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  • Science
    JNCASR’s molecule improves recovery after spinal cord injury

    Spinal cord injury can now be repaired using a small molecule (TTK21) synthesised by a team led by Tapas Kumar Kundu from the Molecular Biology and Genetics Unit at Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, a study has found. The small molecule tested both on mice and rat models promoted regeneration and growth of new sensory and motor axons leading to recovery of sensory and motor functions in the animals with spinal cord injury.
    more...
    https://www.thehindu.com/sci-tech/sc...le26830296.ece

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    • Originally posted by manouli View Post
      Science
      JNCASR’s molecule improves recovery after spinal cord injury

      Spinal cord injury can now be repaired using a small molecule (TTK21) synthesised by a team led by Tapas Kumar Kundu from the Molecular Biology and Genetics Unit at Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, a study has found. The small molecule tested both on mice and rat models promoted regeneration and growth of new sensory and motor axons leading to recovery of sensory and motor functions in the animals with spinal cord injury.
      more...
      https://www.thehindu.com/sci-tech/sc...le26830296.ece

      This study is on acute injury rats
      "That's not smog! It's SMUG!! " - randy marsh, southpark

      "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


      2010 SCINet Clinical Trial Support Squad Member
      Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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      • REPROCELL and Q Therapeutics to co-develop clinical grade iGRP for treatment of various CNS disorders. REPROCELL will manufacture clinical grade iGRP at the cGMP suite to conduct preclinical safety/efficacy studies and clinical trials.

        REPROCELL Inc. today announced that it has established the current good manufacturing practice (cGMP) cell processing suite at Life Innovation Center (LIC) in Tonomachi area in Kawasaki city for production of iPS Cell-derived Glial Progenitors (iGRP) for treatment of CNS disorders. The suite has been designed to support Clinical Trials of cell therapy products.
        REPROCELL has been jointly developing iGRP with Q Therapeutics Inc. (Utah, USA) for treatment of various intractable CNS diseases and injuries. The target indications of iGRP include Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS) Transverse Myelitis (TM), Spinal Cord Injuries (SCI) and Stroke. REPROCELL will manufacture clinical grade iGRP at the suite to conduct preclinical safety/efficacy studies and clinical trials.
        In addition, REPROCELL plans to manufacture and store clinical grade iPS Cell Bank as raw material for iPS Cell-derived cellular products at the suite according to US/EU/Japan regulations and guidelines and plans to support academia and industry for manufacturing materials for animal studies and clinical trials.
        read....
        https://www.prweb.com/releases/repro...eb16308451.htm

        Comment


        • Kessler Foundation receives $1 million gift to study groundbreaking treatments for spinal cord injury
          Download PDF Copy
          Reviewed by James Ives, M.Psych. (Editor)Jun 7 2019
          Tim Reynolds, co-founder of the Wall Street firm Jane Street Capital, and his wife, Caroline, made a $1 million gift to Kessler Foundation to launch groundbreaking research at the Foundation's new Center for Spinal Stimulation. The Reynolds gave this gift in recognition of the compassionate care delivered by Barbara Benevento, MD, of Kessler Institute for Rehabilitation and to the work of the spinal cord research team. Mr. Reynolds sustained a spinal cord injury in 2000 as a passenger in a motor vehicle accident, and underwent rehabilitation at Kessler Institute.
          more....
          https://www.news-medical.net/news/20...rd-injury.aspx

          Comment


          • ReNetX Bio, Inc. Announces U.S. FDA Authorization to Proceed for IND Application to Treat Patients with Chronic Spinal Cord Injury
            Published: Jun 19, 2019
            NEW HAVEN, Conn., June 19, 2019 /PRNewswire/ -- ReNetX Bio, Inc., a leading biotechnology company committed to reversing disease and damage for patients suffering from central nervous system disorders, has announced that the U.S. Food and Drug Administration (FDA) has allowed the Company's Investigational New Drug (IND) application for its lead drug candidate, fusion protein AXER-204.

            read...
            https://www.biospace.com/article/rel...l-cord-injury/

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            • https://medicalxpress.com/archive/09-07-2019/
              July 9, 2019
              Bias erodes translational value in animal spinal cord injury studies
              by Eileen Scahill, The Ohio State University
              An analysis led by researchers from The Ohio State University College of Medicine at The Ohio State University Wexner Medical Center found that bias in the design and reporting of spinal cord injury (SCI) studies in animals results in overestimation of the effectiveness of a potential treatment to prevent infections in human patients with SCI.
              read...
              https://medicalxpress.com/news/2019-...inal-cord.html

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              • injection of nanoparticles for spinal cord injuries
                Download PDF Copy
                By Dr. Ananya Mandal, MDJul 11 2019
                Researchers from the University of Michigan used nanopaticles injection to prevent the immune cells of the body from impairing the healing of injured brain and spinal cord. They call this an “EpiPen” or emergency rescue drug for the brain and spinal cord when they suffer trauma.


                https://www.news-medical.net/news/20...-injuries.aspx

                Comment


                • Originally posted by manouli View Post
                  https://medicalxpress.com/archive/09-07-2019/
                  July 9, 2019
                  Bias erodes translational value in animal spinal cord injury studies
                  by Eileen Scahill, The Ohio State University
                  An analysis led by researchers from The Ohio State University College of Medicine at The Ohio State University Wexner Medical Center found that bias in the design and reporting of spinal cord injury (SCI) studies in animals results in overestimation of the effectiveness of a potential treatment to prevent infections in human patients with SCI.
                  read...
                  https://medicalxpress.com/news/2019-...inal-cord.html

                  This is so f'ing true!
                  T3 complete since Sept 2015.

                  Comment


                  • Science News
                    from research organizations

                    Boosting the discovery of new drugs to treat spinal cord injuries using zebrafish
                    New platform allows effective drug screening
                    Date:
                    July 19, 2019
                    Source:
                    Instituto de Medicina Molecular
                    Summary:
                    A research team led by Leonor Sa?de, Principal Investigator at Instituto de Medicina Molecular, in partnership with the company Technophage, SA, has designed a simple and efficient platform that uses zebrafish to discover and identify new drugs to treat spinal cord lesions. This study is the proof-of-concept for the use of this zebrafish platform that, combined with drug repurposing, has the potential to accelerate the translation period from the discovery to the clinics.
                    more.....
                    https://www.sciencedaily.com/release...0719102103.htm

                    Comment


                    • Originally posted by manouli View Post
                      Science News
                      from research organizations

                      Boosting the discovery of new drugs to treat spinal cord injuries using zebrafish
                      New platform allows effective drug screening
                      Date:
                      July 19, 2019
                      Source:
                      Instituto de Medicina Molecular
                      Summary:
                      A research team led by Leonor Sa?de, Principal Investigator at Instituto de Medicina Molecular, in partnership with the company Technophage, SA, has designed a simple and efficient platform that uses zebrafish to discover and identify new drugs to treat spinal cord lesions. This study is the proof-of-concept for the use of this zebrafish platform that, combined with drug repurposing, has the potential to accelerate the translation period from the discovery to the clinics.
                      more.....
                      https://www.sciencedaily.com/release...0719102103.htm








                      Nanoparticles promote functional healing following spinal cord injury
                      Share:
                      Science Highlights
                      July 24, 2019
                      Novel approach also shows promise for autoimmune diseases
                      Paralyzing damage in spinal cord injury (SCI) is often caused by the zealous immune response to the injury. NIBIB-funded engineers have developed nanoparticles that lure immune cells away from the spinal cord, allowing regeneration that restored spinal cord function in mice.
                      Just as in the brain, the spinal cord has a blood brain barrier that protects the delicate nerves from potential damage from various insults, including blocking immune cells from moving in to clean up debris from the injury.

                      more....


                      https://www.nibib.nih.gov/news-event...al-cord-injury

                      Comment


                      • Nanoparticles promote functional healing following spinal cord injury
                        Share:
                        Science Highlights
                        July 24, 2019
                        Novel approach also shows promise for autoimmune diseases
                        Paralyzing damage in spinal cord injury (SCI) is often caused by the zealous immune response to the injury. NIBIB-funded engineers have developed nanoparticles that lure immune cells away from the spinal cord, allowing regeneration that restored spinal cord function in mice.
                        Just as in the brain, the spinal cord has a blood brain barrier that protects the delicate nerves from potential damage from various insults, including blocking immune cells from moving in to clean up debris from the injury.

                        more....


                        https://www.nibib.nih.gov/news-event...al-cord-injury

                        Comment


                        • Thank you.

                          For some reason the hyperlink isn't working on your post .. https://www.nibib.nih.gov/news-event...al-cord-injury
                          Originally posted by manouli View Post
                          Nanoparticles promote functional healing following spinal cord injury
                          Share:
                          Science Highlights
                          July 24, 2019
                          Novel approach also shows promise for autoimmune diseases
                          Paralyzing damage in spinal cord injury (SCI) is often caused by the zealous immune response to the injury. NIBIB-funded engineers have developed nanoparticles that lure immune cells away from the spinal cord, allowing regeneration that restored spinal cord function in mice.
                          Just as in the brain, the spinal cord has a blood brain barrier that protects the delicate nerves from potential damage from various insults, including blocking immune cells from moving in to clean up debris from the injury.

                          more....


                          https://www.nibib.nih.gov/news-event...al-cord-injury

                          Comment


                          • Originally posted by NW-Will View Post
                            Thank you.

                            For some reason the hyperlink isn't working on your post .. https://www.nibib.nih.gov/news-event...al-cord-injury
                            Thank you! I don't know what did happen.

                            Comment


                            • NEWS FEATURE
                              31 July 2019
                              How a revolutionary technique got people with spinal-cord injuries back on their feet
                              Electrical stimulation has promised huge gains for people with paralysis. Now comes the hard part ? getting beyond those first steps.

                              Rob Summers was flat on his back at a rehabilitation institute in Kentucky when he realized he could wiggle his big toe. Up, down, up, down. This was new ? something he hadn?t been able to do since a hit-and-run driver left him paralysed from the chest down. When that happened four years earlier, doctors had told him that he would never move his lower body again. Now he was part of a pioneering experiment to test the power of electrical stimulation in people with spinal-cord injuries.
                              ?Susie, look, I can wiggle my toe,? Summers said.
                              Susan Harkema, a neurophysiologist at the University of Louisville in Kentucky, sat nearby, absorbed in the data on her computer. She was incredulous. Summers?s toe might be moving, but he was not in control. Of that she was sure. Still, she decided to humour him. She asked him to close his eyes and move his right toe up, then down, and then up. She moved on to the left toe. He performed perfectly.
                              more...
                              https://www.nature.com/articles/d41586-019-02306-z

                              Comment


                              • I can wiggle my toes on left anytime I want to right I really really have to concentrate but that's it nothing for 17 years

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