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Spinal Cord Injury Articles Posted by Manouli

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  • People With Spinal Injuries Are Regaining Use of Their Limbs in an Amazing Way
    Inside UCLA’s Neuroplasticity and Repair Laboratory
    March 30, 2018 Nate Berg Top Doctors 1 Comment
    Brian Gomez has his fingers wrapped around a small bar attached to three short springs in a rectangular metal frame. It’s similar to the handlebar brake lever of a dirt bike, like the one Gomez was riding in 2011 that malfunctioned, causing a crash that left him paralyzed below the neck. He’s trying to close his hand, but the bar doesn’t budge. Then a switch is flipped, and tiny electrodes implanted on his spinal cord begin firing. “It’s like a fluid shock going through” his body, he says. Gomez straightens in his wheelchair. His forearm twitches, and his grip tightens. The metal bar moves.
    more...

    http://www.lamag.com/mag-features/spinal-injuries-ucla/

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    • 'Doctors said we'd never walk again, but we will prove them wrong': Paralysed pair vow to defy odds with pioneering treatment
      Martin Hibbert, who lost the use of his legs in the Manchester Arena attack, and pal Steve Cook, who lost his through a bike accident, have declared war on their spinal injuries through a ground-breaking treatment in Queensland
      https://www.mirror.co.uk/news/uk-new...-walk-12326677

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      • Pitt engineer uses ultrasound technology to help people walk again
        Download PDF Copy
        April 3, 2018
        Spinal cord injuries impact more than 17,000 Americans each year, and although those with incomplete injuries may regain control of their limbs, overall muscle strength and mobility is weakened. Neurorehabilitation using robotic exoskeletons or electrical stimulation devices can help a person regain movement through repeated exercise. The amount of assistance through these devices during neurorehabilitation is based on the measurement of the user's remaining muscle function.
        https://www.news-medical.net/news/20...alk-again.aspx

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        • Stem cell therapy trial helps those with restrictive injuries

          By OMAR YOUSIF
          April 16, 2018 https://dailytrojan.com/2018/04/16/s...ve-injuries/in News
          In March, 21-year-old Kris Boesen was driving on a wet road in Maricopa, Calif., when his car suddenly fishtailed out of control into a tree and a telephone pole. As a result of the accident, Boesen broke his neck, was no longer able to walk and could only move his left arm up and down. Both of his hands were stuck in a clenched position.
          read...
          https://dailytrojan.com/2018/04/16/s...tive-injuries/

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          • Government of India seeks to define stem cells as drug, regulate use in therapy; scientists term move 'long overdue'
            India Rishiraj Bhagawati Apr 18, 2018 06:53:07 IST
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            Tweet https://web.whatsapp.com/send?text=Government of India seeks to define stem cells as drug, regulate use in therapy; scientists term move 'long overdue' - https://www.firstpost.com/india/gove...ext=Government of India seeks to define stem cells as drug, regulate use in therapy; scientists term move 'long overdue' - https://www.firstpost.com/india/gove...e-4435689.html
            The Ministry of Health and Family Welfare, in a proposal to amend the Drugs and Cosmetics Act 1940, is pushing to bring stem cells and cell-based products under legal regulations: A move scientists have termed as long overdue.
            The ministry defined the category of stem cells and their derivatives that would be termed a drug, and would thereby have to follow the protocols mandated for any drug development, The Times of India reported. The notification, dated 4 April, said stem cells and products which are substantially altered, amounting to a change in biological characteristics, will be treated as a drug and will hence have to seek the regulator’s approval before coming to the market.
            more...
            https://www.firstpost.com/india/gove...e-4435689.html

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            • Inclusion Completed of Patients With Complete Spinal Cord Injury in the First Panel of BioArctic's Ongoing Study

              News provided by
              BioArctic
              Apr 25, 2018, 05:26 ET
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              STOCKHOLM, April 25, 2018 /PRNewswire/ -- BioArctic AB (publ) (Nasdaq Stockholm: BIOA B) announced today that the inclusion of patients with complete spinal cord injury in the first panel has been completed in the company's ongoing clinical Phase 1/2 study.
              BioArctic develops a new innovative treatment for patients with complete spinal cord injury. The product candidate, SC0806, is a combination of a medical device and a drug.
              read..
              https://www.prnewswire.com/news-rele...300636201.html

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              • Paralysis Victims Regain Use Of Their Hands After A Nonsurgical Treatment Procedure
                ⦁ /sites/kevinmurnane/⦁ Kevin Murnane , Contributor

                An exploratory study published in the Journal of Neurotrauma reports a nonsurgical treatment procedure that restored at least partial function to people whose hands were paralyzed as a result of a spinal cord injury. Six people participated in the study, all had been paralyzed for at least one year, and all regained partial use of their hands.
                The treatment procedure
                The research team from UCLA based their procedure on the idea that a voluntary nerve signal generated when a person tries to use their hands can be combined with external stimulation of the nerves in the spinal cord that play a role in hand movement to partially overcome paralysis caused by a spinal cord injury. The external stimulation was provided by electrodes placed on the skin. The voluntary nerve signal was generated when the participants attempted to grasp a device that measures grip strength.
                read...
                https://www.forbes.com/sites/kevinmu.../#2212efdd59dd

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                • Are Neuro-Spinal Scaffolds the Answer to a SCI Cure?
                  Tiffiny Carlson | April 02, 2018
                  Bridges are full of symbolism. They have the capability of bringing two things together that would be impossible otherwise. Because of this, it should come as no surprise that bridges may hold the key to finding a cure for spinal cord injuries.
                  The bridge we speak of is called a neuro-spinal scaffold, or in other research labs across the world, it’s called a nerve graft. Whatever you call it, researchers have put extensive time and money into this new area of research. When you combine a nerve regenerating serum with a neuro-scaffold/graft (or even a bridge), miracles could occur. In studies done in rats, many began walking because of this combo.
                  Currently, there are two ongoing trials that are hoping for this very thing. One is located in Estonia and is funded by BioArctic. The other trial is located right here in the United States and is funded by Invivo Therapeutics.
                  Read on for an overview of each of these exciting trials.
                  https://www.spinalcord.com/blog/are-...-to-a-sci-cure

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                  • WATCH THIS VIDEO ON CBS
                    special stem cell treatment for spinal cord injury

                    https://www.cbsnews.com/video/specia...shows-promise/

                    Comment


                    • Spinal cord injury research overview
                      Update: March 2018


                      This overview was set up by Corinne Jeanmaire, for the endParalysis foundation and for the ESCIF (European Spinal Cord Injury Federation) Research Group. With thanks to Sam Maddox, Chris Powell (blog) and Harvey Sihota (Neurokinex) their input and to Beverley Saunders and Barbara Carlile for their editing support.
                      We have to be clear: there is still no cure, therapy or treatment for (chronic) spinal cord injury. Judging by the increasing number of ongoing and planned clinical trials though, it seems that we might have come a bit closer to achieving a certain level of recovery.
                      The data displayed in the tabs in this page is far from exhaustive but is simply meant to give an idea of the momentum currently at play. We have divided up the data into four blocks, being:
                      (Stem) cells & combination regeneration/repair strategies.
                      Scar and growth inhibitors reduction & regeneration/repair combination strategies.
                      Electrical stimulation of the spinal cord (e-stim), Transcranial Stimulation (TMS), Brain-Machine-Interface (BMI), etc
                      Unproven/ commercial therapies.

                      continue...
                      https://endparalysis.org/cure-spinal...research-2018/

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                      • Adipose-derived mesenchymal stem cells combined with fibrin matrix influences restoration of motor functions
                        Download PDF Copy
                        April 24, 2018
                        The research team used model spinal cord injuries in rats for their purposes. As a result, it was found out that therapy by adipose-derived mesenchymal stem cells combined with fibrin matrix influences the restoration of motor functions. It also decreases the area of pathological cavities and reduces astroglial activation.
                        read..
                        https://www.news-medical.net/news/20...functions.aspx

                        Comment


                        • Spinal cord injury research: Bonus benefit to activity-based training
                          January 31, 2018 by Betty Coffman, University of Louisville
                          Credit: CC0 Public Domain
                          Activity-based training has resulted in unexpected benefits for individuals with severe spinal cord injury (SCI). Researchers in the Kentucky Spinal Cord Injury Research Center (KSCIRC) at the University of Louisville have discovered that the training, designed to help individuals with SCI improve motor function, also leads to improved bladder and bowel function and increased sexual desire.

                          read....
                          https://medicalxpress.com/news/2018-...s-benefit.html

                          Comment


                          • Experimental drug restores some bladder function after spinal cord injury, study finds
                            Mice given test compound show marked improvements
                            By: Misti Crane
                            Published on June 04, 2018
                            COLUMBUS, Ohio – An experimental drug that blocks abnormal neural communication after spinal cord injury could one day be the key to improving quality of life by improving bladder function, new research suggests.
                            Researchers at The Ohio State University tested the drug – which is currently available only for research – to gauge its potential to improve bladder function after spinal cord injury in mice and saw promising results.
                            The experimental drug (LM11A-31) appears to help by blocking the dual activity of pro-nerve growth factor (proNGF) and a receptor called p75. ProNGF is known to be secreted from the cell after nerve injury.
                            read...
                            https://news.osu.edu/news/2018/06/04...spinal-injury/

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                            • chronic spinal cord injuries! Yahoo!


                              Possible new treatment for spinal cord injuries identified in animal studies
                              June 11, 2018 by Steve Tally, Purdue University



                              An experimental drug has shown promise as a potential therapy for spinal cord injuries in animal studies.
                              The compound, 4-aminopyridine-3-methanol, works in a similar way as a drug previously developed at Purdue, 4-aminopyridine (4-AP), which has been approved by the U.S. Food and Drug Administration to treat multiple sclerosis.
                              Dr. Riyi Shi, professor in the Department of Basic Medical Sciences, College of Veterinary Medicine and Weldon School of Biomedical Engineering, who was involved in the development of both drugs, compared the two compounds in both cell cultures and animal models.
                              "For the first time, 4-aminopyridine-3-methanol is shown to restore function in chronic spinal cord injuries," he says. "It also reduces neuropathic pain to a greater degree than 4-AP.
                              more...
                              https://medicalxpress.com/news/2018-...es-animal.html

                              Comment


                              • Originally posted by manouli View Post
                                chronic spinal cord injuries! Yahoo!


                                Possible new treatment for spinal cord injuries identified in animal studies
                                June 11, 2018 by Steve Tally, Purdue University



                                An experimental drug has shown promise as a potential therapy for spinal cord injuries in animal studies.
                                The compound, 4-aminopyridine-3-methanol, works in a similar way as a drug previously developed at Purdue, 4-aminopyridine (4-AP), which has been approved by the U.S. Food and Drug Administration to treat multiple sclerosis.
                                Dr. Riyi Shi, professor in the Department of Basic Medical Sciences, College of Veterinary Medicine and Weldon School of Biomedical Engineering, who was involved in the development of both drugs, compared the two compounds in both cell cultures and animal models.
                                "For the first time, 4-aminopyridine-3-methanol is shown to restore function in chronic spinal cord injuries," he says. "It also reduces neuropathic pain to a greater degree than 4-AP.
                                more...
                                https://medicalxpress.com/news/2018-...es-animal.html
                                Awesome news, I'll need to read more!

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