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Spinal Cord Injury Articles Posted by Manouli

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    May 16, 2016, 4:11 a.m. EDT
    Europe Spinal Cord Injury Market 2016 - Analysis & Trends - Research and Markets

    DUBLIN, May 16, 2016 (BUSINESS WIRE) -- Research and Markets has announced the addition of the "Europe Spinal Cord Injury Market and Competitive Landscape Highlights - 2016" report to their offering.
    The latest research report provides comprehensive insights into Spinal Cord Injury pipeline products, epidemiology, market valuations and forecast, products sales and competitive landscape.
    The research focuses on key countries such as Germany, France, Italy, Spain, and UK. This report is classified into nine sections - Spinal Cord Injury overview including etiology, pathophysiology, and diagnosis, treatment options, pipeline products, market analysis in Europe and by each country.
    Benefits of this Research:


      Improving cell transplantation after spinal cord injury: When, where and how?
      Spinal cord injuries are mostly caused by trauma, often incurred in road traffic or sporting incidents, often with devastating and irreversible consequences, and unfortunately having a relatively high prevalence. One currently explored approach to restoring function after spinal cord injury is the transplantation of olfactory ensheathing cells (OECs) into the damaged area. The hope is that these will encourage the repair of damaged neurons, but does it work? And if so, how can it be optimised?
      According to a systematic analysis of the literature published this week in PLOS Biology, after experimental spinal cord injury, transplanting OECs into the site of damage does indeed significantly improve locomotor performance. To reach this conclusion, Ralf Watzlawick, Jan Schwab, and their colleagues at the Ohio State University Wexner Medical Center, Charit? Universtaetsmedizin Berlin and the CAMARADES consortium (Collaborative Approach to Meta Analysis and Review of Animal Data from Experimental Studies), analysed 49 studies, published between 1949 and 2014, which included 62 experiments involving 1164 animals.


        Stem cells improve blood vessel function following spinal cord injury

        6 hours 30 minutes ago
        Durham, NC – A new study published in STEM CELLS Translational Medicine (SCTM) by Badner et al shows how a minimally invasive stem cell treatment in rats can reduce secondary damage in traumatic spinal cord injury (SCI). While similar studies have also demonstrated the promise of stem cells as a therapy for SCI, what makes this one different is the type of stem cell used. For the first time, researchers evaluated whether a brain-derived stromal cell would be better suited to target the acute phase of SCI than cells derived from other tissue sources. The answer was yes.
        SCI is a life-threatening condition with limited treatment options. It occurs in two phases. The primary phase takes place when the initial trauma causes mechanical injury to the spinal cord. The secondary injury comes in the hours after. As the body attempts to deal with what has happened, it releases a surge of chemicals causing inflammation, decreased spinal cord blood flow and cell death – which further exacerbates the injury. As the body cannot readily replace dying cells after spinal cord injury, neurological function becomes permanently impaired, resulting in in severe movement and sensory disabilities.


          Spinal cord impairment registry goes live
 Monday 1st August, 2016

          A national registry which goes live today will lead to better services and better care and support for people living with a spinal cord impairment, say Health Minister Jonathan Coleman and ACC Minister Nikki Kaye.
          "This registry will collect and record a wide range of information about people throughout their lifetime, from the moment they're affected by a spinal cord impairment," says Dr Coleman.
          "Information captured will include demographic information, details of the cause of impairment, and details of all subsequent support received, including medical, physical, psychological and social support.
          "The more information we capture, the better we can identify how people are progressing, and if they're receiving the right treatment and support. We can also shape services to better meet people's needs."
          The registry will be run out of Counties Manukau and Canterbury DHBs, where New Zealand's two adult specialist spinal centres are based.
          The New Zealand registry will be a satellite of the Rick Hansen Spinal Cord Injury Registry, developed in Canada.
          "There's a relatively small pool of people worldwide who are affected by spinal cord impairment, compared with other health conditions," says Dr Coleman.
          "By collaborating internationally, we can contribute to and draw on the expertise and insights being developed around the world to improve treatment and support."



            8 Paralyzed Patients Regain Movement, Feeling with VR
            By admin on August 11, 2016
            In a first-of-its-kind study, neuroscientists from Duke University report today that eight long-term paraplegics have regained feeling and some movement in their legs after training with a brain-controlled robotic device.
            The patients used what’s called a brain-machine interface, including a virtual reality system that used their own brain activity to help them recover sensation in their paralyzed limbs. It’s the first time that partial neurological recovery has been reported in patients with long-term paralysis, a result that surprised even the researchers.
            “We couldn’t have predicted this surprising clinical outcome when we began the project”, said Dr. Miguel Nicolelis, co-director of the Duke Center for Neuroengineering, as part of the Walk Again Project in Sao Paulo, Brazil.



              I live about 40 minutes from this place. I might go too.

              Progress in Motor Control XI


                Experimental stem cell therapy helps paralyzed man regain use of arms and hands

                The 21-year-old who suffered a cervical spine injury in March gains significant improvement in his motor function at Keck Hospital of USC
                BY Meg Aldrich September 8, 2016

                On March 6, just shy of his 21st birthday, Kristopher (Kris) Boesen of Bakersfield suffered a traumatic injury to his cervical spine when his car fishtailed on a wet road, hit a tree and slammed into a telephone pole.
                His parents were warned there was a good chance their son would be permanently paralyzed from the neck down. However, they also learned that he could possibly qualify for a clinical study that might help.
                Enter the Keck Medical Center of USC, which announced that a team of doctors became the first in California to inject its patient with an experimental treatment made from stem cells as part of a multi-center clinical trial.
                Charles Liu, director of the USC Neurorestoration Center, led the surgical team, working in collaboration with the Rancho Los Amigos National Rehabilitation Center and Keck Medicine of USC, that injected an experimental dose of 10 million AST-OPC1 cells directly into Boesen’s cervical spinal cord in early April.



                  That's sounds good!

                  Asterias Biotherapeutics Announces Positive Efficacy Data in Patients with Complete Cervical Spinal Cord Injuries

                  FREMONT, Calif., Sept. 14, 2016 /PRNewswire/ -- Asterias Biotherapeutics, Inc. (NYSE MKT: AST), today presented positive interim efficacy data from the 10 million cell cohort in the Company's ongoing AST-OPC1 SCiSTAR Phase 1/2a multicenter clinical study in complete cervical spinal cord injury patients. While early in the study, with only 4 of the 5 patients in the cohort having reached 90 days after dosing, all patients have shown at least one motor level of improvement so far and the efficacy target of 2 of 5 patients in the cohort achieving two motor levels of improvement on at least one side of their body has already been achieved. Patient improvements are being measured by the ISNCSCI neurological classification scale widely used to quantify functional status of patients with spinal cord injuries. As suggested by existing research, patients with complete cervical spinal cord injuries that show two motor levels of improvement on at least one side may regain the ability to perform daily activities such as feeding, dressing and bathing.
                  The efficacy target was recommended by the independent Spinal Cord Outcomes Partnership Endeavor (SCOPE) based on recently published data (Steeves et al., Topics in Spinal Cord Injury Rehabilitation, 2012). SCOPE is affiliated with the American Spinal Injury Association.


                  Last edited by manouli; 14 Sep 2016, 4:27 PM.


                    Human neurons used to help treat spinal injuries in mice shows positive results
                    By Luke Dormehl — September 26, 2016 3:09 PM

                    Spinal cord injuries can be profoundly life-altering for those who suffer them, but a significant advance may have been made by researchers at the University of California, San Francisco. As detailed in a new paper, published in the journal Cell Stem Cell, investigators were able to transplant human neurons into mice with spinal cord injuries — and found that the cells successfully wired up with the damaged spinal cord.
                    While the spinal cord was not repaired, the study did serve to improve the mice’s bladder control, while reducing pain — the former of which actually outranks walking as something many quadriplegics consider their highest priority for treatment, according to a 2004 study.

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                      InVivo adds Beth Israel, Canadian site to neuro-spinal scaffold trial

                      CAMBRIDGE, Mass. (Oct 20, 2016) – InVivo Therapeutics Holdings Corp. (NVIV) today announced that Beth Israel Deaconess Medical Center (BIDMC) in Boston, MA has been added as a clinical site for The INSPIRE Study: InVivo Study of Probable Benefit of the Neuro-Spinal Scaffold™ for Safety and Neurologic Recovery in Subjects with Complete Thoracic AIS A Spinal Cord Injury. A teaching hospital of Harvard Medical School, BIDMC consistently ranks as a national leader among independent hospitals in National Institutes of Health funding.


                        Asterias Biotherapeutics Announces Treatment of First Spinal Cord Injury Patient with Maximum Dose of AST-OPC1 in SCiStar Clinical Trial
                        November 8, 2016
                        -Complete cervical spinal cord injury patient (AIS-A) has for the first time received maximum 20 million cell dose of AST-OPC1-
                        -Enrollment and dosing of patients with incomplete cervical spinal cord injuries (AIS-B) continues; second AIS-B patient recently dosed with 10 million cells-
                        FREMONT, Calif. – Nov. 8, 2016 – Asterias Biotherapeutics, Inc. (NYSE MKT: AST), a biotechnology company pioneering the field of regenerative medicine, today announced that the first patient with complete (AIS-A) cervical spinal cord injury was successfully administered the highest dose of 20 million cells of AST-OPC1 (oligodendrocyte progenitor cells) in the SCiStar clinical trial at Santa Clara Valley Medical Center (SCVMC) in San Jose, CA. In addition, enrollment continues in the AIS-B 10 million cell cohort with a second patient now dosed.


                          Asterias Biotherapeutics Inc (AST) Stock Rips Higher
                          Published on November 14, 2016 at 9:35 am by Joshua Rodriguez in News,Stock Analysis
                          Asterias Biotherapeutics Inc (NYSEMKT:AST) is continuing to trade higher, tacking on an additional 22% gain to its share price on Friday, pushing its gains for the week to 40%.
                          AST is expected to release earnings this afternoon, however, investors appear to be looking past those numbers and are focused on the news that AST has treated its first patient in itsdose escalation SciStar clinical trial, treating patients with complete cervical spinal cord injury.


                            Chinese doctors fix animal spinal cord injuries
                            Updated 2016-11-25 16:32:19 Xinhua

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                            A team of Chinese doctors has claimed success in fixing spinal cord injuries in animals.
                            "We used polyethylene glycol (PEG) compounds to stimulate the injured nerve cells to regenerate. Previous tests on guinea pigs, rats and dogs showed positive results," said Ren Xiaoping, a research fellow with the 2nd Affiliated Hospital of Harbin Medical University in north China's Heilongjiang Province.


                              This is great news. What makes it better is it is even published in US journal.


                                Originally posted by scimike View Post
                                This is great news. What makes it better is it is even published in US journal.
                                Well, not really so much. To achieve a successful spinal cord anastomosis (an effective technique to assure rapid reinnervation of the body across a divided segment of the CNS) would be mostly impractical for the general population. People don't generally have a clean cut transected cord and a syringe full of PEG handy to immediately glue the cut back together.


                                Here's another recent thread where they were doing a fast glue on an animal cord transection.

                                Last edited by GRAMMY; 28 Nov 2016, 5:04 PM.