Announcement

Collapse
No announcement yet.

Spinal Cord Injury Articles Posted by Manouli

Collapse
This is a sticky topic.
X
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

    No One Wants To Hear It, But Geron Has A Stake In Spinal Cord Injury Again
    May. 9.17 | About: Geron Corporation (GERN)
    https://seekingalpha.com/author/zach...n-phd/articles https://seekingalpha.com/author/zach...n-phd/articles
    Zach Hartman, PhD
    Biotech, healthcare, Deep Value, contrarian
    (2,300 followers)
    Summary
    Geron's train is driven almost entirely by imetelstat, and most long-term shareholders seem to want to forget their past regenerative medicine follies.
    But development has continued by BioTime after it sold the assets, and Geron stands to benefit from the approval.
    Promising data from spinal cord injury should be a catalyst to consider that alternative sources of revenue may be possible in the future.
    There was a time when the fate of Geron Corporation (NASDAQ:GERN) rested entirely on its nascent regenerative medicine platform, which was supported by the first ever approval for a stem cell based clinical trial in the US in January 2009.
    read.....
    https://seekingalpha.com/article/407...al-cord-injury

    Comment


      Geron's stake hasn't changed. They'll get royalties of Asterias' stem cells work as they would've a month ago or a year ago. The only reason it's in the news is some recent pr from the Asterias trials which is tempered by reports (via participants on Facebook) that their increase from 10 million to 20 million cells hasn't resulted in any additional improvements.
      T3 complete since Sept 2015.

      Comment


        Improved blood flow can restore motor function after spinal cord injury, new research reveals
        Study overturns long-held belief that blood supply below injury site naturally returns to normal.
        By Laurie Wang on May 9, 2017

        A new discovery at the University of Alberta will fundamentally alter how spinal cord function and rehabilitation are viewed after spinal cord injuries.
        Neuroscientists found that spinal blood flow was unexpectedly restricted after a spinal cord injury, and that improving blood flow or simply inhaling more oxygen produces lasting improvements in cord oxygenation and motor functions.
        Previous work had shown that while blood flow was temporarily disrupted at the injury site, it resumed rapidly. It was more or less assumed that the blood flow was normal below the injury. This turns out to be wrong.
        “We’ve shown for the first time that a spinal cord injury leads to a chronic state of poor blood flow and lack of oxygen to neuronal networks in the spinal cord,” said co-principal investigator Karim Fouad, professor in the Faculty of Rehabilitation Medicine and Canada Research Chair for spinal cord injury.
        “By elevating oxygen in the spinal cord we can improve function and re-establish activity in different parts of the body.”
        more...

        https://www.ualberta.ca/news-and-eve...search-reveals

        Comment


          Robotics are helping paralyzed people walk again, but the price tag is huge

          Ashley Barnes was 35 years old when doctors told her she would never walk again.
          A botched spinal procedure in 2014 paralyzed her from the waist down. The Tyler, Tex., resident had been an avid runner, clocking six miles daily when not home with her then-9-year-old autistic son, whom she raised alone. Life in a wheelchair was not an option.
          “I needed to be the best mom I could be,” Barnes said. “I needed to be up and moving.”
          So she threw herself into physical therapy, convinced she would one day run again. Soon she realized that wasn’t a reality.
          Although she wore a brave face, “I would save my moments of crying for my room,” she said.
          more....
          http://www.denverpost.com/2017/06/10...zed-expensive/

          Comment


            Licensing agreements target spinal cord injury, cancer
            /footer/benefits?tsid=17
            (Ref: UT Health San Antonio)
            June 26th, 2017
            ⦁ UT Health San Antonio and UT Health Houston announced agreements June 23 to grant exclusive global licenses for two unique biologic therapeutics to AlaMab Therapeutics Inc., a subsidiary of CSPC Pharmaceutical Group Ltd. The biologics will be developed into novel, first-in-class therapies for spinal cord injury and breast cancer bone metastasis.

            read...
            https://www.firstwordpharma.com/node/1483435

            Comment


              New surgery may offer treatment for spinal injuries

              By: Emily Lunardo | General Health | Wednesday, August 02, 2017 - 05:30 AM

              The spinal cord makes up a key part of the body’s motor and nervous systems. It is what relays communications between neurons in our muscles and neurons in the brain, ultimately controlling muscle movements. It also delivers sensory information regarding pain, temperature, and touch between the brain and other body parts.

              This is why spinal cord injuries are so inhibiting. Where motor neurons connect with the spinal cord, they form what is known as the motor root (this is called the sensory root for sensory neurons), which is essentially a clump or knot of neurons surrounding the site of attachment. When traumatic injuries occur to the spine, these roots are often torn, causing the patient to lose neuron function in those areas. Scientists have spent years researching treatments for these injuries that may help patients recover some of the functions provided by the spinal cord.

              read...

              http://www.belmarrahealth.com/new-su...inal-injuries/

              Reply Reply to All Forward More

              Comment


                It’s Not a Rat’s Race for Human Stem Cells Grafted to Repair Spinal Cord Injuries
                Lengthy study finds that implanted neural stem cells grow slow and steady, and success needs to be measured accordingly
                August 28, 2017 | Scott LaFee

                ​More than one-and-a-half years after implantation, researchers at University of California San Diego School of Medicine and the San Diego Veterans Administration Medical Center report that human neural stem cells (NSCs) grafted into spinal cord injuries in laboratory rats displayed continued growth and maturity, with functional recovery beginning one year after grafting.
                The findings are published in the September issue of the Journal of Clinical Investigation .
                “The NSCs retained an intrinsic human rate of maturation despite being placed in a traumatic rodent environment,” said Paul Lu, PhD, associate professor of neurosciences and lead author of the study. “That’s a finding of great importance in planning for human clinical trials.”
                Neural stem cells differentiate into neurons and glia or support cells. Researchers like Lu and colleague, Mark Tuszynski, MD, PhD, professor of neuroscience and director of the UC San Diego Translational Neuroscience Institute, have explored their potential as a sort of patch and remedy for spinal cord injuries, implanting NSCs derived from induced pluripotent stem cells into animal models of spinal cord injuries to repair damage. In previously published animal studies, Lu and Tuszynski have shown NSCs can survive implantation and make new connections, even beginning to restore limited physical function, such as foot movement, that had been lost to paralyzing injury.

                more...
                https://health.ucsd.edu/news/release...-injuries.aspx

                Comment


                  spinal cord injury stem cell therapies, rat study suggests
                  August 29, 2017 / Todd Dubnicoff
                  2017 has been an exciting year for Asterias Biotherapeutics’ clinical trial which is testing a stem cell-based therapy for spinal cord injury. We’ve written several stories about patients who have made remarkable recoveries after participating in the trial (here and here).
                  But that doesn’t mean researchers at other companies or institutes who are also investigating spinal cord injury will be closing up shop. There’s still a long way to go with the Asterias trial and there’s still a lot to be learned about the cellular and molecular mechanisms of spinal cord injury repair, which could lead to alternative options for victims. Continued studies will also provide insights on optimizing the methods and data collection used in future clinical trials.

                  more...
                  https://blog.cirm.ca.gov/2017/08/29/...tudy-suggests/

                  Comment


                    Future of You
                    Spinal Patients Continue Remarkable Recovery After Stem Cell Injections, Company Says
                    By David Gorn
                    Future of You October 4, 2017
                    ⦁ Patients with spinal injuries have continued to heal long after they’ve received an initial injection of stem cells, ⦁ according to data released Oct. 2 by the biotech company conducting a clinical trial on the treatment.

                    read,,,

                    https://ww2.kqed.org/futureofyou/201...-company-says/


                    Regenerative Medicine Restores Movement After Paralysis

                    October 5, 2017
                    Twelve-month data from spinal cord injury trial shows two-thirds of subjects recovered two or more motor levels
                    /news/press-releases/regenerative-medicine-restores-movement-after-paralysis
                    This 67 percent recovery rate is more than double the rates of recovery seen in both matched historical controls and published data in a similar population. Each of the six participants in the study had lost all motor function below the location of the spinal injury.
                    They each received a surgical injection of 10 million of the cells being studied. Asterias Biotherapeutics, the biotechnology company that manufactures the cell therapy, reported the 12-month results of the study Oct. 2.
                    ‘Vastly better than anything we’ve ever seen before’

                    read....
                    https://www.rush.edu/news/press-rele...fter-paralysis
                    Last edited by manouli; 11 Oct 2017, 1:53 PM.

                    Comment


                      Leading Spinal Cord Injury Experts Join ReNetX Scientific Advisory Board
                      /footer/benefits?tsid=17
                      (Ref: GlobeNewswire)
                      October 10th, 2017
                      ⦁ NEW HAVEN, Conn., Oct. 10, 2017 (GLOBE NEWSWIRE) -- ⦁ ReNetX Bio, a company developing first-in-class therapeutics to treat injury to the central nervous system, is expanding its Scientific Advisory Board with key opinion leaders specializing in spinal cord injury. Andrew Blight, PhD, brings experience as the former Chief Scientific Officer of Acorda Therapeutics, Inc., where he helped move forward therapies for stroke and spinal cord injury (SCI) and ran two of the largest multicenter clinical trials in chronic SCI around the potassium channel blocker, 4-aminopyridine, which achieved FDA approval for the treatment of walking impairment in persons with multiple sclerosis. Blight also brings significant academic research experience, particularly surrounding the role of inflammation and demyelination in SCI, and held faculty roles at New York University Medical Center, Purdue University and the University of North Carolina where he was Professor and Director of the Neurosurgery Research Laboratory.
                      ⦁ "I have closely followed the developing science behind ReNetX and I am delighted to see this technology ready to be brought to the clinic for testing in people with spinal cord injury," Blight says.
                      read...
                      https://www.firstwordpharma.com/node/1512414?tsid=1

                      Comment


                        Leading Spinal Cord Injury Experts Join ReNetX Scientific Advisory Board


                        10/12/17

                        NEW HAVEN, Conn., Oct. 10, 2017 (GLOBE NEWSWIRE) -- ReNetX Bio, a company developing first-in-class therapeutics to treat injury to the central nervous system, is expanding its Scientific Advisory Board with key opinion leaders specializing in spinal cord injury. Andrew Blight, PhD, brings experience as the former Chief Scientific Officer of Acorda Therapeutics, Inc., where he helped move forward therapies for stroke and spinal cord injury (SCI) and ran two of the largest multicenter clinical trials in chronic SCI around the potassium channel blocker, 4-aminopyridine, which achieved FDA approval for the treatment of walking impairment in persons with multiple sclerosis. Blight also brings significant academic research experience, particularly surrounding the role of inflammation and demyelination in SCI, and held faculty roles at New York University Medical Center, Purdue University and the University of North Carolina where he was Professor and Director of the Neurosurgery Research Laboratory.


                        read...


                        http://boston.citybizlist.com/articl...advisory-board

                        Comment


                          New approach helps rodents with spinal cord injury breathe on their own
                          October 17, 2017
                          One of the most severe consequences of spinal cord injury in the neck is losing the ability to control the diaphragm and breathe on one's own. Now, investigators show for the first time in laboratory models that two different sets of neural signals control the movement of the diaphragm—one that originates in the brain and one that starts in the spinal cord. The researchers used a drug to turn on this alternative nerve pathway and restore breath-like movements in rodents. The study appears October 17 in Cell Reports.
                          "We realized that in order to further our research on how to direct nerve regeneration after spinal cord injury, we needed to first understand how this spinal activity arises," says first author Jared Cregg, a graduate student in neuroscience at Case Western Reserve University (CWRU) School of Medicine. "We took a basic approach to get at this question, which revealed the true nature of the mechanism."
                          Rhythms in the nervous system are controlled by neural networks within the brain called central pattern generators. For breathing, the central pattern generator is located in the medulla region at the base of the skull. When the connection between the brain and the nerves that control the diaphragm is interrupted due to injury, the ability to breathe is lost.
                          read...
                          https://medicalxpress.com/news/2017-...rd-injury.html

                          Comment


                            Science News
                            from research organizations

                            Discovery offers new hope to repair spinal cord injuries
                            Scientists produce a type of stem cell-derived neuron that could potentially help restore movement
                            Date:
                            April 24, 2017
                            Source:
                            Gladstone Institutes
                            Summary:
                            Scientists have created a special type of neuron from human stem cells that could potentially repair spinal cord injuries. These cells, called V2a interneurons, transmit signals in the spinal cord to help control movement. When the researchers transplanted the cells into mouse spinal cords, the interneurons sprouted and integrated with existing cells.
                            read...
                            https://www.sciencedaily.com/release...0424152544.htm

                            Comment


                              New surgical strategy offers hope for repairing spinal injuries
                              Date:
                              July 28, 2017
                              Source:
                              Frontiers
                              Summary:
                              Repairing spinal injuries is a difficult business. Scientists previously developed a new surgical technique to reconnect sensory neurons to the spinal cord after traumatic spinal injuries. Now, they have gained new insight into how the technique works at a cellular level by recreating it in rats. The technique succeeds because offshoots from the spinal cord grow into the implanted sensory neurons to complete a spinal circuit.

                              more...
                              https://www.sciencedaily.com/release...0728100837.htm

                              Comment


                                from research organizations

                                Introduction of a novel system for in vitro analyses of zebrafish oligodendrocyte progenitor cells
                                Date:
                                October 23, 2017
                                Source:
                                Technische Universit?t Dresden
                                Summary:
                                Spinal cord injuries result from a blunt or penetrating trauma. This is generally caused by accidents that occur during sport activities or when driving. Injuries of the spinal cord can lead to extreme pain (e.g. pressure in the head, neck or back), the loss of sensation (e.g. in fingers or feet), the loss of control over different parts of the body, an abnormal sense of balance and many other symptoms. According to the World Health Organization (WHO), as many as 500,000 people suffer from spinal cord injuries each year. Humans do not regain spinal cord function after injury. However, zebrafish have the remarkable ability to functionally recover from spinal cord injury. They repair injured connections, replace damaged motor neurons and oligodendrocytes, enabling them to regain full movement within six weeks after injury.
                                read...
                                https://www.sciencedaily.com/release...1023182602.htm

                                Comment

                                Working...
                                X