Announcement

Collapse
No announcement yet.

Spinal Cord Injury Articles Posted by Manouli

Collapse
This is a sticky topic.
X
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

    I live 50 minutes from there, maybe I give them a call and see what's going on.


    Partially paralyzed Sherwood Park man prepares for life-changing clinical trial
    Edmonton Journal
    Updated: September 11, 2018
    Okay, I did call them and they say that he is the last person of the other four that already done this and is face 1 trial, and then they would start face 2. I asked them if I can participate too and they say for me to register so I can go there to try other things and see if they can help me with my level of paralysis. Maybe they can learn more from anyone from us. Gee, my butt is tired of sitting for 36 years now.

    After suffering a spinal cord injury at a local trampoline park early last year, a young Sherwood Park man is preparing to take the next step in his recovery.
    Landon Smith, 20, has been accepted to participate in a clinical trial at the University of Miami Miller School of Medicine, which may ultimately help him to walk again.
    He will be the first Canadian — and youngest candidate — to take part in the U.S. Food and Drug Administration-approved trial, which is set to begin in early October.
    “I’m very excited to be a part of this research,” Smith said Monday at the ReYu Paralysis Recovery Centre, where he has trained for more than one year to try to regain functionality.
    “I really want to be that person to show people that no matter what you face in life, there’s always something you can do to change it and change that trajectory.”
    Smith was at a birthday party when he did a front-flip into a foam pit and broke his neck at Jump Park Trampoline in Sherwood Park in January 2017.
    The incident left him paralyzed from the chest down and he spent more than seven months at the University of Alberta Hospital and the Glenrose Rehabilitation Centre.
    read more...
    https://edmontonjournal.com/news/loc...clinical-trial
    Last edited by manouli; 11 Sep 2018, 12:57 PM.

    Comment


      Asterias Provides 24 Month Cohort 2 Update for its OPC1 Phase 1/2a Clinical Trial in Severe Spinal Cord Injury
      \l "\l "\l "https://plus.google.com/share?url=http://globenewswire.com/news-release/2018/09/12/1569609/0/en/Asterias-Provides-24-Month-Cohort-2-Update-for-its-OPC1-Phase-1-2a-Clinical-Trial-in-Severe-Spinal-Cord-Injury.htmlEmail Print Friendly Share
      September 12, 2018 07:00 ET | Source: Asterias Biotherapeutics
      FREMONT, Calif., Sept. 12, 2018 (GLOBE NEWSWIRE) -- Asterias Biotherapeutics, Inc. (NYSE American: AST), a biotechnology company dedicated to developing cell-based therapeutics to treat neurological conditions associated with demyelination and cellular immunotherapies to treat cancer, today provided additional data from the Company’s ongoing Phase 1/2a SCiStar study designed to evaluate the safety and potential efficacy of OPC1 in the treatment of severe cervical spinal cord injury. All 6 subjects from Cohort 2 in the SCiStar study have now completed a 24-month follow-up as part of the study’s long-term follow-up protocol and each subject either retained the motor function recovery seen through 12 months or saw further motor function recovery from 12 to 24 months.
      “While the primary endpoint for the SCiStar trial was 12 months, we are further encouraged by this additional follow-up data that shows both durable engraftment and motor function recovery being maintained or improved upon at 24 months,” commented Ed Wirth, Chief Medical Officer. “We believe the primary goal of SCiStar, which was to observe the safety of OPC1 in cervical spinal cord injury patients and to accumulate data related to important factors such as optimal dosing levels, the immunosuppression regimen, engraftment of the cells, and rates of motor recovery observed among different study subpopulations, have been successfully achieved and increases our confidence as we prepare to meet the FDA later this year to discuss the next trial design.”
      Below are a summary of key findings at 24 months for the Cohort 2 subjects:
      https://globenewswire.com/news-relea...rd-Injury.html

      Comment


        Study reveals way to regrow lost spinal cord connections
        Download PDF Copy
        Reviewed by Alina Shrourou, BScAug 30 2018
        For many years, researchers have thought that the scar that forms after a spinal cord injury actively prevents damaged neurons from regrowing. In a study of rodents, scientists supported by the National Institutes of Health showed they could overcome this barrier and reconnect severed spinal cord nerves by turning back the neurons' clocks to put them into an early growth state. Once this occurs, neurons could be induced to regrow across the scarred tissue. The research was supported by the National Institute of Neurological Disorders and Stroke (NINDS), part of NIH.
        "For decades researchers have been trying to make severed neurons regrow across a spinal cord injury and reconnect with neurons on the other side. This study suggests that may require manipulating three key growth processes," said Lyn Jakeman, Ph.D., program director, NINDS. "These insights are important for understanding the mechanisms of injury and regeneration that may one day be applied to develop potential treatments for spinal cord injury."

        more...
        https://www.news-medical.net/news/20...nnections.aspx

        Comment


          Epidural stimulation aids in recovery of individuals with spinal cord injury
          Download PDF Copy
          Reviewed by Alina Shrourou, BScSep 17 2018
          For the first time since 2009, Stefanie Putnam is able to prepare - and eat - meals for herself, put the vest on her service dog, Kaz, and drive herself to activities with her horse without losing consciousness or gasping for breath.
          "My whole life has opened up for me again!" Putnam said.
          A C4 spinal cord injury in 2009 left Putnam paralyzed from the neck down and suffering from chronic low blood pressure. She relied on medication and tight corsets to maintain her blood pressure, but she still passed out five or six times a day.
          read....
          https://www.news-medical.net/news/20...rd-injury.aspx

          Comment


            FDA Accepts Asterias Biotherapeutics’ Request to Meet and Discuss Next Phase of Development for OPC1 Spinal Cord Injury Clinical Program

            Quote:
            The Company is currently completing the ongoing SCiStar trial, an open-label, single-arm trial testing three sequential escalating doses of OPC1 administered at up to 20 million OPC1 cells in 25 subjects with subacute motor complete (AIS-A or AIS-B) cervical (C-4 to C-7) spinal cord injuries (SCI). All of the patients have been enrolled and dosed and the Company believes the data presented to date have been consistently positive and reaffirm the Company’s view that OPC1 is safe and durably engrafts and has the potential to improve motor function.
            read...

            https://globenewswire.com/news-relea...l-Program.html

            Comment


              I don't remember if we have seen this one: watch video

              Yale Scientist Aiming To Reverse Spinal Cord Injuries
              http://www.courant.com/business/hc-b...718-story.html

              Comment


                Public Release: 24-Sep-2018
                Technology and therapy help individuals with chronic spinal cord injuries take steps
                New research documents the effectiveness of epidural stimulation with locomotor training following chronic, complete spinal cord injury
                University of Louisville
                LOUISVILLE, Ky. - Of four research participants living with traumatic, motor complete spinal cord injury, two are able to walk over ground with epidural stimulation following epidural stimulation paired with daily locomotor training. In addition, all four participants achieved independent standing and trunk stability when using the stimulation and maintaining their mental focus. The study was conducted at the Kentucky Spinal Cord Injury Research Center at the University of Louisville (UofL) and is published in this week's New England Journal of Medicine. The study was funded by the Leona M. and Harry B. Helmsley Charitable Trust, University of Louisville Hospital and Medtronic plc.
                more...
                https://eurekalert.org/pub_releases/...-tat092418.php

                Comment


                  Sep 24, 2018, 11:02am Paralyzed Patients Go From Wheelchairs To Walkers With Experimental Treatment /sites/matthewherper/ /sites/matthewherper/Matthew Herper Forbes Staff Healthcare I cover science and medicine, and believe this is biology's century.
                  Two different groups of researchers have shown that electrical stimulation of the spinal cord, combined with months of intense training, can allow some people who have been paralyzed to regain some walking ability.
                  So far, only three patients in total have regained the ability to walk based on this approach. Two more underwent similar treatment without being able to reclaim the ability to take steps, and one suffered a hip fracture during the arduous physical therapy sessions. All the patients who can walk need walkers, and all but one are walking only within the confines of the laboratory.
                  Still, spine researchers not associated with the work expressed optimism that the dramatic case studies mean that technologies that can stimulate the spinal cord will eventually allow some people who are paralyzed from spinal cord injuries to walk again.
                  more...
                  https://www.forbes.com/sites/matthew.../#6848866e3e2e

                  Comment


                    'Amazing' treatment helps paralyzed people walk again
                    /profiles/wayne-drash /profiles/wayne-drash
                    By Wayne Drash, CNN
                    Updated 1:07 PM ET, Mon September 24, 2018
                    Homosassa, Florida (CNN)Kelly Thomas inches across the soft grass, using a walker to navigate her way. Each step is exhilarating and exhausting. She pauses amid the 90-degree Florida heat and smiles.
                    "It only takes a little bit of try -- and by a little, I mean a lot," she says.
                    Thomas, 24, is one of three paralyzed patients who can now walk again, thanks to a stimulation device implanted in her lower back coupled with intense physical therapy. News of the patients' progress -- considered an important medical advancement -- was published in separate studies in two scientific journals on Monday.
                    On a recent sunny day, Thomas returned to the spot that took so much from her on July 19, 2014. It's where the truck she was driving came to a halt after flipping four times around a bend on Halls River Road and smashing into a tree. Her body was motionless, hanging halfway out of the mangled wreckage. She was blue and getting cold.
                    more...
                    https://www.cnn.com/2018/09/24/healt...ain/index.html

                    Comment


                      Health + Behavior
                      UCLA scientist gives couple hope while searching for a cure for paralysis
                      Mark Pollock, Simone George tell their remarkable life story in new TED talk
                      If you think listening to a paralyzed, blind man discuss his life does not sound uplifting, meet Mark Pollock. Social psychologist Amy Cuddy, whose TED talk about body language has nearly 15 million views, describes the new talk by Pollock and his partner, human rights lawyer, Simone George, as “the most powerful, moving talk I have ever seen at TED.”
                      Pollock lost his vision at 22 and became paralyzed after an accident at 39 that left him, in his words, “on the very edge of survival.” You certainly wouldn’t know that seeing him now in this talk, titled “A love letter to realism in a time of grief,” and the fulfilling life he is living.
                      In the talk, he and George discuss how during the 16 months spent in hospitals, doctors discouraged them from hoping for a cure for paralysis.
                      read...
                      http://newsroom.ucla.edu/stories/ucl...-for-paralysis

                      Comment


                        Hope for paraplegics in the horizon
                        Download PDF Copy
                        By Ananya Mandal, MDSep 26 2018
                        According to a new study from the University of Louisville, four paraplegics have found hope. Paraplegia is complete paralysis of the lower limbs due to damage or injury to the spinal cord. The team of researchers have published their success story in a study in the latest issue of the New England Journal of Medicine.
                        The four patients had a surgical implant on their spinal cords. This implant stimulates electrical activity. These patients also underwent months of regular physiotherapy. At the end of the study the researchers noted that two of the four patients could take a few limited steps after the therapy and the other two could walk independently. This novel device is manufactured by Medtronic. The study was supported by the University of Louisville Hospital.
                        more....
                        https://www.news-medical.net/news/20...e-horizon.aspx

                        Comment


                          Researchers discover how nerve cells control movement
                          Download PDF Copy
                          Reviewed by James Ives, MPsychOct 3 2018
                          Researchers at Karolinska Institutet in Sweden have discovered a new way in which nerve cells can control movement. In a study on zebrafish published in the journal PNAS they show that the contact between neurons and muscles is more dynamic than previously thought. The results can open up new avenues to treating spinal cord injury and certain neurological diseases.
                          The ability to move deliberately is essential to the survival of all animal life, and is based on an interaction between the muscles and the brain. The site where motor neurons and muscle cells communicate with each other is called the neuromuscular junction. This is where the neurons transfer signal substances that can be taken up by the muscle cells to make them contract.
                          read...
                          https://www.news-medical.net/news/20...-movement.aspx

                          Comment


                            New knowledge on how neurons talk to muscles
                            Date:
                            October 2, 2018
                            Source:
                            Karolinska Institutet
                            Summary:
                            Researchers have discovered a new way in which nerve cells can control movement. In a study on zebrafish they show that the contact between neurons and muscles is more dynamic than previously thought. The results can open up new avenues to treating spinal cord injury and certain neurological diseases.
                            read..
                            https://www.sciencedaily.com/release...1002102942.htm

                            Comment


                              from research organizations

                              Gene signature predicts outcome after spinal cord injury
                              Date:
                              October 5, 2018
                              Source:
                              eLife
                              Summary:
                              Scientists have determined a gene signature that is linked to the severity of spinal cord injury in animals and humans.
                              Scientists have determined a gene signature that is linked to the severity of spinal cord injury in animals and humans, according to a study in the open-access journal eLife.

                              The discovery of key genes that are switched on or off in response to spinal cord injury could inform the development of biomarkers that predict recovery and possibly pinpoint new targets for treatment.
                              read...

                              https://www.sciencedaily.com/release...1005111442.htm


                              Scientists discover gene signature linked to spinal cord injury
                              Health
                              Updated Oct 06, 2018 | 15:42 IST | ANI
                              Scientists have determined a gene signature that is linked to the severity of spinal cord injury in animals and humans.

                              Washington D.C: Scientists have determined a gene signature that is linked to the severity of spinal cord injury in animals and humans. The discovery of key genes that are switched on or off in response to spinal cord injury could inform the development of biomarkers that predict recovery and possibly pinpoint new targets for treatment. At the moment, there are no widely available treatments capable of immediately restoring motor and sensory function after injury. A major barrier is the lack of understanding of the complex cascade of biological processes that occur when a spinal cord injury happens.
                              Senior author Michael Skinnider said, "Our understanding of the pathophysiological processes triggered by spinal cord injury is fragmentary. We set out to integrate the data from decades of small-scale studies using a systems biology approach."
                              https://www.timesnownews.com/health/...-injury/295233

                              Comment


                                BioArctic Receives European Patent Protection for a Medical Device for Treatment of Patients with Complete Spinal Cord Injury
                                PRESS RELEASE PR Newswire Oct. 3, 2018, 08:45 AM
                                STOCKHOLM, Oct. 3, 2018 /PRNewswire/ --
                                BioArctic AB (publ) (Nasdaq Stockholm: BIOA B) announced today that the European Patent Office (EPO) has issued a decision to grant the company's patent application in Europe, EP12815796.3, for a medical device, which is one of the main components in the product candidate SC0806. The product candidate is a combination of a medical device (implant) and a medicinal product (FGF1) for patients with complete spinal cord injury. The decision states that the European patent, EP 2 787 900 B1, will enter into force on October 24, 2018.
                                read....

                                https://markets.businessinsider.com/...ury-1027586923

                                Comment

                                Working...
                                X