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    Originally posted by vjls View Post
    I can wiggle my toes on left anytime I want to right I really really have to concentrate but that's it nothing for 17 years
    mmm

    Comment


      ReNetX Bio Announces Initiation of Patient Dosing in the First Phase 1 Clinical Trial of Fusion Protein AXER-204





      August 14, 2019 09:02 ET | Source: ReNetx Bio


      NEW HAVEN, Conn., Aug. 14, 2019 (GLOBE NEWSWIRE) -- ReNetX Bio, Inc., a leading biotechnology company committed to reversing disease and damage for patients suffering from central nervous system (CNS) disorders, has announced a successful first patient dosing in a Phase 1 clinical trial of its lead drug candidate, fusion protein AXER-204.


      more...


      https://www.globenewswire.com/news-r...-AXER-204.html

      Comment


        Originally posted by manouli View Post
        ReNetX Bio Announces Initiation of Patient Dosing in the First Phase 1 Clinical Trial of Fusion Protein AXER-204





        August 14, 2019 09:02 ET | Source: ReNetx Bio


        NEW HAVEN, Conn., Aug. 14, 2019 (GLOBE NEWSWIRE) -- ReNetX Bio, Inc., a leading biotechnology company committed to reversing disease and damage for patients suffering from central nervous system (CNS) disorders, has announced a successful first patient dosing in a Phase 1 clinical trial of its lead drug candidate, fusion protein AXER-204.



        https://www.globenewswire.com/news-r...-AXER-204.html


        Watch: Spinal Cord Injury Research
        Larry Wong, Edmonton Journal
        Updated: August 15, 2019
        ShareAdjustCommentPrint
        Ana Lucas-Osma, a research associate at the University of Alberta?s Faculty of Rehabilitation Medicine, suffered a T7 spinal cord injury in Spain when she was 18.
        She was one of seven passengers in a school van that rolled down a hill and it left her in a wheelchair.
        The University of Alberta and the University of California, San Francisco are teaming up to launch the world?s first Open Data Commons for preclinical Spinal Cord Injury research (ODC-SCI).
        A consortium of international organizations will be providing $3.3 million CAD to help fund the initiative. The ODC-SCI will improve spinal cord injury research and treatment worldwide by reducing data bias and equipping scientists by making data more accessible.

        more...
        https://edmontonjournal.com/news/loc...njury-research

        Comment


          Animal studies of protein AXER-204?

          Originally posted by manouli View Post
          ReNetX Bio Announces Initiation of Patient Dosing in the First Phase 1 Clinical Trial of Fusion Protein AXER-204





          August 14, 2019 09:02 ET | Source: ReNetx Bio


          NEW HAVEN, Conn., Aug. 14, 2019 (GLOBE NEWSWIRE) -- ReNetX Bio, Inc., a leading biotechnology company committed to reversing disease and damage for patients suffering from central nervous system (CNS) disorders, has announced a successful first patient dosing in a Phase 1 clinical trial of its lead drug candidate, fusion protein AXER-204.


          more...


          https://www.globenewswire.com/news-r...-AXER-204.html



          Is anybody aware of animal studies of ReNetX Bio fusion protein AXER-204 prior to this Phase 1 trial?

          I've looked everywhere I can't find it ..... doesn't mean it doesn't exist I just can't find anything.

          Comment


            Originally posted by spayne View Post
            Is anybody aware of animal studies of ReNetX Bio fusion protein AXER-204 prior to this Phase 1 trial?

            I've looked everywhere I can't find it ..... doesn't mean it doesn't exist I just can't find anything.
            https://www.carecure.net/forum/showt...=1#post1878432
            http://spinalcordresearchandadvocacy.wordpress.com/

            Comment


              Originally posted by manouli View Post
              mmm
              w mechanisms to enable regeneration of injured nerve fibers
              Download PDF Copy
              Reviewed by James Ives, M.Psych. (Editor)Aug 23 2019
              Injuries to nerve fibers in the brain, spinal cord, and optic nerves usually result in functional losses as the nerve fibers are unable to regenerate. A team from the Department of Cell Physiology at Ruhr-Universit?t Bochum (RUB) led by Professor Dietmar Fischer has deciphered new mechanisms that enable the regeneration of such fibers. This could open up new treatment approaches for the brain, optic nerve, and spinal cord injuries. The researchers report on these results in the journal Nature Communications Biology on 23 August 2019.
              read....


              https://www.news-medical.net/news/20...ve-fibers.aspx

              Comment


                Originally posted by manouli View Post
                w mechanisms to enable regeneration of injured nerve fibers
                Download PDF Copy
                Reviewed by James Ives, M.Psych. (Editor)Aug 23 2019
                Injuries to nerve fibers in the brain, spinal cord, and optic nerves usually result in functional losses as the nerve fibers are unable to regenerate. A team from the Department of Cell Physiology at Ruhr-Universit?t Bochum (RUB) led by Professor Dietmar Fischer has deciphered new mechanisms that enable the regeneration of such fibers. This could open up new treatment approaches for the brain, optic nerve, and spinal cord injuries. The researchers report on these results in the journal Nature Communications Biology on 23 August 2019.
                read....


                https://www.news-medical.net/news/20...ve-fibers.aspx
                Surgeon turned test subject: Paralyzed doctor gets second implant in Thailand
                Bill Graveland
                20 hrs ago


                A paralyzed Alberta man is back from Thailand after having a second experimental surgery that has given him some hope he'll be able to move more of his body.
                Dr. Richi Gill of Calgary worked as a surgeon before he had a freak accident on a boogie board during a family vacation in Hawaii that broke his neck. He doesn't have any movement or sensation below that point but does have some use of his arms.
                Gill travelled to Thailand last year to have an epidural stimulation implant placed in his lower back. The device, programmed to stimulate certain nerves mapped out by surgeons and therapists, has allowed him to take assisted steps with the help of physiotherapists and helped regulate his blood pressure.
                He recently had a second unit installed below his injury to help restore more movement to his arms and hands.
                "It's more unknown with this one for sure," Gill, 38, said following a physiotherapy session in Calgary.
                more...
                https://www.msn.com/en-ca/news/canad...and/ar-AAGjrcf

                Comment


                  ReNetx has supporting peer-reviewed in animal studies listed under technology on their site (https://www.renetx.com/publications.html)

                  This ref from their list might be what you are after most, JOURNAL OF NEUROTRAUMA 31:1955?1966 (December 15, 2014). If you cannot get to the .pdf, let me know

                  Comment


                    Originally posted by manouli View Post
                    w mechanisms to enable regeneration of injured nerve fibers
                    Download PDF Copy
                    Reviewed by James Ives, M.Psych. (Editor)Aug 23 2019
                    Injuries to nerve fibers in the brain, spinal cord, and optic nerves usually result in functional losses as the nerve fibers are unable to regenerate. A team from the Department of Cell Physiology at Ruhr-Universit?t Bochum (RUB) led by Professor Dietmar Fischer has deciphered new mechanisms that enable the regeneration of such fibers. This could open up new treatment approaches for the brain, optic nerve, and spinal cord injuries. The researchers report on these results in the journal Nature Communications Biology on 23 August 2019.
                    read....


                    https://www.news-medical.net/news/20...ve-fibers.aspx
                    The reference you are cited is talking about PTEN, not Strittmatter's Nogo trap (AXER-204). Can I steer you towards both the Technology section of ReNetX's cite?
                    https://www.renetx.com/publications.html

                    This paper along with 10+ others may interest you.

                    J Neurotrauma. 2014 Dec 15;31(24):1955-66. doi: 10.1089/neu.2014.3355. Epub 2014 Oct 16.

                    Comment


                      Originally posted by cadamson View Post
                      The reference you are cited is talking about PTEN, not Strittmatter's Nogo trap (AXER-204). Can I steer you towards both the Technology section of ReNetX's cite?
                      https://www.renetx.com/publications.html

                      This paper along with 10+ others may interest you.

                      J Neurotrauma. 2014 Dec 15;31(24):1955-66. doi: 10.1089/neu.2014.3355. Epub 2014 Oct 16.


                      First global Open Data Commons for preclinical Spinal Cord Injury research will be a ?game-changer?
                      University of Alberta research team receives $3.3 million to create open-source database for international spinal cord injury research
                      By Laurie Wang on August 15, 2019


                      The University of Alberta and the University of California, San Francisco are teaming up to launch the world?s first Open Data Commons for preclinical Spinal Cord Injury research (ODC-SCI). A consortium of international organizations will be providing $3.3 million CAD to help fund the initiative. The ODC-SCI will improve spinal cord injury research and treatment worldwide by reducing data bias and equipping scientists by making data more accessible, enhancing research and translational efforts.
                      more....
                      https://www.ualberta.ca/rehabilitati...a-game-changer



                      A New Japanese Stem Cell Treatment Raises Hopes ? And Ethical Questions
                      The country fast-tracked the controversial therapy, opening an international rift over who should make health care decisions.


                      In 2015, Shinji Kusachi, a 47-year-old teacher living in the Japanese prefecture of Okayama, was high-diving at a local pool ? a passion he had developed in his 30s ? when a tricky dive went awry. ?I hit my head on the bottom,? Kusachi recalled of the incident that damaged his spinal cord and left him mostly paralyzed. ?They said I couldn?t use my arms and legs. I was really in despair.?
                      But Kusachi soon joined a clinical trial for a new treatment for spinal cord injuries called Stemirac. Researchers at Sapporo Medical University drew fluid from his bone marrow, isolated a type of stem cell found there, multiplied the cells in the lab, and infused them back into his bloodstream intravenously. The day after the treatment, Kusachi dramatically improved. ?That was a real surprise to us,? said Toshihiko Yamashita, an orthopedic surgeon at the university. ?In the afternoon, he could rise up from his bed and sit. In the evening, he was getting around in a wheelchair.?
                      read....
                      https://www.sci-info-pages.com/news/...cal-questions/

                      Comment


                        Originally posted by manouli View Post
                        First global Open Data Commons for preclinical Spinal Cord Injury research will be a ?game-changer?
                        University of Alberta research team receives $3.3 million to create open-source database for international spinal cord injury research
                        By Laurie Wang on August 15, 2019


                        The University of Alberta and the University of California, San Francisco are teaming up to launch the world?s first Open Data Commons for preclinical Spinal Cord Injury research (ODC-SCI). A consortium of international organizations will be providing $3.3 million CAD to help fund the initiative. The ODC-SCI will improve spinal cord injury research and treatment worldwide by reducing data bias and equipping scientists by making data more accessible, enhancing research and translational efforts.
                        more....
                        https://www.ualberta.ca/rehabilitati...a-game-changer



                        A New Japanese Stem Cell Treatment Raises Hopes ? And Ethical Questions
                        The country fast-tracked the controversial therapy, opening an international rift over who should make health care decisions.


                        In 2015, Shinji Kusachi, a 47-year-old teacher living in the Japanese prefecture of Okayama, was high-diving at a local pool ? a passion he had developed in his 30s ? when a tricky dive went awry. ?I hit my head on the bottom,? Kusachi recalled of the incident that damaged his spinal cord and left him mostly paralyzed. ?They said I couldn?t use my arms and legs. I was really in despair.?
                        But Kusachi soon joined a clinical trial for a new treatment for spinal cord injuries called Stemirac. Researchers at Sapporo Medical University drew fluid from his bone marrow, isolated a type of stem cell found there, multiplied the cells in the lab, and infused them back into his bloodstream intravenously. The day after the treatment, Kusachi dramatically improved. ?That was a real surprise to us,? said Toshihiko Yamashita, an orthopedic surgeon at the university. ?In the afternoon, he could rise up from his bed and sit. In the evening, he was getting around in a wheelchair.?
                        read....
                        https://www.sci-info-pages.com/news/...cal-questions/


                        Scientists develop an 'EpiPen' for brain and spinal cord injuries
                        This new research could help individuals recover from one of the most dreaded types of injury.
                        https://bigthink.com/u/matthewdavisMatt Davis19 July, 2019

                        Brain and spinal cord injuries are notoriously difficult to treat, with many existing methods of treatment provoking undesirable side effects. Now, new research demonstrated a novel technique using nanoparticles to "program" the body's immune cells such that they don't cause any unintended damage and promote healing. Since they don't involve any pharmaceuticals, the use of nanoparticles circumvents the dangerous side effects of other treatments.
                        more...

                        https://bigthink.com/surprising-scie...1#rebelltitem1

                        Injectable Peptide Might Help Spinal Cord Injury Patients Walk Again
                        Published: May 27, 2019 By Gaius J. Augustus, PhD, Multimedia Science Communicator

                        A systemically injectable peptide, which may make it possible to restore lost functions in spinal cord injury patients, is moving toward clinical trials in early 2020.
                        The treatment, which was developed by Jerry Silver, a professor of neurosciences at Case Western Reserve University?s School of Medicine and advisor for NervGen Pharma, is the culmination of decades of work, and in pre-clinical studies, it has shown robust results in animal models.

                        more....
                        https://www.biospace.com/article/inj...ts-walk-again/

                        Comment


                          Originally posted by manouli View Post
                          Scientists develop an 'EpiPen' for brain and spinal cord injuries
                          This new research could help individuals recover from one of the most dreaded types of injury.
                          https://bigthink.com/u/matthewdavisMatt Davis19 July, 2019

                          Brain and spinal cord injuries are notoriously difficult to treat, with many existing methods of treatment provoking undesirable side effects. Now, new research demonstrated a novel technique using nanoparticles to "program" the body's immune cells such that they don't cause any unintended damage and promote healing. Since they don't involve any pharmaceuticals, the use of nanoparticles circumvents the dangerous side effects of other treatments.
                          more...

                          https://bigthink.com/surprising-scie...1#rebelltitem1

                          Injectable Peptide Might Help Spinal Cord Injury Patients Walk Again
                          Published: May 27, 2019 By Gaius J. Augustus, PhD, Multimedia Science Communicator

                          A systemically injectable peptide, which may make it possible to restore lost functions in spinal cord injury patients, is moving toward clinical trials in early 2020.
                          The treatment, which was developed by Jerry Silver, a professor of neurosciences at Case Western Reserve University?s School of Medicine and advisor for NervGen Pharma, is the culmination of decades of work, and in pre-clinical studies, it has shown robust results in animal models.

                          more....
                          https://www.biospace.com/article/inj...ts-walk-again/

                          Intel, Brown University AI project will work on spinal cord ailments treatment

                          Intel is working along with Brown University to develop artificial intelligence (AI) in medicine to help correct spinal cord defects. It will deal with the toughest spinal cord defects including paralysis.
                          read....

                          https://www.msn.com/en-gb/finance/te...ent/ar-AAIgC6x

                          Comment


                            Originally posted by manouli View Post
                            Intel, Brown University AI project will work on spinal cord ailments treatment

                            Intel is working along with Brown University to develop artificial intelligence (AI) in medicine to help correct spinal cord defects. It will deal with the toughest spinal cord defects including paralysis.
                            read....

                            https://www.msn.com/en-gb/finance/te...ent/ar-AAIgC6x

                            Technology
                            Intel, Brown University AI project will work on spinal cord ailments treatment
                            The work could help restore movement to paralysed people.
                            ⦁ By ⦁ Rishabh Jain October 4, 2019 11:26 BST
                            ntel is working along with Brown University to develop artificial intelligence (AI) in medicine to help correct spinal cord defects. It will deal with the toughest spinal cord defects including paralysis.
                            "A spinal cord injury is devastating, and little is known about how remaining circuits around the injury may be leveraged to support rehabilitation and restoration of lost function. Listening for the first time to the spinal circuits around the injury and then taking action in real time with Intel's combined AI hardware and software solutions will uncover new knowledge about the spinal cord and accelerate innovation toward new therapies," David Borton, Assistant Professor of engineering, Brown University, stated in the official press release posted on the Intel Website on Thursday.
                            more...
                            https://www.ibtimes.co.uk/intel-brow...atment-1669878

                            Comment


                              Originally posted by manouli View Post
                              Technology
                              Intel, Brown University AI project will work on spinal cord ailments treatment
                              The work could help restore movement to paralysed people.
                              ⦁ By ⦁ Rishabh Jain October 4, 2019 11:26 BST
                              ntel is working along with Brown University to develop artificial intelligence (AI) in medicine to help correct spinal cord defects. It will deal with the toughest spinal cord defects including paralysis.
                              "A spinal cord injury is devastating, and little is known about how remaining circuits around the injury may be leveraged to support rehabilitation and restoration of lost function. Listening for the first time to the spinal circuits around the injury and then taking action in real time with Intel's combined AI hardware and software solutions will uncover new knowledge about the spinal cord and accelerate innovation toward new therapies," David Borton, Assistant Professor of engineering, Brown University, stated in the official press release posted on the Intel Website on Thursday.
                              more...
                              https://www.ibtimes.co.uk/intel-brow...atment-1669878
                              New $6.3 million DARPA grant to help researchers develop "intelligent spinal interface"
                              Download PDF Copy
                              Reviewed by Kate Anderton, B.Sc. (Editor)Oct 3 2019
                              Supported with a new grant of $6.3 million from the U.S. Defense Advanced Research Projects Agency (DARPA), a team led by Brown University researchers will develop and test an "intelligent spinal interface" aimed at helping to restore limb movement and bladder control for people who have suffered spinal cord injuries.
                              Developed in collaboration with physicians at Rhode Island Hospital, a Lifespan partner, along with commercial partners at Intel and Micro-Leads Medical, the experimental spinal interface will be designed to bridge the gap in neural circuitry created by a spinal injury, the researchers say. The idea is to record signals traveling down the spinal cord above an injury site and use them to drive electrical spinal stimulation below the lesion. At the same time, information coming up the cord from below will be used to drive stimulation above the injury. The device could potentially help to restore both volitional control of limbs muscles as well as feeling and sensation lost due to injury.

                              more
                              https://www.news-medical.net/news/20...interface.aspx

                              Comment


                                VirTrial Awarded FDA-Approved Decentralized Clinical Trial with Hope Biosciences

                                Originally posted by manouli View Post
                                New $6.3 million DARPA grant to help researchers develop "intelligent spinal interface"
                                Download PDF Copy
                                Reviewed by Kate Anderton, B.Sc. (Editor)Oct 3 2019
                                Supported with a new grant of $6.3 million from the U.S. Defense Advanced Research Projects Agency (DARPA), a team led by Brown University researchers will develop and test an "intelligent spinal interface" aimed at helping to restore limb movement and bladder control for people who have suffered spinal cord injuries.
                                Developed in collaboration with physicians at Rhode Island Hospital, a Lifespan partner, along with commercial partners at Intel and Micro-Leads Medical, the experimental spinal interface will be designed to bridge the gap in neural circuitry created by a spinal injury, the researchers say. The idea is to record signals traveling down the spinal cord above an injury site and use them to drive electrical spinal stimulation below the lesion. At the same time, information coming up the cord from below will be used to drive stimulation above the injury. The device could potentially help to restore both volitional control of limbs muscles as well as feeling and sensation lost due to injury.

                                more
                                https://www.news-medical.net/news/20...interface.aspx
                                VirTrial Awarded FDA-Approved Decentralized Clinical Trial with Hope Biosciences
                                by VirTrial | Oct 9, 2019 | Press and News | 0 comments
                                Scottsdale, AZ (October 9, 2019) ? VirTrial has been awarded an FDA-approved hybrid decentralized clinical trial (DCT) with Hope Biosciences. The study provides Hope Biosciences? autologous, adipose-derived culture-expanded mesenchymal stem cells (HB-adMSC?s) for the treatment of spinal cord injury/disorder (SCI/D). Study protocol incorporates remote visits via VirTrial?s telehealth platform.
                                read....
                                https://virtrial.com/virtrial-awarde...e-biosciences/

                                Comment

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