Sates. It is believed that an estimated 1.3 million people in the U.S are suffering from spinal cord injury, experiencing paralysis and difficulties that comprise of bladder, bowel and sexual dysfunction and persistent pain.
              A new research claims that an inflammatory response following a spinal cord injury seems to cause further tissue damage instead of encouraging healing. Researchers examining this inflammatory response in mice found that the kinds of cells enrolled to the location of the injury are apparently conquered within a week by those that endorse continue.....

              NEW ARTICLE 6/5/21
              Clinical Trial Could Help Paraplegics Walk Trial In Australia
              CANBERRA, Australia — Australians paralyzed by spinal injury could soon move and walk again, if an Australian clinical trial exploring a neurological treatment is successful.

              Led by researchers at Neuroscience Research Australia (NeuRA) the landmark international trial aims to restore the function of remaining spinal nerves through neurostimulation. Neuroscience Research Australia (NeuRA) is an independent, not-for-profit research institute based in Sydney, Australia. As a leader in brain and nervous system research, our goal is to prevent, treat and cure brain and nervous system diseases, disorders, and injuries through medical research.


              How to recover from a spinal cord injury
              The Hindu6 Jun 2021Aswathi Pacha The Hindu.

              Spotlight on recovery: A high-resolution image of the treated spinal cord.
              A violent fall, a vehicular accident, or a sports injury can sometimes damage the spinal cord and brain leading to paralysis and other lifethreatening health problems. The nerve fibres that carry important information are unable to regrow, leading to irreversible damage. Using novel bioinformatics frameworks and screening platforms, researchers have now identified a new gene combination that can help enhance the growth of nerve fibres after an injury.

              Last edited by manouli; 6 Jul 2021, 5:37 PM.


                New treatment targeting senescent cells boosts functional recovery from spinal cord injury
                James Ducker, MRes
                By James Ducker, MResJul 6 2021
                Reviewed by Emily Henderson, B.Sc.
                Senescent cells prevent tissue recovery following spinal cord injury, and a new drug targeting these cells could therefore improve functional recovery capacity.
                Exploring treatments for spinal cord injury in animal models
                Notorious for having a poor ability to recover from spinal cord injuries, mammals often suffer from whole-body paralysis following such recoveries. This contrasts to other taxonomic groups, such as fish, that can recover from injury relatively rapidly in comparison.

                NEW ARTICLE

                Recovery Q&A - Is a Full Recovery Possible?
                Author: Team
                Publish Date: July 27, 2021
                Q: Is a Full Recovery Possible?
                A: It is true. There are people who experience a full recovery after their spinal cord injury. It’s exciting and it gives hope to others with paralysis. These recoveries range from "complete" injuries to "incomplete" injuries. Simply put - doctors do not know everything, even if they have experience treating others with spinal cord injuries similar to yours. "They may know books, but they do not know you," is the common phrase said by people recovering from a spinal cord injury.
                The fact is that there's a lot of mystery still left regarding the spinal cord and how it functions and more importantly, how it heals. For example, doctors and researchers know that epidural stimulation can help return mobility to those with spinal cord injuries, but they still aren't exactly sure how it works. The same goes for spinal cord injuries. There are some who experience spontaneous recovery years after their injury, and they don’t know why.
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                AUGUST 12, 2021

                Unexpected functions of the spinal locomotor network
                by Karolinska Institutet

                Researchers at Karolinska Institutet, the German Center for Neurodegenerative Diseases (DZNE) and Columbia University Irving Medical Center have found an unexpected link between spinal locomotor network activity and adult neurogenesis in the adult zebrafish spinal cord. The study has recently been published in Nature Communications.


                ersey Shore University Medical Center Surgeon’s Research on the Phrenic Nerve Reconstruction Surgery He Pioneered Published in the Annals of Plastic Surgery
                September 10, 2021 sarah JonasAnnouncement
                Post Views: 29
                Study results, supporting the efficacy of phrenic nerve reconstruction surgery, from Matthew Kaufman, M.D., FACS, and colleagues at Hackensack Meridian Jersey Shore University Medical Center were recently published in the Annals of Plastic Surgery.1

                Dr. Kaufman, medical director of the academic medical center’s Center for Paralysis and Reconstructive Nerve Surgery has pioneered phrenic nerve reconstruction. As a board-certified plastic and reconstructive and otolaryngology-head and neck surgeon, he understands how to reconstruct and treat peripheral nerve injuries. In 2007, he began applying those skills in innovative ways to successfully treat phrenic nerve injuries and diaphragmatic paralysis.


                Study shows resilience as a character trait to overcome spinal cord injuries

                Clinical Trials & Research
                September is Spinal Cord Injury (SCI) Awareness month. According to the National Spinal Cord Injury Statistical Center, approximately 296,000 Americans are currently living with SCI, with around 17,900 new cases occurring each year.

                Those who don’t personally know someone with SCI have almost certainly heard the stories of people such as Teddy Pendergrass, an R&B singer that was injured in a car crash, or Roy “Campy” Campanella, the Hall of Fame catcher for the Brooklyn Dodgers who also was injured in a car crash. Likely one of the most famous stories is that of Christopher Reeve, the actor who played Superman during the ’70s and ’80s and suffered an SCI after he fell off his horse during an equestrian competition.

                Strict lineage tracing crucial to nerve cell regeneration research, study says

                DALLAS – Sept. 27, 2021 – UT Southwestern stem cell scientists find that stringent lineage tracing is crucial for studies of nerve cell regeneration. Their results, which are published in Cell, show that this tracing is far from routine in the field and suggest that earlier studies reporting “striking” regeneration results must be reexamined.

                Lineage tracing, which is a fundamental approach in developmental biology, refers to tests used to map out the progeny – or descendants – of a given cell in an organism.

                Lineage tracing is also central to the field of stem cell biology, so it was surprising to learn how often such testing had been omitted, the authors write in the newly published study in Cell, one of the world’s most highly regarded scientific journals. The two corresponding authors are Chun-Li Zhang, Ph.D., a Professor of Molecular Biology and a W.W. Caruth, Jr. Scholar in Biomedical Research; and Lei-Lei Wang, Ph.D., an Instructor of Molecular Biology and member of the Zhang lab, which studies nerve cell regeneration in the brain and spinal cord.

                Last edited by manouli; 29 Sep 2021, 11:08 AM. Reason: NEW 09/29/21


                  Check this videoyou might like it.



                    New Hope for Treating Neurodegenerative Diseases
                    Oct 5, 2021 Updated Oct 7, 2021

                    (NAPSI)—Scientists have searched for decades without success for ways to repair the devastating damage caused by neurodegenerative diseases, but there are now new compounds in clinical development that offer hope.

                    The Problem

                    When there is a mass die-off of neurons in the body, the central nervous system misfires like a faulty circuit board—one that cannot be fixed without replacing the blown fuses. This major physiological malfunction tends to trigger the onset of some of the hardest-to-treat neurodegenerative diseases, including Alzheimer’s disease and multiple sclerosis (MS).

                    These are terrible afflictions that affect millions of North Americans. They also cost the healthcare system billions of dollars a year, mostly spent on managing physical and mentally debilitating symptoms that inexorably get worse.

                    What’s more, current treatments can only “modify” (slow down or mitigate) the destructive effects on the human body caused by the mass death of neurons in the brain or spine.


                      Drug helps sensory neurons regrow in the mouse central nervous system
                      Targeting support cells with cholesterol drug could improve recovery after spinal cord injury
                      October 19, 2021
                      Washington University School of Medicine
                      Researchers have discovered that an FDA-approved drug acts on support cells in the central nervous system to encourage sensory neurons to regrow after injury.

                      A spinal cord injury damages the lines of communication between the body and brain, impeding the signals that drive movement and sensation. Injured motor and sensory neurons in the central nervous system -- the brain and spinal cord -- have limited ability to heal, so people who survive such injuries can be left with chronic paralysis, numbness and pain.


                      Shockwave therapy brings new healing opportunities for heart attack patients and hope for people with spinal cord
                      read .....


                      Last edited by manouli; 6 Nov 2021, 12:03 PM. Reason: NEW ARTICLE


                        Dutch stem cell biotech Neuroplast announces successful clinical Phase I trial with Neuro-Cells® stem cell treatment for Traumatic Spinal Cord Injury

                        Tue, November 9, 2021, 3:00 AM·6 min read
                        Positive safety profile and well tolerated, without product-related adverse effects

                        Demonstrated clinical feasibility to collect, manufacture and treat Spanish patients from its Dutch GMP production facility

                        Preparation for randomized, placebo-controlled, international multi-center Phase II study in sub-acute patients

                        Orientation on additional funding to expand clinical trials to other geographies

                        GELEEN, Netherlands, Nov. 9, 2021 /PRNewswire/ -- Dutch clinical phase biotech company Neuroplast and Hospital Nacional de Parapléjicos de Toledo in Spain, today announced positive clinical Phase I results after analysis of ten patients suffering from Traumatic Spinal Cord Injury (TSCI). Data demonstrate that Neuroplast's investigational stem cell treatment Neuro-Cells® appears to be safe and well tolerated, without product-related adverse events. The transformative treatment uses the patient's own stem cells to prevent (further) loss of function after sustaining TSCI, to potentially limit loss of mobility and independence of otherwise life-long impairment.


                        Reuters Videos
                        Scientists reverse paralysis in mice, seek human trials
                        Thu, November 11, 2021, 1:34 PM
                        (SOUNDBITE) (English) SAMUEL I. STUPP, NORTHWESTERN UNIVERSITY, SAYING: "Spinal cord injury has been a major challenge for science for decades.”

                        Scientists at Northwestern University say they may have found a breakthrough treatment for reversing paralysis in humans after successfully administering a new injectable therapy in mice.
                        Last edited by manouli; 13 Nov 2021, 12:32 PM. Reason: NEW ARTICLE YAHOOOOO!


                          ISSICON 2021: Global experts virtually discuss ongoing research on treatment for spinal injury patients
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